Opposing Actions of Phosphatidylinositol 3‐Kinase and Glycogen Synthase Kinase‐3β in the Regulation of HSF‐1 Activity

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Neurochemistry

• Publication date

  2000-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1471-4159.2000.0752401.xPMID 11080191
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glycogen Synthase Kinase-3β Facilitates Staurosporine- and Heat Shock-induced Apoptosis

  2000cited by this paper
• Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium.

  2000cited by this paper
• Up‐Regulation of Protein Chaperones Preserves Viability of Cells Expressing Toxic Cu/Zn‐Superoxide Dismutase Mutants Associated with Amyotrophic Lateral Sclerosis

  1999cited by this paper
• Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals.

  1999cited by this paper
• Analysis of the Role of Heat Shock Protein (Hsp) Molecular Chaperones in Polyglutamine Disease

  1999cited by this paper
• Proteasome inhibition leads to the activation of all members of the heat shock factor family

  1999cited by this paper
• Cellular localization of the heat shock transcription factors HSF1 and HSF2 in the rat brain during postnatal development and following hyperthermia.

  1999cited by this paper
• Heat shock proteins as cellular lifeguards.

  1999cited by this paper
• The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2.

  1998cited by this paper
• Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.

  1998cited by this paper
• Molecular chaperones as HSF1-specific transcriptional repressors.

  1998influential reference
• Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1.

  1998cited by this paper
• Activation of the Heat Shock Factor 1 by Serine Protease Inhibitors

  1998cited by this paper
• Apoptosis, the heat shock response, hyperthermia, birth defects, disease and cancer. Where are the common links?

  1998cited by this paper
• Proteasome inhibition leads to the activation of all members of the heat-shock-factor family.

  1998cited by this paper
• Glycogen Synthase Kinase 3β and Extracellular Signal-Regulated Kinase Inactivate Heat Shock Transcription Factor 1 by Facilitating the Disappearance of Transcriptionally Active Granules after Heat Shock

  1998cited by this paper
• Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1

  1998cited by this paper
• Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

  1998cited by this paper
• Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway*

  1998cited by this paper
• Heat Shock Activates c-Src Tyrosine Kinases and Phosphatidylinositol 3-Kinase in NIH3T3 Fibroblasts*

  1997cited by this paper
• Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance*

  1997cited by this paper
• Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation

  1997cited by this paper
• The heat-shock transcription factor HSF1 is rapidly activated by either hyper- or hypo-osmotic stress in mammalian cells.

  1997cited by this paper
• Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.

  1997cited by this paper
• Hyperphosphorylation of Heat Shock Transcription Factor 1 Is Correlated with Transcriptional Competence and Slow Dissociation of Active Factor Trimers*

  1997cited by this paper
• Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins.

  1996cited by this paper
• Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1*

  1996cited by this paper
• Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin.

  1996cited by this paper
• Activation of Heat Shock Factor by Alkylating Agents Is Triggered by Glutathione Depletion and Oxidation of Protein Thiols (*)

  1996cited by this paper
• Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

  1996cited by this paper
• Wingless inactivates glycogen synthase kinase‐3 via an intracellular signalling pathway which involves a protein kinase C.

  1996cited by this paper
• A molecular mechanism for the effect of lithium on development.

  1996cited by this paper
• Repression of human heat shock factor 1 activity at control temperature by phosphorylation.

  1996cited by this paper
• Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock

  1996cited by this paper
• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

  1995cited by this paper
• A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function

  1995cited by this paper
• Multiple layers of regulation of human heat shock transcription factor 1

  1995cited by this paper
• Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1.

  1994cited by this paper
• Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress

  1993cited by this paper
• Activation of Heat Shock Gene Transcription by Heat Shock Factor 1 Involves Oligomerization, Acquisition of DNA-Binding Activity, and Nuclear Localization and Can Occur in the Absence of Stress

  1993cited by this paper
• Heat shock in cultured neurons and astrocytes: correlation of ultrastructure and heat shock protein synthesis

  1991cited by this paper
• 70‐Kilodalton Heat Shock Protein Induction in Cerebellar Astrocytes and Cerebellar Granule Cells In Vitro: Comparison with Immunocytochemical Localization After Hyperthermia In Vivo

  1990cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Elucidating the pivotal molecular mechanisms, therapeutic and neuroprotective effects of lithium in traumatic brain injury

  2024cites this paper
• Association between insulin and Nrf2 signalling pathway in Alzheimer's disease: A molecular landscape.

  2023cites this paper
• The Influence of Heat Stress on Chicken Immune System and Mitigation of Negative Impacts by Baicalin and Baicalein

  2023cites this paper
• Molecular chaperones in stroke-induced immunosuppression

  2023cites this paper
• Prediction of binding affinity of 1,2-diphenyline ketone analogues at adenosine triphosphate binding site of glycogen synthase kinase-3β: a molecular docking and dynamic simulation study

  2022cites this paper
• Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

  2021cites this paper
• Transthyretin as a Biomarker to Predict and Monitor Major Depressive Disorder Identified by Whole-Genome Transcriptomic Analysis in Mouse Models

  2021cites this paper
• AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation

  2020cites this paper
• Modulation of Heat-Shock Proteins Mediates Chicken Cell Survival against Thermal Stress

  2020cites this paper
• Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies.

