Delineation of antigen contact residues on an MHC class II molecule.

No abstract is available for this paper.

• Publication year

  1990

• Venue

  EMBO Journal

• Publication date

  1990-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/j.1460-2075.1990.tb07869.xPMID 2265605PMCID PMC552203
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specificity pockets for the side chains of peptide antigens in HLA-Aw68

  1990cited by this paper
• Peptides recognized by class I restricted T cells also bind to MHC class II molecules.

  1990cited by this paper
• An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself

  1990cited by this paper
• Structural analysis of a peptide--HLA class II complex: identification of critical interactions for its formation and recognition by T cell receptor.

  1989cited by this paper
• Alloreactivity studied with mutants of HLA-A2.

  1989cited by this paper
• Enhanced immunogenicity of a T cell immunogenic peptide by modifications of its N and C termini.

  1989cited by this paper
• Implications of a Fab-like structure for the T-cell receptor.

  1989cited by this paper
• A beta polymorphic residues responsible for class II molecule recognition by alloreactive T cells

  1989cited by this paper
• Polymorphic residues on the I-A beta chain modulate the stimulation of T cell clones specific for the N-terminal peptide of the autoantigen myelin basic protein.

  1989cited by this paper
• I-A alpha polymorphic residues that determine alloreactive T cell recognition

  1989cited by this paper
• I-Ak polymorphisms define a functionally dominant region for the presentation of hen egg lysozyme peptides.

  1989cited by this paper
• T cell receptor gene segment usage in a panel of hen-egg white lysozyme specific, I-Ak-restricted T helper hybridomas.

  1989cited by this paper
• Structural requirements for the interaction between peptide antigens and I-Ed molecules.

  1989cited by this paper
• Epitopic analysis by anti-I-Ak monoclonal antibodies of I-Ak-restricted presentation of lysozyme peptides.

  1989cited by this paper
• Co-recognition of endogenous antigens with HLA-DR1 by alloreactive human T cell clones.

  1989cited by this paper
• Functional sites on the A alpha-chain. Polymorphic residues involved in antigen presentation to insulin-specific, Ab alpha:Ak beta-restricted T cells.

  1989cited by this paper
• Comparison of the secondary structures of human class I and class II major histocompatibility complex antigens by Fourier transform infrared and circular dichroism spectroscopy.

  1989cited by this paper
• Allorecognition of DR1 by T cells from a DR4/DRw13 responder mimics self-restricted recognition of endogenous peptides.

  1989cited by this paper
• Identical peptides recognized by MHC class I- and II-restricted T cells

  1989cited by this paper
• Peptide-dependent recognition of H–2Kb by alloreactive cytotoxic T lymphocytes

  1989cited by this paper
• Reconstruction of the immunogenic peptide RNase(43-56) by identification and transfer of the critical residues into an unrelated peptide backbone

  1989cited by this paper
• A panel of unique HLA-A2 mutant molecules define epitopes recognized by HLA-A2-specific antibodies and cytotoxic T lymphocytes.

  1989cited by this paper
• Identification of an immunodominant region on the I-A beta chain using site-directed mutagenesis and DNA-mediated gene transfer

  1988cited by this paper
• Compartmentalization of MHC class II gene expression in transgenic mice.

  1988cited by this paper
• A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

  1988cited by this paper
• The outline structure of the T‐cell alpha beta receptor.

  1988cited by this paper
• T cell recognition of bovine ribonuclease. Self/non-self discrimination at the level of binding to the I-Ak molecule.

  1988cited by this paper
• Regulation of murine MHC class II molecule expression. Identification of A beta residues responsible for allele-specific cell surface expression

  1988cited by this paper
• T-cell antigen receptor genes and T-cell recognition

  1988cited by this paper
• Fine specificity of murine class II-restricted T cell clones for synthetic peptides of influenza virus hemagglutinin. Heterogeneity of antigen interaction with the T cell and the Ia molecule.

  1988cited by this paper
• Three-dimensional structure of antibodies.

  1988cited by this paper
• Molecular characterization of the C3HfB/HeN H-2Kkm2 mutation. Implications for the molecular basis of alloreactivity

  1988cited by this paper
• Peptide-mediated modulation of T-cell allorecognition.

  1988cited by this paper
• Slot-machine mutagenesis of a polymorphic residue on the A kappa alpha-chain.

  1988cited by this paper
• Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor.

  1988cited by this paper
• Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex alpha beta dimer expression.

  1987cited by this paper
• Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

  1987cited by this paper
• Structure of the human class I histocompatibility antigen, HLA-A2

  1987cited by this paper
• The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.

  1986cited by this paper
• The T cell repertoire may be biased in favor of MHC recognition.

