Cognitive function in young and adult IL (interleukin)-6 deficient mice.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Behavioural Brain Research

• Publication date

  2004-08-31

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/J.BBR.2003.12.018PMID 15265638
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in mice.

  2003cited by this paper
• Involvement of μ1-opioid receptors and cholinergic neurotransmission in the endomorphins-induced impairment of passive avoidance learning in mice

  2002cited by this paper
• Changes in expressions of proinflammatory cytokines IL-1beta, TNF-alpha and IL-6 in the brain of senescence accelerated mouse (SAM) P8.

  2000cited by this paper
• Effects of Intrahippocampal Infusion of lnterleukin-6 on Passive Avoidance and Nitrite and Prostaglandin Levels in the Hippocampus in Rats

  2000cited by this paper
• Effects of endomorphins-1 and -2, endogenous mu-opioid receptor agonists, on spontaneous alternation performance in mice.

  2000cited by this paper
• Lack of interleukin-6 expression is not protective against focal central nervous system ischemia.

  2000cited by this paper
• Presence of a reduced opioid response in interleukin‐6 knock out mice

  1999cited by this paper
• IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6.

  1998cited by this paper
• Cytokines and cognitive function in mice.

  1998cited by this paper
• Cytokines and Cognitive Function in Mice

  1998cited by this paper
• Chronic Interleukin-6 Alters NMDA Receptor-Mediated Membrane Responses and Enhances Neurotoxicity in Developing CNS Neurons

  1998cited by this paper
• Cerebral Interleukin-6 is Neuroprotective during Permanent Focal Cerebral Ischemia in the Rat

  1998cited by this paper
• Behavioural characterization of interleukin‐6 overexpressing or deficient mice during agonistic encounters

  1998cited by this paper
• Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain.

  1997influential reference
• Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice.

  1997cited by this paper
• Interleukin‐6 affects scopolamine‐induced amnesia, but not brain amino acid levels in mice

  1997cited by this paper
• Immune-neuro-endocrine interactions: facts and hypotheses.

  1996cited by this paper
• Oxotremorine infusions into the medial septal area of middle-aged rats affect spatial reference memory and ChAT activity.

  1996cited by this paper
• Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils.

  1996cited by this paper
• The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease.

  1996cited by this paper
• Alpha‐phenyl-tert‐butyl-nitrone (PBN) reverses age‐related maze learning performance and motor activity deficits in C57 BL/6 mice

  1996cited by this paper
• Animal models in cognitive behavioural pharmacology: an overview.

  1996cited by this paper
• Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6.

  1995cited by this paper
• Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.

  1994cited by this paper
• Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development.

  1994cited by this paper
• Dynorphin A-(1-13) potently improves the impairment of spontaneous alternation performance induced by the mu-selective opioid receptor agonist DAMGO in mice.

  1994cited by this paper
• Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6.

  1994cited by this paper
• Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival

  1994cited by this paper
• Decrease of hippocampal choline acetyltransferase activity induced by formalin pain.

  1993cited by this paper
• Interleukin-2 enhances scopolamine-induced amnesia and hyperactivity in the mouse.

  1993cited by this paper
• Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats.

  1993cited by this paper
• Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

  1993cited by this paper
• Interleukin-6 and its receptor: a paradigm for cytokines.

  1992cited by this paper
• Effect of centrally administered atropine and pirenzepine on radial arm maze performance in the rat.

  1991cited by this paper
• Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.

  1991cited by this paper
• Interleukin-6: an overview.

  1990cited by this paper
• Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid.

  1989cited by this paper
• Animal models of Alzheimer's disease: experimental cholinergic denervation.

  1988cited by this paper
• Use of the radial maze in studies of phencyclidine and other drugs of abuse.

  1987cited by this paper
• Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

  1986cited by this paper
• Preserved spatial memory in old rats survives 10 months without training.

  1986cited by this paper
• Radial maze performance in young and aged mice: neurochemical correlates.

  1985cited by this paper
• Radial maze performance in three strains of mice: role of the fimbria/fornix.

  1983cited by this paper
• Spatial memory and hippocampal function.

  1979cited by this paper
• A radiochemical method for the estimation of choline acetyltransferase.

  1966cited by this paper

• Low-dose combination of ultramicronized palmitoylethanolamide and docosahexaenoic acid on neurosteroid and neuroinflammatory dysregulation in autism spectrum disorders.

  2025cites this paper
• Controversies and insights into cytokine regulation of neurogenesis and behavior in adult rodents

  2025cites this paper
• Effect of Interleukin-6 on Long-Term Potentiation Induction and Development in Rat Hippocampal Slices

  2025cites this paper
• PHYSIOLOGICAL FRACTURE HEALING IS UNAFFECTED BY NEUTROPHIL-DERIVED IL-6 OR IL-6R SIGNALING IN MICE

  2025cites this paper
• The fate of neuronal synapse homeostasis in aging, infection, and inflammation.

  2024cites this paper
• Decoding Paradoxical Links of Cytokine Markers in Cognition: Cross talk between Physiology, Inflammaging, and Alzheimer's Disease- Related Cognitive Decline.

