Plakophilins in Desmosomal Adhesion and Signaling

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Cell Communication & Adhesion

• Publication date

  2014-01-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3109/15419061.2013.876017PMID 24460199
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plakophilin 2 affects cell migration by modulating focal adhesion dynamics and integrin protein expression.

  2014cited by this paper
• Obligatory roles of filamin A in E-cadherin-mediated cell-cell adhesion in epidermal keratinocytes.

  2014cited by this paper
• Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation

  2013cited by this paper
• Genomic Signatures of Pregnancy-Associated Breast Cancer Epithelia and Stroma and their Regulation by Estrogens and Progesterone

  2013cited by this paper
• Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers

  2013cited by this paper
• Cross-Study Homogeneity of Psoriasis Gene Expression in Skin across a Large Expression Range

  2013cited by this paper
• HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: Array‐based DNA methylation and expression profiling

  2013cited by this paper
• Fragile hearts: new insights into translational control in cardiac muscle.

  2013cited by this paper
• The AKT genes and their roles in various disorders

  2013cited by this paper
• A 13-Gene Signature Prognostic of HPV-Negative OSCC: Discovery and External Validation

  2013cited by this paper
• The Investigational Aurora Kinase A Inhibitor MLN8237 Induces Defects in Cell Viability and Cell-Cycle Progression in Malignant Bladder Cancer Cells In Vitro and In Vivo

  2013cited by this paper
• Differential immunohistochemical localization of desmosomal plaque‐related proteins in non‐small‐cell lung cancer

  2013cited by this paper
• Mechanistic Basis of Desmosome-Targeted Diseases

  2013cited by this paper
• p120-catenin in cancer – mechanisms, models and opportunities for intervention

  2013cited by this paper
• Human 14-3-3 Paralogs Differences Uncovered by Cross-Talk of Phosphorylation and Lysine Acetylation

  2013cited by this paper
• Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas

  2013cited by this paper
• An alternative promoter of the human plakophilin-3 gene controls the expression of the new isoform PKP3b

  2013cited by this paper
• Plakophilin-1 protects keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes

  2013cited by this paper
• In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis.

  2013cited by this paper
• Stratifin (14-3-3 σ) Limits Plakophilin-3 Exchange with the Desmosomal Plaque

  2013cited by this paper
• The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer

  2012cited by this paper
• Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas.

  2012cited by this paper
• Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

  2012cited by this paper
• Comparison of Microarray Platforms for Measuring Differential MicroRNA Expression in Paired Normal/Cancer Colon Tissues

  2012cited by this paper
• Combined Use of Laser Capture Microdissection and cDNA Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions

  2012cited by this paper
• Post-Therapeutic Relapse of Psoriasis after CD11a Blockade Is Associated with T Cells and Inflammatory Myeloid DCs

  2012cited by this paper
• Transcriptional Profiling of Formalin Fixed Paraffin Embedded Tissue: Pitfalls and Recommendations for Identifying Biologically Relevant Changes

  2012cited by this paper
• Genome-scale analysis of aberrant DNA methylation in colorectal cancer.

  2012cited by this paper
• Estrogens promote cell-cell adhesion of normal and malignant mammary cells through increased desmosome formation.

  2012cited by this paper
• Expression of Plakophilins (PKP1, PKP2, and PKP3) in breast cancers

  2012cited by this paper
• Look who's talking: deregulated signaling in colorectal cancer.

  2012cited by this paper
• Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma

  2012cited by this paper
• Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer

  2012cited by this paper
• Up-regulation of plakophilin-2 and Down-regulation of plakophilin-3 are correlated with invasiveness in bladder cancer.

  2012cited by this paper
• Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin‐dependent kinases and the phosphoinositide 3‐kinase/AKT signaling cascade

  2012cited by this paper
• Fragile X mental retardation protein: past, present and future.

  2012cited by this paper
• Cell–cell connectivity: desmosomes and disease

  2012cited by this paper
• Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma

  2012cited by this paper
• Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis

  2012cited by this paper
• Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues*

  2012cited by this paper
• Genome-Wide Expression Profiling of Five Mouse Models Identifies Similarities and Differences with Human Psoriasis

  2011cited by this paper
• E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly

  2011cited by this paper
• Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.

  2011cited by this paper
• A gene expression signature identifies two prognostic subgroups of basal breast cancer

  2011cited by this paper
• FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.

  2011cited by this paper
• Systematic and quantitative assessment of the ubiquitin-modified proteome.

  2011cited by this paper
• Desmosomes: new perpetrators in tumour suppression

  2011cited by this paper
• MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins

  2011influential reference
• Gene expression profiling reveals novel biomarkers in nonsmall cell lung cancer

  2011cited by this paper
• Global Gene Expression Profiling and Validation in Esophageal Squamous Cell Carcinoma and Its Association with Clinical Phenotypes

  2011cited by this paper
• Gene Expression Signature–Based Prognostic Risk Score in Gastric Cancer

  2011cited by this paper
• Expression of Plakophilins (PKP1, PKP2, and PKP3) in Gastric Cancers

  2011cited by this paper
• Assisted peptide folding by surface pattern recognition.

