Glycosylation-Dependent Interactions of C-Type Lectin DC-SIGN with Colorectal Tumor-Associated Lewis Glycans Impair the Function and Differentiation of Monocyte-Derived Dendritic Cells1

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Immunology

• Publication date

  2008-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.180.5.3347PMID 18292560
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recognition of tumor glycans by antigen-presenting cells.

  2006cited by this paper
• Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin.

  2005influential reference
• TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells

  2005cited by this paper
• Characterization of Oligosaccharide Ligands Expressed on SW1116 Cells Recognized by Mannan-binding Protein

  2005cited by this paper
• Mechanisms and functional significance of tumour-induced dendritic-cell defects

  2004cited by this paper
• Self- and nonself-recognition by C-type lectins on dendritic cells.

  2004cited by this paper
• Increased expression of DC‐SIGN+IL‐12+IL‐18+ and CD83+IL‐12–IL‐18– dendritic cell populations in the colonic mucosa of patients with Crohn's disease

  2003cited by this paper
• Some interfaces of dendritic cell biology

  2003cited by this paper
• Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

  2003influential reference
• C-type lectin receptors on dendritic cells and langerhans cells

  2002cited by this paper
• Carcinoembryonic antigen as a target for therapeutic anticancer vaccines: a review.

  2002cited by this paper
• Myeloma and the newly diagnosed patient: a focus on treatment and management.

  2002cited by this paper
• Immunologic mechanisms of antitumor activity.

  2002cited by this paper
• Mature dendritic cells make clusters with T cells in the invasive margin of colorectal carcinoma

  2002cited by this paper
• IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

  2001cited by this paper
• Regulation of T cell immunity by dendritic cells.

  2001cited by this paper
• Glycosylation, Immunity, and Autoimmunity

  2001cited by this paper
• Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR

  2001influential reference
• Glycosylation and the immune system.

  2001cited by this paper
• A Novel Mechanism of Carbohydrate Recognition by the C-type Lectins DC-SIGN and DC-SIGNR

  2001cited by this paper
• Dendritic Cell Infiltration in Colon Cancer

  2001cited by this paper
• DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.

  2000cited by this paper
• Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses.

  2000cited by this paper
• Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells1

  2000cited by this paper
• Immunobiology of dendritic cells.

  2000cited by this paper
• In Breast Carcinoma Tissue, Immature Dendritic Cells Reside within the Tumor, Whereas Mature Dendritic Cells Are Located in Peritumoral Areas

  1999cited by this paper
• Dendritic cells and the control of immunity

  1998cited by this paper
• Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor.

  1998cited by this paper
• The C‐type lectin superfamily in the immune system

  1998cited by this paper
• Prognostic value of tumour‐infiltrating lymphocytes (TILs) in colorectal cancer

  1997cited by this paper
• The host-tumor immune conflict: from immunosuppression to resistance and destruction.

  1997cited by this paper
• Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

  1996cited by this paper
• Carbohydrate signals in metastasis and prognosis of human carcinomas.

  1993cited by this paper
• Carcinoembryonic antigen has a different molecular weight in normal colon and in cancer cells due to N-glycosylation differences.

  1991cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
• Glycans in melanoma: Drivers of tumour progression but sweet targets to exploit for immunotherapy

  2024cites this paper
• The melanoma tumor glyco-code impacts human dendritic cells’ functionality and dictates clinical outcomes

  2023influential citation
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  2023cites this paper
• Melanoma tumour‐derived glycans hijack dendritic cell subsets through C‐type lectin receptor binding

  2023cites this paper
• Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin‐1 downregulation

  2023cites this paper
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  2023cites this paper
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  2022cites this paper
• The transcriptional landscape of glycosylation-related genes in cancer

  2022cites this paper
• Advances in the Immunomodulatory Properties of Glycoantigens in Cancer

  2022cites this paper
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  2022cites this paper
• Tinker, tailor, soldier, cell: the role of C-type lectins in the defense and promotion of disease

  2022influential citation
• From structure to function – Ligand recognition by myeloid C-type lectin receptors

  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019influential citation
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  2018cites this paper
• Innate Immune Receptors in the Regulation of Tumor Immunity

  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015influential citation
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  2015cites this paper
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  2015cites this paper
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• Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense

  2014cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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