Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor.

Cultured mouse peritoneal macrophages secrete a growth-promoting activity that stimulates 3 types of nonlymphoid mesenchymal cells in vitro: fibroblasts, vascular smooth muscle, and vascular endothelium. Production of this macrophage-derived growth factor (MDGF) is directly related to the number of viable macrophages and their time in culture, and is independent of platelet- or plasma-derived serum growth factors. Treatment of cultured macrophages with latex, bacterial lipopolysaccharide, or phorbol myristate acetate results in increased growth factor activity. Preliminary biochemical characterization of MDGF indicates that it is a heat labile (100 degrees C, 2 min), non-dialyzable protein, which contains at least 1 essential disulfide bond. Growth-promoting activity is not adsorbed by CM-Sephadex chromatography, under conditions that effectively remove platelet-derived growth factor(s). Serine protease activity is not required for the action of MDGF. Secretion of macrophage-derived growth factor may be relevant to the function of mononuclear phagocytes in several pathologic processes, including the neovascularization and fibroplasia of wound healing, smooth muscle hyperplasia in atherosclerosis, and proliferative glomerulonephritis.

• Publication year

  1981

• Venue

  Journal of Immunology

• Publication date

  1981-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.126.4.1510PMID 7204974
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages.

  1980cited by this paper
• Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli.

  1980cited by this paper
• Purification of human platelet-derived growth factor.

  1979cited by this paper
• The tumor promoter 12‐0‐tetradecanoyl‐phorbol‐13‐acetate enhances the proliferative response of Balb/c‐3T3 cells to hormonal growth factors

  1979cited by this paper
• Stimulation of wound blood vessel growth by wound macrophages.

  1979cited by this paper
• Macrophage activation by mycobacterial water soluble compounds and synthetic muramyl dipeptide.

  1979cited by this paper
• Platelet-derived growth factor: purification and partial characterization.

  1979cited by this paper
• Production of macrophage-dependent fibroblast-stimulating activity (M-FSA) by murine macrophages. Effects on BALBc 3T3 fibroblasts.

  1978cited by this paper
• Factors influencing endothelial cell proliferation in vitro

  1978cited by this paper
• Coordinate control of 3T3 cell proliferation by platelet-derived growth factor and plasma components.

  1978cited by this paper
• Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor

  1978cited by this paper
• Endothelial proliferation in inflammation. II. Autoradiographic studies in x-irradiated leukopenic rats after thermal injury to the skin.

  1978cited by this paper
• The proliferative response in vitro of vascular endothelial and smooth muscle cells exposed to wound fluids and macrophages

  1978cited by this paper
• Monocytes, proliferation, and glomerulonephritis.

  1978cited by this paper
• Platelet factors and the human vascular wall. Part 2. Such factors are not required for endothelial cell proliferation and migration.

  1978cited by this paper
• Selection and characterization of bovine aortic endothelial cells

  1978cited by this paper
• A mononuclear cell component in experimental immunological glomerulonephritis

  1978cited by this paper
• The stimulation of DNA synthesis and cell division in chondrocytes and 3T3 cells by a growth factor isolated from cartilage.

  1977cited by this paper
• Radioimmunoassay of a human serum growth factor for Balb/c-3T3 cells: derivation from platelets.

  1977cited by this paper
• Activated macrophages induce vascular proliferation

  1977cited by this paper
• Endothelial proliferation in the delayed hypersensitivity reaction: an autoradiographic study.

  1977cited by this paper
• A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro.

  1976cited by this paper
• Role of macrophages in would healing.

  1976cited by this paper
• The pathogenesis of atherosclerosis (second of two parts).

  1976cited by this paper
• The pathogenesis of atherosclerosis (first of two parts).

  1976cited by this paper
• The modulation of lymphocyte functions by molecules secreted by macrophages. I. Description and partial biochemical analysis

  1975cited by this paper
• The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

  1975cited by this paper
• A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro.

  1974cited by this paper
• Platelets as a source of fibroblast growth-promoting activity.

  1974cited by this paper
• HUMAN VASCULAR ENDOTHELIAL CELLS IN CULTURE

  1974cited by this paper
• Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis.

  1973cited by this paper
• THE SMOOTH MUSCLE CELL

  1971cited by this paper
• Substrate and product inhibition of rabbit muscle lactic dehydrogenase heart (H4) and muscle (M4) isozymes.

  1966cited by this paper
• The fine structure of human atherosclerotic lesions.

  1961cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• The Use of Organ Cultures to Study Vessel Wall Pathobiology

  2021cites this paper
• Wound Healing Subsequent to Injury

  2018cites this paper
• Interaction of Lipoproteins with the Artery Wall

  2012cites this paper
• Interrelationship of Hypertension, Plasma Lipids and Atherosclerosis

  2012cites this paper
• Pathology Reviews · 1989

  2011cites this paper
• Porcine alveolar macrophages, isolation, morphological and functional characteristics.

