The IκB kinase complex: master regulator of NF-κB signaling

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Immunologic research

• Publication date

  2008-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12026-008-8025-1PMID 18626576PMCID PMC2965074
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell penetrating peptide inhibitors of Nuclear Factor-kappa B

  2008cited by this paper
• Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.

  2008influential reference
• Shared principles in NF-kappaB signaling.

  2008cited by this paper
• A Dual Role of the NF-&kgr;B Pathway in Neonatal Hypoxic-Ischemic Brain Damage

  2008cited by this paper
• Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.

  2008influential reference
• High-affinity interaction between IKKbeta and NEMO.

  2008cited by this paper
• Cloning and characterization of an IKK homologue from pearl oyster, Pinctada fucata.

  2008cited by this paper
• Strong Neuroprotection by Inhibition of NF-&kgr;B After Neonatal Hypoxia-Ischemia Involves Apoptotic Mechanisms but Is Independent of Cytokines

  2008cited by this paper
• Caspase Inhibition Sensitizes Inhibitor of NF-κB Kinase β-deficient Fibroblasts to Caspase-independent Cell Death via the Generation of Reactive Oxygen Species*

  2007cited by this paper
• Inhibitor ?B Kinase Binding by Inhibitor ?B Kinase ?

  2007cited by this paper
• NEMO oligomerization in the dynamic assembly of the IκB kinase core complex

  2007cited by this paper
• Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.

  2007cited by this paper
• Surfactant “fortification” by topical inhibition of nuclear factor-&kgr;B activity in a newborn piglet lavage model*

  2007cited by this paper
• Protein transduction: identification, characterization and optimization.

  2007influential reference
• Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma.

  2007cited by this paper
• Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes

  2007cited by this paper
• Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis.

  2007cited by this paper
• Heptad Repeats Regulate Protein Phosphatase 2A Recruitment to I-κB Kinase γ/NF-κB Essential Modulator and Are Targeted by Human T-lymphotropic Virus Type 1 Tax*

  2007cited by this paper
• Interleukin-1-induced NF-κB Activation Is NEMO-dependent but Does Not Require IKKβ*

  2007cited by this paper
• Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease

  2007cited by this paper
• Amelioration of Chronic Murine Colitis by Peptide-Mediated Transduction of the IκB Kinase Inhibitor NEMO Binding Domain Peptide1

  2007cited by this paper
• Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species.

  2007cited by this paper
• Cutting Edge: The IκB Kinase (IKK) Inhibitor, NEMO-Binding Domain Peptide, Blocks Inflammatory Injury in Murine Colitis1

  2007cited by this paper
• NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex.

  2007cited by this paper
• Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax.

  2007cited by this paper
• NF-κB and the immune response

  2006cited by this paper
• Mutations in the NF-kappaB signaling pathway: implications for human disease.

  2006cited by this paper
• Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta.

  2006influential reference
• IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.

  2006influential reference
• Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity.

  2006influential reference
• Regulation of IκB Kinase (IKK) Complex by IKKγ-dependent Phosphorylation of the T-loop and C Terminus of IKKβ*

  2006cited by this paper
• Nuclear factor-κB in cancer development and progression

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• IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300

  2006cited by this paper
• Inhibition of IKK activation, through sequestering NEMO, blocks PMMA‐induced osteoclastogenesis and calvarial inflammatory osteolysis

  2006cited by this paper
• Regulation and Function of IKK and IKK-Related Kinases

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• IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.

  2006cited by this paper
• Introduction to NF-kappaB: players, pathways, perspectives.

  2006influential reference
• Nuclear factor-kappaB in cancer development and progression.

  2006cited by this paper
• Dimerization of the IκB Kinase-Binding Domain of NEMO Is Required for Tumor Necrosis Factor Alpha-Induced NF-κB Activity

  2006influential reference
• NF-kappaB and the immune response.

  2006cited by this paper
• NEMO binding domain of IKK‐2 encompasses amino acids 735–745

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• Topical inhibition of nuclear factor-&kgr;B enhances reduction in lung edema by surfactant in a piglet model of airway lavage

  2005cited by this paper
• Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei

  2005cited by this paper
• Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei.

  2005cited by this paper
• IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

  2005cited by this paper
• NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain.

