Innate immunity and aging.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Experimental Gerontology

• Publication date

  2008-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.exger.2008.05.016PMID 18586079PMCID PMC2564282
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• COMPARISON OF THE EFFECTS OF AGING AND IL-6 ON THE HEPATIC INFLAMMATORY RESPONSE IN TWO MODELS OF SYSTEMIC INJURY: SCALD INJURY VERSUS I.P. LPS ADMINISTRATION

  2009cited by this paper
• Sex Hormones and Immunosenescence

  2009cited by this paper
• Biology of dendritic cells

  2008cited by this paper
• Aging and impairment of innate immunity.

  2008cited by this paper
• Aging of the immune system as a prognostic factor for human longevity.

  2008cited by this paper
• Effect of Senescence on Macrophage Polarization and Angiogenesis

  2008cited by this paper
• Macrophage activation and polarization.

  2008influential reference
• An age‐associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition

  2008cited by this paper
• Age-related changes in eosinophil function in human subjects.

  2008influential reference
• Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice.

  2007cited by this paper
• Invariant NKT and NKT-like lymphocytes: two different T cell subsets that are differentially affected by ageing.

  2007influential reference
• In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection

  2007cited by this paper
• Estrogen and progestogen use in peri- and postmenopausal women: March 2007 position statement of The North American Menopause Society

  2007cited by this paper
• Aging and estrogen: modulation of inflammatory responses after injury.

  2007cited by this paper
• Age-Associated Defect in Human TLR-1/2 Function1

  2007influential reference
• Effects of aging on triggering receptor expressed on myeloid cells (TREM)‐1‐induced PMN functions

  2007influential reference
• Role of Inositol 1,4,5-Triphosphate and p38 Mitogen-Activated Protein Kinase in Reactive Oxygen Species Generation by Granulocytes in a Cyclic AMP-Dependent Manner: An Age-Related Phenomenon

  2007cited by this paper
• Pulmonary effects of inhaled limonene ozone reaction products in elderly rats.

  2007influential reference
• Aged rats lose vasoprotective and anti-inflammatory actions of estrogen in injured arteries

  2007cited by this paper
• TGF-β1 Upregulation in the Aging Varicose Vein

  2007cited by this paper
• High serum YKL‐40 level in a cohort of octogenarians is associated with increased risk of all‐cause mortality

  2007cited by this paper
• The biology of NKT cells.

  2007cited by this paper
• TGF-beta1 upregulation in the aging varicose vein.

  2007cited by this paper
• Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue1

  2007influential reference
• Mast cells--key effector cells in immune responses.

  2007cited by this paper
• Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins.

  2007cited by this paper
• GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals

  2007influential reference
• Biology of Dendritic Cells in Aging

  2007cited by this paper
• Basal activity of Kupffer cells increases with old age.

  2007cited by this paper
• Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis.

  2007cited by this paper
• Eosinophils in the pathogenesis of allergic airways disease

  2007cited by this paper
• Aging Impairs IGF‐I Receptor Activation and Induces Skeletal Resistance to IGF‐I

  2007cited by this paper
• Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1

  2007influential reference
• The effect of age on the development and outcome of adult sepsis*

  2006cited by this paper
• Immunogenetics, Gender, and Longevity

  2006cited by this paper
• Toll-like receptors and atherosclerosis

  2006cited by this paper
• Impairment of SHP‐1 down‐regulation in the lipid rafts of human neutrophils under GM‐CSF stimulation contributes to their age‐related, altered functions

  2006cited by this paper
• Molecular basis of age‐associated cytokine dysregulation in LPS‐stimulated macrophages

  2006influential reference
• Aging and innate immunity.

  2006cited by this paper
• Decreased frequency and proliferative response of invariant Valpha24Vbeta11 natural killer T (iNKT) cells in healthy elderly.

  2006cited by this paper
• Testosterone and estrogen have opposing actions on inflammation-induced plasma extravasation in the rat temporomandibular joint.

