Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Clinical Investigation

• Publication date

  2001-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI13296PMID 11560956PMCID PMC200936
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Generation and maintenance of memory T cells.

  2001cited by this paper
• Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

  2001cited by this paper
• Skewed maturation of memory HIV-specific CD8 T lymphocytes

  2001cited by this paper
• Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

  2001cited by this paper
• Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

  2001cited by this paper
• The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis.

  2000cited by this paper
• Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

  2000cited by this paper
• Control of homeostasis of CD8+ memory T cells by opposing cytokines.

  2000cited by this paper
• Differentiating between Memory and Effector Cd8 T Cells by Altered Expression of Cell Surface O-Glycans

  2000cited by this paper
• Naive, effector, and memory CD8 T cells in protection against pulmonary influenza virus infection: homing properties rather than initial frequencies are crucial.

  1999cited by this paper
• Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

  1999cited by this paper
• Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

  1999influential reference
• Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection

  1999cited by this paper
• The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens.

  1999cited by this paper
• Distinct migration patterns of naive and effector CD8 T cells in the spleen: correlation with CCR7 receptor expression and chemokine reactivity

  1999cited by this paper
• A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo.

  1999influential reference
• Linear differentiation of cytotoxic effectors into memory T lymphocytes.

  1999cited by this paper
• Death deflected: IL‐15 inhibits TNF‐α‐mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL‐15Rα chain

  1999cited by this paper
• Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.

  1999cited by this paper
• Mechanisms that regulate the function of the selectins and their ligands.

  1999influential reference
• Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

  1998cited by this paper
• DISTINCTIONS IN LYMPHOCYTE RESPONSES TO IL-2 AND IL-15 REFLECT DIFFERENTIAL LIGAND BINDING INTERACTIONS WITH THE IL-2Rβ CHAIN AND SUGGEST DIFFERENTIAL ROLES FOR THE IL-2Rα AND IL-15Rα SUBUNITS

  1998cited by this paper
• Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity.

  1998cited by this paper
• Therapy with monoclonal antibodies. II. The contribution of Fc gamma receptor binding and the influence of C(H)1 and C(H)3 domains on in vivo effector function.

  1998cited by this paper
• Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

  1998cited by this paper
• Massive expansion of antigen-specific CD8+ T cells during an acute virus infection.

  1998cited by this paper
• Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

  1998cited by this paper
• Distinctions in lymphocyte responses to IL-2 and IL-15 reflect differential ligand binding interactions with the IL-2Rbeta chain and suggest differential roles for the IL-2Ralpha and IL-15Ralpha subunits.

  1998cited by this paper
• Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.

  1998cited by this paper
• IL‐7 promotes the survival and maturation but not differentiation of human post‐thymic CD4+ T cells

  1998cited by this paper
• Interleukin-2, interleukin-15, and their receptors.

  1998cited by this paper
• A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro

  1997cited by this paper
• Interleukin-15 protects from lethal apoptosis in vivo

  1997cited by this paper
• Cytokines: shared receptors, distinct functions.

  1997cited by this paper
• Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7*

  1997cited by this paper
• Immunological memory.

  1997cited by this paper
• Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐xL) but not pro‐apoptotic (bax, bcl‐xS) gene expression

  1996cited by this paper
• Immunological Memory and Protective Immunity: Understanding Their Relation

  1996cited by this paper
• The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

  1996cited by this paper
• Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

  1995cited by this paper
• Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment.

  1995cited by this paper
• T and B memory cells.

  1994cited by this paper
• Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

  1991cited by this paper
• Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis.

  1991cited by this paper
• Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope.

  1990influential reference
• Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

  1989cited by this paper

• Phytochemical profiling of Syzygium nervosum fruit pulp extracts and their modulatory effects on oxidative stress and cytokine production

  2026cites this paper
• Intratumoural vaccination via checkpoint degradation-coupled antigen presentation

  2026cites this paper
• Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors

  2025cites this paper
• Elderly female CTLs maintain their initial activation and cytotoxicity independent of IL-2

  2025cites this paper
• Pyruvate–GPR31 axis induces LysoDC dendrite protrusion to M-cell pockets for effective immune responses

  2025cites this paper
• Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression.

  2025cites this paper
• Chromatin landscape alteration uncovers multiple transcriptional circuits during memory CD8+ T-cell differentiation

  2025cites this paper
• Single-cell profiling aligns CD56bright and cytomegalovirus-induced adaptive natural killer cells to a naïve-memory relationship

  2024cites this paper
• S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes

  2024cites this paper
• Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: Critical process parameters and analytical technologies.

