Specificity pockets for the side chains of peptide antigens in HLA-Aw68

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Nature

• Publication date

  1990-04-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/342692A0PMID 2594067
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Polymorphism in the α3 domain of HLA-A molecules affects binding to CD8

  1989cited by this paper
• Class I cross-restricted T cells reveal low responder allele due to processing of viral antigen

  1989cited by this paper
• Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

  1989cited by this paper
• Complete nucleotide sequence of a unique HLA class I C locus product expressed on the human choriocarcinoma cell line BeWo.

  1989cited by this paper
• Antigen recognition by class I-restricted T lymphocytes.

  1989cited by this paper
• Nature of polymorphism in HLA-A, -B, and -C molecules.

  1988cited by this paper
• The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses

  1988cited by this paper
• A sequence pattern common to T cell epitopes.

  1988cited by this paper
• In vitro mutagenesis of HLA-B27. Substitution of an unpaired cysteine residue in the alpha 1 domain causes loss of antibody-defined epitopes.

  1988cited by this paper
• I-Ad-binding peptides derived from unrelated protein antigens share a common structural motif.

  1988cited by this paper
• Processing of a minimal antigenic peptide alters its interaction with MHC molecules

  1988cited by this paper
• Structure of the human class I histocompatibility antigen, HLA-A2

  1987cited by this paper
• Class discrimination in the world of immunology

  1987cited by this paper
• Crystallographic R Factor Refinement by Molecular Dynamics

  1987cited by this paper
• The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides

  1987cited by this paper
• Immunology: The ins and outs of antigen processing and presentations

  1986cited by this paper
• H—2-restricted cytolytic T cells specific for HLA can recognize a synthetic HLA peptide

  1986cited by this paper
• The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides.

  1986cited by this paper
• Cytotoxic T cells recognize fragments of the influenza nucleoprotein.

  1985cited by this paper
• Binding of immunogenic peptides to Ia histocompatibility molecules

  1985cited by this paper
• Crystallization and X-ray diffraction studies on the histocompatibility antigens HLA-A2 and HLA-A28 from human cell membranes.

  1985cited by this paper
• Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level.

  1985cited by this paper
• Exon shuffling in vivo can generate novel HLA class I molecules.

  1985cited by this paper
• GENETIC CONTROL OF THE ANTIBODY RESPONSE IN INBRED MICE

  1968cited by this paper

• Learning predictive signatures of HLA type from T-cell repertoires

  2025cites this paper
• HLA-B27 and spondyloarthritis: at the crossroads of innate and adaptive immunity

  2024cites this paper
• Permissible HLA mismatches in 9/10 unrelated donor pediatric stem cell transplants using HLA-EMMA: an EBMT Inborn Errors Working Party study

  2024cites this paper
• Learning predictive signatures of HLA type from T-cell repertoires

  2024cites this paper
• The electrostatic landscape of MHC-peptide binding revealed using inception networks.

  2024cites this paper
• Betacoronaviral lectins: Identification through a genomic search—A structural and evolutionary biology perspective

  2023cites this paper
• Immunogenic self-peptides - the great unknowns in autoimmunity: Identifying T-cell epitopes driving the autoimmune response in autoimmune diseases

  2023cites this paper
• Opening opportunities for Kd determination and screening of MHC peptide complexes

  2022cites this paper
• Natural Killer Cell Receptors and Ligands Are Associated With Markers of HIV-1 Persistence in Chronically Infected ART Suppressed Patients

  2022cites this paper
• Alternative splicing and genetic variation of mhc-e: implications for rhesus cytomegalovirus-based vaccines

  2022cites this paper
• Snowflake: A deep learning-based human leukocyte antigen matching algorithm considering allele-specific surface accessibility

  2022cites this paper
• Plant-Based Vaccines: Antigen Design, Diversity, and Strategies for High Level Production

  2022cites this paper
• Antigen Processing, Presentation, and Tolerance: Role in Autoimmune Skin Diseases.