  2005cited by this paper
• Protein transduction technology

  2005cited by this paper
• Gene expression profiling in conjunction with physiological rescues of IKKalpha-null cells with wild type or mutant IKKalpha reveals distinct classes of IKKalpha/NF-kappaB-dependent genes.

  2005cited by this paper
• Zebrafish IκB Kinase 1 Negatively Regulates NF-κB Activity

  2005cited by this paper
• The effect of fever‐like temperatures on neutrophil signaling

  2005cited by this paper
• Cell-penetrating peptides: tools for intracellular delivery of therapeutics

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• Cell-penetrating peptides: mechanism and kinetics of cargo delivery.

  2005cited by this paper
• Characterisation of cell‐penetrating peptide‐mediated peptide delivery

  2005cited by this paper
• Prevention of NF-kappaB activation in vivo by a cell-permeable NF-kappaB inhibitor peptide.

  2005cited by this paper
• Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity.

  2005cited by this paper
• IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation.

  2005cited by this paper
• NFκB Activates in vivo the Synthesis of Inducible Cox-2 in the Brain

  2005cited by this paper
• Prevention of NF-κB activation in vivo by a cell-permeable NF-κB inhibitor peptide

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• Gene Expression Profiling in Conjunction with Physiological Rescues of IKKα-null Cells with Wild Type or Mutant IKKα Reveals Distinct Classes of IKKα/NF-κB-dependent Genes*

  2005cited by this paper
• Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

  2004cited by this paper
• Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation*

  2004cited by this paper
• IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.

  2004cited by this paper
• Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity.

  2004cited by this paper
• Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization.

  2004cited by this paper
• The two NF-κB activation pathways and their role in innate and adaptive immunity

  2004influential reference
• The two NF-kappaB activation pathways and their role in innate and adaptive immunity.

  2004influential reference
• Integral UBL domain proteins: a family of proteasome interacting proteins.

  2004cited by this paper
• A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase.

  2004cited by this paper
• IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis

  2004cited by this paper
• A Novel Ubiquitin-like Domain in IκB Kinase β Is Required for Functional Activity of the Kinase*

  2004cited by this paper
• Inhibition of NF-κB Activation by Peptides Targeting NF-κB Essential Modulator (NEMO) Oligomerization*

  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
• Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.

  2003cited by this paper
• Faculty Opinions recommendation of Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.

  2003cited by this paper
• Protein Phosphatase 2Cβ Association with the IκB Kinase Complex Is Involved in Regulating NF-κB Activity*

  2003cited by this paper
• Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.

  2003cited by this paper
• Inhibition of NF-kappaB by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis.

  2003cited by this paper
• Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

  2003cited by this paper
• Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

  2003cited by this paper
• A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression.

  2003cited by this paper
• The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination

  2003cited by this paper
• Human T-lymphotropic Virus Type I Tax Activates I-κB Kinase by Inhibiting I-κB Kinase-associated Serine/Threonine Protein Phosphatase 2A*

  2003cited by this paper
• Tetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation

  2003cited by this paper
• Protection of Islets by in SituPeptide-mediated Transduction of the IκB Kinase Inhibitor Nemo-binding Domain Peptide*

  2003cited by this paper
• Roles for Homotypic Interactions and Transautophosphorylation in IκB Kinase (IKKβ) Activation*

  2003cited by this paper
• Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected].

  2003cited by this paper
• Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.

  2003cited by this paper
• Characterization of the IκB-kinase NEMO Binding Domain*

  2002cited by this paper
• The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.

  2002influential reference
• The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.

  2002cited by this paper
• Characterization of the Ikappa B-kinase NEMO binding domain.

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• The Zinc Finger Domain of NEMO Is Selectively Required for NF-κB Activation by UV Radiation and Topoisomerase Inhibitors

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• BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

  2002influential reference
• The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

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• IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

  2002cited by this paper
• The Carboxyl-Terminal Region of IκB Kinase γ (IKKγ) Is Required for Full IKK Activation

  2002cited by this paper
• Protein transduction technology.

  2002cited by this paper
• CD40 regulates the processing of NF-kappaB2 p100 to p52.

  2002influential reference
• IKKα, IKKβ, and NEMO/IKKγ Are Each Required for the NF-κB-mediated Inflammatory Response Program*

  2002cited by this paper

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