Regulation of glutamine synthetase in cultured 3T3-L1 cells by insulin, hydrocortisone, and dibutyryl cyclic AMP.

No abstract is available for this paper.

• Publication year

  1978

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1978-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.75.3.1418PMID 26055PMCID PMC411483
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alterations in insulin binding accompanying differentiation of 3T3-L1 preadipocytes.

  1977cited by this paper
• Insulin receptors in 3T3 fibroblasts. Relationship to growth phase, transformation and differentiation into new cell types.

  1977cited by this paper
• Increasing activity of enzymes on pathway of triacylglycerol synthesis during adipose conversion of 3T3 cells.

  1977cited by this paper
• Development of lipoprotein lipase in cultured 3T3-L1 cells.

  1977cited by this paper
• Membrane receptors for hormones and neurotransmitters

  1976cited by this paper
• Cytological and enzymological characterization of adult human adipocyte precursors in culture.

  1976cited by this paper
• Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells.

  1976cited by this paper
• Induction of lipogenesis during differentiation in a "preadipocyte" cell line.

  1976cited by this paper
• Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells.

  1976cited by this paper
• The effect of insulin and glucocorticoids on the synthesis and degradation of phosphoenolpyruvate carboxykinase (GTP) in rat adipose tissue cultured in vitro.

  1976cited by this paper
• Specificity of the glutamine-binding site involved in the reguation of glutamine-synthetase activity in hepatoma tissue-culture cells.

  1975cited by this paper
• An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion.

  1975cited by this paper
• Immunochemical evidence for glutamine-mediated degradation of glutamine synthetase in cultured Chinese hamster cells.

  1975cited by this paper
• Single-antibody technique for radioimmunoassay of cortisol in unextracted serum or plasma.

  1974cited by this paper
• Zinc-induced paracrystalline aggregation of glutamine synthetase.

  1974cited by this paper
• Regulation of glutamine synthetase activity of hepatoma tissue culture cells by glutamine and dexamethasone.

  1973cited by this paper
• Regulation of glutamine synthetase in cultured Chinese hamster cells. Induction and repression by glutamine.

  1972cited by this paper
• Rat liver glutamine synthetase. Preparation, properties, and mechanism of inhibition by carbamyl phosphate.

  1972cited by this paper
• CLONAL DIFFERENCES IN GLUTAMINE SYNTHETASE ACTIVITY OF HEPATOMA CELLS

  1972cited by this paper
• Effects of insulin on the adaptation of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in rat adipose tissue.

  1972cited by this paper
• Hormonal effects on the neural retina: induction of glutamine synthetase by cyclic-3',5'-AMP.

  1971cited by this paper
• A rapid radioactive assay for glutamine synthetase, glutaminase, asparagine synthetase, and asparaginase.

  1970cited by this paper
• Effect of insulin on the synthesis in vitro of hexokinase in rat epididymal adipose tissue.

  1970cited by this paper
• Multiple hexokinases of rat tissues. Purification and comparison of soluble forms.

  1966cited by this paper
• Coated charcoal immunoassay of insulin.

  1965cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Binge ethanol withdrawal: Effects on post-withdrawal ethanol intake, glutamate-glutamine cycle and monoamine tissue content in P rat model.

  2016cites this paper
• Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats.

  2015cites this paper
• Weighing in on adipocyte precursors.

  2014cites this paper
• A Fluorescence-Coupled Assay for Gamma Aminobutyric Acid (GABA) Reveals Metabolic Stress-Induced Modulation of GABA Content in Neuroendocrine Cancer

  2014cites this paper
• Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.

