The role of the brain reward system in depression.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Progress in Neuro-psychopharmacology and Biological Psychiatry

• Publication date

  2001-05-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/S0278-5846(01)00156-7PMID 11383978
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acquisition of IV amphetamine and cocaine self-administration in rats as a function of dose

  2009cited by this paper
• Rate of increase of plasma drug level influences subjective response in humans

  2005cited by this paper
• Voltammetric evidence that subsensitivity to reward following chronic mild stress is associated with increased release of mesolimbic dopamine

  2005cited by this paper
• Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress

  2005cited by this paper
• Subjective and behavioral effects of diazepam depend on its rate of onset

  2005cited by this paper
• Discriminative stimulus effects ofd-amphetamine, methylphenidate, and diazepam in humans

  2005cited by this paper
• Separate mechanisms for behavioral, cardiovascular, and hormonal responses to dextroamphetamine in man

  2004cited by this paper
• Drug preference and mood in humans: Preference for d-amphetamine and subject characteristics

  2004cited by this paper
• The discriminative stimulus and subjective effects of d-amphetamine in humans

  2004cited by this paper
• Phenylpropanolamine: reinforcing and subjective effects in normal human volunteers

  2004cited by this paper
• Discriminative stimulus effects of caffeine and benzphetamine in amphetamine-trained volunteers

  2004cited by this paper
• The discriminative stimulus and subjective effects of d-amphetamine, phenmetrazine and fenfluramine in humans

  2004cited by this paper
• The orbitofrontal cortex: Neuronal activity in the behaving monkey

  2004cited by this paper
• Dual Effects of d-Amphetamine on Dopamine Neurons Mediated by Dopamine and Nondopamine Receptors

  2000cited by this paper
• Prolactin response to D-fenfluramine and suicidal behavior in depressed patients.

  2000cited by this paper
• Rewarding effects of opiates are absent in mice lacking the receptor for substance P

  2000cited by this paper
• Different mechanisms for dopaminergic excitation induced by opiates and cannabinoids in the rat midbrain.

  2000cited by this paper
• A behavioural model to reveal place preference to Δ9-tetrahydrocannabinol in mice

  2000cited by this paper
• Modulation of the discriminative stimulus effects of d-amphetamine by mu and kappa opioids in squirrel monkeys.

  2000cited by this paper
• Firing Rate of Nucleus Accumbens Neurons Is Dopamine-Dependent and Reflects the Timing of Cocaine-Seeking Behavior in Rats on a Progressive Ratio Schedule of Reinforcement

  2000cited by this paper
• The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans.

  2000cited by this paper
• Naltrexone Alters Subjective and Psychomotor Responses to Alcohol in Heavy Drinking Subjects

  2000cited by this paper
• Orbital and medial prefrontal cortex and psychostimulant abuse: studies in animal models.

  2000cited by this paper
• Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations.

  2000cited by this paper
• Intracranial self-stimulation and sucrose intake differ as hedonic measures following chronic mild stress: interstrain and interindividual differences.

  2000cited by this paper
• PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review

  2000cited by this paper
• Reward-related neuronal activity during go-nogo task performance in primate orbitofrontal cortex.

  2000cited by this paper
• Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism.

  2000cited by this paper
• Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder.

  2000cited by this paper
• Role of dopamine receptor subtypes in the acquisition of a testosterone conditioned place preference in rats.

  2000cited by this paper
• Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex.

  2000cited by this paper
• Evidence for a biochemical lesion in depression.

  2000cited by this paper
• NMDA, But Not Dopamine D2, Receptors in the Rat Nucleus Accumbens Are Involved in Guidance of Instrumental Behavior by Stimuli Predicting Reward Magnitude

  2000cited by this paper
• Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats

  2000cited by this paper
• Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments

  2000cited by this paper
• Role of dopamine in the behavioural actions of nicotine related to addiction.

  2000cited by this paper
• Activation of 5-HT2A/2C receptors within the nucleus accumbens increases local dopaminergic transmission.

  2000cited by this paper
• Delay activity of orbital and lateral prefrontal neurons of the monkey varying with different rewards.

  2000cited by this paper
• Dissociable Neural Responses in Human Reward Systems

  2000cited by this paper
• Intra-medial prefrontal cortex injections of scopolamine increase instrumental responses for cocaine: an intravenous self-administration study in rats.