  2024cites this paper
• Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation

  2024cites this paper
• Inflammation at diagnosis and cognitive impairment two years later in breast cancer patients from the Canto-Cog study

  2024cites this paper
• Efecto del estímulo masticatorio y estrés agudo sobre la interleuquina 6, la memoria y el aprendizaje espacial en ratones Balb/c

  2023cites this paper
• Glucose tolerance status associates with improvements in cognitive function following high-intensity exercise in adults with obesity.

  2023cites this paper
• A Comprehensive Review on Molecular Mechanism Involved in Arsenic Trioxide Mediated Cerebral Neurodegenerative and Infectious Diseases.

  2023cites this paper
• Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19

  2023cites this paper
• Brain Derived Neurotrophic Factor (BDNF) as a Mediator of Microglia-Induced Neuroinflammation

  2022cites this paper
• CARDIOVASCULAR EXERCISE, LEARNING, MEMORY, AND CYTOKINES: RESULTS OF A TEN-WEEK RANDOMIZED CONTROLLED TRAINING STUDY IN YOUNG ADULTS.

  2022cites this paper
• Maresin 1 alleviates sevoflurane-induced neuroinflammation in neonatal rats via JAK2/STAT3/IL-6 pathways.

  2022cites this paper
• The role of sleep disturbance and inflammation for spatial memory

  2021cites this paper
• Effects of long-term infliximab and tocilizumab treatment on anxiety-like behavior and cognitive function in naive rats

  2021cites this paper
• Chronic developmental exposure to low-dose ([C8mim][PF6]) induces neurotoxicity and behavioural abnormalities in rats.

  2021cites this paper
• Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction

  2021cites this paper
• Neuroimmune Mechanisms as Novel Treatment Targets for Substance Use Disorders and Associated Comorbidities

  2021cites this paper
• Effect of Anesthesia/Surgery on Gut Microbiota and Fecal Metabolites and Their Relationship With Cognitive Dysfunction

  2021cites this paper
• An emerging role for microglia in stress‐effects on memory

  2021cites this paper
• Inflammatory Markers May Inform the Effects of Electroconvulsive Therapy on Cognition in Patients with Depression

  2021cites this paper
• Effects of Toll-like receptor 4 inhibition on spatial memory and cell proliferation in male and female adult and aged mice.

  2021cites this paper
• Characterisation of the Mouse Cerebellar Proteome in the GFAP-IL6 Model of Chronic Neuroinflammation

  2021cites this paper
• Maternal Interleukin-6 Hampers Hippocampal Neurogenesis in Adult Rat Offspring in a Sex-Dependent Manner

  2021cites this paper
• Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring.

  2021cites this paper
• Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging

  2021cites this paper
• The differential effects of isoflurane and sevoflurane on neonatal mice

  2020cites this paper
• Memory decline correlates with increased plasma cytokines in amyloid-beta (1-42) rat model of alzheimer's disease.

  2020cites this paper
• n-3 Polyunsaturated Fatty Acids and Their Derivates Reduce Neuroinflammation during Aging

  2020cites this paper
• Post-chemotherapy cognitive impairment in hematological patients: current understanding of chemobrain in hematology

  2020cites this paper
• Neurobiological Principles: Psycho-Neuro-Immuno-Endocrinology

  2020cites this paper
• Inflammation, hippocampal volume, and cognition in schizophrenia: results from the Northern Finland Birth Cohort 1966

  2020cites this paper
• Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes

  2020cites this paper
• Interleukin-6: A neuro-active cytokine contributing to cognitive impairment in Duchenne muscular dystrophy?

  2020cites this paper
• Potential Cytokine Biomarkers in Intellectual Disability.

  2020cites this paper
• The role of cytokines in modulating learning and memory and brain plasticity

  2020cites this paper
• Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice.

  2020cites this paper
• Significance of IL-6 Deficiency in Recognition Memory in Young Adult and Aged Mice

  2019cites this paper
• Microglial cell‐derived interleukin‐6 influences behavior and inflammatory response in the brain following traumatic brain injury

  2019cites this paper
• Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease.

  2019cites this paper
• Obesity-related cognitive impairment: The role of endothelial dysfunction.

  2019cites this paper
• IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer's disease.

  2019cites this paper
• NMDA receptor in the hippocampus alters neurobehavioral phenotypes through inflammatory cytokines in rats with sporadic Alzheimer-like disease.

  2019cites this paper
• Facilitatory Effect of IL-6 Deficiency on Long-Term Spatial Memory in Young Adult Mice

  2018influential citation
• Post‐Operative Cognitive Dysfunction: An exploration of the inflammatory hypothesis and novel therapies

  2018cites this paper
• A Logic Model of Neuronal-Glial Interaction Suggests Altered Homeostatic Regulation in the Perpetuation of Neuroinflammation

  2018cites this paper
• IL‐6 deficiency alters spatial memory in 4‐ and 24‐month‐old mice

  2018cites this paper
• The Interest of Adding Micronutrients to Docosahexaenoic Acid Supplementation to Prevent Age-Related Cognitive Decline

  2018cites this paper
• Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy

  2018cites this paper
• Chemotherapy-Induced Cognitive Impairment Is Associated with Cytokine Dysregulation and Disruptions in Neuroplasticity

  2018cites this paper
• The X-Linked Intellectual Disability Protein IL1RAPL1 Regulates Dendrite Complexity

  2017cites this paper
• Treatment with Mountain-Cultivated Ginseng Alleviates Trimethyltin-Induced Cognitive Impairments in Mice via IL-6-Dependent JAK2/STAT3/ERK Signaling

  2017cites this paper
• Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.

