Defined Subunit Arrangement and Rab Interactions Are Required for Functionality of the HOPS Tethering Complex

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Traffic : the International Journal of Intracellular Transport

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1600-0854.2010.01097.xPMID 20604902
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1.

  2009cited by this paper
• The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.

  2009cited by this paper
• Phosphoinositides and SNARE chaperones synergistically assemble and remodel SNARE complexes for membrane fusion

  2009cited by this paper
• Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites.

  2009cited by this paper
• Vps-C complexes: gatekeepers of endolysosomal traffic.

  2009cited by this paper
• Membrane Fusion: Grappling with SNARE and SM Proteins

  2009cited by this paper
• Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components

  2009cited by this paper
• Yeast vacuole fusion: A model system for eukaryotic endomembrane dynamics

  2008cited by this paper
• Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase

  2008cited by this paper
• Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones

  2008cited by this paper
• HOPS proofreads the trans-SNARE complex for yeast vacuole fusion.

  2008cited by this paper
• Rab cascades and tethering factors in the endomembrane system

  2007cited by this paper
• Structural basis for Rab GTPase activation by VPS9 domain exchange factors

  2007cited by this paper
• The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis.

  2007cited by this paper
• Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p

  2006cited by this paper
• Rabs and their effectors: Achieving specificity in membrane traffic

  2006cited by this paper
• The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex

  2005cited by this paper
• Self-assembly properties of a model RING domain

  2002cited by this paper
• Vacuole fusion at a ring of vertex docking sites leaves membrane fragments within the organelle.

  2002cited by this paper
• The tandem affinity purification (TAP) method: a general procedure of protein complex purification.

  2001cited by this paper
• The N-terminal domain of the t-SNARE Vam3p coordinates priming and docking in yeast vacuole fusion.

  2001cited by this paper
• Vam3p structure reveals conserved and divergent properties of syntaxins

  2001cited by this paper
• New Component of the Vacuolar Class C-Vps Complex Couples Nucleotide Exchange on the Ypt7 Gtpase to Snare-Dependent Docking and Fusion

  2000influential reference
• Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion.

  2000cited by this paper
• A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion.

  2000cited by this paper
• A generic protein purification method for protein complex characterization and proteome exploration

  1999cited by this paper
• Vps9p Is a Guanine Nucleotide Exchange Factor Involved in Vesicle-mediated Vacuolar Protein Transport*

  1999cited by this paper
• GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell‐free system

  1999cited by this paper
• A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole.

  1997cited by this paper
• An MBoC Favorite: Morphological classification of the yeast vacuolar protein-sorting mutants: evidence for a prevacuolar compartment in class E vps mutants

  1992cited by this paper

• Vps41 functions as a molecular ruler for HOPS tethering complex function.

  2025cites this paper
• Understanding cargo sorting and interactive effects of membrane vesicles in fungal phytopathogens: Current knowledge and research gaps

  2025cites this paper
• VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b

  2025cites this paper
• Vacuole protein sorting 18 (Vps18) suppresses epithelial growth factor receptor (EGFR) expression and lung tumorigenesis

  2025cites this paper
• Structuring of the endolysosomal system by HOPS and CORVET tethering complexes.

  2025cites this paper
• The Plasmodium falciparum homolog of Vps16 interacts with the core members of the Vps-C tethering complex

  2025cites this paper
• Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis

  2025cites this paper
• VPS16-Associated Dystonia: A Cohort-Based Clinical, Imaging and Genetic Profile

  2025cites this paper
• GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes

  2024cites this paper
• CORVET-specific subunit levels determine the balance between HOPS/CORVET endosomal tethering complexes

  2024influential citation
• The vacuolar fusion regulated by HOPS complex promotes hyphal initiation and penetration in Candida albicans

  2024cites this paper
• Complex-specific subunits of endosomal tethering factors determine the balance between HOPS/CORVET complexes

  2023cites this paper
• Tethering proteins of the same contact site affect the localization and mobility of each other.

  2023cites this paper
• Case report: atypical Silver-Russell syndrome patient with hand dystonia: the valuable support of the consensus statement to the wide syndromic spectrum

  2023cites this paper
• HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis

  2023cites this paper
• CP204L Is a Multifunctional Protein of African Swine Fever Virus That Interacts with the VPS39 Subunit of the Homotypic Fusion and Vacuole Protein Sorting Complex and Promotes Lysosome Clustering

  2023cites this paper
• HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells

  2023cites this paper
• Structure of the endosomal CORVET tethering complex

  2023cites this paper
• C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy

  2023cites this paper
• Multiple tethers of organelle contact sites are involved in α-synuclein toxicity in yeast

  2023cites this paper
• Genetics and Pathogenesis of Dystonia.

  2023cites this paper
• The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity

  2022cites this paper
• Arabidopsis HOPS subunit VPS41 carries out plant-specific roles in vacuolar transport and vegetative growth.

  2022cites this paper
• Structure of the lysosomal membrane fusion machinery

  2022cites this paper
• Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery

  2022cites this paper
• The yeast LYST homolog Bph1 is a Rab5 effector and prevents Atg8 lipidation at endosomes.

  2022cites this paper
• Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole

  2021cites this paper
• HOPS-associated neurological disorders (HOPSANDs): linking endolysosomal dysfunction to the pathogenesis of dystonia.

