Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Molecular and Cellular Biology

• Publication date

  1996-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.16.9.4591PMID 8756615PMCID PMC231458
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.

  1996cited by this paper
• IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination.

  1996cited by this paper
• Antibody class switching.

  1996cited by this paper
• Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis

  1995cited by this paper
• REL/NF-?B/I?B Story

  1995cited by this paper
• Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

  1995cited by this paper
• Rel/NF-kappa B/I kappa B story.

  1995cited by this paper
• Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

  1995cited by this paper
• Evidence for a CD40 response element, distinct from the IL-4 response element, in the germline epsilon promoter.

  1995cited by this paper
• Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis

  1995cited by this paper
• IL-4 plus CD40 monoclonal antibody induces human B cells gamma subclass-specific isotype switch: switching to gamma 1, gamma 3, and gamma 4, but not gamma 2.

  1995cited by this paper
• Activation of IL-2 receptor alpha-chain gene by individual members of the rel oncogene family in association with serum response factor.

  1995cited by this paper
• The non‐histone chromosomal protein HMG‐I(Y) contributes to repression of the immunoglobulin heavy chain germ‐line ε RNA promoter

  1995cited by this paper
• Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B.

  1995cited by this paper
• I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B.

  1995cited by this paper
• Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF- IL-4, a C/EBP family member and NF-kappa B/p50

  1995cited by this paper
• Switch transcripts in immunoglobulin class switching.

  1995cited by this paper
• Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A redefinition of the TI-2 vs T cell-dependent antigen dichotomy.

  1995cited by this paper
• Induction of the transcription factors NF-kappa B, AP-1 and NF-AT during B cell stimulation through the CD40 receptor.

  1995influential reference
• NF-kappa B and rel proteins in innate immunity.

  1995cited by this paper
• Mechanistic aspects of NF-kappa B regulation: the emerging role of phosphorylation and proteolysis.

  1995cited by this paper
• IL-4 activates a latent DNA-binding factor that binds a shared IFN-gamma and IL-4 response element present in the germ-line gamma 1 Ig promoter.

  1995cited by this paper
• Receptor-specific induction of individual AP-1 components in B lymphocytes.

  1995cited by this paper
• Induction of germ-line gamma 1 and epsilon Ig gene expression in murine B cells. IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals.

  1995cited by this paper
• Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

  1995cited by this paper
• Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses.

  1995cited by this paper
• Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family.

  1995cited by this paper
• Evidence for a CD40 response element, distinct from the IL-4 response element, in the germline ε promoter

  1995cited by this paper
• Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site.

  1994cited by this paper
• Suppression of polyclonal and antigen‐specific murine IgG1 but not IgE responses by neutralizing interleukin‐6 in vivo

  1994cited by this paper
• The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.

  1994cited by this paper
• Differential interactions of Rel‐NF‐kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF‐kappa B activity.

  1994cited by this paper
• An interleukin-4-induced transcription factor: IL-4 Stat.

  1994cited by this paper
• Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.

  1994cited by this paper
• B cells from CBA/N mice do not proliferate following ligation of CD40

  1994influential reference
• Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.

  1994cited by this paper
• The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line epsilon transcription.

  1994cited by this paper
• A proteasome inhibitor prevents activation of NF‐kappa B and stabilizes a newly phosphorylated form of I kappa B‐alpha that is still bound to NF‐kappa B.

  1994cited by this paper
• The CD40 antigen and its ligand.

  1994cited by this paper
• CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

  1994cited by this paper
• Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4.

  1994cited by this paper
• Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti‐mouse CD40 antibodies

  1994cited by this paper
• Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression

  1994cited by this paper
• Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

  1994cited by this paper
• Mice deficient for the CD40 ligand.

  1994cited by this paper
• S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

  1994cited by this paper
• Shutdown of class switch recombination by deletion of a switch region control element

  1993cited by this paper
• CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

  1993cited by this paper
• Allergy‐associated Iϵ and Fcϵ receptor II (CD23b) genes activated via binding of an interleukin‐4‐induced transcription factor to a novel responsive element

  1993cited by this paper
• The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.

  1993cited by this paper
• Allergy-associated I epsilon and Ec epsilon receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element.

  1993cited by this paper
• CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome

  1993cited by this paper
• Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements.

  1993cited by this paper
• T cell-dependent induction of NF-kappa B in B cells

  1993cited by this paper
• A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

  1993cited by this paper
• A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization

  1993cited by this paper
• Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

  1993cited by this paper
• Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.

  1993cited by this paper
• Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

  1993cited by this paper
• Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B.

  1993cited by this paper
• In vivo control of NF‐kappa B activation by I kappa B alpha.

  1993cited by this paper
• The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus.

  1993cited by this paper
• T cell-dependent B cell activation.

  1993cited by this paper
• Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation

  1993cited by this paper
• Regulation of expression of the ligand for CD40 on T helper lymphocytes.

  1993influential reference
• Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif

  1993cited by this paper
• Regulation of C gamma subclass germ-line transcripts in human peripheral blood B cells.

  1993cited by this paper
• Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

  1993cited by this paper
• Regulation of transcription of immunoglobulin germ‐line gamma 1 RNA: analysis of the promoter/enhancer.

  1992cited by this paper
• T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.

  1992cited by this paper
• Modulation of IL-4 induced germline ε RNA synthesis in human B cells by tumor necrosis factor-α, anti-CD40 monoclonal antibodies or transforming growth factor-β correlates with levels of IgE production

  1992cited by this paper
• Induction of IgG3 secretion by interferon gamma: a model for T cell- independent class switching in response to T cell-independent type 2 antigens

  1992cited by this paper
• A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

  1992cited by this paper
• Induction of IgG3 Secretion by Interferon A Model for T Cell-independent Class Switching in Response to T Cell-independent Type 2 Antigens By Clifford M. Snapper,* Tina M. Mclntyre,* Raya Mandler,*

  1992cited by this paper
• Activated human T cells express a ligand for the human B cell‐associated antigen CD40 which participates in T cell‐dependent activation of B lymphocytes

  1992cited by this paper
• Nuclear factor of activated T cells contains Fos and Jun

  1992cited by this paper
• Soluble forms of CD40 inhibit biologic responses of human B cells.

  1992cited by this paper
• Modulation of IL-4 induced germline epsilon RNA synthesis in human B cells by tumor necrosis factor-alpha, anti-CD40 monoclonal antibodies or transforming growth factor-beta correlates with levels of IgE production.

  1992cited by this paper
• Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements.

  1992cited by this paper
• RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B

  1992cited by this paper
• Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways.

  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• Generation and analysis of interleukin-4 deficient mice.

  1991cited by this paper
• IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL-4.

  1991cited by this paper
• Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts

  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• The v-rel oncogene encodes a kappa B enhancer binding protein that inhibits NF-kappa B function.

  1990cited by this paper
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  1990cited by this paper
• Association between IL-6 and CD40 signaling. IL-6 induces phosphorylation of CD40 receptors.

  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal.

  1990cited by this paper
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  1989cited by this paper

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