  2006cited by this paper
• The Eosinophil: The Cell and Its Weapons, the Cytokines, Its Locations

  2006cited by this paper
• The eosinophil.

  2006cited by this paper
• Serum from aged F344 rats conditions the activation of young macrophages.

  2006cited by this paper
• ABERRANT ACUTE-PHASE RESPONSE IN AGED INTERLEUKIN-6 KNOCKOUT MICE

  2006cited by this paper
• Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure

  2006cited by this paper
• Role of phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways in granulocyte macrophage-colony-stimulating factor failure to delay fas-induced neutrophil apoptosis in elderly humans.

  2006influential reference
• Protective Roles of Mast Cells and Mast Cell-Derived TNF in Murine Malaria

  2006cited by this paper
• Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology.

  2006cited by this paper
• Aging of the immune system: how much can the adaptive immune system adapt?

  2006cited by this paper
• Aging of the immune system: a risk factor for autoimmunity?

  2006cited by this paper
• Long-Term Retention of Mature NK1.1+ NKT Cells in the Thymus1

  2006cited by this paper
• Decreased frequency and proliferative response of invariant Vα24Vβ11 natural killer T (iNKT) cells in healthy elderly

  2006cited by this paper
• MacrophAging: a cellular and molecular review.

  2005cited by this paper
• Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age‐associated microenvironmental changes

  2005cited by this paper
• Total and differential white blood cell counts and their associations with circulating interleukin-6 levels in community-dwelling older women.

  2005cited by this paper
• Age-dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double-positive CD4[+] CD8[+] cells and B220[+] T cells, in mice

  2005cited by this paper
• The aging of early B‐cell precursors

  2005cited by this paper
• CD1d-Restricted NKT Cells Contribute to the Age-Associated Decline of T Cell Immunity1

  2005influential reference
• NephrologyDialysis Transplantation Successful immunosenescence and the remodelling of immune responses with ageing

  2005cited by this paper
• The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging

  2005influential reference
• Age-Induced Reprogramming of Mast Cell Degranulation1

  2005influential reference
• Macrophages Sequentially Change Their Functional Phenotype in Response to Changes in Microenvironmental Influences1

  2005cited by this paper
• The hormonal fountains of youth: myth or reality?

  2005cited by this paper
• The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function

  2005influential reference
• Aging Increases Stromal/Osteoblastic Cell‐Induced Osteoclastogenesis and Alters the Osteoclast Precursor Pool in the Mouse

  2005influential reference
• Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway.

  2005influential reference
• Mast cells as "tunable" effector and immunoregulatory cells: recent advances.

  2005influential reference
• The aging innate immune system.

  2005cited by this paper
• Response of aged mice to primary virus infections

  2005influential reference
• B cells, E2A, and aging

  2005cited by this paper
• Human immunosenescence: is it infectious?

  2005cited by this paper
• B cell development and receptor diversity during aging.

  2005cited by this paper
• Increased carrageenan‐induced acute lung inflammation in old rats

  2005cited by this paper
• Estrogen replacement, aging, and cell‐mediated immunity after injury

  2004cited by this paper
• Macrophage hypo-responsiveness to interferon-gamma in aged mice is associated with impaired signaling through Jak-STAT.

  2004cited by this paper
• Estradiol and progesterone treatments change the lipid profile in naturally menopausal rats from different age groups

  2004cited by this paper
• Triggering Receptor Expressed on Myeloid Cells-1 in Neutrophil Inflammatory Responses: Differential Regulation of Activation and Survival

  2004cited by this paper
• AGE AND CALORIC RESTRICTION DIETS ARE CONFOUNDING FACTORS THAT MODIFY THE RESPONSE TO LIPOPOLYSACCHARIDE BY PERITONEAL MACROPHAGES IN C57BL/6 MICE

  2004cited by this paper
• Aging and innate immune cells

  2004cited by this paper
• Immunity to influenza

  2004cited by this paper
• The variations during the circadian cycle of liver CD1d-unrestricted NK1.1+TCR gamma/delta+ cells lead to successful ageing. Role of metallothionein/IL-6/gp130/PARP-1 interplay in very old mice.