  2019cites this paper
• Glycogen synthase kinase-3β may contribute to neuroprotective effects of Sargassum oligocystum against amyloid-beta in neuronal SH-SY5Y cells

  2019cites this paper
• Double Labeling and Simultaneous Monitoring for Hsp70 and Hsf-1 Kinetics in SCC-25 Cells with a Short-Term Dietary Restriction of Leucine Following Heat Shock

  2019cites this paper
• Heat acclimation increases inflammatory and apoptotic responses to subsequent LPS challenge in C2C12 myotubes

  2018cites this paper
• Diabetes mellitus and Alzheimer's disease: GSK‐3&bgr; as a potential link

  2018cites this paper
• Topiramate mitigates 3-nitropropionic acid-induced striatal neurotoxicity via modulation of AMPA receptors.

  2018cites this paper
• Lithium posttreatment confers neuroprotection through glycogen synthase kinase-3β inhibition in intracerebral hemorrhage rats.

  2017cites this paper
• Association between integrin-linked kinase and hyperthermia in oral squamous cell carcinoma

  2017cites this paper
• Rational combination of immunotherapy for triple negative breast cancer treatment.

  2017cites this paper
• Health Benefits of Fasting and Caloric Restriction

  2017cites this paper
• Sensing mechanisms and individuality of heat stress in mammalian cells

  2017cites this paper
• HEAT SHOCK PROTEINS: KNOWLEDGE SO FAR AND ITS FUTURE PROSPECTS

  2016cites this paper
• Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer

  2016cites this paper
• A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts

  2016cites this paper
• Experimental Brain Ischemic Preconditioning: A Concept to Putative Targets.

  2016cites this paper
• The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

  2016cites this paper
• Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

  2016cites this paper
• Human Umbilical Cord Blood Cells Induce Neuroprotective Change in Gene Expression Profile in Neurons after Ischemia through Activation of Akt Pathway

  2015cites this paper
• Quercetin: A Phytoestrogen Attenuate GSK-3β Inhibitors Induced Delayed Cardioprotection in Diabetic Rat Heart

  2015cites this paper
• Impact of DBP on histology and expression of HSP 70 in gill and liver tissue of Cyprinus carpio

  2015cites this paper
• shockand signaling pathways in survival of heat Invited Review: Interplay between molecular

  2015cites this paper
• 14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma

  2014cites this paper
• Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.

  2014cites this paper
• Chronic neuroprotective effects of low concentration lithium on SH-SY5Y cells: possible involvement of stress proteins and gene expression

  2014cites this paper
• HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

  2014cites this paper
• A randomized, phase 2 clinical trial of lithium carbonate in Machado‐Joseph disease

  2014cites this paper
• Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

  2013cites this paper
• Can Be Inhibited by Natural Adjuvant Activity Leads to Activated T Cell Death and β Unrestrained Glycogen Synthase Kinase-3

  2013cites this paper
• Sodium Valproate Alleviates Neurodegeneration in SCA3/MJD via Suppressing Apoptosis and Rescuing the Hypoacetylation Levels of Histone H3 and H4

  2013cites this paper
• Recherche des mécanismes impliqués dans les dérégulations de l'épissage alternatif à l'origine de la progéria et étude du rôle de l'étape d'épissage dans les changements globaux d'expression des gènes en réaction au choc thermique

  2013cites this paper
• The regulation and function of the heat shock response

  2013cites this paper
• Positive feedback regulation of heat shock protein 70 (Hsp70) is mediated through Toll-like receptor 4-PI3K/Akt-glycogen synthase kinase-3β pathway.

  2013cites this paper
• Glycogen Synthase Kinase 3 influences cell motility and chemotaxis by regulating phosphatidylinositol 3 kinase localization in Dictyostelium discoideum

  2013cites this paper
• Pharmacological inhibition of GSK-3β produces late phase of cardioprotection in hyperlipidemic rat: possible involvement of HSP 72

  2012cites this paper
• Lithium Ameliorates Neurodegeneration, Suppresses Neuroinflammation, and Improves Behavioral Performance in a Mouse Model of Traumatic Brain Injury

  2012cites this paper
• ��eptem�er� leads to a cascade of events that link the initiating stimuli to cellular death

  2012cites this paper
• The intersection between DNA damage response and cell death pathways.

  2012cites this paper
• Neuroprotection of early and short-time applying berberine in the acute phase of cerebral ischemia: up-regulated pAkt, pGSK and pCREB, down-regulated NF-κB expression, ameliorated BBB permeability.

  2012cites this paper
• Neuroprotective action of lithium in disorders of the central nervous system.

  2011influential citation
• Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression

  2011cites this paper
• The Role of Glutathione Metabolism in the Neuroprotective Effect of Mood Stabilizers

  2011influential citation
• L-DOPA neurotoxicity is prevented by neuroprotective effects of erythropoietin.