  2021cites this paper
• A HOPS protein, CfVps39, is required for appressorium formation, environmental stress response and vacuolar fusion of Colletotrichum fructicola

  2021cites this paper
• A Novel Homozygous VPS11 Variant May Cause Generalized Dystonia

  2021cites this paper
• Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

  2021cites this paper
• Identification of new interactions between endolysosomal tethering factors.

  2021cites this paper
• The Nma1 protein promotes long distance transport mediated by early endosomes in Ustilago maydis

  2021cites this paper
• AP‐3 vesicle uncoating occurs after HOPS‐dependent vacuole tethering

  2020cites this paper
• A conserved and regulated mechanism drives endosomal Rab transition

  2020cites this paper
• Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly

  2020cites this paper
• List of tables

  2020cites this paper
• The road to lysosome‐related organelles: Insights from Hermansky‐Pudlak syndrome and other rare diseases

  2019cites this paper
• Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling

  2019cites this paper
• Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt

  2019cites this paper
• Diversification of CORVET tethers facilitates transport complexity in Tetrahymena thermophila

  2019influential citation
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  2018cites this paper
• New insights into autophagy regulation using yeast Saccharomyces cerevisiae

  2018cites this paper
• Distinct functional roles of Vps41‐mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration

  2018cites this paper
• Subversion of the Endocytic and Secretory Pathways by Bacterial Effector Proteins

  2018cites this paper
• A proteomic analysis unravels novel CORVET and HOPS proteins involved in Toxoplasma gondii secretory organelles biogenesis

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Abnormal cell-clearance and accumulation of autophagic vesicles in lymphocytes from patients affected with Ataxia-Teleangiectasia.

  2017cites this paper
• Retromer-driven membrane tubulation separates endosomal recycling from Rab7/Ypt7-dependent fusion

  2017cites this paper
• Genetic studies on the physiological role of CORVET in Aspergillus nidulans

  2017cites this paper
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  2017cites this paper
• AtVps11 is essential for vacuole biogenesis in embryo and participates in pollen tube growth in Arabidopsis.

  2017cites this paper
• A cascade of multiple proteins and lipids catalyzes membrane fusion

  2017cites this paper
• Characterization of VPS33B and VPS16B in Megakaryocyte and Platelet Îą-granule Biogenesis

  2016influential citation
• The Hops Tethering Complex and the Dynamin Homolog Vps1 Coordinate Distinct Stages in Intracellular Membrane Fusion

  2016influential citation
• The Hops Tethering Complex and the Dynamin Homolog Vps1 Coordinate Distinct Stages in Intracellular Membrane Fusion

  2016influential citation
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  2016cites this paper
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  2016cites this paper
• Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

  2016cites this paper
• Cargo trafficking from the trans‐Golgi network towards the endosome

  2016cites this paper
• AtVPS41-mediated endocytic pathway is essential for pollen tube–stigma interaction in Arabidopsis

  2016cites this paper
• Investigating the Architecture and Vesicle Tethering Function of the Yeast Exocyst Complex: A Dissertation

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  2015cites this paper
• The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis

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• The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes

  2015cites this paper
• Failure of lysosome clustering and positioning in the juxtanuclear region in cells deficient in rapsyn

  2015cites this paper
• Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole

  2015cites this paper
• Spatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport

  2015cites this paper
• The Habc Domain of the SNARE Vam3 Interacts with the HOPS Tethering Complex to Facilitate Vacuole Fusion*

  2015cites this paper
• Molecular dynamics at the endocytic portal and regulations of endocytic and recycling traffics.

  2015cites this paper
• Investigating the role of TOR signalling, and the link between actin binding protein cofilin and mitochondrial function and their effects on recombinant protein production

  2015cites this paper
• Hypomyelination and developmental delay associated with VPS11 mutation in Ashkenazi-Jewish patients

  2015cites this paper
• Vps33B is required for delivery of endocytosed cargo to lysosomes

  2015cites this paper
• Toxoplasma gondii Vps11, a subunit of HOPS and CORVET tethering complexes, is essential for the biogenesis of secretory organelles

  2015cites this paper
• Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity*

  2015cites this paper
• The Vps39-like TRAP1 is an effector of Rab5 and likely the missing Vps3 subunit of human CORVET

  2014cites this paper
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  2014cites this paper
• Dynamic association of the PI 3 P-interacting Mon 1-Ccz 1 GEF with vacuoles is controlled through its phosphorylation by the type 1 casein kinase Yck 3

  2014cites this paper
• Are All Multisubunit Tethering Complexes Bona Fide Tethers?

  2014cites this paper
• Tracking of the dynamic localization of the Rab-specific HOPS subunits reveal their distinct interaction with Ypt7 and vacuoles

  2014cites this paper
• Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1

  2014cites this paper
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  2014cites this paper
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  2014influential citation
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  2014cites this paper
• Endolysosomal Membrane Trafficking Complexes Drive Nutrient-Dependent TORC1 Signaling to Control Cell Growth in Saccharomyces cerevisiae

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014influential citation
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  2014cites this paper
• Cellular metabolism regulates contact sites between vacuoles and mitochondria.

  2014cites this paper
• Mammalian CORVET Is Required for Fusion and Conversion of Distinct Early Endosome Subpopulations

  2014cites this paper
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  2014cites this paper
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  2014cites this paper