Stressors affect urocortin 1 and urocortin 2 gene expression in rat spleen: The role of glucocorticoids.

The mechanisms underlying stress-related modulation of immune function via urocortin 1 and urocortin 2 have been only vaguely described. Therefore, we investigated the effect of LPS injection or immobilization stress on gene expression of urocortin 1 and urocortin 2 in the rat spleen, along with the potential involvement of glucocorticoids. Our data showed: a) different regulation of urocortin 1 and urocortin 2 gene expression in the rat spleen under different stressful conditions (LPS vs. immobilization stress) and b) diverse effects of stress-induced adrenal glucocorticoids on this process. Our findings indicate a specific, rather than general regulation of splenic immune function by urocortins during stressful conditions.

• Publication year

  2019

• Venue

  Journal of Neuroimmunology

• Publication date

  2019-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jneuroim.2019.577030PMID 31473519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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