Side-chain contributions to membrane protein structure and stability.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Molecular Biology

• Publication date

  2004-01-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.JMB.2003.10.041PMID 14659758
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An orientation-dependent hydrogen bonding potential improves prediction of specificity and structure for proteins and protein-protein complexes.

  2003cited by this paper
• How do helix–helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo‐oligomeric helical bundles

  2003cited by this paper
• Construction of helix-bundle membrane proteins.

  2003cited by this paper
• Sequence context strongly modulates association of polar residues in transmembrane helices.

  2003cited by this paper
• Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles.

  2003cited by this paper
• Why are proteins marginally stable?

  2002cited by this paper
• Full Subunit Coverage Liquid Chromatography Electrospray Ionization Mass Spectrometry (LCMS+) of an Oligomeric Membrane Protein

  2002cited by this paper
• Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein

  2002cited by this paper
• Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations.

  2002cited by this paper
• Bicelle crystallization: a new method for crystallizing membrane proteins yields a monomeric bacteriorhodopsin structure.

  2002cited by this paper
• Non-alpha-helical elements modulate polytopic membrane protein architecture.

  2001cited by this paper
• Stabilizing membrane proteins.

  2001cited by this paper
• Polar residues drive association of polyleucine transmembrane helices

  2001cited by this paper
• Helix-helix packing and interfacial pairwise interactions of residues in membrane proteins.

  2001cited by this paper
• Polar side chains drive the association of model transmembrane peptides.

  2001cited by this paper
• Are proteins well-packed?

  2001cited by this paper
• Specificity in transmembrane helix–helix interactions can define a hierarchy of stability for sequence variants

  2001cited by this paper
• Non-α-helical elements modulate polytopic membrane protein architecture

  2001cited by this paper
• Building a Thermostable Membrane Protein*

  2000cited by this paper
• Phosphothreonine recognition comes into focus

  2000cited by this paper
• Asparagine-mediated self-association of a model transmembrane helix

  2000cited by this paper
• Interhelical hydrogen bonding drives strong interactions in membrane proteins

  2000cited by this paper
• Internal packing of helical membrane proteins.

  2000cited by this paper
• Role of helix-helix interactions in assembly of the bacteriorhodopsin lattice.

  1999cited by this paper
• Membrane protein folding and stability: physical principles.

  1999cited by this paper
• Probing the folding and unfolding of wild-type and mutant forms of bacteriorhodopsin in micellar solutions: evaluation of reversible unfolding conditions.

  1999cited by this paper
• Changing single side-chains can greatly enhance the resistance of a membrane protein to irreversible inactivation.

  1999cited by this paper
• Structure of bacteriorhodopsin at 1.55 A resolution.

  1999cited by this paper
• Hydrophobic interactions of peptides with membrane interfaces.

  1998cited by this paper
• Structure-based prediction of the stability of transmembrane helix-helix interactions: the sequence dependence of glycophorin A dimerization.

  1998cited by this paper
• Threshold hydrophobicity dictates helical conformations of peptides in membrane environments.

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• [22] Detecting and overcoming crystal twinning.

  1997cited by this paper
• A Transmembrane Helix Dimer: Structure and Implications

  1997cited by this paper
• X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases.

  1997cited by this paper
• A biophysical study of integral membrane protein folding.

  1997cited by this paper
• A method for assessing the stability of a membrane protein.

  1997cited by this paper
• Slow alpha helix formation during folding of a membrane protein.

  1997cited by this paper
• The effect of point mutations on the free energy of transmembrane alpha-helix dimerization.

  1997cited by this paper
• Structural and genetic analysis of the folding and function of T4 lysozyme

  1996cited by this paper
• Forces contributing to the conformational stability of proteins

  1996cited by this paper
• Strong hydrogen bonding interactions involving a buried glutamic acid in the transmembrane sequence of the neu/erbB-2 receptor

  1996cited by this paper
• Peptides in membranes: Helicity and hydrophobicity

  1995cited by this paper
• Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis.

