Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Diabetologia

• Publication date

  1988-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF00276849PMID 3286343
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Amyloid fibril protein AA. Characterization of uncommon subspecies from a patient with rheumatoid arthritis.

  1987cited by this paper
• Immunocytochemistry: 2nd edn., by J.M. Polak and S. Van Noorden (eds.), 703 pages, Wright, Bristol, 1986, £65.00, ISBN 0 7236 0870 9.

  1987cited by this paper
• Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone.

  1987cited by this paper
• Insulin delivery systems.

  1987cited by this paper
• Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

  1987cited by this paper
• Silicone Oil Released From Disposable Insulin Syringes

  1986cited by this paper
• A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.

  1986cited by this paper
• Clinical spectrum of connective tissue disease after cosmetic surgery. Observations on eighteen patients and a review of the Japanese literature.

  1984cited by this paper
• Islet amyloid in type 2 (non-insulin-dependent) diabetes is related to insulin

  1983cited by this paper
• Iatrogenic, insulin-dependent, local amyloidosis.

  1983cited by this paper
• Electron Microscopy of Insulin Precipitates

  1982cited by this paper
• Amyloid P component is located on elastic fibre microfibrils in normal human tissue

  1981cited by this paper
• Electron probe microanalysis in biology

  1978cited by this paper
• Potassium permanganate reaction in amyloidosis. A histologic method to assist in differentiating forms of this disease.

  1977cited by this paper
• Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid

  1976cited by this paper
• β-PLEATED SHEET FIBRILS A COMPARISON OF NATIVE AMYLOID WITH SYNTHETIC PROTEIN FIBRILS

  1974cited by this paper
• On the nature of the amyloid in human islets of langerhans

  1974cited by this paper
• Amyloid nephropathy of Ostertag with special reference to renal glomerular giant cells.

  1973cited by this paper
• Regeneration of insulin from insulin fibrils by the action of alkali.

  1948cited by this paper

• Recent advances in small molecules for amyloid fibril inhibition: chemical strategies and molecular mechanistic insights from lysozyme and insulin models.

  2026cites this paper
• Gangliosides GM3 And GD3 Modulate Insulin Aggregation Pathways and Reduce Cytotoxicity Through Structural Remodeling

  2026cites this paper
• Facially Amphiphilic Cholate-Conjugated Polymers for Regulating Insulin Fibrillation.

  2025cites this paper
• Inhibition of Insulin Amyloid Fibrillation by the Putative Anticancer Alkaloid Chelerythrine: Spectroscopic, Imaging, and Theoretical Investigations.

  2025cites this paper
• Genetic and structural aspects of amyloid diseases.

  2025cites this paper
• Molecular Crosstalk between Artificial Sweetener Aspartame and Diabetes-Linked Insulin Hormone Unveils Possible Amyloidosis Risks.

  2025cites this paper
• Probing the Effects of Chirality on Self-Assembling Peptides: Hydrogel Formation, Degradation, Antigen Release, and Adjuvancy

  2024cites this paper
• A Coumarin-Based Array for the Discrimination of Amyloids.

  2024cites this paper
• Nanochaperones Based on Hydrophobic Interaction and Coordination Inhibit Protein Misfolding and Fibrillation

  2024cites this paper
• A Hydroxyquinoline Polymer with Excellent Amyloidosis Inhibition and Protein Delivery Ability to Combat Amyloid-β-Mediated Neurotoxicity.

  2024cites this paper
• Atomic resolution structure of full-length human insulin fibrils

  2024cites this paper
• Mechanistic Insights Behind the Self-Assembly of Human Insulin under the Influence of Surface-Engineered Gold Nanoparticles

  2024cites this paper
• Raman Spectroscopic Insights of Phase-Separated Insulin Aggregates

  2024cites this paper
• Insulin-Related Skin Lipohypertrophy in Type Two Diabetes: A Clinical Study of a Case Series, with Ultrasonographic and Histopathologic Implications

  2024cites this paper
• Comprehensive investigation of insulin-induced amyloidosis lesions in patients with diabetes at clinical and histological levels: A systematic review.

  2024cites this paper
• Gel tracking dye “Bromophenol blue” promote amorphous aggregation in insulin

  2023cites this paper
• An unnatural amino acid modified human insulin derivative for visual monitoring of insulin aggregation.

  2023cites this paper
• Why and by How Much is Insulin Absorption Reduced by Insulin-derived Amyloidosis? A Scoping Review.

  2023cites this paper
• Localized Insulin-Derived Amyloidosis in Diabetes Mellitus Type 1 Patient: A Case Report

  2023cites this paper
• Insulin-Derived Cutaneous Amyloidosis: A Possible Complication of Repeated Insulin Injections

  2023cites this paper
• Dual Role of a Fluorescent Small Molecule as a Sensor and Inhibitor of Protein Fibrillation.