  1986cited by this paper
• Immune response (Ir) genes of the murine major histocompatibility complex.

  1986cited by this paper
• Analysis of the expression and function of class-II major histocompatibility complex-encoded molecules by DNA-mediated gene transfer.

  1986cited by this paper
• Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity.

  1986cited by this paper
• Antigenic competition at the level of peptide-Ia binding.

  1986cited by this paper
• Murine major histocompatibility complex class-I mutants: molecular analysis and structure-function implications.

  1986cited by this paper
• Characterization of cell lines expressing mutant I-Ab and I-Ak molecules allows the definition of distinct serologic epitopes on A alpha and A beta polypeptides.

  1986cited by this paper
• The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments

  1985cited by this paper
• T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex.

  1985cited by this paper
• Direct evidence that a class II molecule and a simple globular protein generate multiple determinants

  1985cited by this paper
• Specificity of the T cell receptor: two different determinants are generated by the same peptide and the I-Ak molecule.

  1985cited by this paper
• A molecular basis for the Ia.2 and Ia.19 antigenic determinants.

  1985cited by this paper
• Genetics and expression of mouse Ia antigens.

  1985cited by this paper
• Identical V beta T-cell receptor genes used in alloreactive cytotoxic and antigen plus I-A specific helper T cells.

  1985cited by this paper
• Structure of class I major histocompatibility antigens.

  1983cited by this paper
• Empirical predictions of protein conformation.

  1978cited by this paper

• An update of murine models and their methodologies in immune-mediated joint damage and pain research.

  2024cites this paper
• Genetically modified mice as a tool for the study of human diseases

  2024cites this paper
• Endogenous glucocorticoid signaling in chondrocytes attenuates joint inflammation and damage

  2018cites this paper
• Pillars article: three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 1993. 364: 33-39.

  2014cites this paper
• Autoantigen Specificity from Distinguish Foreign Peptide Recognition Two MHC Surface Amino Acid Differences

  2012cites this paper
• Mapping pathogenesis of arthritis through small animal models.

  2012cites this paper
• What Have We Learned about the Pathogenesis of Rheumatoid Arthritis from TNF-Targeted Therapy?

  2012influential citation
• The role of IL-17 in inflammatory hyperalgesia

  2010cites this paper
• Genome-based expression profiling study of Hunner’s ulcer type interstitial cystitis: an array of 40-gene model

  2010cites this paper
• The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function.

  2008cites this paper
• Initiation of an autoimmune response

  2005cites this paper
• Models of rheumatoid arthritis.

  2005cites this paper
• Gene expression and differentiation

  2005cites this paper
• Exonic polymorphism vs intronic simple repeat hypervariability in MHC-DRB genes

  2004cites this paper
• T cells are not as degenerate as you think, once you get to know them.

  2004cites this paper
• Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.

  2003cites this paper
• Role of Pathogenic Antibodies in Rheumatic Diseases

  2003cites this paper
• The KRN mouse model of inflammatory arthritis

  2003cites this paper
• Genes and cellular requirements for autoimmune diabetes susceptibility in nonobese diabetic mice.

  2001cites this paper
• Two MHC Surface Amino Acid Differences Distinguish Foreign Peptide Recognition from Autoantigen Specificity1

  2001cites this paper
• current as Distinct MHC Molecules by a Single TCR Arthritic Peptide and a Foreign Epitope on Molecular Basis for Recognition of an Fremont and

  2000cites this paper
• Conformational restriction of the Tyr53 side-chain in the decapeptide HE.

  2000cites this paper
• Molecular Basis for Recognition of an Arthritic Peptide and a Foreign Epitope on Distinct MHC Molecules by a Single TCR1

  2000cites this paper
• Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.

  1999cites this paper
• Alteration of a Single Hydrogen Bond between Class II Molecules and Peptide Results in Rapid Degradation of Class II Molecules after Invariant Chain Removal

  1998cites this paper
• Strong alloantigenicity of the alpha-helices residues of the MHC class I molecule.

  1998cites this paper
• Strong Alloantigenicity of the α-Helices Residues of the MHC Class I Molecule

  1998cites this paper
• Use of T cell receptor/HLA-DRB1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis.

  1997cites this paper
• Alloreactive T cell recognition of MHC class I molecules: the T cell receptor interacts with limited regions of the MHC class I long alpha helices.

  1997cites this paper
• Conformational changes in MHC class I molecules

  1997cites this paper
• Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody.

  1997cites this paper
• Major histocompatibility complex recognition by immune receptors: Differences among T cell receptor versus antibody interactions with the VSV8/H‐2Kb complex

  1997cites this paper
• Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions

  1996cites this paper
• Organ-specific disease provoked by systemic autoimmunity.

