High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia.

To the editor: Large granular lymphocyte (LGL) leukemia is a group of chronic lymphoproliferative disorders of cytotoxic T or natural killer (NK) cells frequently complicated with cytopenia and autoimmune phenomena.[1][1],[2][2] In the current World Health Organization (WHO) classification, T-LGL

• Publication year

  2016

• Venue

  Blood

• Publication date

  2016-11-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2016-06-724856PMID 27697773PMCID PMC5114490
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma

  2016cited by this paper
• Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells

  2015cited by this paper
• The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia

  2015influential reference
• The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

  2014cited by this paper
• Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

  2014cited by this paper
• Identification of STAT5A and STAT5B Target Genes in Human T Cells

  2014cited by this paper
• Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.

  2014cited by this paper
• Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas

  2014cited by this paper
• Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.

  2013influential reference
• Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation

  2013cited by this paper
• Somatic STAT3 mutations in large granular lymphocytic leukemia.

  2012cited by this paper
• STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.

  2012cited by this paper
• Large granular lymphocytic leukemia: molecular pathogenesis, clinical manifestations, and treatment.

  2012cited by this paper
• WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview.

  2010cited by this paper
• Laboratory findings in CD4(+) large granular lymphocytoses

  2010cited by this paper
• Expanded cells in monoclonal TCR-alphabeta+/CD4+/NKa+/CD8-/+dim T-LGL lymphocytosis recognize hCMV antigens.

  2008cited by this paper
• Monoclonal TCR-Vbeta13.1+/CD4+/NKa+/CD8-/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin.

  2007cited by this paper
• TCRalphabeta+/CD4+ large granular lymphocytosis: a new clonal T-cell lymphoproliferative disorder.

  2003cited by this paper
• TCRαβ+/CD4+ Large Granular Lymphocytosis: A New Clonal T-Cell Lymphoproliferative Disorder

  2003cited by this paper
• Clonal diseases of large granular lymphocytes.

  1993cited by this paper

• Diagnostic Conundrums of T-CLPDs: A Case Report of a CD4-Positive T-LGLL with Overlapping Morphological Features of T-PLL

  2026cites this paper
• Recurrent Missense Driver STAT5B N642H Mutation in Children Transiting into Adolescence, with Acute Lymphoid Leukemia and its In silico Inhibition.

  2025cites this paper
• STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

  2025cites this paper
• Transcriptomic landscape of CD8+ and CD4 + T-LGL leukemia revealed the distinct impact of STAT3 and STAT5B activating mutations

  2025cites this paper
• Crescentic glomerulonephritis associated with NK-large granular lymphocytic leukemia: A case report

  2025cites this paper
• Diagnosis and Management of Large Granular Lymphocytic Leukaemia and Its Differentiation From T Cell Clones of Uncertain Significance

  2025cites this paper
• Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism

  2025cites this paper
• Updates on Non-B-Lymphoid Neoplasms: A Review of the 5th Edition of the WHO Classification of Hematolymphoid Tumors

  2024cites this paper
• Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia

  2024cites this paper
• Large Granular Lymphocytic Leukemia: Clinical Features, Molecular Pathogenesis, Diagnosis and Treatment

  2024cites this paper
• Unveiling myeloid transformation: T‐LGLL with eosinophilia masking myeloid‐associated STAT5B mutation culminating in AML

  2024cites this paper
• Extrinsic and intrinsic drivers of natural killer cell clonality

  2024cites this paper
• A tower of babel of acronyms? The shadowlands of MGUS/MBL/CHIP/TCUS.

  2024cites this paper
• A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia

  2024cites this paper
• STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

  2024cites this paper
• HSP and CD279 gene expression as candidate biomarkers in symptomatic LGLL patients

  2024cites this paper
• Sequential mosaic variants in KRAS and STAT5B associated with a mixed phenotype of two acquired errors of immunity

  2024cites this paper
• Aleukemic variant of T-cell large granular lymphocyte leukemia in patients with rheumatoid arthritis - diagnostically challenging subtype

  2024cites this paper
• How I diagnose large granular lymphocytic leukemia.