  2000cited by this paper
• Amphetamine Blocks Long-Term Synaptic Depression in the Ventral Tegmental Area

  2000cited by this paper
• Evidence for a biochemical lesion in depression.

  2000cited by this paper
• Dopamine D3 receptor agents as potential new medications for drug addiction

  2000cited by this paper
• Pharmacological magnetic resonance imaging: a new application for functional MRI.

  2000cited by this paper
• Are all antidepressants the same?

  2000cited by this paper
• The role of stress in the pathophysiology of the dopaminergic system

  2000cited by this paper
• Antidepressant effects of ketamine in depressed patients.

  2000cited by this paper
• Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability.

  2000cited by this paper
• Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule.

  2000cited by this paper
• Reward processing in primate orbitofrontal cortex and basal ganglia.

  2000cited by this paper
• Effect of amphetamine on extracellular acetylcholine and monoamine levels in subterritories of the rat medial prefrontal cortex.

  2000cited by this paper
• Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.

  2000cited by this paper
• Increased cerebrospinal fluid glutamine levels in depressed patients.

  2000cited by this paper
• Role of dopamine in the behavioural actions of nicotine related to addiction.

  2000cited by this paper
• The dopaminergic hyper‐responsiveness of the shell of the nucleus accumbens is hormone‐dependent

  2000cited by this paper
• Age-related cognitive deficits mediated by changes in the striatal dopamine system.

  2000cited by this paper
• Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor.

  2000cited by this paper
• A Chronic Stress that Impairs Reactivity in Rats Also Decreases Dopaminergic Transmission in the Nucleus Accumbens: A Microdialysis Study

  1999cited by this paper
• Attenuation of some subjective effects of amphetamine following tyrosine depletion

  1999cited by this paper
• Subjective and physiological effects of intravenous nicotine and cocaine in cigarette smoking cocaine abusers.

  1999cited by this paper
• Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli

  1999cited by this paper
• Dopaminergic and opioidergic mediations of tricyclic antidepressants in the learned helplessness paradigm.

  1999cited by this paper
• Selective destruction of brain serotonin neurons by 5,7-dihydroxytryptamine increases responding for a conditioned reward

  1999cited by this paper
• Attenuation of the euphoric effects of cocaine by the dopamine D1/D5 antagonist ecopipam (SCH 39166)

  1999cited by this paper
• Mesolimbic Neuronal Activity across Behavioral States

  1999cited by this paper
• Modulation of feeding‐induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state

  1999cited by this paper
• Endomorphins: Novel Endogenous μ‐Opiate Receptor Agonists in Regions of High μ‐Opiate Receptor Density

  1999cited by this paper
• The Synaptic Framework for Chemical Signaling in Nucleus Accumbens

  1999cited by this paper
• Neo-striatal rCBF correlates of psychomotor slowing in patients with major depression.

  1999cited by this paper
• A role for AMPA/kainate receptors in conditioned place preference induced by diazepam in the rat.

  1999cited by this paper
• Regional brain metabolic activation during craving elicited by recall of previous drug experiences.

  1999cited by this paper
• Striatal dopamine transporter density in major depression

  1999cited by this paper
• Functional Magnetic Resonance Imaging of Brain Reward Circuitry in the Human

  1999cited by this paper
• Involvement of Acetylcholine in the Nucleus Accumbens in Cocaine Reinforcement

  1999cited by this paper
• Limbic activation during cue-induced cocaine craving.

  1999cited by this paper
• Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation

  1999cited by this paper
• Amphetamine Depresses Excitatory Synaptic Transmission via Serotonin Receptors in the Ventral Tegmental Area

  1999cited by this paper
• Covariation of activity in habenula and dorsal raphé nuclei following tryptophan depletion.

  1999cited by this paper
• Serotonin‐Mediated Increases in the Extracellular Levels of β‐Endorphin in the Arcuate Nucleus and Nucleus Accumbens : A Microdialysis Study

  1999cited by this paper
• Cocaine Is Self‐administered into the Shell Region of the Nucleus Accumbens in Wistar Rats

  1999cited by this paper
• Amphetamine Microinfusion in the Dorso‐Ventral Axis of the Prefrontal Cortex Differentially Modulates Dopamine Neurotransmission in the Shell‐Core Subterritories of the Nucleus Accumbens

  1999cited by this paper
• Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness.