  2004cited by this paper
• Age‐dependent decrease in Toll‐like receptor 4‐mediated proinflammatory cytokine production and mitogen‐activated protein kinase expression

  2004influential reference
• Inflammatory mediators in the elderly.

  2004cited by this paper
• Aging and Wound Healing

  2004cited by this paper
• Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function.

  2004influential reference
• Immunosuppression after injury in aged mice is associated with a TH1-TH2 shift, which can be restored by estrogen treatment.

  2004cited by this paper
• Regulation of myeloid development and function by colony stimulating factors.

  2004cited by this paper
• Macrophage hypo-responsiveness to interferon-γ in aged mice is associated with impaired signaling through Jak-STAT

  2004cited by this paper
• The LPS receptor (CD14) links innate immunity with Alzheimer's disease

  2004cited by this paper
• Effect of Particulate and Gaseous Pollutants on Spontaneous Arrhythmias in Aged Rats

  2004cited by this paper
• NK and NKT cell functions in immunosenescence

  2004influential reference
• [Asthma in the elderly].

  2004cited by this paper
• Age‐dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double‐positive CD4+ CD8+ cells and B220+ T cells, in mice

  2004cited by this paper
• Innate immunity in aging: impact on macrophage function

  2004influential reference
• Age-related changes in lymphocyte development and function

  2004influential reference
• Signal transduction and functional changes in neutrophils with aging

  2004influential reference
• Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis.

  2003cited by this paper
• Ceramide-induced and Age-associated Increase in Macrophage COX-2 Expression Is Mediated through Up-regulation of NF-κB Activity*

  2003cited by this paper
• Genetic regulation of osteoclast development and function

  2003cited by this paper

• A machine learning-based prediction model for poor prognosis in sepsis using lymphocyte count: a national, multicenter prospective cohort

  2026cites this paper
• The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities

  2025cites this paper
• Associations between long-term exposure to particulate matter and mortality from multiple causes among the oldest-old people.

  2025cites this paper
• Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence

  2025cites this paper
• A Connection Between the Gut Microbiome and Epigenetic Modification in Age-Related Cancer: A Narrative Review

  2025cites this paper
• Aging and immunity: the age-old tango

  2025cites this paper
• Senescent macrophages in cancer: roles in tumor progression and treatment opportunities

  2025cites this paper
• Aging impairs the antiviral defense in Caenorhabditis elegans due to loss of DRH-1/RIG-I deSUMOylation by ULP-4/SENP7

  2025cites this paper
• Anthraquinones and Aloe Vera Extracts as Potential Modulators of Inflammaging Mechanisms: A Translational Approach from Autoimmune to Onco-Hematological Diseases

  2025cites this paper
• Single-cell transcriptomic analysis reveals immune remodeling in bone marrow during aged sepsis.

  2025cites this paper
• A Molecular Study of Covid-19 By Using ROF1b\N\E Gene in Wasit Province

  2024cites this paper
• Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis

  2024cites this paper
• Systemic Factors Affecting Human Beta-Defensins in Oral Cavity

  2024cites this paper
• The Impairment of Endothelial Autophagy Accelerates Renal Senescence by Ferroptosis and NLRP3 Inflammasome Signaling Pathways with the Disruption of Endothelial Barrier

  2024cites this paper
• Postoperative trachomatous trichiasis and associated factors among adults who underwent trachomatous trichiasis surgery in Ambassel District, North-East Ethiopia

  2024cites this paper
• ROS-Induced Gingival Fibroblast Senescence: Implications in Exacerbating Inflammatory Responses in Periodontal Disease

  2024cites this paper
• The nature and origin of immunosuppressive disorders

  2024cites this paper
• Age‐associated myeloid malignancies – the role of STAT3 and STAT5 in myelodysplastic syndrome and acute myeloid leukemia

  2024cites this paper
• Alterations in metabolic pathways: a bridge between aging and weaker innate immune response

  2024cites this paper
• Association between C-reactive protein, neutrophils, lymphocytes, cognition, and functional capacity in an oldest old population

  2023cites this paper
• Impact of Immunosenescence on Viral Infections with an Emphasis on COVID-19.

