Mitochondria in cancer: not just innocent bystanders.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Seminars in Cancer Biology

• Publication date

  2009-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.semcancer.2008.11.008PMID 19101633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma.

  2008cited by this paper
• Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

  2008cited by this paper
• Tumor Cell Metabolism Imaging

  2008cited by this paper
• Tumor cell metabolism: cancer's Achilles' heel.

  2008cited by this paper
• The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.

  2008cited by this paper
• Mitochondria in cancer cells: what is so special about them?

  2008cited by this paper
• Hypoxia, HIF1 and glucose metabolism in the solid tumour

  2008cited by this paper
• Aerobic glycolysis in cancers: Implications for the usability of oxygen‐responsive genes and fluorodeoxyglucose‐PET as markers of tissue hypoxia

  2008cited by this paper
• Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice

  2008cited by this paper
• New insights into the mechanism of precursor protein insertion into the mitochondrial membranes.

  2008cited by this paper
• PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

  2008cited by this paper
• Cancer cell metabolism: Warburg and beyond.

  2008cited by this paper
• ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

  2008cited by this paper
• Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

  2008cited by this paper
• AKT/PKB signaling: navigating downstream.

  2007cited by this paper
• A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

  2007cited by this paper
• The maximum uptake of 18F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1α and GLUT-1 in non-small cell lung cancer

  2007cited by this paper
• The maximum uptake of (18)F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1alpha and GLUT-1 in non-small cell lung cancer.

  2007cited by this paper
• The magic garden.

  2007cited by this paper
• Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1

  2007cited by this paper
• Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors

  2007cited by this paper
• HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.

  2007cited by this paper
• Hypoxia and cancer

  2007cited by this paper
• Cell-Permeating α-Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells

  2007cited by this paper
• Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

  2007cited by this paper
• Oxygen, a source of life and stress

  2007cited by this paper
• Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis

  2007cited by this paper
• Energy metabolism in tumor cells

  2007cited by this paper
• Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

  2007cited by this paper
• Lack of correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in non-small cell lung cancer assessed by 18F-Fluoromisonidazole and 18F-FDG PET.

  2006cited by this paper
• Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.

  2006cited by this paper
• Mitochondrial DNA mutations in renal cell carcinomas revealed no general impact on energy metabolism

  2006cited by this paper
• Mitochondrial DNA mutations in human cancer

  2006cited by this paper
• Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III.

  2006cited by this paper
• TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

  2006cited by this paper
• Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer

  2006cited by this paper
• HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

  2006cited by this paper
• Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer

  2006cited by this paper
• Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells.

  2006cited by this paper
• HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

  2006cited by this paper
• p53 Regulates Mitochondrial Respiration

  2006cited by this paper
• A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.

  2005cited by this paper
• RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells

  2005cited by this paper
• RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells.

  2005cited by this paper
• Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions.

  2005cited by this paper
• Glycolytic enzymes can modulate cellular life span.

  2005cited by this paper
• Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

  2005cited by this paper
• A Critical Reassessment of the Role of Mitochondria in Tumorigenesis

  2005cited by this paper
• A practical guide to mitochondrial DNA error prevention in clinical, forensic, and population genetics.

  2005cited by this paper
• HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

  2005cited by this paper
• Dioxygenases as O2-dependent regulators of the hypoxic response pathway.

  2005cited by this paper
• Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

  2005cited by this paper
• Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.

  2005cited by this paper
• Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.

  2005cited by this paper
• Mitochondrial tumour suppressors: a genetic and biochemical update

  2005cited by this paper
• Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.

  2005cited by this paper
• ATP citrate lyase inhibition can suppress tumor cell growth.

  2005cited by this paper
• Signalling hypoxia by HIF hydroxylases.

  2005cited by this paper
• Akt-dependent transformation: there is more to growth than just surviving

  2005cited by this paper
• Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells

  2004cited by this paper
• The Warburg hypothesis fifty years later

  2004cited by this paper
• Keilin, Cytochrome, and the Respiratory Chain

  2003cited by this paper
• Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology.