  1999cited by this paper
• The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking.

  1999cited by this paper
• A dopamine D1 agonist elevates self-stimulation thresholds: comparison to other dopamine-selective drugs.

  1999cited by this paper
• [Anhedonia--a general nosology surmounting correlate of a dysfunctional dopaminergic reward system?].

  1999cited by this paper
• Alnespirone (S 20499), an agonist of 5-HT1A receptors, and imipramine have similar activity in a chronic mild stress model of depression.

  1999cited by this paper
• Nicotinic receptors in the brain: correlating physiology with function.

  1999cited by this paper
• Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography.

  1999cited by this paper
• Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans

  1999cited by this paper
• Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels.

  1999cited by this paper
• Regulation of Neurotransmitter Interactions in the Ventral Striatum

  1999cited by this paper
• Changes in pupil reaction to light in melancholic patients.

  1999cited by this paper
• Self-administration of intravenous amphetamine: effect of nucleus accumbens CCKB receptor activation on fixed-ratio responding

  1999cited by this paper
• Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.

  1999cited by this paper
• CART peptides: novel addiction- and feeding-related neuropeptides.

  1999cited by this paper
• Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion

  1999cited by this paper
• Naltrexone blockade of nicotine effects in cigarette smokers

  1999cited by this paper
• Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine.

  1999cited by this paper
• The rewarding properties of NMDA and MK-801 (dizocilpine) as indexed by the conditioned place preference paradigm.

  1999cited by this paper
• The effect of naloxone on adrenocorticotropin and cortisol release: evidence for a reduced response in depression.

  1999cited by this paper

• Career Effects of Mental Health: Evidence from an Innovation in Treating Bipolar Disorder

  2025cites this paper
• Imaging of brain electric field networks with spatially resolved EEG

  2025cites this paper
• Exploring risky decision-making dynamics during antidepressant treatment in major depressive disorder: a computational modeling approach

  2025cites this paper
• A Clinically Aligned Murine Model of Electroconvulsive Stimulation Reverses Social Aversion and Displays Fear Memory Impairment After Chronic Social Defeat Stress

  2025cites this paper
• The Role of Various Types of Diets in the Treatments of Depressive Disorders

  2025cites this paper
• Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile.

  2024cites this paper
• ERK2 Signaling in the Nucleus Accumbens Facilitates Stress Susceptibility and Cocaine Reinstatement

  2024cites this paper
• Imaging of brain electric field networks with spatially resolved EEG

  2024cites this paper
• Viral-mediated expression of Erk2 in the nucleus accumbens regulates responses to rewarding and aversive stimuli

  2023cites this paper
• Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence

  2023cites this paper
• Molecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen

  2022cites this paper
• Activation of Somatostatin-Expressing Neurons in the Lateral Septum Improves Stress-Induced Depressive-like Behaviors in Mice

  2022cites this paper
• The Effect of Depression on Motivation to Study

  2022cites this paper
• Smartphone-based ecological momentary assessment reveals mental health benefits of birdlife

  2022cites this paper
• The Functional Domain of Self-Other Regulation

  2021cites this paper
• Pharmacological Characterization of Toludesvenlafaxine as a Triple Reuptake Inhibitor

  2021cites this paper
• NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA

  2021cites this paper
• Shorter Duration and Lower Quality Sleep Have Widespread Detrimental Effects on Developing Functional Brain Networks in Early Adolescence

  2021cites this paper
• Convergence of clinically relevant manipulations on dopamine-regulated prefrontal activity underlying stress-coping responses

  2021cites this paper
• [Inclusion of gaming disorder as a behavioral addiction in ICD-11].

  2021cites this paper
• Fronto-limbic neuroimaging biomarkers for diagnosis and prediction of treatment responses in major depressive disorder.

  2020cites this paper
• The place of neuroscience in social rehabilitation pedagogy

  2020cites this paper
• Mapping social reward and punishment processing in the human brain: A voxel-based meta-analysis of neuroimaging findings using the Social Incentive Delay task

  2020cites this paper
• Depression and anxiety in recurrent giant cell tumor of bone

  2020cites this paper
• Differentiating the abnormalities of social and monetary reward processing associated with depressive symptoms

  2020cites this paper
• Retinoic Acid and Depressive Disorders: Evidence and Possible Neurobiological Mechanisms.

  2020cites this paper
• Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.

