Intramembrane Proteolysis in Regulated Protein Trafficking

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Traffic : the International Journal of Intracellular Transport

• Publication date

  2011-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1600-0854.2011.01219.xPMID 21585636
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulated intramembrane proteolysis – lessons from amyloid precursor protein processing

  2011cited by this paper
• Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease.

  2011cited by this paper
• Mammalian EGF receptor activation by the rhomboid protease RHBDL2

  2011cited by this paper
• Intramembrane Cleavage of AMA1 Triggers Toxoplasma to Switch from an Invasive to a Replicative Mode

  2011cited by this paper
• The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

  2011cited by this paper
• PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

  2010cited by this paper
• Structure, mechanism and inhibition of γ-secretase and presenilin-like proteases

  2010cited by this paper
• The secretases: enzymes with therapeutic potential in Alzheimer disease

  2010cited by this paper
• The structural basis for catalysis and substrate specificity of a rhomboid protease

  2010cited by this paper
• PINK1 cleavage at position A103 by the mitochondrial protease PARL

  2010cited by this paper
• Signaling from the Endoplasmic Reticulum Activates Brassinosteroid Signaling and Promotes Acclimation to Stress in Arabidopsis

  2010cited by this paper
• Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

  2010cited by this paper
• Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.

  2010cited by this paper
• PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

  2010cited by this paper
• The PARL family of mitochondrial rhomboid proteases.

  2010cited by this paper
• Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission*

  2009cited by this paper
• The role of protease activity in ErbB biology.

  2009cited by this paper
• γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

  2009cited by this paper
• PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

  2009cited by this paper
• Structure and mechanism of intramembrane protease.

  2009cited by this paper
• Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

  2009cited by this paper
• Trafficking, a key player in regulated intramembrane proteolysis.

  2009cited by this paper
• Distinct roles of the two isoforms of the dynamin‐like GTPase Mgm1 in mitochondrial fusion

  2009cited by this paper
• Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria.

  2009cited by this paper
• Genomic and proteomic biomarkers for Parkinson disease

  2009cited by this paper
• Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteases.

  2008cited by this paper
• Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

  2008cited by this paper
• Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b*

  2008cited by this paper
• Intramembrane Processing by Signal Peptide Peptidase Regulates the Membrane Localization of Hepatitis C Virus Core Protein and Viral Propagation

  2008cited by this paper
• Coordinated protein sorting, targeting and distribution in polarized cells

  2008cited by this paper
• Endoplasmic reticulum retention of the γ‐secretase complex component Pen2 by Rer1

  2007cited by this paper
• Rer1p competes with APH-1 for binding to nicastrin and regulates γ-secretase complex assembly in the early secretory pathway

  2007cited by this paper
• The membrane protein universe: what's out there and why bother?

  2007cited by this paper
• Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

  2007cited by this paper
• Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1

  2007cited by this paper
• Structure of a Site-2 Protease Family Intramembrane Metalloprotease

  2007cited by this paper
• Cutting proteins within lipid bilayers: rhomboid structure and mechanism.

  2007cited by this paper
• Rer1p Competes with Aph-1 for Binding to Nicastrin and Regulates gamma-secretase Complex Assembly

  2007cited by this paper
• Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases.

  2007cited by this paper
• A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.

  2006cited by this paper
• Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.

  2006cited by this paper
• SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production

  2006cited by this paper
• Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology

  2006cited by this paper
• Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function.

  2006cited by this paper
• A chloroplastic inner envelope membrane protease is essential for plant development

  2006cited by this paper
• Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

  2006cited by this paper
• Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation

  2006cited by this paper
• A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b

  2006cited by this paper
• Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

  2006cited by this paper
• Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

  2006cited by this paper
• Crystal structure of a rhomboid family intramembrane protease

  2006cited by this paper
• A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma.

  2005cited by this paper
• Differential Localization and Identification of a Critical Aspartate Suggest Non-redundant Proteolytic Functions of the Presenilin Homologues SPPL2b and SPPL3*

  2005cited by this paper
• Co‐expressed presenilin 1 NTF and CTF form functional γ‐secretase complexes in cells devoid of full‐length protein

  2004cited by this paper
• Mechanism of γ-secretase cleavage activation: Is γ-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

  2004cited by this paper
• Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor

  2004cited by this paper
• EGF Signal Propagation during C. elegans Vulval Development Mediated by ROM-1 Rhomboid

  2004cited by this paper
• Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by Mammalian rhomboids.

  2004cited by this paper
• Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila.

  2004cited by this paper
• Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.

  2004cited by this paper
• Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

  2004cited by this paper
• γ-Secretase: proteasome of the membrane?

  2004cited by this paper
• Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.

  2003cited by this paper
• γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

  2003cited by this paper
• Reconstitution of γ-secretase activity

  2003cited by this paper
• Reconstitution of gamma-secretase activity.

  2003cited by this paper
• The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers

  2003cited by this paper
• The role of presenilin cofactors in the gamma-secretase complex.

  2003cited by this paper
• Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

  2003cited by this paper
• The role of presenilin cofactors in the γ-secretase complex

  2003cited by this paper
• Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA*

  2003influential reference
• Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis.

  2002cited by this paper
• Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease

  2002cited by this paper
• A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.

  2002influential reference
• Toxic Proteins in Neurodegenerative Disease

  2002cited by this paper
• Identification of a novel family of presenilin homologues.

  2002cited by this paper
• Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

  2002cited by this paper
• Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.

  2002cited by this paper
• Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes1

  2001cited by this paper
• Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases.

  2001cited by this paper
• Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

  2001cited by this paper
• Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila.

