Systematic analysis of Ca2+ homeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles

Farzan Ghanegolmohammadi,M. Yoshida,S. Ohnuki,Y. Sukegawa,Hiroki Okada,K. Obara,A. Kihara,Kuninori Suzuki,T. Kojima,Nozomu Yachie,D. Hirata,Y. Ohya

Published 2017 in Molecular Biology of the Cell

ABSTRACT

The global landscape of Ca2+ homeostasis in budding yeast is deciphered. Quantified morphological responses under high concentration of Ca2+ and obtained high-dimensional Ca2+-genetic interaction profiles show functional gene clusters, which are used to build a global network among the Ca2+ homeostasis units acting in various cellular compartments.

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