  1995cited by this paper
• Structure and stability of membrane proteins.

  1995cited by this paper
• Protein stability effects of a complete set of alanine substitutions in Arc repressor

  1994cited by this paper
• Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect.

  1992cited by this paper
• Proline kinks in transmembrane α-helices☆

  1991cited by this paper
• Proline kinks in transmembrane alpha-helices.

  1991cited by this paper
• A method to identify protein sequences that fold into a known three-dimensional structure.

  1991cited by this paper
• Membrane protein folding and oligomerization: the two-stage model.

  1990cited by this paper
• Hydrophobic organization of membrane proteins.

  1989cited by this paper
• Structure-function studies on bacteriorhodopsin. VIII. Substitutions of the membrane-embedded prolines 50, 91, and 186: the effects are determined by the substituting amino acids.

  1989cited by this paper
• Amino acid preferences for specific locations at the ends of alpha helices.

  1988cited by this paper
• Efficient transfection of the archaebacterium Halobacterium halobium

  1987cited by this paper
• Refolding of an integral membrane protein. Denaturation, renaturation, and reconstitution of intact bacteriorhodopsin and two proteolytic fragments.

  1981cited by this paper
• A natural CD label to probe the structure of the purple membrane from Halobacterium halobium by means of exciton coupling effects.

  1975cited by this paper
• Hydrophobic bonding and accessible surface area in proteins

  1974cited by this paper
• Isolation of the cell membrane of Halobacterium halobium and its fractionation into red and purple membrane.

  1974cited by this paper

• Single Molecule Force Spectroscopy to Probe Intermediates and Energetics of Membrane Protein Folding.

  2026cites this paper
• Native Top-Down Mass Spectrometry Characterization of Model Integral Membrane Protein Bacteriorhodopsin.

  2025cites this paper
• Effects of stand-alone polar residue on membrane protein stability and structure.

  2024cites this paper
• Steric trapping strategy for studying the folding of helical membrane proteins.

  2024cites this paper
• Quantifying a light-induced energetic change in bacteriorhodopsin by force spectroscopy

  2024cites this paper
• Gold nanoparticle-powered screening of membrane protein-specific lipids from complex lipid mixtures.

  2023cites this paper
• Effects of Sodium Dodecyl Sulfate on the Enzyme Catalysis and Conformation of a Recombinant γ-Glutamyltranspeptidase from Bacillus licheniformis

  2023cites this paper
• Stability of Alternative Bacteriorhodopsin Folds

  2023cites this paper
• Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP

  2022cites this paper
• Untangling the complexity of membrane protein folding.

  2022cites this paper
• De novo-designed transmembrane domains tune engineered receptor functions

  2022cites this paper
• How do surfactants unfold and refold proteins?

  2022cites this paper
• Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator

  2021cites this paper
• Optimizing the linker length for fusing an alcohol dehydrogenase with a cyclohexanone monooxygenase.

  2021cites this paper
• Free-energy changes of bacteriorhodopsin point mutants measured by single-molecule force spectroscopy

  2021cites this paper
• Functional Oligomeric Forms of Uncoupling Protein 2: Strong Evidence for Asymmetry in Protein and Lipid Bilayer Systems.

  2020cites this paper
• Structural cavities are critical to balancing stability and activity of a membrane-integral enzyme

  2020cites this paper
• Quantifying the Native Energetics Stabilizing Bacteriorhodopsin by Single-Molecule Force Spectroscopy.

  2020cites this paper
• De novo designed receptor transmembrane domains enhance CAR-T cell cytotoxicity and attenuate cytokine release

  2020cites this paper
• Protein structure predictions by enhanced conformational sampling methods

  2019cites this paper
• A concise method for quantitative analysis of interactions between lipids and membrane proteins.

