Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Blood

• Publication date

  2006-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2006-04-016923PMID 16728694
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection.

  2006cited by this paper
• Analysis of FOXP3 protein expression in human CD4(+)CD25(+) regulatory T cells at the single-cell level.

  2006cited by this paper
• Are regulatory T-cells linked with aging?

  2006cited by this paper
• To the Editor – Eur. J. Immunol. 1/2006

  2006cited by this paper
• Depletion of Regulatory T Cells in HIV Infection Is Associated with Immune Activation1

  2005cited by this paper
• Replication of M-tropic HIV-1 in Activated Human Intestinal Lamina Propria Lymphocytes Is the Main Reason for Increased Virus Load in the Intestinal Mucosa

  2005cited by this paper
• FOXP3 mRNA Levels are Decreased in Peripheral Blood CD4+ Lymphocytes From HIV-Positive Patients

  2005cited by this paper
• Natural regulatory T cells in infectious disease

  2005cited by this paper
• Cutting Edge: The Prevalence of Regulatory T Cells in Lymphoid Tissue Is Correlated with Viral Load in HIV-Infected Patients 1

  2005cited by this paper
• Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single‐cell level

  2005cited by this paper
• Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients

  2005cited by this paper
• Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

  2005cited by this paper
• Homing to suppress: address codes for Treg migration.

  2005cited by this paper
• Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease.

  2005cited by this paper
• Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS.

  2005cited by this paper
• Mucosal FOXP3-Expressing CD4+ CD25high Regulatory T Cells in Helicobacter pylori-Infected Patients

  2005cited by this paper
• The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients.

  2005cited by this paper
• Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.

  2004cited by this paper
• Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients.

  2004cited by this paper
• CD4+CD25bright T Cells in Human Intestinal Lamina Propria as Regulatory Cells1

  2004cited by this paper
• Human CD4+ CD25+ Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

  2004cited by this paper
• Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract

  2004cited by this paper
• Regulatory Cells and Infectious Agents: Détentes Cordiale and Contraire

  2004cited by this paper
• CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status

  2004cited by this paper
• CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract

  2004cited by this paper
• Suppressor T Cells in Human Diseases

  2004cited by this paper
• Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.

  2003cited by this paper
• Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

  2003cited by this paper
• Control of autoimmunity by naturally arising regulatory CD4+ T cells.

  2003cited by this paper
• Suppression of HCV‐specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection

  2003cited by this paper
• Persistent immune activation in HIV-1 infection is associated with progression to AIDS

  2003cited by this paper
• CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.

  2002cited by this paper
• CD4 T Cell Depletion Is Linked Directly to Immune Activation in the Pathogenesis of HIV-1 and HIV-2 but Only Indirectly to the Viral Load1

  2002cited by this paper
• Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

  2002cited by this paper
• Emerging concepts in gastrointestinal aspects of HIV-1 pathogenesis and management

  2001cited by this paper
• Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

  2000cited by this paper
• Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

  2000cited by this paper
• Rapid mucosal CD4(+) T-cell depletion and enteropathy in simian immunodeficiency virus-infected rhesus macaques.

  1999cited by this paper
• CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

  1998cited by this paper
• HIV‐1 p24 but not proviral load is increased in the intestinal mucosa compared with the peripheral blood in HIV‐infected patients

  1998cited by this paper
• CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activities in vitro

  1998cited by this paper
• Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group.

  1995cited by this paper
• Abnormalities in subset distribution, activation, and differentiation of T cells isolated from large intestine biopsies in HIV infection. The Berlin Diarrhoea/Wasting Syndrome Study Group.

  1994cited by this paper
• Abnormalities in subset distribution, activation, and differentiation of T ceils isolated from large intestine biopsies in HIV infection

  1994cited by this paper
• Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study.

  1993cited by this paper
• The frequency of a Norwalk-like pattern of illness in outbreaks of acute gastroenteritis.

