Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia.

Elizabeth A. Morgan,Mark N Lee,D. DeAngelo,D. Steensma,Richard M. Stone,Frank C. Kuo,Jon C. Aster,C. Gibson,R. C. Lindsley

Published 2017 in Blood Advances

ABSTRACT

TO THE EDITOR: Large granular lymphocytic (LGL) leukemia and myelodysplastic syndromes (MDSs) both typically present with unexplained cytopenias, yet these diseases are pathobiologically distinct and associated with substantial differences in prognosis and therapy. LGL leukemias, including both T-

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