  2023cites this paper
• Pancreatic adenocarcinoma and aging: understanding the menace for better management

  2023cites this paper
• Macrophages in immunoregulation and therapeutics

  2023cites this paper
• Aging microenvironment and antitumor immunity for geriatric oncology: the landscape and future implications

  2023cites this paper
• Prospective Analysis of B Lymphocyte Subtypes, before and after Initiation of Dialysis, in Patients with End-Stage Renal Disease

  2023cites this paper
• Mortality of hospitalized patients with COVID-19: Effects of treatment options (vitamin D, anticoagulation, isoprinosine, ivermectin) assessed by propensity score matching, retrospective analysis.

  2023cites this paper
• The pathophysiology of chronic subdural hematoma revisited: emphasis on aging processes as key factor

  2022cites this paper
• Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks

  2022cites this paper
• Periodontitis and peri‐implantitis in elderly people experiencing institutional and hospital confinement

  2022cites this paper
• Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis

  2022cites this paper
• Microbiome-by-ethanol interactions impact Drosophila melanogaster fitness, physiology, and behavior

  2022cites this paper
• Variations in immune parameters with age in a wild rodent population and links with survival

  2022cites this paper
• Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock

  2022cites this paper
• Prognostic role of modified Glasgow Prognostic score in elderly non-small cell lung cancer patients treated with anti-PD-1 antibodies.

  2022cites this paper
• Effect of Ageing on The Immune System, A Review

  2022cites this paper
• Mechanotherapy Reprograms Aged Muscle Stromal Cells to Remodel the Extracellular Matrix during Recovery from Disuse

  2022cites this paper
• Cellular Senescence and Periodontitis: Mechanisms and Therapeutics

  2022cites this paper
• Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant

  2021cites this paper
• Immunesenescence and Compromised Removal of Senescent Cells: Implications for Health in Old Age

  2021cites this paper
• Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach

  2021cites this paper
• Sonographic septation: a useful diagnostic predictor of complicated parapneumonic effusion

  2021cites this paper
• Investigation of innate immune function in adult and geriatric horses.

  2021cites this paper
• Risk factors for serious infections in inpatients with systemic lupus erythematosus.

  2021cites this paper
• Microbiota profiling in aging-associated inflammation and liver degeneration.

  2021cites this paper
• The role of vitamin D in reducing SARS-CoV-2 infection: An update

  2021cites this paper
• Effect of Age on Bleeding on Probing (BOP) as an Indicator of Periodontal Inflammation in Patients Enrolled in Supportive Periodontal Therapy

  2021cites this paper
• The Lanostane Triterpenoids in Poria cocos Play Beneficial Roles in Immunoregulatory Activity

  2021cites this paper
• Impact of aging and senescence on phenotype and function of murine brain microglia in vitro and in vivo Dissertation

  2021cites this paper
• Sirtuins and the prevention of immunosenescence.

  2021cites this paper
• A Point-of-Care Serum Lactate Level and Mortality in Adult Sepsis Patients: A Community Hospital Setting

  2021cites this paper
• Contribution of the Microbiota to Healthy Aging

  2021cites this paper
• The relationships between PD-L1 expression, CD8+ TILs and clinico-histomorphological parameters in malignant melanomas.

  2020cites this paper
• Impact of Surfactant Protein-A Variants on Survival in Aged Mice in Response to Klebsiella pneumoniae Infection and Ozone: Serendipity in Action

  2020cites this paper
• The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients

  2020cites this paper
• Role of neutrophil-lymphocyte-ratio in the mortality of males diagnosed with COVID-19

  2020cites this paper
• Pharmacological management of human respiratory syncytial virus infection

  2020cites this paper
• Periodontitis: A Hastened and Destructive Inflammatory Induced Senescence

  2020cites this paper
• The Role of Vitamin D in Suppressing Cytokine Storm in COVID-19 Patients and Associated Mortality

  2020cites this paper
• Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy.

