Role of PTIP in Class Switch Recombination and Long-Range Chromatin Interactions at the Immunoglobulin Heavy Chain Locus

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecular and Cellular Biology

• Publication date

  2011-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00990-10PMID 21282469PMCID PMC3135287
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination

  2010cited by this paper
• Chromatin loops in gene regulation.

  2009cited by this paper
• Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways

  2009cited by this paper
• Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region

  2009cited by this paper
• Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II

  2009cited by this paper
• Control of histone methylation and genome stability by PTIP

  2009cited by this paper
• Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways

  2009cited by this paper
• Transcription factors mediate long-range enhancer–promoter interactions

  2009cited by this paper
• The Role of PTIP in Maintaining Embryonic Stem Cell Pluripotency

  2009cited by this paper
• Mechanism and regulation of class switch recombination.

  2008cited by this paper
• Perplexing Pax: From puzzle to paradigm

  2008cited by this paper
• Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation.

  2008cited by this paper
• Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.

  2007cited by this paper
• PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex*♦

  2007cited by this paper
• Evidence for Physical Interaction between the Immunoglobulin Heavy Chain Variable Region and the 3′ Regulatory Region*

  2007cited by this paper
• Pax5: the guardian of B cell identity and function

  2007cited by this paper
• The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

  2007cited by this paper
• S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.

  2007cited by this paper
• Transcriptional control thrown for a loop.

  2006cited by this paper
• A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

  2006cited by this paper
• A PANorama of PAX genes in cancer and development

  2006cited by this paper
• Knockdown of ALR (MLL2) Reveals ALR Target Genes and Leads to Alterations in Cell Adhesion and Growth

  2006cited by this paper
• The 3′ end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four γ genes

  2005cited by this paper
• BRCT Domain-Containing Protein PTIP Is Essential for Progression through Mitosis

  2003cited by this paper
• BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

  2003cited by this paper
• Reversion of B Cell Commitment upon Loss of Pax5 Expression

  2002cited by this paper
• Getting your Pax straight: Pax proteins in development and disease.

  2002cited by this paper
• Phosphorylation of Pax2 by the c-Jun N-terminal Kinase and Enhanced Pax2-dependent Transcription Activation*

  2002cited by this paper
• COMPASS: A complex of proteins associated with a trithorax-related SET domain protein

  2001cited by this paper
• Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene.

  2001cited by this paper
• Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination.

  2001cited by this paper
• Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.

  2001cited by this paper
• Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development.

  2000cited by this paper
• Ig heavy chain expression and class switching in vitro from an allele lacking the 3' enhancers DNase I-hypersensitive hs3A and hs1,2.

  1999cited by this paper
• Regulation of the germline immunoglobulin Cγ1 promoter by CD40 ligand and IL-4: dual role for tandemNF-κB binding sites

  1999cited by this paper
• Regulation of the germline immunoglobulin Cgamma1 promoter by CD40 ligand and IL-4: dual role for tandem NF-kappaB binding sites.

  1999cited by this paper
• STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination.

  1998cited by this paper
• B lymphocyte-specific, Cre-mediated mutagenesis in mice.

  1997cited by this paper
• Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter

  1996cited by this paper
• B cell lineage-specific activator protein (BSAP). A player at multiple stages of B cell development.

  1996cited by this paper
• Transcription complex stability and chromatin dynamics in vivo

  1995cited by this paper
• A class switch control region at the 3' end of the immunoglobulin heavy chain locus.

  1994influential reference
• Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP.

  1994cited by this paper

• Ptip and the Trr-COMPASS-like Complex Regulate Cardiac Progenitor Cell Division in the Drosophila Embryonic Heart Tube

  2025cites this paper
• PAX-Interacting Protein 1 (PTIP) Promotes Apoptosis

  2025cites this paper
• A Newly Characterized, Two BRCT Domain-Containing Isoform of PAX-Interacting Protein (PTIP) Generated via Frame Shift and Alternative Pre-mRNA Splicing

  2025cites this paper
• PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1

  2024cites this paper
• Unfolding the Symbiosis of AID, Chromatin Remodelers, and Epigenetics - The ACE Phenomenon of Antibody Diversity.

  2024cites this paper
• CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin

  2022cites this paper
• The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape

  2021cites this paper
• The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination

  2021cites this paper
• Genome Instability in Multiple Myeloma: Facts and Factors

  2021cites this paper
• Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation.

  2021cites this paper
• Long-Range Control of Class Switch Recombination by Transcriptional Regulatory Elements

  2021cites this paper
• Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2

  2021cites this paper
• KIAA1841, a novel SANT and BTB domain-containing protein, inhibits class switch recombination

  2020cites this paper
• Regeneration after acute kidney injury requires PTIP mediated epigenetic modifications.

  2020cites this paper
• KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies

  2020cites this paper
• Mechanism and regulation of class switch recombination by IgH transcriptional control elements.

  2020cites this paper
• Cis- and trans-factors affecting AID targeting and mutagenic outcomes in antibody diversification.