  2001cited by this paper
• The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

  2001cited by this paper
• ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.

  2000cited by this paper
• Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.

  2000cited by this paper
• A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling.

  2000cited by this paper
• Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

  2000cited by this paper
• Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

  1999cited by this paper
• Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.

  1999influential reference
• A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

  1999cited by this paper
• Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.

  1998cited by this paper
• Second-site Cleavage in Sterol Regulatory Element-binding Protein Occurs at Transmembrane Junction as Determined by Cysteine Panning*

  1998cited by this paper
• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

  1998cited by this paper
• Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

  1998influential reference
• Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.

  1997cited by this paper
• Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein.

  1996cited by this paper
• Candidate gene for the chromosome 1 familial Alzheimer's disease locus

  1995cited by this paper
• Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

  1995cited by this paper
• Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

  1995cited by this paper
• Biosynthesis and biochemical properties of the hepatitis C virus core protein

  1994cited by this paper

• Death, taxes, and rhomboids: Understanding the ubiquitous roles of the rhomboid protein superfamily

  2025cites this paper
• Advances in targeted therapy for triple-negative breast cancer: a review of key antigens and recent advances

  2025cites this paper
• Trop2-targeted therapy in breast cancer

  2024cites this paper
• HO-1 impairs the efficacy of radiotherapy by redistributing cGAS and STING in tumors

  2024cites this paper
• Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids

  2023cites this paper
• The relationship of early- and late-onset Alzheimer’s disease genes with COVID-19

  2022cites this paper
• Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids

  2021cites this paper
• Signal Peptide Peptidase-Type Proteases: Versatile Regulators with Functions Ranging from Limited Proteolysis to Protein Degradation.

  2020cites this paper
• The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients

  2019cites this paper
• The intramembrane protease SPP impacts morphology of the endoplasmic reticulum by triggering degradation of morphogenic proteins

  2018cites this paper
• Chapter 23 – Osteogenesis Imperfecta

  2018cites this paper
• The metastable XBP1u transmembrane domain defines determinants for intramembrane proteolysis by signal peptide peptidase

  2018cites this paper
• Intramembrane proteases as drug targets

  2017cites this paper
• Influence of the Lipid Environment on the Dimerization Properties of the Amyloid Precursor Protein Transmembrane Domain

  2016cites this paper
• Ectodomain cleavage of FLT1 regulates receptor activation and function and is not required for its downstream intracellular cleavage.

  2016cites this paper
• What we know about TMEM106B in neurodegeneration

  2016cites this paper
• Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

  2016cites this paper
• Inhibitors of rhomboid proteases.

  2016cites this paper
• Yeast membrane proteomics using leucine metabolic labelling: Bioinformatic data processing and exemplary application to the ER-intramembrane protease Ypf1.

  2016cites this paper
• Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase

  2016cites this paper
• Trop2: From development to disease

  2015cites this paper
• Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy

  2015cites this paper
• Can agrin CSF concentration be used as an early biomarker for Alzheimer ’ s disease ?

  2015cites this paper
• Lentivirus-mediated knockdown of rhomboid domain containing 1 inhibits colorectal cancer cell growth.

  2015cites this paper
• [Degradome Components in Progression of Squamous Cell Carcinoma of the Head and Neck].

  2015cites this paper
• Membrane-Bound Selenoproteins

  2015cites this paper
• Clipping or Extracting: Two Ways to Membrane Protein Degradation.

  2015cites this paper
• Characterization of the Regulatory Process of Pyrethroid Resistance in the House Fly, Musca domestica

  2015cites this paper
• Substrate-free Rhomboid Protease Assays for the Discovery of Novel Inhibitors

  2015cites this paper
• Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

  2014cites this paper
• Regulated Intramembrane Proteolysis of the Frontotemporal Lobar Degeneration Risk Factor, TMEM106B, by Signal Peptide Peptidase-like 2a (SPPL2a)*

  2014cites this paper
• The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance.

  2014cites this paper
• Flavonoids as regulators of amyloid precursor protein processing

  2014cites this paper
• Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures

  2014cites this paper
• Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum

  2014cites this paper
• Glioma-Associated Proteases

  2014cites this paper
• Regulated intramembrane proteolysis of the TGFβ type I receptor conveys oncogenic signals.

  2014cites this paper
• Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana

  2014cites this paper
• EmTIP, a T-Cell Immunomodulatory Protein Secreted by the Tapeworm Echinococcus multilocularis Is Important for Early Metacestode Development

  2014cites this paper
• Origin of chordate peptides by horizontal protozoan gene transfer in early metazoans and protists: evolution of the teneurin C-terminal associated peptides (TCAP).

  2013cites this paper
• A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization

  2013cites this paper
• A whole transcriptomal linkage analysis of gene co-regulation in insecticide resistant house flies, Musca domestica

  2013cites this paper
• Sampling the membrane: function of rhomboid-family proteins.

  2013cites this paper
• The very many faces of presenilins and the γ-secretase complex

  2013cites this paper
• Receptor tyrosine kinases in the nucleus.

  2013cites this paper
• Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein

  2013cites this paper
• Emerging role of rhomboid family proteins in mammalian biology and disease.

  2013cites this paper
• The Transcriptome Profile of the Mosquito Culex quinquefasciatus following Permethrin Selection

  2012cites this paper
• Cell-specific processing and release of the hormone-like precursor and candidate tumor suppressor gene product, Ecrg4

  2012cites this paper
• A ubiquitin-binding rhomboid protease aimed at ERADication.

  2012cites this paper
• Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.

  2012cites this paper