CORVET and HOPS tethering complexes – coordinators of endosome and lysosome fusion

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Cell Science

• Publication date

  2013-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.107805PMID 23645161
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cellular microcompartments constitute general suborganellar functional units in cells

  2013cited by this paper
• hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins

  2013cited by this paper
• The HOPS Proteins hVps41 and hVps39 Are Required for Homotypic and Heterotypic Late Endosome Fusion

  2013cited by this paper
• Tethering complexes in the endocytic pathway: CORVET and HOPS

  2013cited by this paper
• The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes

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  2012cited by this paper
• Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase

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• 1 FUNCTIONAL SEPARATION OF ENDOSOMAL FUSION FACTORS AND THE CORVET TETHERING COMPLEX IN ENDOSOME BIOGENESIS

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• Functional Separation of Endosomal Fusion Factors and the Class C Core Vacuole/Endosome Tethering (CORVET) Complex in Endosome Biogenesis*

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• Rab7 and Arl8 GTPases are Necessary for Lysosome Tubulation in Macrophages

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• Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

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• Phosphorylation of the effector complex HOPS by the vacuolar kinase Yck3p confers Rab nucleotide specificity for vacuole docking and fusion

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• Role of Rab7/Ypt7 in Organizing Membrane Trafficking at the Late Endosome

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• Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex

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• The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles

  2012cited by this paper
• Termination of Isoform‐Selective Vps21/Rab5 Signaling at Endolysosomal Organelles by Msb3/Gyp3

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• GTPases involved in vesicular trafficking: structures and mechanisms.

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• Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells

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• Merkel Cell Polyomavirus Large T Antigen Disrupts Lysosome Clustering by Translocating Human Vam6p from the Cytoplasm to the Nucleus

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• Lysosomal Membrane Protein Composition, Acidic pH and Sterol Content are Regulated via a Light‐Dependent Pathway in Metazoan Cells

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• Rab GEFs and GAPs.

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• The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome

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• Defined Subunit Arrangement and Rab Interactions Are Required for Functionality of the HOPS Tethering Complex

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• Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization

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• Mapping of Vps21 and HOPS Binding Sites in Vps8 and Effect of Binding Site Mutants on Endocytic Trafficking

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  2010cited by this paper
• Differential Effects of TBC1D15 and Mammalian Vps39 on Rab7 Activation State, Lysosomal Morphology, and Growth Factor Dependence*

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• Identification of the switch in early-to-late endosome transition.

  2010influential reference
• University of Groningen Phosphorylation of a membrane curvature-sensing motif switches function of the HOPS subunit Vps41 in membrane tethering

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• HOPS prevents the disassembly of trans‐SNARE complexes by Sec17p/Sec18p during membrane fusion

  2010cited by this paper
• Phosphorylation of a membrane curvature–sensing motif switches function of the HOPS subunit Vps41 in membrane tethering

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• Aspergillus RabBRab5 Integrates Acquisition of Degradative Identity with the Long Distance Movement of Early Endosomes

  2010influential reference
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  2010cited by this paper
• HOPS Initiates Vacuole Docking by Tethering Membranes before trans-SNARE Complex Assembly

  2010cited by this paper
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• Vps-C complexes: gatekeepers of endolysosomal traffic.

  2009cited by this paper
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  2009influential reference
• Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

  2009cited by this paper
• The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.

  2009influential reference
• Membrane Fusion: Grappling with SNARE and SM Proteins

  2009influential reference
• SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.

  2009cited by this paper
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  2009influential reference
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  2009influential reference
• The Major Role of the Rab Ypt7p in Vacuole Fusion Is Supporting HOPS Membrane Association*♦

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  2008influential reference
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  2008cited by this paper
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  2007influential reference
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  2005cited by this paper
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• Rab7 Associates with Early Endosomes to Mediate Sorting and Transport of Semliki Forest Virus to Late Endosomes

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