Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of the National Cancer Institute

• Publication date

  2001-05-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/JNCI/93.9.691PMID 11333291PMCID PMC4374741
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998influential reference
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  1998influential reference
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  1997cited by this paper
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