  2019cites this paper
• Insertion of Bacteriorhodopsin Helix C Variants into Biological Membranes

  2019cites this paper
• Membrane curvature affects the stability and folding kinetics of bacteriorhodopsin

  2019cites this paper
• Structure–Function of MamC Loop and Its Effect on the in Vitro Precipitation of Biomimetic Magnetite Nanoparticles

  2019cites this paper
• Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis

  2019cites this paper
• Consensus designs and thermal stability determinants of a human glutamate transporter

  2018cites this paper
• Experimental and Computational Evidence for Self-Assembly of Mitochondrial UCP2 in Lipid Bilayers

  2018cites this paper
• Bicelle size modulates the rate of bacteriorhodopsin folding

  2018cites this paper
• Optimization and 13CH3 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies.

  2018cites this paper
• Characterization of Denatured States and Reversible Unfolding of Sensory Rhodopsin II.

  2018cites this paper
• Insertion studies of model transmembrane segments into bacterial and eukaryotic membranes

  2017cites this paper
• The function of a membrane protein : studies of structure and dynamics by NMR

  2017cites this paper
• Kinetic stability of membrane proteins

  2017cites this paper
• Discrimination of Native-like States of Membrane Proteins with Implicit Membrane-based Scoring Functions.

  2017cites this paper
• Kinetic stability of membrane proteins.

  2017cites this paper
• Role of cardiolipin in stability of integral membrane proteins.

  2017cites this paper
• Reversible Unfolding of Rhomboid Intramembrane Proteases.

  2016cites this paper
• Convergence and Sampling in Determining Free Energy Landscapes for Membrane Protein Association

  2016cites this paper
• Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability

  2016cites this paper
• A many-body term improves the accuracy of effective potentials based on protein coevolutionary data.

  2015cites this paper
• Principal Component Analysis of Binding Energies for Single-Point Mutants of hT2R16 Bound to an Agonist Correlate with Experimental Mutant Cell Response

  2015cites this paper
• Bacteriorhodopsin: Would the real structural intermediates please stand up?

  2015cites this paper
• Protein structure elucidation by combining computational and experimental methods

  2015cites this paper
• Folding and Stability of Transmembrane b-Barrels of Bacterial and Human Origin: Probing Underlying Similarities and Principal Differences Using In vitro Systems

  2015cites this paper
• Observation of helix associations for insertion of a retinal molecule and distortions of helix structures in bacteriorhodopsin.

  2015cites this paper
• Crystal Structure of Escherichia coli-Expressed Haloarcula marismortui Bacteriorhodopsin I in the Trimeric Form

  2014influential citation
• Energetics of membrane protein folding.

  2014cites this paper
• Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.

  2014cites this paper
• Unfolding study of a trimeric membrane protein AcrB

  2014cites this paper
• Structural studies of microbial rhodopsins and other membrane proteins by means of X-ray crystallography and computer modeling

  2014cites this paper
• Bacteriorhodopsin Folds through a Poorly Organized Transition State

  2014cites this paper
• Life at the border: Adaptation of proteins to anisotropic membrane environment

  2014cites this paper
• Sequence-Specific Dimerization of a Transmembrane Helix in Amphipol A8-35

  2014influential citation
• A delocalized proton-binding site within a membrane protein.

  2014cites this paper
• Small-angle scattering gives direct structural information about a membrane protein inside a lipid environment.

  2014cites this paper
• The safety dance: biophysics of membrane protein folding and misfolding in a cellular context

  2014cites this paper
• Intrinsic Conformational Plasticity of Native EmrE Provides a Pathway for Multidrug Resistance

  2014cites this paper
• The Free Energy Landscape of Dimerization of a Membrane Protein, NanC

  2014cites this paper
• STABILITY STUDIES OF MEMBRANE PROTEINS

  2014cites this paper
• Retinal proteins as model systems for membrane protein folding.

  2014cites this paper
• Kinetics and Thermodynamics of Membrane Protein Folding

  2014cites this paper
• Toward understanding driving forces in membrane protein folding.

