Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of NutriLife

• Publication date

  2010-06-01

• Fields of study

  Agricultural and Food Sciences, Medicine, Biology

• Identifiers
  DOI 10.3945/jn.109.120725PMID 20375261PMCID PMC2869499
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
• Selenium deficiency and viral infection.

  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1988cited by this paper
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  1985cited by this paper
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  1983cited by this paper
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  1980cited by this paper
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  1977cited by this paper
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  1976cited by this paper

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