  2013cites this paper
• THE ROLE OF GLUTAMINE IN THE FUNCTION AND CYTOKINE SECRETION OF 3T3-L1 ADIPOCYTES AND RAW264.7 MACROPHAGES By

  2013cites this paper
• Gene expression profiles analyzed by DNA sequencing of cDNA clones constructed from porcine preadipocytes and adipocytes

  2012cites this paper
• INTERAÇÃO DA GLUTAMINA SINTETASE (GS) E PÉPTIDO β AMILÓIDE COMO UMA ESTRATÉGIA DE PURIFICAÇÃO

  2012cites this paper
• Gender-dependent Protein Expression in White Adipose Tissues of Lean and Obese Rats Fed a High Fat Diet

  2012cites this paper
• Distinct changes in neuronal and astrocytic amino acid neurotransmitter metabolism in mice with reduced numbers of synaptic vesicles

  2008cites this paper
• High-affinity glycine and glutamate transport in pig forebrain white and gray matter: a quantitative study.

  2007cites this paper
• Glutamine, insulin and glucocorticoids regulate glutamine synthetase expression in C2C12 myotubes, Hep G2 hepatoma cells and 3T3 L1 adipocytes.

  2007cites this paper
• Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease.

  2006cites this paper
• Glucocorticoid-Inducible Glutamine Synthetase in GH Cells of Chick Embryos, Gallus domesticus: Ontogeny of Glutamine Synthetase, GH, and Pit-1 Protein in the Pituitary Gland

  2006cites this paper
• Cellular concentrations of glutamine synthetase in murine organs.

  2006cites this paper
• REDOX PROTEOMICS IDENTIFICATION OF OXIDATIVELY MODIFIED PROTEINS AND THEIR PHARMACOLOGICAL MODULATION: INSIGHT INTO OXIDATIVE STRESS IN BRAIN AGING, AGE-RELATED COGNITIVE IMPAIRMENT

  2005cites this paper
• Induction of glutamine synthetase and transient co-expression with carbamoylphosphate synthetase in hepatocytes transplanted into fat pads of syngeneic hosts

  2004cites this paper
• Antisense directed at the Aβ region of APP decreases brain oxidative markers in aged senescence accelerated mice

  2004cites this paper
• Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice.

  2004cites this paper
• Research report Antisense directed at the Ah region of APP decreases brain oxidative markers in aged senescence accelerated mice

  2004cites this paper
• Concentrations of physiologically important metal ions in glial cells cultured from chick cerebral cortex

  2004cites this paper
• Glutamate transport, glutamine synthetase and phosphate‐activated glutaminase in rat CNS white matter. A quantitative study

  2003cites this paper
• In vitro and in vivo dose-dependent inhibition of methylmercury on glutamine synthetase in the brain of different species.

  2003cites this paper
• Elevatio no fBrai nGlutathion eB y- glutamylcystein eEthy lEste rProtect sAgainst Peroxynitrite-induce dOxidativ eStress

  2002cites this paper
• Parameters of dietary selenium and vitamin E deficiency in growing rabbits.

  2002cites this paper
• Elevation of brain glutathione by γ‐glutamylcysteine ethyl ester protects against peroxynitrite‐induced oxidative stress

  2002cites this paper
• CAAT/enhancer binding protein activates an enhancer in the glutamine synthetase distal 5'-flanking sequence.

  2002cites this paper
• Short-term zinc deficiency affects nuclear factor-kappab nuclear binding activity in rat testes.

  2001cites this paper
• PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

  2001cites this paper
• Up‐regulation of hippocampal glutamate transport during chronic treatment with sodium valproate

  2001influential citation
• Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group.

  2000cites this paper
• Protein oxidation and enzyme susceptibility in white and gray matter with in vitro oxidative stress: relevance to brain injury from intracerebral hemorrhage.

  2000cites this paper
• Indicators of oxidative injury and alterations of the cell membrane in the skeletal muscle of rats submitted to ischemia and reperfusion.

  2000cites this paper
• Zinc in the prevention of Fe2+-initiated lipid and protein oxidation.

  2000cites this paper
• Advances in animal cell recombinant protein production: GS-NS0 expression system

  2000cites this paper
• Amyloid beta-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer's disease.

  1999cites this paper
• Cadmium-induced testes oxidative damage in rats can be influenced by dietary zinc intake.