  2010cites this paper
• The Response-to-Retention Hypothesis of Early Atherogenesis

  2010cites this paper
• PHOTO-STIMULATORY EFFECT OF LOW ENERGY HELIUM-NEON LASER IRRADIATION ON EXCISIONAL DIABETIC WOUND HEALING DYNAMICS IN WISTAR RATS

  2009cites this paper
• Host immune factors regulating fibrosis.

  2008cites this paper
• Grundlagen und Biologie der Anastomosenheilung

  2007cites this paper
• Complications and Adverse Sequelae of Sclerotherapy

  2007cites this paper
• Dietary Cho estero-Induced Changes in Macrophage Characteristics Relationship to A therosclerosis

  2007cites this paper
• Endothelial Stimulation of Intimal Cell Proliferation in a Porcine Aortic Organ Culture

  2007cites this paper
• The development of vitreous membranes and retinal detachment induced by intravitreal carbon microparticles

  2005cites this paper
• Smooth Muscle Proliferation in Hypertension

  2005cites this paper
• Macrophage modulation of retinal pigment epithelial cell migration and proliferation

  2005cites this paper
• Macrophages and cellular immunity in experimental glomerulonephritis

  2005cites this paper
• Vascular Endothelial Growth Factor Expression and Cyclosporine Toxicity in Renal Allograft Rejection

  2005cites this paper
• Senile macular degeneration: The involvement of immunocompetent cells

  2005cites this paper
• Mantovani products Stimulation of prostacyclin synthesis in vascular cells by mononuclear cell

  2005cites this paper
• 954 1 , 25-Dihydroxyvitamin D 3 and Rat Vascular Smooth Muscle Cell Growth

  2005cites this paper
• Panretinal photocoagulation aggravates experimental proliferative vitreoretinopathy

  2004cites this paper
• Sequential changes in the cell mediators of peritoneal and wound fluids after surgery

  2004cites this paper
• The role of cellular constituents and their interactions with the extracellular matrix through integrins in peritoneal healing and adhesion formation

  2003cites this paper
• Applications of the Neodymium:YAG Laser in Plastic Surgery of the Face and Lacrimal Surgery. Wound Repair

  2002cites this paper
• Role of macrophages and lymphocytes in the induction of neovascularization in renal allograft rejection.

  2002cites this paper
• Multi‐tiered treatment of pressure sores in two cynomologous macaques (Macaca fascicularis)

  2001cites this paper
• Peritoneal Tissue Repair Cells

  2000cites this paper
• Anastomosenheilung

  2000cites this paper
• Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro.

  1998cites this paper
• Long‐Term Evaluation of the Behavior of a Polytetrafluoroethylene Microprosthesis in the Rat Iliac Artery Myointimal Regression

  1998cites this paper
• Overview and General Considerations of Wound Repair

  1998cites this paper
• A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits.

  1998cites this paper
• External Biodegradable Supporting Conduit Protects Endothelium in Vein Graft in Arterial Interposition

  1997cites this paper
• Inhibitory Effect of Type 1 Collagen Gel Containing α-Elastin on Proliferation and Migration of Vascular Smooth Muscle and Endothelial Cells

  1997cites this paper
• Biochemical Messengers in Postsurgical Repair and Adhesion Formation

  1997cites this paper
• The regulatory effects of cytokines on lymphatic angiogenesis.

  1997cites this paper
• Stimulation of fibroblast proliferation and matrix contraction by wound fluid.

  1997cites this paper
• Monocyte recruitment and neointimal hyperplasia in rabbits. Coupled inhibitory effects of heparin.

  1996cites this paper
• Increased expression of platelet-derived growth factor A and insulin-like growth factor-I in BAL cells during the development of bleomycin-induced pulmonary fibrosis in mice.

  1996cites this paper
• Influence of luminal pore size on the patency rate and endothelialization of polymeric microvenous prostheses

  1995cites this paper
• Glomerular macrophages in nephrotoxic serum nephritis are activated to oxidize low-density lipoprotein.

  1995cites this paper
• The response-to-retention hypothesis of early atherogenesis.

  1995cites this paper
• The protective effect of vein cuffed anastomoses is not mechanical in origin.

  1995cites this paper
• A dialysis culture system for the study of the production and modulation of growth-regulatory molecules: studies using the P388D1 macrophage cell line.

  1995cites this paper
• Morphological and pathogenetic aspects of proliferative vitreo-retinopathy

  1994cites this paper
• Lipolysaccharide-Induced Monocyte Retention in the Lung

  1994cites this paper
• Inhibition of human monocyte adhesion to endothelial cells by the coumarin derivative, cloricromene

  1994cites this paper
• Lipolysaccharide-induced monocyte retention in the lung. Role of monocyte stiffness, actin assembly, and CD18-dependent adherence.

  1994cites this paper
• Arterial autografts and PTFE vascular microprostheses: similarities in the healing process.

  1994cites this paper
• Proliferative responses of endothelial cell populations to experimentally induced inflammatory lesions of gingival connective tissues in the cynomolgus monkey (Macaca fascicularis)

  1994cites this paper
• Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury.

  1993cites this paper
• Interactions between the monocyte/macrophage and the vascular smooth muscle cell. Stimulation of mitogenesis by a soluble factor and of prostanoid synthesis by cell-cell contact.

