Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2008-03-14

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bbrc.2007.12.192PMID 18191635
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Peroxisome Proliferator–Activated Receptor-γ Regulates Expression of PDX-1 and NKX6.1 in INS-1 Cells

  2007cited by this paper
• Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells.

  2007cited by this paper
• The emerging role of FOXO transcription factors in pancreatic beta cells.

  2007cited by this paper
• Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide

  2006cited by this paper
• Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion.

  2005cited by this paper
• FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.

  2005cited by this paper
• Expression and functional activity of PPARγ in pancreatic β cells

  2004cited by this paper
• Convergence of Peroxisome Proliferator-activated Receptor γ and Foxo1 Signaling Pathways*

  2003cited by this paper
• Peroxisome Proliferator-Activated Receptor (PPAR)-α Activation Prevents Diabetes in OLETF Rats: Comparison With PPAR-γ Activation

  2003cited by this paper
• BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells.

  2003cited by this paper
• Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways.

  2003cited by this paper
• Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation.

  2003cited by this paper
• Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells.

  2002cited by this paper
• The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects.

  2002cited by this paper
• Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

  2002cited by this paper
• Insulin Gene Transcription Is Mediated by Interactions between the p300 Coactivator and PDX-1, BETA2, and E47

  2002cited by this paper
• Thiazolidinediones: metabolic actions in vitro

  2002cited by this paper
• The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

  2002cited by this paper
• Peroxisomal Proliferator-Activated Receptor-γ Upregulates Glucokinase Gene Expression in β-Cells

  2002cited by this paper
• Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance.

  2001cited by this paper
• Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats.

  2001cited by this paper
• The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

  2001cited by this paper
• Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter.

  2000cited by this paper
• The Homeodomain of PDX-1 Mediates Multiple Protein-Protein Interactions in the Formation of a Transcriptional Activation Complex on the Insulin Promoter

  2000cited by this paper
• PPARγ, the ultimate thrifty gene

  1999cited by this paper
• The NeuroD1/BETA2 Sequences Essential for Insulin Gene Transcription Colocalize with Those Necessary for Neurogenesis and p300/CREB Binding Protein Binding

  1999cited by this paper
• PPARgamma, the ultimate thrifty gene.

  1999cited by this paper
• Medical significance of peroxisome proliferator-activated receptors.

  1999cited by this paper
• Differential Regulation of the Glucagon and Insulin I Gene Promoters by the Basic Helix-Loop-Helix Transcription Factors E47 and BETA2*

  1998cited by this paper
• Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats*

  1998cited by this paper
• p300 Mediates Transcriptional Stimulation by the Basic Helix-Loop-Helix Activators of the Insulin Gene

  1998cited by this paper
• Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice.

  1997cited by this paper
• Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.

  1994cited by this paper
• Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle.

  1993cited by this paper
• Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins

  1991cited by this paper
• Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice.

  1991cited by this paper
• In vitro studies on the action of CS-045, a new antidiabetic agent.

  1990cited by this paper
• Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats

  1988cited by this paper
• Ciglitazone, a hypoglycemic agent: early effects on the pancreatic islets of ob/ob mice.

  1988cited by this paper

• PPAR-γ Activation Alleviates Intestinal Dysfunction and Lactose Malabsorption in Experimental Food Allergy Rats.

  2026cites this paper
• Therapeutic Targeting of PPARγ in Nonalcoholic Fatty Liver Disease: Efficacy, Safety, and Drug Development

  2025cites this paper
• A novel nonsense mutation c.747C>G in the NEUROD1 gene detected within a Chinese family affected by maturity‐onset diabetes of the young type 6

  2024cites this paper
• Potential Antidiabetic Activity of β-sitosterol from Zingiber roseum Rosc. via Modulation of Peroxisome Proliferator-activated Receptor Gamma (PPARγ).