  2023cites this paper
• Insulin amyloidosis: A case report

  2023cites this paper
• Differences in clinicopathological characteristics between lipohypertrophy and localized insulin‐derived amyloidosis: A scoping review

  2023cites this paper
• Peroxynitric acid inhibits amyloid β aggregation.

  2023cites this paper
• Amyloid Fibrils of Pisum sativum L. Vicilin Inhibit Pathological Aggregation of Mammalian Proteins

  2023cites this paper
• Surface-modified cerium dioxide nanoparticles with improved anti-amyloid and preserved nanozymatic activity.

  2023cites this paper
• Nontoxic Aggregation-Induced Emissive Luminogen for the Detection of Amyloid Fibrils and Cellular Protein Aggregates.

  2023cites this paper
• Orange G is a potential inhibitor of human insulin amyloid fibrillation and can be used as a probe to study mechanism of amyloid fibrillation and its inhibition.

  2022cites this paper
• Multistep growth of amyloid intermediates and its inhibition toward exploring therapeutic way: A case study using insulin B chain and fibrinogen

  2022cites this paper
• Differences in interaction lead to the formation of different types of insulin amyloid

  2022cites this paper
• Dual-Functional Antioxidant and Antiamyloid Cerium Oxide Nanoparticles Fabricated by Controlled Synthesis in Water-Alcohol Solutions

  2022cites this paper
• The intriguing dose-dependent effect of selected amphiphilic compounds on insulin amyloid aggregation: Focus on a cholesterol-based detergent, Chobimalt

  2022cites this paper
• Nanochaperones tailored for insulin delivery to reduce immune clearance and enhance bioavailability of insulin

  2022cites this paper
• Tissue-based diagnosis of systemic amyloidosis: Experience of the informal diagnostic center at Uppsala University Hospital

  2022cites this paper
• Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation.

  2022cites this paper
• Molecular Aspects of Insulin Aggregation and Various Therapeutic Interventions

  2022cites this paper
• Insulin fibrillation: Strategies for inhibition.

  2022cites this paper
• Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer’s Disease

  2022cites this paper
• Formation of subvisible particles in commercial insulin formulations.

  2022cites this paper
• Modulating Insulin Aggregation with Charge Variable Cholic Acid-Derived Polymers.

  2021cites this paper
• Understanding the Role of Protein Glycation in the Amyloid Aggregation Process

  2021cites this paper
• A hemicyanine based fluorescence turn-on sensor for amyloid fibril detection in the far-red region

  2021cites this paper
• Monitoring the surface tension by the pendant drop technique for detection of insulin fibrillogenesis.

  2021cites this paper
• Alizarin and Purpurin from Rubia tinctorum L. Suppress Insulin Fibrillation and Reduce the Amyloid-Induced Cytotoxicity.

  2021cites this paper
• Efficient Amyloid Fibrillation Inhibition and Remodeling of Preformed Fibrils of Bovine Insulin by Propolis Polyphenols-Based Nanosheets.

  2021cites this paper
• Heat-stability study of various insulin types in tropical temperature conditions: New insights towards improving diabetes care

  2021cites this paper
• Amyloidogenicity of peptides targeting diabetes and obesity.

  2021cites this paper
• Simultaneous occurrence of insulin-derived amyloidosis and acanthosis nigricans at the abdominal site of insulin injection

  2021cites this paper
• Degradation of insulin amyloid by antibiotic minocycline and formation of toxic intermediates

  2021cites this paper
• Inhibition of amyloid formation of amyloid β (1-42), amylin and insulin by 1,5-diazacyclooctanes, a spermine-acrolein conjugate.

  2021cites this paper
• Sulfated polysaccharide ascophyllan prevents amyloid fibril formation of human insulin and inhibits amyloid-induced hemolysis and cytotoxicity in PC12 cells.

  2021cites this paper
• Comparative study of the hydrophobic interaction effect of pH and ionic strength on aggregation/emulsification of Congo red and amyloid fibrillation of insulin.

  2021cites this paper
• Basic Orange 21: A molecular rotor probe for fluorescence turn-on sensing of amyloid fibrils

  2020cites this paper
• Nanomaterials to avoid and destroy protein aggregates

  2020cites this paper
• Insulin-derived amyloidosis: The insulin ball, amyloidoma

  2020cites this paper
• Resveratrol as a nontoxic excipient stabilizes insulin in a bioactive hexameric form

  2020cites this paper
• A biocompatible fluorescent probe for selective detection of amyloid fibrils.

  2020cites this paper
• Protein Aggregation, Related Pathologies, and Aging

  2020cites this paper
• Amyloid formation of bovine insulin is retarded in moderately acidic pH and by addition of short-chain alcohols

  2020cites this paper
• Role of surface oxygen-containing functional groups of graphene oxide quantum dots on amyloid fibrillation of two model proteins.