  1982cited by this paper

• Functional and phenotypic analysis of CD4 T cell dynamics in peripheral blood of human visceral leishmaniasis patients confers increased frequencies of CD25 expressing regulatory T cells that contribute to disease pathogenesis

  2025cites this paper
• Making a Monkey out of Human Immunodeficiency Virus/Simian Immunodeficiency Virus Pathogenesis: Immune Cell Depletion Experiments as a Tool to Understand the Immune Correlates of Protection and Pathogenicity in HIV Infection

  2024cites this paper
• Regulatory T cell frequency in peripheral blood of women with advanced cervical Cancer including women living with HIV

  2023cites this paper
• Transforming Growth Factor β Signaling Promotes HIV-1 Infection in Activated and Resting Memory CD4+ T Cells

  2023cites this paper
• Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load

  2023cites this paper
• A prospective study of clinical outcomes of HIV-associated and HIV-negative Kaposi sarcoma in Uganda

  2022cites this paper
• The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence

  2022cites this paper
• Preterm Birth in Women With HIV: The Role of the Placenta

  2022cites this paper
• Profound Defect of Amphiregulin Secretion by Regulatory T Cells in the Gut of HIV-Treated Patients

  2022cites this paper
• The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection

  2021cites this paper
• PD-1 dependent expansion of Amphregulin+FOXP3+ cells is associated with oral immune dysfunction in HIV patients on therapy

  2021cites this paper
• Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregulin+ T cells during HIV infection

  2021cites this paper
• HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies

  2021cites this paper
• Regulatory T cells and T helper 17 cells in viral infection

  2020cites this paper
• Immunology of EBV-Related Lymphoproliferative Disease in HIV-Positive Individuals

  2020cites this paper
• Phylogenetic comparison of plasma- and cell subset-derived viral sequences to identify the cellular origin of HIV plasma viremia

  2020cites this paper
• Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection

  2019cites this paper
• The Role of Natural Killer Cells and Regulatory T Cells While Aging with Human Immunodeficiency Virus

  2019cites this paper
• Short Communication: Tracking Tregs: Translocation of CD49b/LAG-3+ Type 1 T Regulatory Cells to the Gut-Associated Lymphoid Tissue of HIV+ Patients.

  2019cites this paper
• Immune signatures for HIV-1 and HIV-2 induced CD4+T cell dysregulation in an Indian cohort

  2019cites this paper
• Regulatory T Cells As Potential Targets for HIV Cure Research

  2018cites this paper
• Frequency and phenotype of Immune cell subsets in different regions of the human cervix : implications for HIV susceptibility.

  2018cites this paper
• The Yin and Yang of regulatory T cells in infectious diseases and avenues to target them

  2017cites this paper
• The Role of Transforming Growth Factor Beta-1 in the Progression of HIV/AIDS and Development of Non-AIDS-Defining Fibrotic Disorders

  2017cites this paper
• HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication

  2017cites this paper
• Characterization of regulatory T cells and Th17 cells as reservoir of HIV-1 in chronic infection

  2017cites this paper
• Contributions of macrophages in lymph nodes and gut mucosa to SIV disease control and progression

  2017cites this paper
• Immunologic characteristics of HIV‐infected individuals who make broadly neutralizing antibodies

  2017cites this paper
• CD8 T‐cell regulation by T regulatory cells and the programmed cell death protein 1 pathway

  2017cites this paper
• Reversing Gut Damage in HIV Infection: Using Non-Human Primate Models to Instruct Clinical Research

  2016cites this paper
• Reduced Frequencies and Activation of Regulatory T Cells After the Treatment of HIV-1-Infected Individuals with the CCR5 Antagonist Maraviroc Are Associated with a Reduction in Viral Loads Rather Than a Direct Effect of the Drug on Regulatory T Cells

  2016cites this paper
• CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals

  2016cites this paper
• Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination.

