Fungal secondary metabolism has become an important research topic with great biomedical and biotechnological value. In the postgenomic era, understanding the diversity and the molecular control of secondary metabolites (SMs) are two challenging tasks addressed by the research community. Discovery of the LaeA methyltransferase 10 years ago opened up a new horizon on the control of SM research when it was found that expression of many SM gene clusters is controlled by LaeA. While the molecular function of LaeA remains an enigma, discovery of the velvet family proteins as interaction partners further extended the role of the LaeA beyond secondary metabolism. The heterotrimeric VelB–VeA–LaeA complex plays important roles in development, sporulation, secondary metabolism, and pathogenicity. Recently, three other methyltransferases have been found to associate with the velvet complex, the LaeA-like methyltransferase F and the methyltransferase heterodimers VipC–VapB. Interaction of VeA with at least four methyltransferase proteins indicates a molecular hub function for VeA that questions: Is there a VeA supercomplex or is VeA part of a highly dynamic cellular control network with many different partners?
One Juliet and four Romeos: VeA and its methyltransferases
Özlem Sarikaya-Bayram,J. Palmer,N. Keller,G. Braus,Özgür Bayram
Published 2015 in Frontiers in Microbiology
ABSTRACT
PUBLICATION RECORD
- Publication year
2015
- Venue
Frontiers in Microbiology
- Publication date
2015-01-20
- Fields of study
Biology, Medicine, Chemistry, Environmental Science
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- highly dynamic cellular control network
Highly dynamic cellular control network is the alternative model in which VeA participates through many changing partners rather than a single stable assembly.
Aliases: dynamic cellular control network
- laea
LaeA is a methyltransferase that is part of the velvet-complex regulatory context described in the abstract.
- laea-like methyltransferase f
LaeA-like methyltransferase F is a LaeA-related methyltransferase named as an additional velvet-complex-associated partner.
Aliases: methyltransferase F
- molecular hub function
Molecular hub function is the proposed role of VeA as a central connector for multiple methyltransferase partners.
Aliases: hub function
- vea
VeA is the velvet-family regulatory protein discussed as the central interaction partner in this abstract.
- vea supercomplex
VeA supercomplex is the hypothesized larger assembly that could include VeA and several associated proteins.
- velb-vea-laea complex
The VelB-VeA-LaeA complex is the heterotrimeric velvet complex centered on VelB, VeA, and LaeA.
Aliases: VelB–VeA–LaeA complex, heterotrimeric VelB–VeA–LaeA complex
- vipc-vapb heterodimers
VipC-VapB heterodimers are paired methyltransferase proteins reported as additional partners associated with the velvet complex.
Aliases: VipC–VapB, VipC/VapB heterodimers
REFERENCES
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