  2003cited by this paper
• Modelling the molecular circuitry of cancer

  2002cited by this paper
• The bioenergetic signature of cancer: a marker of tumor progression.

  2002cited by this paper
• A Novel, Enzymatically Active Conformation of theEscherichia coli NADH:Ubiquinone Oxidoreductase (Complex I)*

  2002cited by this paper
• Mitochondrial defects in cancer

  2002cited by this paper
• Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

  2002cited by this paper
• Mitochondrial DNA in human malignancy.

  2001cited by this paper
• Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents.

  2001cited by this paper
• Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer.

  2001cited by this paper
• The promising role of 18F-FDG PET in detecting infected lower limb prosthesis implants.

  2001cited by this paper
• Hypoxia-Induced increase in FDG uptake in MCF7 cells.

  2001cited by this paper
• The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway.

  2001cited by this paper
• Positron-emission tomography with [18F]fluorodeoxyglucose

  2000cited by this paper
• Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma.

  2000cited by this paper
• Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells

  1999cited by this paper
• Myc target genes in neoplastic transformation.

  1997cited by this paper
• Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells*

  1997cited by this paper
• Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells.

  1996cited by this paper
• Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

  1994cited by this paper
• Glutamine and Cancer

  1993cited by this paper
• Glutamine and glucose as energy substrates for Ehrlich ascites tumour cells.

  1988cited by this paper
• The effects of pH and ionic strength on cytochrome c oxidase steady-state kinetics reveal a catalytic and a non-catalytic interaction domain for cytochrome c.

  1986cited by this paper
• Mechanism of oxidative phosphorylation.

  1977cited by this paper
• The Crabtree effect: a review.

  1961cited by this paper
• Mechanism of Oxidative Phosphorylation

  1958cited by this paper
• [Origin of cancer cells].

  1956cited by this paper
• On the origin of cancer cells.

  1956cited by this paper
• On respiratory impairment in cancer cells.

  1956cited by this paper
• On respiratory impairment in cancer cells.

  1956cited by this paper
• Oxidative metabolism of neoplastic tissues.

  1955cited by this paper
• Observations on the carbohydrate metabolism of tumours.

  year unknowncited by this paper

• The return of metabolism: biochemistry and physiology of glycolysis

  2025cites this paper
• Polyclonality and metabolic heterogeneity in a colorectal tumor model

  2025cites this paper
• Targeting Wnt-driven metabolic adaptations in cancer: integrating glycolysis, glutaminolysis, IDO1-mediated immune evasion, and therapeutic delivery strategies

  2025cites this paper
• Is malathion oncogenic for mosquitoes? A transcriptomic and histological study of adults derived from malathion exposed larvae.

  2025cites this paper
• Revisiting concepts of mitochondrial transport and energy metabolism in health and cancer

  2025cites this paper
• Tumor hypoxia and cancer stem cell markers expression in oral squamous cell carcinoma- An Immunohistochemical analysis.

  2025cites this paper
• Mitochondrial respiratory chain component NDUFA4: a promising therapeutic target for gastrointestinal cancer

  2024cites this paper
• Mitochondrial lipid metabolism in metastatic breast cancer

  2024cites this paper
• A Review of Advances in Mitochondrial Research in Cancer

  2024cites this paper
• MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism

  2023cites this paper
• Mitochondria in Health, Disease, and Ageing.

  2023cites this paper
• Potentially Lethal But Rarely Considered. Risk of Developing Refeeding Syndrome in Primary Oral Squamous Cell Carcinoma.

  2023cites this paper
• Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximise Healthspan

  2023cites this paper
• Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis

  2023cites this paper
• Physiology of PNS axons relies on glycolytic metabolism in myelinating Schwann cells

  2022cites this paper
• Studies on metabolic alterations due to hypobaric hypoxia in serum using NMR spectroscopy

  2022cites this paper
• New Insights Into the Molecular Underpinnings of LVNC.