  2024cites this paper
• A guide to adaptive immune memory

  2024cites this paper
• Electroacupuncture Ameliorates Knee Osteoarthritis By Rebalancing T Cell Homeostasis as Revealed By Immune Repertoire (IR) Sequencing

  2024cites this paper
• Next-generation adjuvant systems containing furfurman drives potent adaptive immunity and host defense as a foot-and-mouth disease vaccine adjuvant

  2024cites this paper
• Metabolic immunoengineering approaches to enhance CD8+ T cell-based cancer immunotherapy.

  2024cites this paper
• The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects.

  2024cites this paper
• Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells

  2024cites this paper
• Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation.

  2023cites this paper
• Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation

  2023cites this paper
• Differentiation of Memory CD8 T Cells Unravel Gene Expression Pattern Common to Effector and Memory Precursors

  2022influential citation
• Measuring glomerular blood transfer rate in kidney using diffusion‐weighted arterial spin labeling

  2022cites this paper
• Modulating Regulatory T Cells for Treatment of Glomerulonephritis and Acute Kidney Injury

  2022cites this paper
• FKBP4 correlates with CD8+ T cells and lymphatic metastases in oral squamous cell carcinoma.

  2022cites this paper
• A purine metabolic checkpoint that prevents autoimmunity and autoinflammation

  2022cites this paper
• Fc-comprising scDb-based trivalent, bispecific T-cell engagers for selective killing of HER3-expressing cancer cells independent of cytokine release

  2021cites this paper
• CXCL12-stimulated lymphocytes produce secondary stimulants that affect the surrounding cell chemotaxis

  2021cites this paper
• Protective effect of Urtica dioica in induced neurobehavioral changes, nephrotoxicity and hepatotoxicity after chronic exposure to potassium bromate in rats.

  2021cites this paper
• An engineered IL-2 partial agonist promotes CD8+ T cell stemness

  2021cites this paper
• Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

  2021cites this paper
• High-throughput and single-cell T cell receptor sequencing technologies

  2021cites this paper
• Characteristics of T‐cell responses in COVID‐19 patients with prolonged SARS‐CoV‐2 positivity – a cohort study

  2021cites this paper
• A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells

  2021cites this paper
• The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis

  2021cites this paper
• Dendritic cell ICAM-1 strengthens immune synapses but is dispensable for effector and memory responses

  2021cites this paper
• Heparan sulfate is essential for thymus growth

  2021cites this paper
• Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

  2020cites this paper
• Generation of high-affinity CMV-specific T cells for adoptive immunotherapy using IL-2, IL-15, and IL-21.

  2020cites this paper
• Foxo1 Serine 209 Is a Critical Regulatory Site of CD8 T Cell Differentiation and Survival.

  2020influential citation
• Reconstitution of T-cell-mediated immunity in patients after allogeneic stem cell transplantation

  2020cites this paper
• Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

  2020cites this paper
• Augmenting T-cell responses to tumors by in situ nanomanufacturing.

  2020cites this paper
• TCR Transgenic Mice: A Valuable Tool for Studying Viral Immunopathogenesis Mechanisms

  2020cites this paper
• The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome.

  2020cites this paper
• Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity

  2020influential citation
• Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection

  2020cites this paper
• 1-1-2010 Memory CD 8 + T Cell Differentiation

  2019cites this paper
• Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection

  2019cites this paper
• Structure-Guided T Cell Receptor Mutations that Alter Antigen Specificity, Cross-Reactivity, and Polyfunctional Phenotypes in Gene-Modified T Cells

  2019cites this paper
• RSV recombinant candidate vaccine G1F/M2 with CpG as an adjuvant prevents vaccine-associated lung inflammation, which may be associated with the appropriate types of immune memory in spleens and lungs

  2019cites this paper
• Effects of interleukin-2 in immunostimulation and immunosuppression

  2019cites this paper
• Gene expression profiles of CD4/CD8 double-positive T cells in porcine peripheral blood.

  2018cites this paper
• Molecular mechanisms regulating CD8+ T cell differentiation following external cues

  2018cites this paper
• Signaling and Function of Interleukin-2 in T Lymphocytes.