  2021cites this paper
• Mapping the peptide binding groove of MHC class I

  2021cites this paper
• Evaluation of potential MHC-I allele-specific epitopes in Zika virus proteins and the effects of mutations on peptide-MHC-I interaction studied using in silico approaches

  2021cites this paper
• Immunopharmacogenomics: Mechanisms of HLA‐Associated Drug Reactions

  2021influential citation
• Peptidomes and Structures Illustrate Two Distinguishing Mechanisms of Alternating the Peptide Plasticity Caused by Swine MHC Class I Micropolymorphism

  2021cites this paper
• The HLA System in Transfusion Medicine and Transplantation

  2021cites this paper
• Small Molecule/HLA Complexes Alter the Cellular Proteomic Content

  2021cites this paper
• Multifunctional Chaperone and Quality Control Complexes in Adaptive Immunity.

  2020cites this paper
• Structures of peptide-free and partially loaded MHC class I molecules reveal mechanisms of peptide selection

  2020cites this paper
• The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity

  2019cites this paper
• Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats

  2019cites this paper
• MHC Molecules, T cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins-Key Elements of Adaptive and Innate Immunity.

  2019cites this paper
• Estudio de genes hla en atlánticos y mediterráneos: celtas e íberos

  2019cites this paper
• Major Histocompatibility Complex and Hematopoietic Stem Cell Transplantation: Beyond the Classical HLA Polymorphism

  2018cites this paper
• A cold-blooded view of adaptive immunity

  2018cites this paper
• Studies in Antigen Presentation and Antigen Recognition at Different Interfaces of the Adaptive Immune System

  2018cites this paper
• How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins.

  2018cites this paper
• The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques

  2018cites this paper
• The N-terminal region of photocleavable peptides that bind HLA-DR1 determines the kinetics of fragment release

  2018cites this paper
• Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck.

  2018cites this paper
• Treating a Multidrug-Resistant Psoriatic HLA-C*18:01 Allele Carrier with Combination Ustekinumab Apremilast Therapy

  2018cites this paper
• How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

  2018cites this paper
• MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

  2017cites this paper
• HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection

  2017cites this paper
• MUC1 Peptides Presented by Class I H2 and Anti-MUC1 Antibodies React Directly with

  2017cites this paper
• Epstein-Barr virus and multiple sclerosis: investigating EBV antigen-induced T-cell cross-recognition of central nervous system proteins

  2017cites this paper
• 3 Relevance of HLA Expression Variants in Stem Cell Transplantation

  2017cites this paper
• 14 MHC Polymorphism and Tuberculosis Disease

  2017cites this paper
• 11 Immunogenetics of Type 1 Diabetes

  2017cites this paper
• a Bat MHC Class I Molecule Machinery and Endogenous Peptide Characterization of the Antigen Processing

  2016cites this paper
• Human Leukocyte Antigen (HLA) B27 Allotype-Specific Binding and Candidate Arthritogenic Peptides Revealed through Heuristic Clustering of Data-independent Acquisition Mass Spectrometry (DIA-MS) Data*

  2016cites this paper
• Characterization of the Antigen Processing Machinery and Endogenous Peptide Presentation of a Bat MHC Class I Molecule

  2016cites this paper
• Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627.

  2016cites this paper
• Bases moleculares de la presentación de ligandos fosforilados por moléculas HLA-B

  2016cites this paper
• Structure of Classical Class I MHC Molecules

  2016cites this paper
• Molecular Methods for Human Leukocyte Antigen Typing: Current Practices and Future Directions

  2016cites this paper
• Mechanistic understanding and significance of small peptides interaction with MHC class II molecules for therapeutic applications

  2016cites this paper
• Ankylosing Spondylitis: A Multi-Factorial Autoimmune Disease. MHC Class I, Antigen Presentation and others to Blame

  2016cites this paper
• Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus (major histocompatibility complex/major histocompatibility complex binding motif/T-cell receptor-peptide in

  2016cites this paper
• Coupling between side chain interactions and binding pocket flexibility in HLA-B*44:02 molecules investigated by molecular dynamics simulations.

  2015cites this paper
• The Carboxy Terminus of the Ligand Peptide Determines the Stability of the MHC Class I Molecule H-2Kb: A Combined Molecular Dynamics and Experimental Study

  2015cites this paper
• Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?

  2015cites this paper
• HLA Epitopes as Viewed by Antibodies: What Is it All About?