  2022cites this paper
• Metabolic features of naïve and memory CD4+T cells in quiescence and during proliferation

  2022cites this paper
• Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway

  2022cites this paper
• Roles of mitochondrial genetics in cancer metastasis.

  2022cites this paper
• A Three-Dimensional Printed Inertial Microfluidic Platform for Isolation of Minute Quantities of Vital Mitochondria.

  2022cites this paper
• Mitochondrial and metabolic alterations in cancer cells.

  2022cites this paper
• Therapeutic Targeting Hypoxia-Inducible Factor (HIF-1) in Cancer: Cutting Gordian Knot of Cancer Cell Metabolism

  2022cites this paper
• Updates and Original Case Studies Focused on the NMR-Linked Metabolomics Analysis of Human Oral Fluids Part II: Applications to the Diagnosis and Prognostic Monitoring of Oral and Systemic Cancers

  2022cites this paper
• Biomarkers of mitochondrial origin: a futuristic cancer diagnostic.

  2022cites this paper
• Dissociation of a tripodal pyridyl-pyrazole ligand and assortment of metal complex: Synthesis, structure, DFT, thermal stability, cytotoxicity, DNA cleavage, and molecular docking studies

  2022cites this paper
• EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer

  2022cites this paper
• The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer.

  2021cites this paper
• Salivary metabolomics – A diagnostic and biologic signature for oral cancer

  2021cites this paper
• Rewiring of purine metabolism in response to acidosis stress in glioma stem cells

  2021cites this paper
• Blood–Brain Barrier, Cell Junctions, and Tumor Microenvironment in Brain Metastases, the Biological Prospects and Dilemma in Therapies

  2021cites this paper
• 4-Hydroxyphenylpyruvate Dioxygenase-Like Protein Promotes Pancreatic Cancer Cell Progression and Is Associated With Glutamine-Mediated Redox Balance

  2021cites this paper
• Recycling the Interspecific Relations with Epithelial Cells: Bacteria and Cancer Metabolic Symbiosis.

  2020cites this paper
• Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression

  2020cites this paper
• Evaluation of Tissue and Serum Expression Levels of Lactate Dehydrogenase Isoenzymes in Patients with Head and Neck Squamous Cell Carcinoma.

  2020cites this paper
• One Sentence Summary : Lactate-dependent axons rely on Warburg effect in Schwann cells

  2020cites this paper
• Aberrant Expression of Citrate Synthase is Linked to Disease Progression and Clinical Outcome in Prostate Cancer

  2020cites this paper
• Mitochondrial Bioenergetics at the Onset of Drug Resistance in Hematological Malignancies: An Overview

  2020cites this paper
• Physiology of PNS axons relies on glycolic metabolism in myelinating Schwann cells

  2020cites this paper
• Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration

  2020cites this paper
• Physiology and function of PNS axons rely on glycolic metabolism in myelinating Schwann cells.

  2020cites this paper
• Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

  2020cites this paper
• P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers

  2020cites this paper
• Title: Myelinating Schwann cells use Warburg effect to sustain axonal physiology and function One Sentence Summary: Lactate-dependent axons rely on cancer-like metabolism in myelinating Schwann cells

  2020cites this paper
• CMAR_A_255817 6149..6163

  2020cites this paper
• Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review

  2020cites this paper
• Characterization of Glycolysis-Associated Molecules in the Tumor Microenvironment Revealed by Pan-Cancer Tissues and Lung Cancer Single Cell Data

  2020cites this paper
• Persistent cell proliferation signals correlates with increased glycolysis in tumor hypoxia microenvironment across cancer types

  2020cites this paper
• Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy.

  2020cites this paper
• Theranostic Nanomedicine for Malignant Gliomas

  2019cites this paper
• Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy.

  2019cites this paper
• Risk factors and biomarkers for malignant mesothelioma

  2019cites this paper
• Targeted OMA1 therapies for cancer

  2019cites this paper
• Overexpression of Lactate Dehydrogenase in the Saliva and Tissues of Patients with Head and Neck Squamous Cell Carcinoma.