  1993cites this paper
• Patency and healing of microvascular prostheses: A review of 10 years of experimental work in groningen

  1993cites this paper
• Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.

  1993cites this paper
• Antimicrobial activity and in vitro corneal epithelial toxicity of antimicrobial agents for gram-positive corneal pathogens.

  1993cites this paper
• The wound healing process.

  1993cites this paper
• A small molecular mass inhibitor of growth of 3T3 cells and porcine aortic smooth muscle cells released from the macrophage cell line P388D1.

  1993cites this paper
• Pulmonary epithelial cell proliferation in primary culture of alveolar type II cells.

  1993cites this paper
• Influence of rat testicular macrophages on Leydig cell function in vitro.

  1992cites this paper
• Prevention of postoperative pericardial adhesions by closure of the pericardium with absorbable polymer patches. An experimental study.

  1992cites this paper
• A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.

  1992cites this paper
• Fibroblasts and Tissue Repair Cells

  1992cites this paper
• The use of organ cultures to study vessel wall pathobiology.

  1992cites this paper
• A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.

  1992cites this paper
• Uptake, distribution and fate of bacterial lipopolysaccharides in monocytes and macrophages: an ultrastructural and functional correlation.

  1992cites this paper
• Prolonged monocyte accumulation in the lung during bleomycin-induced pulmonary fibrosis. A noninvasive assessment of monocyte kinetics by scintigraphy.

  1992cites this paper
• Abnormal regulation of insulin-like growth factor gene expression in peripheral blood mononuclear cells from patients with IgA nephropathy.

  1992cites this paper
• Modulation of peritoneal re-epithelialization by postsurgical macrophages.

  1992cites this paper
• An ultrastructural study of macrovascular changes in rats with diabetes mellitus and hypertension

  1992cites this paper
• Growth response and androgen receptor expression in seminal vesicles from aging transgenic mice expressing human or bovine growth hormone genes.

  1992cites this paper
• Activated peripheral blood mononuclear cells in IgA nephropathy express platelet-derived growth factor B-chain messenger RNA.

  1992cites this paper
• Oxidative Mechanisms in Arterial Distension Injury: Observations Relevant to Restenosis after Angioplasty

  1992cites this paper
• A new biodegradable patch for closure of atrial septal defect. An experimental study.

  1992cites this paper
• Relation between monocytes in peripheral blood and development of atherosclerosis in hypercholesterolemic rabbits.

  1992cites this paper
• Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy.

  1991cites this paper
• Interaction of lymphocytes and high endothelial venules in irradiated lymph nodes.

  1991cites this paper
• Phenytoin-induced DNA synthesis and inositol 1,4,5-triphosphate formation in L-929 fibroblasts

  1991cites this paper
• Topical fluoroquinolones: antimicrobial activity and in vitro corneal epithelial toxicity.

  1991cites this paper
• Enhanced healing of 30 μm Gore-Tex PTFE microarterial prostheses by alcohol-pretreatment

  1991cites this paper
• Apolipoproteins and immunohistological differentiation of cells in the arterial wall of kidneys in transplant arteriopathy. Morphological parallels with atherosclerosis.

  1991cites this paper
• Macrophage-derived angiogenesis factors.

  1991cites this paper
• Modulation of actin isoform expression in cultured arterial smooth muscle cells by heparin and culture conditions.

  1991cites this paper
• Enhanced healing of 30 microns Gore-Tex PTFE microarterial prostheses by alcohol-pretreatment.

  1991cites this paper
• Intracerebral grafting of cultured autologous skin fibroblasts into the rat striatum: An assessment of graft size and ultrastructure

  1991cites this paper
• Sex hormones and atherosclerosis

  1991cites this paper
• Neointimal formation in the porcine aortic organ culture. I. Cellular dynamics over 1 month.

  1991cites this paper
• Schistosoma mansoni: higher free proline levels in the livers of infected mice.

  1991cites this paper
• Interactions between endothelial cells and the cells of the immune system.

  1991cites this paper
• Identification of an endothelial cell growth-inhibitory activity produced by human monocytes.

  1990cites this paper
• Omental dendritic cells: la expression and relation to macrophages

  1990cites this paper
• In Vitro Evaluation of the Effects of Macrophages and Synthetic Materials on the Fibroblast Proliferation and Collagen Synthesis

  1990cites this paper
• Inflammation and Repair

  1990cites this paper
• Temporal response of leukocyte accumulation in the thoracic cavity after two types of surgical injury.

  1990cites this paper
• Signal Transduction by the PDGF Receptor

  1990cites this paper
• Effect of inflammatory cytokines on human endothelial cell proliferation

  1990cites this paper
• Derivation and properties of platelet-derived growth factor-independent rat smooth muscle cells.

  1990cites this paper
• Interleukin-6 stimulates c-myc expression and proliferation of cultured vascular smooth muscle cells.

  1990cites this paper
• An In Vitro Analysis of Cephalosporin Corneal Epithellal Toxicity

  1990cites this paper
• Pulmonary macrophages can stimulate cell growth of bovine bronchial epithelial cells.

  1990cites this paper