  2019cites this paper
• Are Pax proteins potential therapeutic targets in kidney disease and cancer?

  2018cites this paper
• Régulation de l'expression des immunoglobulines au cours du développement lymphocytaire B tardif

  2018cites this paper
• PAX5A and PAX5B isoforms are both efficient to drive B cell differentiation

  2018cites this paper
• Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin

  2018cites this paper
• Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination

  2017cites this paper
• PTIP chromatin regulator controls development and activation of B cell subsets to license humoral immunity in mice

  2017cites this paper
• A PTIP-PA 1 subcomplex promotes transcription for IgH class switching independently from the associated MLL 3 / MLL 4 methyltransferase complex

  2016cites this paper
• Evidence for a quadruplex structure in the polymorphic hs1.2 enhancer of the immunoglobulin heavy chain 3’ regulatory regions and its conservation in mammals

  2016cites this paper
• A PTIP–PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

  2016cites this paper
• Mild humoral immunodeficiency in a patient with X‐linked Kabuki syndrome

  2016cites this paper
• Epigenetics of Renal Development and Disease

  2016cites this paper
• Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome.

  2016cites this paper
• From the Cover: Sperm Molecular Biomarkers Are Sensitive Indicators of Testicular Injury following Subchronic Model Toxicant Exposure.

  2016cites this paper
• Epigenetic Role of PTIP in Mouse Spermatogenesis

  2015cites this paper
• Epigenetic Codes Programing Class Switch Recombination

  2015cites this paper
• Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms.

  2015cites this paper
• Epigenetics in kidney development and renal disease.

  2015cites this paper
• The Groucho-associated Phosphatase PPM1B Displaces Pax Transactivation Domain Interacting Protein (PTIP) to Switch the Transcription Factor Pax2 from a Transcriptional Activator to a Repressor*

  2015cites this paper
• Pax genes in renal development, disease and regeneration.

  2015cites this paper
• Chapter 2 – Gene Regulatory Networks

  2015cites this paper
• The Role of BRCT-Containing Proteins BRCA1 and PAXIP1 in Cancer

  2015cites this paper
• Characterizing the Role of the DNA Damage Response in Class switch recombination

  2014cites this paper
• IgH Chain Class Switch Recombination: Mechanism and Regulation

  2014cites this paper
• This information is current as Mechanism and Regulation IgH Chain Class Switch Recombination :

  2014cites this paper
• PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex.

  2014cites this paper
• Mechanism and Regulation IgH Chain Class Switch Recombination:

  2014cites this paper
• Mechanisms of gene activation and repression by Pax proteins in the developing kidney

  2014cites this paper
• Paired box 2 upregulates androgen receptor gene expression in androgen‐independent prostate cancer

  2014cites this paper
• Plant homeodomain finger protein 11 promotes class switch recombination to IgE in murine activated B cells

  2014cites this paper
• Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells

  2014cites this paper
• The molecular evolution of reproduction in animals: insights from sexual and asexual rotifers

  2013cites this paper
• Transcription et épissage des gènes d’immunoglobulines non-productifs : étude des mécanismes mis en jeu et de leur influence au cours du développement des lymphocytes B

  2013cites this paper
• On Identifying Signatures of Positive Selection in Human Populations: A Dissertation

  2013cites this paper
• 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

  2013influential citation
• Étude in vivo du rôle de la région régulatrice située en 3' du locus des chaines lourdes d'immunoglobulines dans la lymphopoïèse B

  2013cites this paper
• The Histone Methyltransferase MMSET Regulates Class Switch Recombination

  2013cites this paper
• The genetics and epigenetics of kidney development.

  2013cites this paper
• Comparative transcriptome analysis of obligately asexual and cyclically sexual rotifers reveals genes with putative functions in sexual reproduction, dormancy, and asexual egg production

  2013cites this paper
• The AID-induced DNA damage response in chromatin.

  2013cites this paper
• Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes.

  2013cites this paper
• Gene Regulatory Networks

  2012cites this paper
• Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography.

  2012cites this paper
• Mice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations.

  2012cites this paper
• Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination.

  2012cites this paper
• AID targeting is dependent on RNA polymerase II pausing.

  2012cites this paper
• The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.

  2012cites this paper
• Modulation of Developmentally Regulated Gene Expression Programs through Targeting of Polycomb and Trithorax Group Proteins

  2012cites this paper
• This information is current as Regulates Class Switch Recombination The Histone Methyltransferase MMSET

  2012cites this paper
• A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.

  2012cites this paper
• Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.

  2012cites this paper
• Three‐dimensional architecture of the IgH locus facilitates class switch recombination

  2012cites this paper
• Regulation of DNA Replication within the Immunoglobulin Heavy-Chain Locus During B Cell Commitment

  2012cites this paper
• Human-Specific Histone Methylation Signatures at Transcription Start Sites in Prefrontal Neurons

  2012cites this paper
• Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.

  2012cites this paper
• Dynamic Changes in Binding of Immunoglobulin Heavy Chain 3′ Regulatory Region to Protein Factors during Class Switching*

  2011cites this paper