  2011cited by this paper
• Desmosomes.

  2011cited by this paper
• Desmoplakin and Talin2 Are Novel mRNA Targets of Fragile X–Related Protein-1 in Cardiac Muscle

  2011cited by this paper
• A role of plakophilins in the regulation of translation

  2010cited by this paper
• BLAST-EXPLORER helps you building datasets for phylogenetic analysis

  2010cited by this paper
• Modeling Oncogenic Signaling in Colon Tumors by Multidirectional Analyses of Microarray Data Directed for Maximization of Analytical Reliability

  2010cited by this paper
• Prognostic Biomarkers for Esophageal Adenocarcinoma Identified by Analysis of Tumor Transcriptome

  2010cited by this paper
• Ectodermal dysplasia-skin fragility syndrome.

  2010cited by this paper
• Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA.

  2010cited by this paper
• Plakophilin 2 Couples Actomyosin Remodeling to Desmosomal Plaque Assembly via RhoA

  2010cited by this paper
• Gene expression signatures in breast cancer distinguish phenotype characteristics, histologic subtypes, and tumor invasiveness

  2010cited by this paper
• A tissue-specific atlas of mouse protein phosphorylation and expression.

  2010cited by this paper
• Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma

  2010cited by this paper
• Mutated KRAS results in overexpression of DUSP4, a MAP‐kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas

  2010cited by this paper
• Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data

  2010cited by this paper
• Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma of the breast

  2010cited by this paper
• Gene Expression-Based Classification of Non-Small Cell Lung Carcinomas and Survival Prediction

  2010cited by this paper
• Armadillo-repeat protein functions: questions for little creatures.

  2010cited by this paper
• Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor

  2010cited by this paper
• Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.

  2010cited by this paper
• Plakophilin 1 stimulates translation by promoting eIF4A1 activity

  2010cited by this paper
• A nuclear function for plakophilin-1 in the DNA damage response?

  2010cited by this paper
• The pathogenesis of Barrett's metaplasia and the progression to esophageal adenocarcinoma.

  2010cited by this paper
• Tumorigenesis and Neoplastic Progression Analysis of Orthologous Gene Expression between Human Pulmonary Adenocarcinoma and a Carcinogen-Induced Murine Model

  2010cited by this paper
• Genome profiling of ERBB2-amplified breast cancers

  2010cited by this paper
• Identification of a Novel Biomarker, SEMA5A, for Non–Small Cell Lung Carcinoma in Nonsmoking Women

  2010cited by this paper
• Desmosomes: adhesive strength and signalling in health and disease.

  2010cited by this paper
• Genomic Profiles Associated with Early Micrometastasis in Lung Cancer: Relevance of 4q Deletion

  2009cited by this paper
• Association of survival and disease progression with chromosomal instability: A genomic exploration of colorectal cancer

  2009cited by this paper
• Gene expression profiling reveals overexpression of TSPAN13 in prostate cancer.

  2009cited by this paper
• An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth

  2009cited by this paper
• Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes

  2009cited by this paper
• Whole-Genome Gene Expression Profiling of Formalin-Fixed, Paraffin-Embedded Tissue Samples

  2009cited by this paper
• Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators by oligonucleotide microarray analysis

  2009cited by this paper
• Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer.

  2009cited by this paper
• Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue

  2009cited by this paper
• Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas

  2009cited by this paper
• Early dysregulation of cell adhesion and extracellular matrix pathways in breast cancer progression.

  2009cited by this paper
• Plakophilins: multifunctional scaffolds for adhesion and signaling.

  2009cited by this paper
• DNA microarray expression profiling of bladder cancer allows identification of noninvasive diagnostic markers.

  2009cited by this paper
• Genome-wide expression profile of sporadic gastric cancers with microsatellite instability.

  2009cited by this paper
• The ATM tumour suppressor gene is down‐regulated in EBV‐associated nasopharyngeal carcinoma

  2009cited by this paper
• A compact VEGF signature associated with distant metastases and poor outcomes

  2009cited by this paper
• p120-catenin is a novel desmoglein 3 interacting partner : identification of the p120-catenin association site of desmoglein 3

  2008cited by this paper
• A Precisely Regulated Gene Expression Cassette Potently Modulates Metastasis and Survival in Multiple Solid Cancers

  2008cited by this paper
• The area composita of adhering junctions connecting heart muscle cells of vertebrates. V. The importance of plakophilin-2 demonstrated by small interference RNA-mediated knockdown in cultured rat cardiomyocytes.

  2008cited by this paper
• p120 catenin is associated with desmogleins when desmosomes are assembled in high‐Ca2+ medium but not when disassembled in low‐Ca2+ medium in DJM‐1 cells

  2008cited by this paper
• Plakophilin3 downregulation leads to a decrease in cell adhesion and promotes metastasis

  2008cited by this paper

• Aberrant skeletal muscle morphogenesis and myofiber differentiation characterize equine myotonic dystrophy

  2026cites this paper
• Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas.