  2014cites this paper
• Measuring membrane protein stability under native conditions

  2013cites this paper
• Lipid exposure prediction enhances the inference of rotational angles of transmembrane helices

  2013cites this paper
• Stabilizing membrane proteins through protein engineering.

  2013cites this paper
• Reversible folding of human peripheral myelin protein 22, a tetraspan membrane protein.

  2013cites this paper
• Membrane protein native state discrimination by implicit membrane models

  2013cites this paper
• Effects of a polar amino acid substitution on helix formation and aggregate size along the detergent-induced peptide folding pathway.

  2013cites this paper
• Exploring the active site structure of a photoreceptor protein by Raman optical activity.

  2013cites this paper
• Hydrogen Bond Shaping of Membrane Protein Structure

  2013cites this paper
• Calculation of Membrane Protein Structures in Oriented-Sample NMR and Their Validation Using Rosetta.

  2013cites this paper
• Hepatitis C Virus RNA Replication and Virus Particle Assembly Require Specific Dimerization of the NS4A Protein Transmembrane Domain

  2013cites this paper
• Prediction and design of outer membrane protein-protein interactions.

  2013cites this paper
• A review of factors affecting the success of membrane protein crystallization using bicelles

  2013cites this paper
• Computational studies of membrane proteins: models and predictions for biological understanding.

  2012cites this paper
• A successful change of circumstance: a transition state for membrane protein folding.

  2012cites this paper
• Revisiting the folding kinetics of bacteriorhodopsin

  2012cites this paper
• Oligomerization of polytopic α-helical membrane proteins: causes and consequences

  2012cites this paper
• Identifying and measuring transmembrane helix-helix interactions by FRET.

  2012cites this paper
• 3.13 The Membrane Factor: Biophysical Studies of Alpha Helical Transmembrane Protein Folding

  2012cites this paper
• Shifting hydrogen bonds may produce flexible transmembrane helices

  2012cites this paper
• Membrane Protein Structure and Dynamics

  2012cites this paper
• Thermodynamic stability of bacteriorhodopsin mutants measured relative to the bacterioopsin unfolded state.

  2012cites this paper
• Sequence hydropathy dominates membrane protein response to detergent solubilization.

  2012cites this paper
• Author ' s personal copy COMMUNICATION ProbingMembraneProteinUnfoldingwithPulseProteolysis

  2011cites this paper
• Stabilizing Membrane Proteins in Detergent and Lipid Systems

  2011cites this paper
• Computational design of membrane proteins.

  2011cites this paper
• Exploring the world of helix association: Disease mechanism, basic folding and novel design

  2011cites this paper
• Probing membrane protein unfolding with pulse proteolysis.

  2011cites this paper
• Protein-surfactant interactions: a tale of many states.

  2011cites this paper
• Stable folding core in the folding transition state of an α-helical integral membrane protein

  2011cites this paper
• Aus dem Institut für Medizinische Physik und Biophysik

  2011cites this paper
• A systematic study of fundamentals in α-helical coiled coil mimicry by alternating sequences of β- and γ-amino acids

  2011cites this paper
• The structure and function of the human ghrelin receptor

  2011cites this paper
• Overcoming hysteresis to attain reversible equilibrium folding for outer membrane phospholipase A in phospholipid bilayers.

  2011cites this paper
• Interaction of a two-transmembrane-helix peptide with lipid bilayers and dodecyl sulfate micelles.

  2011cites this paper
• Simple screening method for improving membrane protein thermostability.

  2011cites this paper
• Opposing structural changes in two symmetrical polypeptides bring about opposing changes to the thermal stability of a complex integral membrane protein.

  2011cites this paper
• Contribution of hydrophobic interactions to protein stability.

  2011cites this paper
• Advances in the mass spectrometry of membrane proteins: from individual proteins to intact complexes.

  2011cites this paper