  2016cites this paper
• Bovine leukemia virus reduces anti‐viral cytokine activities and NK cytotoxicity by inducing TGF‐β secretion from regulatory T cells

  2016cites this paper
• T cell regulation of acute and chronic viral infection

  2016cites this paper
• Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation

  2016cites this paper
• Distribución y análisis funcional de Linfocitos T CD4+ regulatorios y T CD4+ convencionales en el contexto de la coinfección por HIV-1 y M. tuberculosis y su modulación por la hormona adrenal Dehidroepiandrosterona

  2016cites this paper
• Microbial Translocation and the Effects of HIV/SIV Infection on Mucosal Barrier Function

  2015cites this paper
• Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection

  2015cites this paper
• Antiretroviral Therapy in Primary HIV-1 Infection: Influences on Immune Activation and Gut Mucosal Barrier Dysfunction.

  2015cites this paper
• Study of the HIV-1-mediated induction of BAFF in primary human monocytes and monocyte-derived macrophages

  2015cites this paper
• CD4 T Cells Mediate Both Positive and Negative Regulation of the Immune Response to HIV Infection: Complex Role of T Follicular Helper Cells and Regulatory T Cells in Pathogenesis

  2015cites this paper
• HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation

  2015cites this paper
• Animal models for viral infection and cell exhaustion

  2014cites this paper
• The Relative Balance between Th17 and Regulatory T cell subsets is Critical for Progression of HIV Infection

  2014influential citation
• Homeostasis and function of Regulatory T Cells during Human Immunodeficiency Virus infection

  2014cites this paper
• Immunoregulatory T Cells May Be Involved in Preserving CD4 T Cell Counts in HIV-Infected Long-Term Nonprogressors and Controllers

  2014cites this paper
• Modulation of Regulatory T-Cell Subsets in Very Long-Term Treated Aviremic HIV+ Patients and Untreated Viremic Patients

  2014cites this paper
• Development and Function of Human CD4+CD25+FOXP3+ Regulatory T Cells in Humanized Mouse and HIV-1 Infection

  2014influential citation
• Distinct Cellular Targets of SIV Infection in Natural and Non-natural Hosts of SIV

  2014cites this paper
• Dendritic Cell Dysfunction : A Key to HIV Spread and Persistence

  2014cites this paper
• Current understanding of HIV-1 and T-cell adaptive immunity: progress to date.

  2014cites this paper
• Epigenetic Modification of FOXP3 in Patients With Chronic HIV Infection

  2014cites this paper
• Regulatory T Cells in HIV-Infected Immunological Nonresponders Are Increased in Blood but Depleted in Lymphoid Tissue and Predict Immunological Reconstitution

  2014cites this paper
• Induction of Multiple Immune Regulatory Pathways with Differential Impact in HCV/HIV Coinfection

  2014cites this paper
• Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients

  2014cites this paper
• Fallen Angels or Risen Apes? A Tale of the Intricate Complexities of Imbalanced Immune Responses in the Pathogenesis and Progression of Immune-Mediated and Viral Cancers

  2014influential citation
• Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?

  2014cites this paper
• Regulatory T Cells Diminish HIV Infection in Dendritic Cells – Conventional CD4+ T Cell Clusters

  2014cites this paper
• Cellular interplay among Th17, Th1, and Treg cells in HIV‐1 subtype “C” infection

  2014cites this paper
• Thymic function in HIV-infection.

  2013cites this paper
• Incomplete Normalization of Regulatory T-Cell Frequency in the Gut Mucosa of Colombian HIV-Infected Patients Receiving Long-Term Antiretroviral Treatment

  2013cites this paper
• The Majority of HIV Type 1 DNA in Circulating CD4+ T Lymphocytes Is Present in Non-Gut-Homing Resting Memory CD4+ T Cells

  2013cites this paper
• Immune response to Streptococcus pneumoniae in asthma patients: comparison between stable situation and exacerbation

  2013cites this paper
• AIDS and HIV Infection after Thirty Years

  2013cites this paper
• HIV‐associated chronic immune activation

  2013cites this paper
• HIV and Tuberculosis co-infection impacts T-cell activation markers but not the numbers subset of regulatory T-cells in HIV-1 infected patients

  2013cites this paper
• Th2-Th1 shift with the multiantigenic formulation TERAVAC-HIV-1 in Balb/c mice.