  2025cites this paper
• Plakophilin 3 Is Involved in Basal Body Docking in Multiciliated Cells

  2025cites this paper
• The Desmoglein 2 interactome in primary neonatal cardiomyocytes

  2025cites this paper
• PEaRL: Pathway-Enhanced Representation Learning for Gene and Pathway Expression Prediction from Histology

  2025cites this paper
• The desmosome as a dynamic membrane domain.

  2024cites this paper
• Diversity of Intercellular Communication Modes: A Cancer Biology Perspective

  2024cites this paper
• Desmosomes at a glance.

  2024cites this paper
• Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers

  2023cites this paper
• Plakophilin-3 Binds the Membrane and Filamentous Actin without Bundling F-Actin

  2023influential citation
• Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling.

  2023cites this paper
• Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels

  2022influential citation
• Desmosomal dualism: the core is stable while plakophilin is dynamic

  2021cites this paper
• Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3

  2021cites this paper
• Desmosome dualism: most of the junction is stable but a plakophilin moiety is persistently dynamic.

  2021cites this paper
• Desmosomes as Signaling Hubs in the Regulation of Cell Behavior

  2021cites this paper
• Plakophilin 3 and Par3 facilitate desmosomes’ association with the apical junctional complex

  2021cites this paper
• The tobacco phosphatidylethanolamine‐binding protein NtFT4 simultaneously improves vitality, growth, and protein yield in human cells

  2021cites this paper
• Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells

  2021cites this paper
• Tracing the Evolutionary Origin of Desmosomes.

  2020cites this paper
• Ectodermal dysplasia‐skin fragility syndrome: Two new cases and review of this desmosomal genodermatosis

  2020cites this paper
• Cardiac-Specific Caveolin-3 Overexpression Prevents Post-Myocardial Infarction Ventricular Arrhythmias by Inhibiting Ryanodine Receptor-2 Hyperphosphorylation

  2020cites this paper
• Plakophilin 3 phosphorylation by ribosomal S6 kinases supports desmosome assembly

  2020cites this paper
• Tracing the Origins of the Desmosome: a Vertebrate Innovation

  2020cites this paper
• The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila

  2020cites this paper
• The value of desmosomal plaque-related markers to distinguish squamous cell carcinoma and adenocarcinoma of the lung

  2019cites this paper
• PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.

  2019cites this paper
• The aberrant expression or disruption of desmocollin2 in human diseases.

  2019cites this paper
• Increased expression of plakophilin 3 is associated with poor prognosis in ovarian cancer

  2019cites this paper
• Plakophilin 1 is methylated and has a tumor suppressive activity in human lung cancer.

  2019cites this paper
• Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering

  2019cites this paper
• Plakophilins and their roles in diseased states

  2019cites this paper
• Desmosomes: Essential contributors to an integrated intercellular junction network

  2019cites this paper
• Desmoplakin Harnesses Rho GTPase and p38 Mitogen-Activated Protein Kinase Signaling to Coordinate Cellular Migration.

  2019cites this paper
• The Interaction of CD97/ADGRE5 With β-Catenin in Adherens Junctions Is Lost During Colorectal Carcinogenesis

  2018cites this paper
• Desmoplakin harnesses Rho GTPase and p38 MAPK signaling to coordinate cellular migration.

  2018cites this paper
• Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective.

  2018influential citation
• 14-3-3 proteins regulate desmosomal adhesion via plakophilins

  2018cites this paper
• Desmosomes in Human Disease.

  2018cites this paper
• Intercalated discs: cellular adhesion and signaling in heart health and diseases

  2018cites this paper
• Intermediate Filaments and the Plasma Membrane.

  2017cites this paper
• Cell-Cell Interactions Leading to Establishment of a Mating Junction in Tetrahymena and Paramecium , Two “Contact-Mediated” Mating Systems

  2016cites this paper
• Evolution of cadherins and associated catenins

  2016cites this paper
• Desmosome assembly, homeostasis, and desmosomal disease

  2016cites this paper
• Biocommunication of Ciliates

  2016cites this paper
• Phosphorylation and isoform use in p120-catenin during development and tumorigenesis.

  2016cites this paper
• Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo.

  2016cites this paper
• Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3.

  2016cites this paper
• Beyond β-catenin: prospects for a larger catenin network in the nucleus

  2015cites this paper
• 150th Anniversary Series: Desmosomes and the Hallmarks of Cancer

  2015cites this paper
• Desmocollin-2 alone forms functional desmosomal plaques, with the plaque formation requiring the juxtamembrane region and plakophilins.

  2015cites this paper
• Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres.

  2015cites this paper
• The twisting tale of woolly hair: a trait with many causes

  2015cites this paper
• Hematopoietic plakophilin‐3 regulates acute tissue‐specific and systemic inflammation in mice

  2015cites this paper
• Role of Zonula Occludens (ZO) proteins in regulating kidney collecting duct principal cell proliferation and adhesion

  2014cites this paper
• Cell Junctions in the Specialized Conduction System of the Heart

  2014cites this paper
• Beyond expectations: novel insights into epidermal keratin function and regulation.

  2014cites this paper