The genetics of breast cancer susceptibility.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Annual Review of Genetics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/ANNUREV.GENET.32.1.95PMID 9928476
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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• p53 mutations in BRCA1-associated familial breast cancer.

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• BRCA2 mutations in primary breast and ovarian cancers

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• Haplotype and phenotype analysis of six recurrent BRCA1 mutations in 61 families: results of an international study.

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• Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer

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• High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients.

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• BRCA1 protein products ... Functional motifs...

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• Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1.

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• Identification of a RING protein that can interact in vivo with the BRCA1 gene product

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• BRCA1 mutations in a population-based sample of young women with breast cancer.

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• BRCA1 is secreted and exhibits properties of a granin

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• Truncation at conserved terminal regions of BRCA1 protein is associated with highly proliferating hereditary breast cancers.

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• Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus

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• Molecular genetic evidence of the occurrence of breast cancer as an integral tumor in patients with the hereditary nonpolyposis colorectal carcinoma syndrome

  1996cited by this paper
• …Functional motifs…

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• Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer.

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• Does this have a familiar RING?

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• Germline BRCA1 185delAG mutations in Jewish women with breast cancer.

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• A polymorphic stop codon in BRCA2

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• The genetic attributable risk of breast and ovarian cancer

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• High allele loss rates at I7q I2‐q2I in breast and ovarian tumors from BRCAI‐linked families

  1995cited by this paper
• Identification of the breast cancer susceptibility gene BRCA2

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• Murine Brca1: sequence and significance for human missense mutations.

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• Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

  1995cited by this paper
• Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

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• Risk modifiers in carriers of brca1 mutations

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• Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.

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• A human BRCA1 gene knockout

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• Aberrant Subcellular Localization of BRCA1 in Breast Cancer

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• High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. The Breast Cancer Linkage Consortium.

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  1994cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

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  1994cited by this paper
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  2023cites this paper
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