  2013cites this paper
• Poor Immune Reconstitution in HIV-Infected Patients Associates with High Percentage of Regulatory CD4+ T Cells

  2013cites this paper
• associated with disease progression in HIV/AIDS HIV-1 driven regulatory T cell accumulation in lymphoid tissues is

  2013cites this paper
• CD4+FOXP3+ Regulatory T-Cell Subsets in Human Immunodeficiency Virus Infection

  2013cites this paper
• HIV impairment of immune responses in dendritic cells.

  2013cites this paper
• Antiviral activity of interferon-γ involved in impaired immune function in infectious diseases

  2013cites this paper
• The split personality of regulatory T cells in HIV infection.

  2013cites this paper
• Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation.

  2013cites this paper
• HIV-Induced T-Cell Activation/Exhaustion in Rectal Mucosa Is Controlled Only Partially by Antiretroviral Treatment

  2012cites this paper
• cAMP During HIV Infection: Friend or Foe?

  2012cites this paper
• Longitudinal Changes of Peripheral Blood DC Subsets and Regulatory T Cells in Chinese Chronic HIV-1-Infected Patients during Antiretroviral Therapy

  2012cites this paper
• Colitis ulcerosa

  2012cites this paper
• T Cell Responses During Human Immunodeficiency Virus (HIV)-1 Infection

  2012cites this paper
• Defining Dendritic Cells and Macrophages in Lymph Nodes and Gut Mucosa During Simian Immunodeficiency Virus Infection

  2012cites this paper
• AMPc: una molécula clave en los eventos de regulación inmune y en el control de la replicación del VIH

  2012cites this paper
• during HIV infection

  2012cites this paper
• Increased expression of regulatory T cells and down-regulatory molecules in lepromatous leprosy.

  2012cites this paper
• High-Dose Vitamin D3 Supplementation Is a Requisite for Modulation of Skin-Homing Markers on Regulatory T Cells in HIV-Infected Patients

  2012cites this paper
• Human immunodeficiency virus and the gastrointestinal immune system: does highly active antiretroviral therapy restore gut immunity?

  2012cites this paper
• Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells

  2012cites this paper
• EVALUATION OF IMMUNE MECHANISMS INVOLVED IN THE LACK OF CD4 T CELL RECOVERY IN HIV-INFECTED PATIENTS NON RESPONDER TO ANTIRETROVIRAL THERAPY

  2012cites this paper
• Homeostasis and Function of Regulatory T Cells in HIV/SIV Infection

  2012influential citation
• Die Rolle regulatorischer T-Zellen bei der Masernviruspathogenese

  2012influential citation
• Chronically HIV-1 Infected Patients Exhibit Low Frequencies of CD25+ Regulatory T Cells

  2012influential citation
• “Wrapped Up” Vaccines in the Context of HIV-1 Immunotherapy

  2012cites this paper
• cAMP: A keymolecule in events of immune regulation and in the control of HIV replication

  2012cites this paper
• Regulatory T cells are converts in simian immunodeficiency virus infection.

  2012cites this paper
• Level of double negative T cells, which produce TGF-&bgr; and IL-10, predicts CD8 T-cell activation in primary HIV-1 infection

  2012cites this paper
• A dendrite in every pie

  2012cites this paper
• Early and long-lasting alteration of effector CD45RA(-)Foxp3(high) regulatory T-cell homeostasis during HIV infection.

  2012cites this paper
• Regulatory T Cell Frequencies Do Not Correlate with Breadth or Magnitude of HIV-1-Specific T Cell Responses

  2012cites this paper
• HCV Coinfection Does Not Alter the Frequency of Regulatory T Cells or CD8+ T Cell Immune Activation in Chronically Infected HIV+ Chinese Subjects

  2012cites this paper
• IL-23 in Infections, Inflammation, Autoimmunity and Cancer: Possible Role in HIV-1 and AIDS

  2012cites this paper