  1999cites this paper
• Lead intoxication: antioxidant defenses and oxidative damage in rat brain.

  1999cites this paper
• Peroxynitrite‐Induced Alterations in Synaptosomal Membrane Proteins

  1999cites this paper
• Behavioral consequences of marginal iron deficiency during development in a murine model.

  1999cites this paper
• Effect of glutamine limitation on the death of attached Chinese hamster ovary cells.

  1999cites this paper
• Glucocorticoids induce glutamine synthetase in folliculostellate cells of rat pituitary glands in vivo and in vitro

  1999cites this paper
• Dose-dependent increase of oxidative damage in the testes of rats subjected to acute iron overload.

  1999cites this paper
• Influence of dietary carbohydrate on zinc-deficiency-induced changes in oxidative defense mechanisms and tissue oxidative damage in rats

  1999influential citation
• Effect of oxidant systems on the ubiquitylation of proteins in the central nervous system

  1999cites this paper
• Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria?

  1999cites this paper
• Incorporation of 15N from ammonium into the N-linked oligosaccharides of an immunoadhesin glycoprotein expressed in Chinese hamster ovary cells.

  1999cites this paper
• Aluminum Enhances Melanin-Induced Lipid Peroxidation

  1999cites this paper
• Transcriptional regulation of the rat glutamine synthetase gene by tumor necrosis factor-alpha.

  1998cites this paper
• The Roles of Different Adipose Depots in Glutamine Metabolism following Feeding, Fasting and Exercise in the Guinea-Pig

  1998cites this paper
• The effect of high altitude and caloric restriction on reactive carbonyl derivatives and activity of glutamine synthetase in rat brain.

  1998cites this paper
• Lipoprotein lipase activity and protein oxidative damage are increased in brain by age but not by fish oil ingestion

  1998cites this paper
• A period of anaerobic exercise increases the accumulation of reactive carbonyl derivatives in the lungs of rats

  1998cites this paper
• Conditioned medium from cultured rat hepatocytes completely blocks induction of glutamine synthetase by dexamethasone in several rat liver epithelial cell lines

  1998cites this paper
• Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary restriction.

  1998cites this paper
• Structural and Functional Changes in Proteins Induced by Free Radical‐mediated Oxidative Stress and Protective Action of the Antioxidants N‐tert‐Butyl‐α‐phenylnitrone and Vitamin E a

  1998cites this paper
• Oxidatively Induced Structural Alteration of Glutamine Synthetase Assessed by Analysis of Spin Label Incorporation Kinetics: Relevance to Alzheimer's Disease

  1997cites this paper
• Oxidative modification of glutamine synthetase by amyloid beta peptide.

  1997cites this paper
• A comparison of changes in nucleotide-protein interactions in the striatal, hippocampus and paramedian cortex after cerebral ischemia and reperfusion: correlations to regional vulnerability.

  1997cites this paper
• Elements in the distal 5'-flanking sequence and the first intron function cooperatively to regulate glutamine synthetase transcription during adipocyte differentiation.

  1997cites this paper
• Developmental appearance of ammonia‐metabolizing enzymes in prenatal murine liver

  1997influential citation
• Free radical production during ethanol intoxication, dependence, and withdrawal.

  1997cites this paper
• Induction of glutamine synthetase by L-alpha-aminoadipate in developmental stages of cultured astrocytes.

  1997cites this paper
• Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone.

  1997cites this paper
• Oligodendrocyte maturation and progenitor cell proliferation are independently regulated by thyroid hormone

  1997cites this paper
• Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone

  1997cites this paper
• Inactivation of glutathione peroxidase by benzaldehyde.

  1996cites this paper
• Ontogeny of Glutamine Synthetase in Rat Small Intestine

  1996cites this paper
• Early and transient increase in oxidative stress in the cerebral cortex of senescence-accelerated mouse.