  2020cites this paper
• Miejsce neuronauki w pedagogice resocjalizacyjnej

  2020cites this paper
• Lithium treatment impacts nucleus accumbens shape in bipolar disorder

  2020cites this paper
• Bipolar Disorder: Diagnosis, Pathophysiology and Therapy

  2020cites this paper
• HOW CAN WE USE NEUROTRANSMITTERS IN EMOTION AND REWARD SYSTEM TO STUDY DEPRESSION?

  2019cites this paper
• The neural markers of MRI to differentiate depression and panic disorder

  2019cites this paper
• Manual or electroacupuncture as an add-on therapy to SSRIs for depression: A randomized controlled trial.

  2019influential citation
• Stress changes amphetamine response, D2 receptor expression and epigenetic regulation in low-anxiety rats.

  2019cites this paper
• Insensitivity to reward shifts in zebrafish (Danio rerio) and implications for assessing affective states

  2019cites this paper
• Role of endocannabinoid system in dopamine signalling within the reward circuits affected by chronic pain

  2019cites this paper
• Metabolic effects induced by chronic stress in the amygdala of diabetic rats: a study based on ex vivo 1H-NMR spectroscopy.

  2019cites this paper
• On the neurobiological redefinition of psychiatric symptoms: elimination, reduction, or what?

  2019cites this paper
• Antidepressant effects of ketamine on depression-related phenotypes and dopamine dysfunction in rodent models of stress.

  2019cites this paper
• Promising Neuroimaging Biomarkers in Depression

  2019cites this paper
• Major Depressive Disorder in Neuroimaging: What is Beyond Fronto-limbic Model?

  2019cites this paper
• Roles of β-adrenergic receptors on the mechanism of action of imipramine in chronic mild stress model of depression.

  2018cites this paper
• Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit

  2018cites this paper
• Agmatine modulates spontaneous activity in neurons of the rat medial habenular complex—a relevant mechanism in the pathophysiology and treatment of depression?

  2018cites this paper
• Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study

  2018cites this paper
• The regional homogeneity of cingulate-precuneus regions: The putative biomarker for depression and anxiety.

  2018cites this paper
• Adults with Autism and Adults with Depression Show Similar Attentional Biases to Social-Affective Images

  2018cites this paper
• The natural context of wellbeing: Ecological momentary assessment of the influence of nature and daylight on affect and stress for individuals with depression levels varying from none to clinical

  2018cites this paper
• Effect of traumatic brain injury on nicotine-induced modulation of dopamine release in the striatum and nucleus accumbens shell

  2018cites this paper
• Impact of frequency of internet use on development of brain structures and verbal intelligence: Longitudinal analyses

  2018cites this paper
• INVESTIGATING INDIVIDUAL PREFERENCES AND BRAIN ACTIVITY IN A WINE TASTING EXPERIENCE: A NEUROMARKETING APPROACH

  2018cites this paper
• Deep brain stimulation electrode insertion and depression: Patterns of activity and modulation by analgesics.

  2018cites this paper
• Triple reuptake inhibitors (TRIs): do they promise us a rose garden?

  2018cites this paper
• Stably maintained microtubules protect dopamine neurons and alleviate depression-like behavior after intracerebral hemorrhage

  2018cites this paper
• Moving Forward with the BAS: Towards a Neurobiology of Multidimensional Model of Approach Motivation

  2017cites this paper
• Low-anxiety rats are more sensitive to amphetamine in comparison to high-anxiety rats

  2017cites this paper
• Real-Life Validation of Reduced Reward Processing in Emerging Adults With Depressive Symptoms

  2017cites this paper
• Cannabis exacerbates depressive symptoms in rat model induced by reserpine

  2017cites this paper
• Acupuncture treatment modulates the corticostriatal reward circuitry in major depressive disorder.