  2024cites this paper
• GCK exonic mutations induce abnormal biochemical activities and result in GCK-MODY

  2023cites this paper
• PPARs at the crossroads of T cell differentiation and type 1 diabetes

  2023cites this paper
• Importance of Heparan Sulfate Proteoglycans in Pancreatic Islets and β-Cells

  2022cites this paper
• Thiazolidinediones (TZDs) enhance insulin secretory response via GPR40 and adenylate cyclase (AC)

  2021cites this paper
• Carnitine Orotate Complex Ameliorates Insulin Resistance and Hepatic Steatosis Through Carnitine Acetyltransferase Pathway

  2021cites this paper
• Rosiglitazone promotes glucose metabolism of GIFT tilapia based on the PI3K/Akt signaling pathway

  2021cites this paper
• PPARs and the Development of Type 1 Diabetes

  2020cites this paper
• Perfluorooctane sulfonate acute exposure stimulates insulin secretion via GPR40 pathway.

  2020cites this paper
• Neuropeptide Y – Its role in human performance and extreme environments

  2019cites this paper
• Pioglitazone Ameliorates Atorvastatin-Induced Islet Cell Dysfunction through Activation of FFA1 in INS-1 Cells

  2019influential citation
• The non-saponin fraction of Korean Red Ginseng (KGC05P0) decreases glucose uptake and transport in vitro and modulates glucose production via down-regulation of the PI3K/AKT pathway in vivo

  2019cites this paper
• PPAR-γ activation increases insulin secretion independent of CASK in INS-1 cells.

  2019cites this paper
• Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice.

  2018cites this paper
• Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells

  2016cites this paper
• G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ)

  2015cites this paper
• Association of PAX4 genetic variants with oral antidiabetic drugs efficacy in Chinese type 2 diabetes patients

  2014cites this paper
• Monascin and AITC attenuate methylglyoxal-induced PPARγ phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation.

  2013cites this paper
• Glitazones Exert Multiple Effects on β-Cell Stimulus-Secretion Coupling

  2013cites this paper
• Anti‐Hyperglycemic Effect of Fermented Ginseng in Type 2 Diabetes Mellitus Mouse Model

  2013cites this paper
• Melatonin-receptor-1-deficiency affects neurogenic differentiation factor immunoreaction in pancreatic islets and enteroendocrine cells of mice

  2013cites this paper
• Maturity onset diabetes of the young: identification and diagnosis

  2013cites this paper
• PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

  2013cites this paper
• PPARs: history and advances.

  2013cites this paper
• Effects of rosiglitazone pretreatment on blood glucose, lipid levels, urea, and microalbuminuria in rats undergoing 70% pancreatectomy

  2013cites this paper
• Beta cell viability and function in hypoxia: towards a clinically reflective model of beta cell transplantation

  2013cites this paper
• Tissue Distribution and Versatile Functions of PPARs

  2013cites this paper
• Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells.

  2013cites this paper
• Procyanidins modify insulinemia by affecting insulin production and degradation.

  2012cites this paper
• Glitazones exert multiple effects on beta-cell stimulus-secretion coupling

  2012cites this paper
• Biology and therapeutic applications of peroxisome proliferator- activated receptors.

  2012cites this paper
• Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats.

  2012cites this paper
• Genetically Programmed Defects in β-Cell Function

  2011cites this paper
• Protection of pancreatic beta cellsby rosiglitazone - mechanisms and pathways

  2011cites this paper
• Notch signaling: a novel regulating differentiation mechanism of human umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells in vitro.

  2010cites this paper
• Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update

  2010cites this paper
• Rosiglitazone improves pancreatic mitochondrial function in an animal model of dysglycemia: role of the insulin-like growth factor axis

  2010cites this paper
• Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids

  2010cites this paper
• The low dose combination of fenofibrate and rosiglitazone halts the progression of diabetes-induced experimental nephropathy.

  2010cites this paper
• Rosiglitazone protects the pancreatic beta-cell death induced by cyclosporine A.

  2009cites this paper
• Monogenic β-cell dysfunction in children: clinical phenotypes, genetic etiology and mutational pathways

  2008cites this paper