  2024cites this paper
• CCL22 mutations in large granular lymphocytic leukemia

  2024cites this paper
• An update on genetic aberrations in T-cell neoplasms.

  2023cites this paper
• TOX as a new diagnostic marker for T cell large granular lymphocytic leukaemia

  2023cites this paper
• Updates in the Classification of T-cell Lymphomas and Lymphoproliferative Disorders

  2023cites this paper
• Systematic analysis reveals distinct roles of USF family proteins in various cancer types

  2023cites this paper
• A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia

  2023cites this paper
• A simplified prognostic score for T-cell large granular lymphocyte leukaemia

  2023cites this paper
• Computational tools for inferring transcription factor activity

  2023cites this paper
• Genomic landscape of T-large granular lymphocyte leukemia and chronic lymphoproliferative disorder of NK cells: a single institution experience

  2023cites this paper
• Case Report: A rare case of CD20-positive T-cell large granular lymphocyte leukemia with renal cell carcinoma: a challenging diagnosis

  2023cites this paper
• Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: low mutational burden of STAT3

  2023cites this paper
• Not all LGL leukemias are created equal.

  2023cites this paper
• STAT5b: A master regulator of key biological pathways

  2023cites this paper
• TF-Prioritizer: a Java pipeline to prioritize condition-specific transcription factors

  2022cites this paper
• Genomic Landscape of TCR Alpha-Beta and TCR Gamma-Delta T-Large Granular Lymphocyte Leukemia.

  2022cites this paper
• T-Cell Large Granular Lymphocyte Leukemia: An Interdisciplinary Issue?

  2022cites this paper
• Large Granular Lymphocytic Leukemia: Current State of Diagnosis, Pathogenesis and Treatment

  2022cites this paper
• Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia

  2022influential citation
• Cytokines in the Pathogenesis of Large Granular Lymphocytic Leukemia

  2022cites this paper
• Search for the cause of anaemia and neutropenia in a patient with well‐controlled systemic lupus erythematosus

  2022cites this paper
• Somatic mutations in acquired pure red cell aplasia.

  2022cites this paper
• The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome.

  2022cites this paper
• CHIPing away the progression potential of CHIP: A new reality in the making.

  2022cites this paper
• Genomic Profiling for Clinical Decision Making in Lymphoid Neoplasms.

  2022cites this paper
• Tγδ LGLL identifies a subset with more symptomatic disease: analysis of an international cohort of 137 patients

  2022cites this paper
• All that glitters is not LGL Leukemia

  2022cites this paper
• Activating STAT5B mutations can cause both primary hypereosinophilia and lymphocyte-variant hypereosinophilia

  2022cites this paper
• Clinical Study of the Relationship between Sjögren Syndrome and T-Cell Large Granular Lymphocytic Leukemia: Single-Center Experience

  2022cites this paper
• STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

  2022cites this paper
• Defining TCRγδ lymphoproliferative disorders by combined immunophenotypic and molecular evaluation

  2022cites this paper
• T‐cell large granular lymphocytic leukaemia with atypical immunophenotypes: A single‐centre retrospective analysis of 17 cases

  2022cites this paper
• CD4+ T‐cell large granular lymphocytic leukemia with STAT3 mutation and neutropenia

  2021cites this paper
• Perturbed NK Cell Homeostasis Associated with Disease Severity in Chronic Neutropenia.

  2021cites this paper
• The Value of Flow Cytometry Clonality in Large Granular Lymphocyte Leukemia

  2021cites this paper
• Large Granular Lymphocytic Leukemia: From Immunopathogenesis to Treatment of Refractory Disease

  2021cites this paper
• Clinicobiological Characteristics and Outcomes of Patients with T-Cell Large Granular Lymphocytic Leukemia and Chronic Lymphoproliferative Disorder of Natural Killer Cells from a Single Institution

  2021cites this paper
• Immunologic effects on the haematopoietic stem cell in marrow failure.