  2017cites this paper
• Advances in Neurobiology

  2017cites this paper
• Cognitive bias as an indicator of emotional state and welfare in captive zebrafish

  2017cites this paper
• Towards a Better Understanding of Consumer Behaviour: Marginal Utility as a Parameter in Neuromarketing Research

  2017cites this paper
• FIELD OF THE INVENTION

  2017cites this paper
• Neural mechanisms of reinforcement learning in unmedicated patients with major depressive disorder

  2017cites this paper
• Methylphenidate modifies the motion of the circadian clock Lamotrigine in mood disorders and cocaine dependence Cortical glutamate in postpartum depression Dopamine Transporter and Reward Anticipation in a Dimensional Perspective : A Multimodal Brain Imaging Study

  2017cites this paper
• The biology of addiction

  2017cites this paper
• Methylene blue and its analogues as antidepressant compounds

  2017cites this paper
• Abnormal Expression of MicroRNAs Induced by Chronic Unpredictable Mild Stress in Rat Hippocampal Tissues

  2017cites this paper
• Approach motivation, goal pursuit, and reward-related neural responses : a combined experience-sampling and fMRI approach

  2017cites this paper
• Risk of mortality during and after the 2011 Great East Japan Earthquake and Tsunami among older coastal residents

  2017cites this paper
• Planning to make economic decisions in the future, but choosing impulsively now: are preference reversals related to symptoms of ADHD and depression?

  2016cites this paper
• Vitamin D and Autism Spectrum Disorder: A Literature Review

  2016cites this paper
• NEURAL REACTIVITY TO REWARD AS A PREDICTOR OF COGNITIVE BEHAVIORAL THERAPY RESPONSE IN ANXIETY AND DEPRESSION

  2016cites this paper
• Traditional and Novel Possible Targets for Antidepressant Drugs

  2016cites this paper
• Enhanced default mode network connectivity with ventral striatum in subthreshold depression individuals.

  2016cites this paper
• The Comparative Effectiveness of EEG Biomarkers in Antidepressant Response and Illness Prediction in Major Depressive Disorder

  2016cites this paper
• Predictive factors for general health status in Iranian high school students an unvariate and multivariate logistic regression analysis

  2015cites this paper
• Opposing Effects of Acute Stress in a Rodent Model of Gambling Behaviour

  2015influential citation
• The gray matter alterations in major depressive disorder and panic disorder: Putative differences in the pathogenesis.

  2015cites this paper
• The role of the VTA NMDA receptors, VTA DA cells and the VTA terminal regions in reward-related learning

  2015cites this paper
• Morphine effects on monetary reward: An fMRI pilot study

  2015cites this paper
• The Time Course of a Perceptual Decision: Linking Neural Correlates of Pre-stimulus Brain State, Decision Formation and Response Evaluation

  2015cites this paper
• Efectos de la intervención desde terapia ocupacional sobre la percepción del dolor crónico y la calidad de vida en pacientes con artritis reumatoide

  2015cites this paper
• Reinforcement learning in depression: A review of computational research.

  2015cites this paper
• A self-medication hypothesis for increased vulnerability to drug abuse in prenatally restraint stressed rats.

  2015cites this paper
• Examining reward-seeking, negative self-beliefs and over-general autobiographical memory as mechanisms of change in classroom prevention programs for adolescent depression

  2015cites this paper
• Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities

  2015cites this paper
• The Role of Lead and Cadmium in Psychiatry

  2014cites this paper
• Anti-anhedonic effect of deep brain stimulation of the prefrontal cortex and the dopaminergic reward system in a genetic rat model of depression: an intracranial self-stimulation paradigm study.

  2014cites this paper
• Nanomedicine: Principles and Perspectives

  2014cites this paper
• An intricate relationship between pain and depression: clinical correlates, coactivation factors and therapeutic targets

  2014cites this paper
• Reward Reactivity and Impulsivity

  2014cites this paper
• Neural reactivity to rewards and losses in offspring of mothers and fathers with histories of depressive and anxiety disorders.

  2014cites this paper
• Effects of psychotropic drugs on second messenger signaling and preference for nicotine in juvenile male mice

  2014cites this paper
• The ups and downs of modelling mood disorders in rodents.

  2014cites this paper
• Neural response to emotional stimuli associated with successful antidepressant treatment and behavioral activation.

  2013cites this paper
• Clinical correlates of nucleus accumbens volume in drug-naïve, adult patients with obsessive–compulsive disorder

  2013cites this paper
• Validation of an ELISA for urinary dopamine: applications in monitoring treatment of dopamine‐related disorders

  2013cites this paper
• Moderate exercise as an adjuvant therapy for treatment-resistant major depressive disorder : 6-month follow-up

  2013cites this paper
• Differential effects of nomifensine and imipramine on motivated behavior in the runway model of intracranial self-stimulation.

  2013cites this paper