  2011cites this paper
• Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis

  2011cites this paper
• Mechanisms of lithium ’ s neuroprotective actions 2 . 1 Lithium as a multi-functional neuroprotectant

  2011influential citation
• Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle

  2011cites this paper
• Antioxidant and Anti-Inflammatory Effects of Exercise in Diabetic Patients

  2011cites this paper
• Role of membranes in mammalian stress response: sensing, lipid signals and adaptation

  2011cites this paper
• GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

  2011cites this paper
• Arsenite stabilizes HIF-1a protein through p85a-mediated up-regulation of inducible Hsp70 protein expression Wei GuoZhuo YangQing XiaJinyi LiuYonghui YuJingxia Li •

  2011cites this paper
• Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway

  2011cites this paper
• Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models

  2011cites this paper
• Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome

  2011cites this paper
• Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

  2010cites this paper
• Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders.

  2010cites this paper
• Essential Role of the Redox-Sensitive Kinase p66shc in Determining Energetic and Oxidative Status and Cell Fate in Neuronal Preconditioning

  2010cites this paper
• EssentialRoleoftheRedox-SensitiveKinasep66 shc in DeterminingEnergeticandOxidativeStatusandCell FateinNeuronalPreconditioning

  2010cites this paper
• NEUROPROTECTIVE EFFECTS OF POSTINJURY LITHIUM TREATMENT: DETERMINING THE OPTIMAL DOSING PARADIGM AND ASSESSING POTENTIAL MECHANISMS OF ACTION

  2010cites this paper
• L-DOPA-induced neurotoxicity is reduced by the activation of the PI3K signaling pathway.

  2009cites this paper
• GSK-3β, a Therapeutic Target for Cardiomyocyte Protection

  2009cites this paper
• Review of Lithium Effects on Brain and Blood

  2009cites this paper
• Valproic acid induces functional heat‐shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

  2009cites this paper
• Functional Consequences of Complete GSK-3 Ablation in Mouse Embryonic Fibroblasts

  2009cites this paper
• The role of RhoA interacting proteins in the Nogo signalling pathway of axon outgrowth inhibition

  2009cites this paper
• Role of glycogen synthase kinase-3 in l-DOPA-induced neurotoxicity

  2009influential citation
• Roleofglycogensynthase kinase-3inl -DOPA-induced neurotoxicity

  2009cites this paper
• The Role of Hsps in Neuronal Differentiation and Development

  2009cites this paper
• GSK-3beta, a therapeutic target for cardiomyocyte protection.

  2009cites this paper
• Inhibiting the transcription factor HSF1 as an anticancer strategy

  2009cites this paper
• Heat shock proteins in diabetes and wound healing.

  2009cites this paper
• Inhibiting the transcription factor HSF1 as an anticancer strategy.

  2009cites this paper
• Membranes: a meeting point for lipids, proteins and therapies

  2008cites this paper
• Inhibition of glycogen synthase kinase-3 reduces L-DOPA-induced neurotoxicity.

  2008cites this paper
• Rescuing cardiac malfunction: the roles of the chaperone-like small heat shock proteins.

  2008cites this paper
• Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity.

  2008cites this paper
• Nerve growth factor regulates the expression of the cholinergic locus and the high‐affinity choline transporter via the Akt/PKB signaling pathway

  2008cites this paper
• Epigallocatechin-3-Gallate Suppressed the Over-Expression of HSP 70 and MDR1 Induced by Heat Shock in SGC 7901

  2008cites this paper
• Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3.

  2008cites this paper
• Protective effects of olanzapine and haloperidol on serum withdrawal-induced apoptosis in SH-SY5Y cells.

  2008cites this paper
• Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stress Response in Motor Neurons

  2008cites this paper
• Transcriptomic and proteomic studies on longevity induced by over-expression of HSP22 in drosophila melanogaster

  2008cites this paper
• Inhibition of GSK-3β mediates expression of MMP-9 through ERK1/2 activation and translocation of NF-κB in rat primary astrocyte

  2007cites this paper
• Molecular aspects of the stress response : chaperones, membranes and networks

  2007cites this paper
• GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder.

  2007cites this paper
• Unrestrained Glycogen Synthase Kinase-3β Activity Leads to Activated T Cell Death and Can Be Inhibited by Natural Adjuvant1

  2007cites this paper
• Glycogen synthase kinase-3β activity plays very important roles in determining the fate of oxidative stress-inflicted neuronal cells

  2007cites this paper
• Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation.

  2007cites this paper
• Regulation of heat shock protein 70 release in astrocytes: Role of signaling kinases

  2007cites this paper
• Activation of PI3-K/Akt pathway for thermal preconditioning to protect cultured cerebellar granule neurons against low potassium-induced apoptosis

  2007cites this paper
• Manipulation of protein kinases reveals different mechanisms for upregulation of heat shock proteins in motor neurons and non-neuronal cells.

  2007cites this paper
• Modulatory interventions in post-natal hippocampal neurogenesis : structural and functional implications

  2007cites this paper
• Can the stress protein response be controlled by 'membrane-lipid therapy'?

  2007cites this paper