  2015cites this paper
• Analysis of MHC immunopeptidomes using mass

  2015cites this paper
• Analysis of Major Histocompatibility Complex (MHC) Immunopeptidomes Using Mass Spectrometry*

  2015cites this paper
• Revisiting the Arthritogenic Peptide Theory: Quantitative Not Qualitative Changes in the Peptide Repertoire of HLA–B27 Allotypes

  2015cites this paper
• Mecanismo molecular implicado en la configuración del peptidoma de HLA-B*27 por variantes naturales de ERAP1 asociadas a la espondilitis anquilosante

  2015cites this paper
• Autophagy and antigen processing : strategies to enhance T cell recognition of cancer cells

  2014cites this paper
• Novel peptide antigens provide insights into the recognition process by T cells

  2014cites this paper
• Structure and function of POTRA domains of Omp85/TPS superfamily.

  2014cites this paper
• Chapter 7 – Antigen Processing and Presentation

  2014cites this paper
• Pillars article: three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 1993. 364: 33-39.

  2014cites this paper
• Functional Implications of MHC Associations in Autoimmune Diseases with Special Reference to Type1 Diabetes, Vitiligo and Hypoparathyroidism

  2014cites this paper
• Transplant Antigen Biology

  2014cites this paper
• Peptide Loading of MHC

  2013cites this paper
• MHC and T cell responses

  2013cites this paper
• Increased Diversity of the HLA-B40 Ligandome by the Presentation of Peptides Phosphorylated at Their Main Anchor Residue*

  2013cites this paper
• Study of the immunological phenotype of metastases obtained from mice receiving different immonotherapy protocols

  2013cites this paper
• The ongoing evolutionary battle between the immune system and viruses : MHC molecules verus HIV

  2013cites this paper
• TRANSPLANTATION Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality

  2013influential citation
• Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality.

  2013influential citation
• PEPTIDES PHOSPHORYLATED AT THEIR MAIN ANCHOR RESIDUE

  2013cites this paper
• Predicting HLA Class I Non-Permissive Amino Acid Residues Substitutions

  2012cites this paper
• DEVELOPMENT OF MHC CLASS I AFRICAN ALLELES AND EX VIVO DETECTION OF M.TUBERCULOSIS- REACTIVE CD8+ T-CELLS

  2012cites this paper
• Single Domain Antibodies

  2012cites this paper
• Relevance of HLA Expression Variants in Stem Cell Transplantation

  2012cites this paper
• Pocketcheck: updating the HLA class I peptide specificity roadmap.

  2012cites this paper
• Nanobodies as structural probes of protein misfolding and fibril formation.

  2012cites this paper
• MHC Polymorphism and Tuberculosis Disease

  2012cites this paper
• The Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular Dynamics

  2012cites this paper
• This information is current as Structure and Molecular Dynamics MHC Class I Molecules : Insight from The Peptide-Receptive Transition State of

  2012cites this paper
• MR1 presents microbial vitamin B metabolites to MAIT cells

  2012cites this paper
• The Major Histocompatibility Complex in Bovines: A Review

  2012cites this paper
• Examining the Roles of PsToc75 POTRA Domains in Chloroplast Protein Import

  2011cites this paper
• Structural diversity of class I MHC-like molecules and its implications in binding specificities.

  2011cites this paper
• Immunogenetics of Type 1 Diabetes

  2011cites this paper
• What is the role of HLA-B27 in spondyloarthropathies?

  2011cites this paper
• Relationship between HLA A*02 A*03 association and the risk of childhood acute leukemia.

  2010cites this paper
• The nature of peptides presented by an HLA class I low expression allele

  2010cites this paper
• Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy

  2010cites this paper
• The role of idiotype-specific immunity in antigen receptor diversity

  2010influential citation
• Identification and characterization of peptide-like MHC- ligand exchange catalyst as immune response enhancer

  2009cites this paper
• In silico methods for predicting T-cell epitopes: Dr Jekyll or Mr Hyde?

  2009cites this paper
• Chapter 1 Antigen Presentation by CD1

  2009cites this paper
• Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity.

  2009cites this paper
• In vivo detection of residues required for ligand-selective activation of the S-locus receptor in Arabidopsis.

  2009cites this paper
• Presentation of Cytosolically Stable Peptides by HLA-B27 Is Not Dependent on the Canonic Interactions of N-Terminal Basic Residues in the A Pocket1

  2009cites this paper
• The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies

  2009cites this paper