Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cell Death and Differentiation

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.cdd.4401801PMID 16311512
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Substrate specificity of the human protein phosphatase 2Cdelta, Wip1.

  2005cited by this paper
• PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.

  2005cited by this paper
• Substrate Specificity of the Human Protein Phosphatase 2Cδ, Wip1†

  2005cited by this paper
• Wip1-deficient mice are resistant to common cancer genes.

  2004cited by this paper
• Recovery from DNA damage checkpoint arrest by PP1‐mediated inhibition of Chk1

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• The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair.

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• Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK–mediated activation of the p16Ink4a-p19Arf pathway

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• PPM1D is a potential target for 17q gain in neuroblastoma.

  2003cited by this paper
• Chk1 and Chk2 kinases in checkpoint control and cancer.

  2003cited by this paper
• Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.

  2003cited by this paper
• Chk2 activates E2F-1 in response to DNA damage

  2003cited by this paper
• PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break.

  2003cited by this paper
• Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.

  2003cited by this paper
• Autophosphorylation of Checkpoint Kinase 2 at Serine 516 Is Required for Radiation-induced Apoptosis*

  2003cited by this paper
• Mice Deficient for the Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control

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• Chk2 Activation and Phosphorylation-Dependent Oligomerization

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• Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

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• Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

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• Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain*

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• PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

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• Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2.

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• Threonine 68 of Chk2 Is Phosphorylated at Sites of DNA Strand Breaks*

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• Critical Role of Caenorhabditis elegansHomologs of Cds1 (Chk2)-Related Kinases in Meiotic Recombination

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• Chk2 kinase — a busy messenger

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• Initial Steps of Ferulic Acid Polymerization by Lignin Peroxidase*

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• The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

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• p53‐inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK‐p53 signaling in response to UV radiation

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• hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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• Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.

  2000cited by this paper
• Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

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• Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1

  2000cited by this paper
• Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.

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• Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.

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• The structure and regulation of protein phosphatases.

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• Gain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor progression.

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• Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks

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• Targeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy.

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• Delay induced Hopf bifurcation and its control in a fractional p53 protein oscillator model

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• Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity

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• Wip1 phosphatase activator QGC-8-52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells.

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• UBE4B Phosphorylation is Essential to Stabilize p53 in Response to DNA Damage

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• Radiotherapy and radio‐sensitization in H3 K27M ‐mutated diffuse midline gliomas

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• Maintaining Genome Integrity: Protein Kinases and Phosphatases Orchestrate the Balancing Act of DNA Double-Strand Breaks Repair in Cancer

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• Calciprotein Particles Induce Cellular Compartment-Specific Proteome Alterations in Human Arterial Endothelial Cells

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• PPM1D in Solid and Hematologic Malignancies: Friend and Foe?

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• MicroRNAs in doxorubicin-induced cardiotoxicity: The DNA damage response

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• Checkpoint Kinase 2 Inhibition Can Reverse Tamoxifen Resistance in ER-Positive Breast Cancer

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• PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response

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• MiR-145-5p Inhibits the Invasion of Prostate Cancer and Induces Apoptosis by Inhibiting WIP1

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• High Expression of PPM1D Induces Tumors Phenotypically Similar to TP53 Loss-of-Function Mutations in Mice

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• A novel assay for screening WIP1 phosphatase substrates in nuclear extracts

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• Targeting oncogenic WIP1 phosphatase sensitizes hypoxic breast cancer cells to doxorubicin induced apoptosis via activation of p53-p21 axis

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