  2017cites this paper
• Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons

  2017cites this paper
• (Putative) sex differences in neuroimmune modulation of memory

  2017influential citation
• Psychoneuroimmunologische Grundlagen psychischer Erkrankungen

  2017cites this paper
• Animal cognition (reasoning) in the light of genetic ideas

  2017cites this paper
• Exploring the role of Interleukin-6 and other host-associated factors in tumor progression and metastasis development

  2017cites this paper
• Dysregulation of cytokine mediated chemotherapy induced cognitive impairment

  2017cites this paper
• Negative Correlation between Serum Cytokine Levels and Cognitive Abilities in Children with Autism Spectrum Disorder

  2017cites this paper
• RAGE antagonism by FPS‑ZM1 attenuates postoperative cognitive dysfunction through inhibition of neuroinflammation in mice.

  2017cites this paper
• Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration

  2017cites this paper
• Anesthesia and Surgery Impair Blood–Brain Barrier and Cognitive Function in Mice

  2017cites this paper
• The Genetic Relationship between Interleukin Genes in Alzheimer’s Disease

  2016cites this paper
• [Pro-inflammatory cytokines in Alzheimer's disease].

  2016cites this paper
• Peripheral surgical wounding may induce cognitive impairment through interlukin-6-dependent mechanisms in aged mice

  2016influential citation
• Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials

  2016cites this paper
• Immunological aspects of cognitive functioning: highlights on the role of the cytokines

  2016cites this paper
• Effect of Chlorovirus ATCV-1 infection on behavior of C57Bl/6 mice.

  2016cites this paper
• The Genetic Relationship between Interleukin Genes in AlzheimerâÂÂsDisease

  2016cites this paper
• Arsenic trioxide mediates HAPI microglia inflammatory response and the secretion of inflammatory cytokine IL-6 via Akt/NF-κB signaling pathway.

  2016cites this paper
• Genetic polymorphisms of interleukin genes and the risk of Alzheimer's disease: An update meta-analysis

  2016cites this paper
• Cognitive dysfunction in Duchenne muscular dystrophy: a possible role for neuromodulatory immune molecules.

  2016cites this paper
• Inflammation and accumulating risk for developing psychiatric disorders

  2016cites this paper
• Selenofuranoside Ameliorates Memory Loss in Alzheimer-Like Sporadic Dementia: AChE Activity, Oxidative Stress, and Inflammation Involvement

  2015cites this paper
• Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats.

  2015cites this paper
• Astrocytic IL-6 mediates locomotor activity, exploration, anxiety, learning and social behavior.

  2015influential citation
• The Role of Inflammation in Alzheimer’s Disease

  2015cites this paper
• Immune challenge but not dietary restriction affects spatial learning in the wild subterranean rodent Ctenomys talarum.

  2015cites this paper
• Cognitive impairment induced by permanent bilateral common carotid occlusion exacerbates depression-related behavioral, biochemical, immunological and neuronal markers.

  2015cites this paper
• Systemic inflammation and late-life cognitive ability

  2015cites this paper
• Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells

  2015cites this paper
• The cytokine model of schizophrenia: emerging therapeutic strategies.

  2014cites this paper
• Intra-amygdala microinfusion of IL-6 impairs the auditory fear conditioning of rats via JAK/STAT activation.

  2014cites this paper
• Microbiota, immunoregulatory old friends and psychiatric disorders.

  2014cites this paper
• Inflammatory Pain May Induce Cognitive Impairment Through an Interlukin-6-Dependent and Postsynaptic Density-95-Associated Mechanism

  2014cites this paper
• Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability.

  2014cites this paper
• Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability

  2014cites this paper
• Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease

  2014cites this paper
• Sevoflurane Induces Tau Phosphorylation and Glycogen Synthase Kinase 3&bgr; Activation in Young Mice

  2014cites this paper
• Interleukin 6 deficiency affects spontaneous activity of mice in age- and sex-dependent manner.

  2014cites this paper
• Mikroglia und immunologische Mechanismen in der neuropsychiatrischen Forschung

  2014cites this paper
• Role of astrocytic IL-6 and IL-6R in normal physiology and neuroinflammation

  2014cites this paper
• A Novel Role for Brain Interleukin-6: Facilitation of Cognitive Flexibility in Rat Orbitofrontal Cortex

  2014influential citation
• Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences.

  2014cites this paper
• The Immune–Neuroendocrine Network in Health and Disease

  2013cites this paper
• Association between interleukin-6 −174G/C polymorphism and the risk of Alzheimer's disease: a meta-analysis

  2013cites this paper
• Metabolic Syndrome

  2013cites this paper