  2020cites this paper
• Bifunctional carbon dots for cell imaging and inhibition of human insulin fibrillation in the whole aggregation process.

  2020cites this paper
• Nigella Sativa : A Potential Inhibitor for Insulin Fibril Formation

  2020cites this paper
• Insulin fibrillation: toward strategies for attenuating the process.

  2020cites this paper
• Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity

  2020cites this paper
• The Behavior of Carbonized Polymer Dots at the Nano‐Bio Interface and Their Luminescent Mechanism: A Physical Chemistry Perspective

  2020cites this paper
• Cutaneous insulin-derived amyloidosis presenting as hyperkeratotic nodules.

  2020cites this paper
• Deciphering the role of premicellar and micellar concentrations of sodium dodecyl benzenesulfonate surfactant in insulin fibrillation at pH 2.0.

  2020cites this paper
• Characterization of insulin cross-seeding: the underlying mechanism reveals seeding and denaturant-induced insulin fibrillation proceeds through structurally similar intermediates

  2020cites this paper
• Mechanistic Studies of the Stabilization of Insulin Helical Structure by Coomassie Brilliant Blue

  2020cites this paper
• Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin

  2020cites this paper
• Zinc Determines Dynamical Properties and Aggregation Kinetics of Human Insulin

  2020cites this paper
• A Biocompatible Fluorescent Probe for the Selective Detection of Amyloid Fibrils

  2020cites this paper
• Nanochaperones mediated delivery of insulin.

  2020cites this paper
• Human Serum Albumin Binds Native Insulin and Aggregable Insulin Fragments and Inhibits Their Aggregation

  2020cites this paper
• Physical PEGylation to prevent insulin fibrillation.

  2019cites this paper
• Modulating Insulin Fibrillation Using Engineered B-Chains with Mutated C-Termini.

  2019cites this paper
• Tracking Insulin Glycation in Real Time by Time-Resolved Emission Spectroscopy.

  2019cites this paper
• Molecular Mechanisms of the Ultra-Strong Inhibition Effect of Oxidized Carbon Dots on Human Insulin Fibrillation.

  2019cites this paper
• AFM-STED correlative nanoscopy provides a new view on the formation process of misfolded protein aggregates

  2019cites this paper
• The air-water interface stabilizes α-helical conformations of the insulin B-chain

  2019cites this paper
• Catanionic nanocarriers as a potential vehicle for insulin delivery.

  2019cites this paper
• Resveratrol prevents amyloid fibrillation of insulin by arresting it in a bioactive oligomeric form

  2019cites this paper
• Insulin adsorption onto zinc oxide nanoparticle mediates conformational rearrangement into amyloid-prone structure with enhanced cytotoxic propensity.

  2019cites this paper
• Toxicity of insulin-derived amyloidosis: a case report

  2019cites this paper
• Submicron polymeric particles accelerate insulin fibrillation by surface adsorption.

  2019cites this paper
• The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG

  2019cites this paper
• Monitoring and modulation of insulin fibers by a protein isomerization targeting dye bromophenol blue

  2019cites this paper
• Insulin‐derived amyloidosis without a palpable mass at the insulin injection site: A report of two cases

  2019cites this paper
• Dual effect of non-ionic detergent Triton X-100 on insulin amyloid formation.

  2019cites this paper
• Effects of Zn2+ Ions and Environmental Conditions on the Fibrillization of Insulin. Zn2+ ioonide ja keskkonnatingimuste mõju insuliini fibrillisatsioonile

  2018cites this paper
• Surface patterns of insulin fibrils revealed by time-resolved spectroscopy measurements of fluorescent probes

  2018cites this paper
• Extreme Adhesion Activity of Amyloid Fibrils Induces Subcutaneous Insulin Resistance

  2018cites this paper
• Protective effects of silibinin on insulin amyloid fibrillation, cytotoxicity and mitochondrial membrane damage.

  2018cites this paper
• Inhibition of insulin amyloid fibrillation by Morin hydrate.

  2018cites this paper
• Effect of natural biopolymers on amyloid fibril formation and morphology.

  2018cites this paper
• Investigation of amyloid formation inhibition of chemically and biogenically from Citrus aurantium L. blossoms and Rose damascena oils of gold nanoparticles: Toxicity evaluation in rat pheochromocytoma PC12 cells.

  2018cites this paper
• Surface patterns of insulin fibrils revealed by time-resolved spectroscopy measurements of fluorescent probes

  2018cites this paper
• Human insulin fibrillogenesis in the presence of epigallocatechin gallate and melatonin: Structural insights from a biophysical approach.

  2018cites this paper
• Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes Mellitus

  2017cites this paper
• Insulin fibrillation: The influence and coordination of Zn2.

  2017cites this paper