Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells

No abstract is available for this paper.

• Publication year

  1998

• Venue

  FEBS Letters

• Publication date

  1998-06-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0014-5793(98)00505-5PMID 9657375
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Overexpression of human mutT homologue gene messenger RNA in renal‐cell carcinoma: Evidence of persistent oxidative stress in cancer

  1996cited by this paper
• Mechanisms involved in the generation of free radicals.

  1996cited by this paper
• DNA damage in human respiratory tract epithelial cells: damage by gas phase cigarette smoke apparently involves attack by reactive nitrogen species in addition to oxygen radicals

  1995cited by this paper
• Persistent oxidative stress in cancer

  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer.

  1994cited by this paper
• Oxy-radicals and cancer.

  1994cited by this paper
• Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
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  1986cited by this paper
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  1986cited by this paper

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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007influential citation
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• Biological Significance of the Defense Mechanisms against Oxidative Damage in Nucleic Acids Caused by Reactive Oxygen Species: From Mitochondria to Nuclei

  2004cites this paper
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  2003cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2001cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper