Orphan G-Protein-Coupled Receptors

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Drugs in R&D

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2165/00126839-200708050-00003PMID 17767394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39.

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• Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.

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• Obestatin reduces food intake and suppresses body weight gain in rodents.

  2007cited by this paper
• Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"

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• Obestatin does not activate orphan G protein-coupled receptor GPR39.

  2006cited by this paper
• The hypothalamus and obesity.

  2006cited by this paper
• Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats

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• Orphan GPCRs and their ligands.

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• Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents.

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• Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake.

  2005cited by this paper
• Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake

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• GPCR deorphanizations: the novel, the known and the unexpected transmitters.

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• Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.

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• Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature.

  2004cited by this paper
• Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.

  2004cited by this paper
• Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein.

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• Novel analogs of ghrelin: physiological and clinical implications.

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• Orphan G protein‐coupled receptors: targets for new therapeutic interventions

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• Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity

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• Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer.

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• The identification of ligands at orphan G-protein coupled receptors.

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• Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

  2003cited by this paper
• Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity

  2003cited by this paper
• A role for neuropeptide W in the regulation of feeding behavior.

  2003cited by this paper
• Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation.

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• Antagonism of ghrelin receptor reduces food intake and body weight gain in mice

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• Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats.

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• Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype

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• Deletion of Ghrelin Impairs neither Growth nor Appetite

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• Identification of Natural Ligands for the Orphan G Protein-coupled Receptors GPR7 and GPR8*

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• Neuropeptide W-immunoreactivity in the hypothalamus and pituitary of the rat.

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• Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity.

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• Ghrelin gets hungry.

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• A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children.

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• Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule

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• Identification of Neuropeptide W as the Endogenous Ligand for Orphan G-protein-coupled Receptors GPR7 and GPR8*

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• Identification of a Neuropeptide Modified with Bromine as an Endogenous Ligand for GPR7*

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• T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.

  2002cited by this paper
• Orphan G protein-coupled receptors and beyond.

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• High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome.

  2002cited by this paper
• Ghrelin and the regulation of food intake and energy balance.

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• Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice.

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• Food fails to suppress ghrelin levels in obese humans.

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• Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.

  2002cited by this paper
• Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression.

  2002cited by this paper
• Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues.

  2001cited by this paper
• A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.

  2001cited by this paper
• Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.

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• Ghrelin causes hyperphagia and obesity in rats.

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• Cloning and molecular characterization of the novel human melanin-concentrating hormone receptor MCH2.

  2001cited by this paper
• Differential expression of orexin receptors 1 and 2 in the rat brain

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• Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats.

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• The Sequence of the Human Genome

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• RAPID COMMUNICATIONS: Mutations in the Preproghrelin/Ghrelin Gene Associated with Obesity in Humans

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• Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance.

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• Circulating ghrelin levels are decreased in human obesity.

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• Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans.

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• Energy expenditure by intracerebroventricular administration of orexin to anesthetized rats.

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• Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa.

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• Initial sequencing and analysis of the human genome

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• A role for ghrelin in the central regulation of feeding

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• Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.

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• Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain

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• Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors.

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• A G Protein-coupled Receptor for UDP-glucose*

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• Ghrelin induces adiposity in rodents

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• Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial.

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• Systemic Administration of Ghrelin Induces Fos and Egr‐1 Proteins in the Hypothalamic Arcuate Nucleus of Fasted and Fed Rats

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• A selective orexin-1 receptor antagonist reduces food consumption in male and female rats.

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• Intracerebroventricular Administration of Melanin‐Concentrating Hormone Suppresses Pulsatile Luteinizing Hormone Release in the Female Rat

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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
• Distribution of orexin receptor mRNA in the rat brain

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