Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Experimental Cell Research

• Publication date

  2011-03-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.yexcr.2011.01.004PMID 21223963PMCID PMC3089961
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Chemokine: receptor structure, interactions, and antagonism.

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• Structural Rearrangement of Human Lymphotactin, a C Chemokine, under Physiological Solution Conditions*

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