Differential induction of adrenomedullin, interleukins and tumour necrosis factor‐αby lipopolysaccharide in rat tissues in vivo

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Clinical and Experimental Pharmacology and Physiology

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1440-1681.2005.04307.xPMID 16445578
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Increased adrenomedullin expression in lungs in endotoxaemia.

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• Adrenomedullin and adrenomedullin binding protein-1 downregulate TNF-alpha in macrophage cell line and rat Kupffer cells.

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• Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice.

  2003cited by this paper
• Suppression of endotoxin-induced renal tumor necrosis factor-alpha and interleukin-6 mRNA by renin-angiotensin system inhibitors.

  2002cited by this paper
• The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).

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• Biosynthesis and secretion of adrenomedullin and proadrenomedullin N-terminal 20 peptide in a rat model of endotoxin shock.

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• Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide.

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• Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility.

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• Nitric oxide synthase inhibitor increases hepatic injury with formation of oxidative DNA damage and microcirculatory disturbance in endotoxemic rats.

  2000cited by this paper
• Mechanism of the beneficial effects of pentoxifylline during sepsis: maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokines.

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• Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature.

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• Expression and self-regulatory function of cardiac interleukin-6 during endotoxemia.

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• beta(2)-adrenoceptor agonist suppresses renal tumour necrosis factor and enhances interleukin-6 gene expression induced by endotoxin.

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• Peripheral distribution and gene expression of adrenomedullin in the rat: possible source of blood adrenomedullin.

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  1999cited by this paper
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• Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells.

  1995cited by this paper
• Mechanisms of adrenomedullin-induced vasodilation in the rat kidney.

  1995cited by this paper
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  1995cited by this paper
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  1993cited by this paper
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• Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide.

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  1990cited by this paper
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  1987cited by this paper

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