  2019cites this paper
• LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation.

  2019cites this paper
• Metabolic reprogramming in breast cancer results in distinct mitochondrial bioenergetics between luminal and basal subtypes

  2019cites this paper
• Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

  2019cites this paper
• Overcoming the Barrier of CD8+ T Cells: Two types of Nano-Sized Carriers for siRNA Transport.

  2019cites this paper
• Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells

  2019cites this paper
• Review: Warburg effect and renal cancer caused by errs in fumarate hydratase encoding gene.

  2019cites this paper
• Kobe University Repository : Kernel タイトル Tit le Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthrit is 著者

  2019cites this paper
• Survival of the fittest: Cancer challenges T cell metabolism.

  2018cites this paper
• Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response

  2018cites this paper
• Possible modifier genes in the variation of neurofibromatosis type 1 clinical phenotypes

  2018cites this paper
• Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses

  2018cites this paper
• The Influence of Metabolism on Drug Response in Cancer

  2018cites this paper
• Roles of the mitochondrial genetics in cancer metastasis: not to be ignored any longer

  2018cites this paper
• Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype

  2018cites this paper
• The splicing program of SRSF1 transcripts is finely tuned by cell metabolism

  2018cites this paper
• Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum

  2018cites this paper
• Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma.

  2018cites this paper
• Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect

  2018cites this paper
• Mitochondrial physiology within myelinated axons in health and disease : an energetic interplay between counterparts

  2018cites this paper
• The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis

  2018cites this paper
• Synthesis, structures, fluorescence studies and cytotoxicity of a new Manganese(II) complex

  2017cites this paper
• Mitochondrial uncoupling in cancer cells: Liabilities and opportunities.

  2017cites this paper
• Metabolic flux control of mitochondrial dynamics in cancer cells

  2017cites this paper
• Induction of differentiation and metabolic reprogramming in human hepatoma cells by adult human serum

  2017cites this paper
• Theories of Aging and Chronic Diseases: Chronic Inflammation an Interdependent ‘Roadmap’ to Age-Associated Illnesses

  2017cites this paper
• Survival of the fittest : Cancer challenges T 1 cell metabolism 2 3

  2017cites this paper
• Genetic alterations in Krebs cycle and its impact on cancer pathogenesis.

  2017cites this paper
• Andrographis paniculata Diterpenoids Protect against Radiation-Induced Transformation in BALB/3T3 Cells

  2017cites this paper
• Bioenergetics of Human Cancer Cells and Normal Cells During Proliferation and Differentiation

  2017cites this paper
• Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

  2017cites this paper
• Metabolism and neural differentiation in childhood neuroblastoma

  2017cites this paper
• New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.

  2017cites this paper
• PET Radiomics in NSCLC: state of the art and a proposal for harmonization of methodology

  2017cites this paper
• Expression and putative role of mitochondrial transport proteins in cancer.

  2017cites this paper
• Crystal structure, cytotoxicity and action mechanism of Zn(II)/Mn(II) complexes with isoquinoline ligands.

  2017cites this paper
• Alteration of cellular metabolism in cancer cells and its therapeutic prospects

  2017cites this paper
• Heterogeneity in Cancer Metabolism: New Concepts in an Old Field

  2017cites this paper
• The Emerging Facets of Non-Cancerous Warburg Effect

  2017cites this paper
• Mitochondrial mutations and metabolic adaptation in pancreatic cancer

  2017cites this paper
• Proton MR spectroscopic imaging of human glioblastomas at 1.5 Tesla.

  2017cites this paper
• Uterine Cervix Cancer Cells Re-Establish the Natural Lactate Rich Microenvironment, favoring Disease Progression

  2017cites this paper
• Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs

  2017cites this paper
• Regulation of glycolysis in head and neck squamous cell carcinoma.

  2017cites this paper
• Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis

  2017cites this paper
• Explorer Inborn and acquired metabolic defects in cancer

  2017cites this paper
• The Updated Role of Oxidative Stress in Subarachnoid Hemorrhage.

  2017cites this paper