  2018cites this paper
• Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

  2018cites this paper
• Clonal expansion of vaccine-elicited T cells is independent of aerobic glycolysis

  2018cites this paper
• The Fate Choice Between Effector and Memory T Cell Lineages: Asymmetry, Signal Integration, and Feedback to Create Bistability.

  2018cites this paper
• Asymmetric Cell Division in the Generation of Immunity and Tolerance

  2018cites this paper
• Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation

  2018influential citation
• CX3CR1: Re-Defining Exhausted CD8+ T Cell Populations

  2017cites this paper
• Altered homeostasis and development of regulatory T cell subsets represent an IL-2R–dependent risk for diabetes in NOD mice

  2017cites this paper
• Intravital Microscopy Analysis of Hepatic T Cell Dynamics.

  2017cites this paper
• Spectrum of T‐lymphocyte activities regulating allergic lung inflammation

  2017cites this paper
• Effect of cytokines (IL-2, IL-7, and IL-15) having common γ-chain of receptors on differentiation and maturation of CD4+/CD8+ T-cells in a CD45RA T-lymphocyte population in vitro

  2017cites this paper
• Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology

  2017cites this paper
• Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma.

  2017cites this paper
• Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.

  2017cites this paper
• Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA-seq

  2017cites this paper
• Elucidating the role of T-box protein family members in influenza-specific T cell immunity

  2017cites this paper
• A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells

  2017cites this paper
• Proteasome regulates T lymphocyte metabolism and fate specification

  2017cites this paper
• M(IL-4) Tissue Macrophages Support Efficient Interferon-Gamma Production in Antigen-Specific CD8+ T Cells with Reduced Proliferative Capacity

  2017cites this paper
• Regulation of CD8+ T Lymphocyte Fate Specification by Proteasome Activity and Cellular Metabolism

  2017cites this paper
• Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans

  2017cites this paper
• Modeling the IL-2-Related Risk in Type One Diabetes by Selectively Lowering IL-2R Signaling in T Lymphocytes in NOD Mice

  2017cites this paper
• Lethal giant larvae‐1 deficiency enhances the CD8+ effector T‐cell response to antigen challenge in vivo

  2016cites this paper
• Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets

  2016cites this paper
• T Cell Memory to Viral Infections

  2016cites this paper
• The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation

  2016cites this paper
• The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis.

  2016cites this paper
• Memory T cells in organ transplantation: progress and challenges

  2016cites this paper
• Mechanisms of T cell organotropism

  2016cites this paper
• Current status and recent advances of next generation sequencing techniques in immunological repertoire

  2016cites this paper
• New immunomodulatory roles of lymphatic endothelium and implications for immunotherapy

  2016cites this paper
• Starved and Asphyxiated: How Can CD8+ T Cells within a Tumor Microenvironment Prevent Tumor Progression

  2016cites this paper
• Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma

  2016cites this paper
• Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells

  2016cites this paper
• Rôle de Dok-1 et Dok-2 lors du développement des cellules T CD8+ effectrices et mémoires

  2016cites this paper
• A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets

  2016cites this paper
• Altered hepatic mRNA expression of immune response‐associated DNA damage in mice liver induced by potassium bromate: Protective role of vanillin

  2016cites this paper
• The role of co-stimulatory receptors in the regulation of regulatory T cell migration

  2016cites this paper
• Immunosurveillance of the liver by intravascular effector CD8(+) T cells.

  2015cites this paper
• Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation

  2015cites this paper
• In vivo TCR Signaling in CD4+ T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity

  2015cites this paper
• Manipulation of effector and memory cd8+ T cells via IL-2-antibody complexes

  2015cites this paper
• Invariant Chain Linkage : Extending the Concept of monocytogenes Listeria Adenovirus-Based Vaccine against

  2015cites this paper
• Induction de réponses mémoires lymphocytaires T CD8 et protection vaccinale après transfert de gènes par le vecteur AAV recombinant

  2015cites this paper
• Targeting T cell metabolism for therapy.

  2015cites this paper
• Harnessing Stem Cell-Like Memory T Cells for Adoptive Cell Transfer Therapy of Cancer

  2015cites this paper
• 4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8+ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling

  2015cites this paper
• The role of donor-derived veto cells in nonmyeloablative haploidentical HSCT

  2015cites this paper
• The biology of CD4+ T cells in the blood and central nervous system

  2015cites this paper