  2020cites this paper
• Assessing the Age-Specific Phagocytic Ability of Adult Drosophila melanogaster Hemocytes using an In Vivo Phagocytosis Assay.

  2020cites this paper
• Biomolecular endotype factors involved in COVID-19 airway infectivity: A systematic review

  2020cites this paper
• Immunosuppressed Patients and the Risk of COVID-19: A Narrative Review

  2020cites this paper
• Development of age-dependent dose modification factors for acute radiation lethality

  2020cites this paper
• Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients

  2020cites this paper
• О соотношении различных путей клеточной смерти на отдельных этапах онтогенеза в норме и при системных заболеваниях соединительной ткани

  2020cites this paper
• The magnitude and associated Factors of Postoperative Trichiasis among adults who underwent Trachomatous Trichiasis Surgery in Ambassel District, North-East Ethiopia

  2020cites this paper
• Dysregulation of the immune system as a driver of the critical course of novel coronavirus disease 2019

  2020cites this paper
• Jurnal Kedokteran dan Kesehatan Indonesia

  2020cites this paper
• Revista Andaluza de Medicina del Deporte Resistance training and innate immunosenescence of the innate immune system

  2020cites this paper
• Immunosenescence, Oxidative Stress, and Cancers

  2020cites this paper
• Resistance training and immunosenescence of the innate immune system

  2019cites this paper
• A History of Burn Care

  2019cites this paper
• Atopic dermatitis in the elderly: a review of clinical and pathophysiological hallmarks

  2019cites this paper
• Secondary immunodeficiency as a consequence of chronic diseases.

  2019cites this paper
• Research progress on immune aging and its mechanisms affecting geriatric diseases

  2019cites this paper
• How the ageing microenvironment influences tumour progression

  2019cites this paper
• Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach

  2019cites this paper
• Aging Immunity and the Impact of Physical Exercise

  2019cites this paper
• Hematuria in the Critically Ill Cancer Patients

  2019cites this paper
• Enhancement of adaptive immune responses of aged mice by dietary intake of β-glucans, with special emphasis on anti-aging activity.

  2019cites this paper
• Mast Cells of the Human Pineal Gland

  2019cites this paper
• Effect of Macrophage Activity and Age on Periodontal Disease in a Mouse Model

  2019influential citation
• Enhanced Efficacy of Vaccination With Vaccinia Virus in Old vs. Young Mice

  2019cites this paper
• Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease

  2019cites this paper
• Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act.

  2019cites this paper
• Particulate Matter and Its Impact on Mortality among Elderly Residents of Seoul, South Korea

  2019cites this paper
• Determinants of patient survival following acute Ebola virus infection

  2019cites this paper
• Is percutaneous nephrolithotomy effective and safe in elderly patients ? Outcomes of a case-control study

  2019cites this paper
• Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age

  2019cites this paper
• Defining the actinic keratosis field: a literature review and discussion

  2018cites this paper
• Age-Associated Changes in the Respiratory Epithelial Response to Influenza Infection

  2018cites this paper
• Time-restricted feeding influences immune responses without compromising muscle performance in older men.

  2018cites this paper
• The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process.

  2018cites this paper
• Chronic ethanol ingestion impairs Drosophila melanogaster health in a microbiome-dependent manner

  2018cites this paper
• Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trial

  2018cites this paper
• DEVELOPMENT OF CYTOKINE ELUTING COATINGS TO MODULATE MACROPHAGE BEHAVIOUR AND MITIGATE THE FOREIGN BODY REACTION AGAINST IMPLANTABLE BIOMATERIALS

  2018cites this paper
• Age and Periodontal Health—Immunological View

  2018cites this paper
• Cardiac stem cell aging and heart failure

  2018cites this paper
• Frailty, sarcopenia and immunesenescence: shared mechanisms and clinical insights

  2018cites this paper
• Aging, inflammation and cancer.

  2018cites this paper