  1996cites this paper
• On the mechanism of the inhibition of glutamine synthetase and creatine phosphokinase by methionine sulfoxide

  1996cites this paper
• Chromosomal mapping of a family of human glutamine synthetase genes: functional gene (GLUL) on 1q25, pseudogene (GLULP) on 9p13, and three related genes (GLULL1, GLULL2, GLULL3) on 5q33, 11p15, and 11q24.

  1996cites this paper
• Prevention of Hyperoxia‐Induced Alterations in Synaptosomal Membrane‐Associated Proteins by N‐tert‐Butyl‐α‐Phenylnitrone and 4‐Hydroxy‐2,2,6,6‐Tetramethylpiperidin‐1‐oxyl (Tempol)

  1996cites this paper
• The importance of ammonia in mammalian cell culture.

  1996cites this paper
• Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

  1995cites this paper
• Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes.

  1995cites this paper
• Glutamine synthetase gene experession in a glioblastoma cell-line of clonal origin: Regulation by dexamethasone and dibutyryl cyclic AMP

  1995cites this paper
• Enhancement of beta-amyloid peptide A beta(1-40)-mediated neurotoxicity by glutamine synthetase.

  1995cites this paper
• Oxidative damage to lipids and DNA concurrent with decrease of antioxidants in rat testes after acute iron intoxication.

  1995cites this paper
• Amyloid beta-peptide spin trapping. I: Peptide enzyme toxicity is related to free radical spin trap reactivity.

  1995cites this paper
• Dietary magnesium supplementation modifies blood pressure and cardiovascular function in mineralocorticoid-salt hypertensive rats but not in normotensive rats.

  1995cites this paper
• Enhancement of β‐Amyloid Peptide Aβ(1–40)‐Mediated Neurotoxicity by Glutamine Synthetase

  1995cites this paper
• Detection of a functional promoter/enhancer in an intron-less human gene encoding a glutamine synthetase-like enzyme.

  1995cites this paper
• Aging‐ and Oxygen‐induced Modifications in Brain Biochemistry and Behavior a

  1994cites this paper
• A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

  1994cites this paper
• Corticosterone-responsive mRNAs in primary rat astrocytes.

  1994cites this paper
• Effects of trans fatty acids on lipid accumulation in 3T3-L1 cells.

  1993cites this paper
• Effects of Dimethylthiourea on Selective Neuronal Vulnerability in Forebrain Ischemia in Rats

  1993cites this paper
• Glucocorticoid regulation of splanchnic glutamine, alanine, glutamate, ammonia, and glutathione fluxes.

  1993cites this paper
• Effects of inhibition of ornithine aminotransferase on thioacetamide-induced hepatogenic encephalopathy

  1993cites this paper
• Does Ischemia with Reperfusion Lead to Oxidative Damage to Proteins in the Brain?

  1993cites this paper
• Effects oftrans fatty acids on lipid accumulation in 3T3-L1 cells

  1993cites this paper
• Uptake of glutamate, not glutamine synthetase, regulates adaptation of mammalian cells to glutamine-free medium.

  1993cites this paper
• Aluminum accumulation and neurotoxicity in Swiss-Webster mice after long-term dietary exposure to aluminum and citrate.

  1993cites this paper
• Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: a potential diagnostic biochemical marker.

  1992cites this paper
• A promoter sequence involved in cell-specific expression of the pea glutamine synthetase GS3A gene in organs of transgenic tobacco and alfalfa.

  1991cites this paper
• FGFs stimulate IGF binding protein synthesis without affecting IGF synthesis in rat astroblasts in primary culture

  1991cites this paper
• Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

  1991cites this paper
• A functional promoter flanks an intronless glutamine synthetase gene.

  1991cites this paper
• Glutamine synthetase expression in rat oligodendrocytes in culture: Regulation by hormones and growth factors

  1991cites this paper
• Glycerol 3-phosphate dehydrogenase gene expression in cultured 3T3-L1 adipocytes: regulation by insulin, dexamethasone and dibutyryl cAMP at the level of mRNA abundance, transcription and mRNA stability.

  1991cites this paper