  1996influential citation
• Amino acid substitutions at position 97 in HLA‐A2 segregate cytolysis from cytokine release in MART‐1/Melan‐A peptide AAGIGILTV‐specific cytotoxic T lymphocytes

  1996cites this paper
• Amino acid residues on the I-Ak alpha-chain required for the binding and stability of two antigenic peptides.

  1996cites this paper
• The T cell receptor

  1996cites this paper
• Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum.

  1996cites this paper
• Appreciating the Complexity of MHC Class II Peptide Binding: Lysozyme Peptide and I‐Ak

  1996cites this paper
• Recognition of multiple peptide cores by a single T cell receptor

  1995cites this paper
• Mutations in residue 61 of H-Ras p21 protein influence MHC class II presentation.

  1995cites this paper
• A phage display system for detection of T cell receptor-antigen interactions.

  1995cites this paper
• Cassette vectors directing expression of T cell receptor genes in transgenic mice.

  1995cites this paper
• Poor loading of major histocompatibility complex class II molecules with endogenously synthesized short peptides in the absence of invariant chain

  1995cites this paper
• Molecular analysis of T cell receptors : mapping T cell recognition and repertoire in two human immune responses.

  1995cites this paper
• Migration of a novel DQA1* allele (DQA1*0502) from African origin to North and South America.

  1995cites this paper
• Critical residue combinations dictate peptide presentation by MHC class II molecules.

  1994cites this paper
• Does a novel form of the breast cancer marker protein, MUC1, act as a receptor molecule that modulates signal transduction?

  1994cites this paper
• The V beta complementarity determining region 1 of a major histocompatibility complex (MHC) class I-restricted T cell receptor is involved in the recognition of peptide/MHC I and superantigen/MHC II complex

  1994cites this paper
• T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

  1994cites this paper
• Effects of MHC II conformation and pH on the recognition of peptide by T cells.

  1994cites this paper
• Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

  1993cites this paper
• A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein.

  1993cites this paper
• A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

  1993cites this paper
• Cell surface expression and function of an HLA class II molecule with class I domain configuration

  1993cites this paper
• The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition.

  1993cites this paper
• Selective immunosuppression of class II-restricted T cells by MHC class II-binding peptides.

  1993cites this paper
• Functional analysis of the antigen binding region of an MHC class II molecule.

  1993cites this paper
• How alpha beta T-cell receptors 'see' peptide/MHC complexes.

  1993cites this paper
• Characterization of the insulin A-chain major immunogenic determinant presented by MHC class II I-Ad molecules.

  1993cites this paper
• How αβ T-cell receptors ‘see’ peptide/MHC complexes

  1993cites this paper
• Most residues on the floor of the antigen binding site of the class I MHC molecule H-2Kd influence peptide presentation.

  1992cites this paper
• Do antigenic drift residues in influenza hemagglutinins of the H3 subtype qualify as contact sites for MHC class II interaction?

  1992cites this paper
• Structure of the TCR-Ag-MHC Complex

  1992cites this paper
• Chemistry of peptide interactions with MHC proteins.

  1992cites this paper
• MOLECULAR COMPONENTS OF

  1992cites this paper
• Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle

  1992cites this paper
• Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

  1992cites this paper
• COMPARISON OF TCR‐αβ SEQUENCES OF CROSS‐REACTIVE ANTI‐DR ALLOREACTIVE T‐CELL CLONES: IDENTIFICATION OF POSSIBLE CONTACT RESIDUES BASED ON CHARGE COMPLEMENTARITY BETWEEN TCR CHAINS AND DR DETERMINANTS

  1992cites this paper
• Molecular components of T-cell recognition.

  1992cites this paper
• An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain

  1992cites this paper
• An MHC interaction site maps to the amino-terminal half of the T cell receptor alpha chain variable domain.

  1992cites this paper
• Structural analysis of class II major histocompatibility complex proteins.

  1992cites this paper
• DRB1*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles.

  1992cites this paper
• Comparison of class I‐ and II‐restricted T cell recognition of the identical peptide

  1991cites this paper
• Local structure of a peptide contact site on Ak alpha.

  1991cites this paper
• The molecular basis of class II MHC allelic control of T cell responses.

  1991cites this paper
• Structural analysis of anti-DR1 allorecognition by using DR1/H-2Ek hybrid molecules. Influence of the beta 2-domain correlates with CD4 dependence.

  1991cites this paper
• Low affinity interaction of peptide-MHC complexes with T cell receptors.

  1991cites this paper
• Self and foreign peptides interact with intact and disassembled MHC class II antigen HLA-DR via tryptophan pockets.

  1991cites this paper
• Biased amino acid distributions in regions of the T cell receptors and MHC molecules potentially involved in their association.

  1991cites this paper