  2021cites this paper
• Somatic Mutations in "Benign" Disease.

  2021cites this paper
• Large Granular Lymphocyte Leukemia

  2021cites this paper
• Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia

  2021cites this paper
• STAT3 and STAT5B mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms

  2021cites this paper
• T-Cell Large Granular Lymphocytic Leukemia with Atypical Immunophenotypes: A Single Center Retrospective Analysis of 17 Cases

  2021cites this paper
• IL-2 Signaling Axis Defects: How Many Faces?

  2021cites this paper
• Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?

  2021cites this paper
• STAT3 and STAT5B Mutations in T/NK-Cell Chronic Lymphoproliferative Disorders of Large Granular Lymphocytes (LGL): Association with Disease Features

  2020influential citation
• High frequency of STAT3 gene mutations in T‐cell receptor (TCR)γδ‐type T‐cell large granular lymphocytic leukaemia: implications for molecular diagnostics

  2020cites this paper
• Insights Into Genetic Landscape of Large Granular Lymphocyte Leukemia

  2020influential citation
• A high definition picture of somatic mutations in chronic lymphoproliferative disorder of natural killer cells

  2020cites this paper
• Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation

  2020cites this paper
• Somatic mutations and T-cell clonality in patients with immunodeficiency

  2019cites this paper
• Acquired and germline predisposition to bone marrow failure: Diagnostic features and clinical implications.

  2019cites this paper
• Fine-Tuning Cytokine Signals.

  2019cites this paper
• What is new in mature T-cell leukemias?

  2019cites this paper
• T-cell large granular lymphocytic (LGL) leukemia consists of CD4+/CD8dim and CD4-/CD8+ LGL populations in association with immune thrombocytopenia, autoimmune neutropenia, and monoclonal B-cell lymphocytosis

  2019cites this paper
• Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia

  2019cites this paper
• JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression

  2019cites this paper
• JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL

  2019cites this paper
• Stat3 mutations impact on overall survival in large granular lymphocyte leukemia: a single-center experience of 205 patients

  2019cites this paper
• Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

  2019cites this paper
• Genomics of LGL leukemia and select other rare leukemia/lymphomas.

  2019cites this paper
• T cell large granular lymphocyte leukemia and chronic NK lymphocytosis.

  2019cites this paper
• Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease

  2019cites this paper
• Structural and functional consequences of the STAT5BN642H driver mutation

  2019cites this paper
• Large Granular Lymphocyte Leukemia

  2019cites this paper
• Somatic mutations in autoimmunity

  2019cites this paper
• Targeting key survival signaling pathways for the treatment of leukemia

  2018cites this paper
• STAT 5 B N 642 H is a driver mutation for T cell neoplasia

  2018cites this paper
• Mutations in the signal transducer and activator of transcription family of genes in cancer

  2018cites this paper
• Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation

  2018cites this paper
• New Insights into Lymphoma Pathogenesis.

  2018cites this paper
• Dominant cytotoxic NK cell subset within CLPD-NK patients identifies a more aggressive NK cell proliferation

  2018cites this paper
• Latest Advances in the Diagnosis and Treatment of Large Granular Lymphocytic Leukemia.

  2018cites this paper
• STAT5BN642H is a driver mutation for T cell neoplasia

  2017cites this paper
• Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias

  2017influential citation
• STAT3 mutation impacts biological and clinical features of T-LGL leukemia

  2017influential citation
• Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56− chronic lymphoproliferative disorder of NK-cells

  2017cites this paper
• CD4-Positive T-Cell Large Granular Lymphocytosis Mimicking Sezary Syndrome in a Patient With Mycosis Fungoides.

  2017cites this paper
• Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia.

  2017cites this paper
• LGL leukemia: from pathogenesis to treatment.

  2017cites this paper
• Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach

  2017cites this paper
• A guilt-by-association mutation network in LGL leukemia

  2017cites this paper