Optogenetic inhibition of behavior with anion channelrhodopsins

Optogenetics uses light exposure to manipulate physiology in genetically modified organisms. Abundant tools for optogenetic excitation are available, but the limitations of current optogenetic inhibitors present an obstacle to demonstrating the necessity of neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit neural systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, thus demonstrating their broad utility in the circuit analysis of behavior.

• Publication year

  2017

• Venue

  Nature Methods

• Publication date

  2017-01-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nmeth.4148PMID 28114289
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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