Integrin Structure and Function in Hemostasis and Thrombosis

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Annals of the New York Academy of Sciences

• Publication date

  1991-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1749-6632.1991.tb43704.xPMID 2024885
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann's thrombasthenia.

  1990cited by this paper
• Modulation of vitronectin receptor binding by membrane lipid composition.

  1990cited by this paper
• The genomic organization of platelet glycoprotein IIIa.

  1990cited by this paper
• The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

  1990cited by this paper
• Organization of the gene for platelet glycoprotein IIb.

  1990cited by this paper
• Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits.

  1990cited by this paper
• Glycoprotein Ib and glycoprotein IX in human platelets are acylated with palmitic acid through thioester linkages.

  1989cited by this paper
• The primary structure of the alpha 4 subunit of VLA‐4: homology to other integrins and a possible cell‐cell adhesion function.

  1989cited by this paper
• The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain

  1989cited by this paper
• A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

  1989cited by this paper
• Human platelet glycoprotein Ia. One component is only expressed on the surface of activated platelets and may be a granule constituent.

  1989cited by this paper
• An alternative cytoplasmic domain of the integrin beta 3 subunit.

  1989cited by this paper
• Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.

  1989cited by this paper
• Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily

  1989cited by this paper
• Structural and functional characterization of major platelet membrane components derived by limited proteolysis of glycoprotein IIIa.

  1989cited by this paper
• Evidence that platelet glycoprotein IIIa has a large disulfide-bonded loop that is susceptible to proteolytic cleavage.

  1989cited by this paper
• A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells.

  1989cited by this paper
• Expression of recombinant platelet glycoprotein IIbIIIa results in a functional fibrinogen-binding complex.

  1989cited by this paper
• The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++- dependent adhesion of platelets to collagen

  1989cited by this paper
• Analysis of the role of glycosylation of the human fibronectin receptor.

  1989cited by this paper
• An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin.

  1989cited by this paper
• Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily.

  1989cited by this paper
• Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells.

  1989cited by this paper
• Isolation and characterization of a platelet membrane protein related to the vitronectin receptor.

  1989cited by this paper
• Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines.

  1989cited by this paper
• Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor

  1989cited by this paper
• Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins.

  1989cited by this paper
• An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments]

  1989cited by this paper
• The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.

  1989cited by this paper
• Complete localization of the intrachain disulphide bonds and the N-glycosylation points in the alpha-subunit of human platelet glycoprotein IIb.

  1989cited by this paper
• Leukocyte adhesion deficiency. Aberrant splicing of a conserved integrin sequence causes a moderate deficiency phenotype.

  1989cited by this paper
• Effects of modifications of the RGD sequence and its context on recognition by the fibronectin receptor.

  1989cited by this paper
• Processing and assembly of the integrin, glycoprotein IIb-IIIa, in HEL cells.

  1989cited by this paper
• Efficient surface expression of platelet GPIIb-IIIa requires both subunits.

  1989cited by this paper
• A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells

  1989cited by this paper
• Palmitylation of the glycoprotein IIb-IIIa complex in human blood platelets.

  1989cited by this paper
• Phorbol ester induces increased expression, altered glycosylation, and reduced adhesion of K562 erythroleukemia cell fibronectin receptors.

  1989cited by this paper
• Site-directed mutagenesis of the cell-binding domain of human fibronectin: separable, synergistic sites mediate adhesive function.

  1988cited by this paper
• Isolation of the human platelet glycoprotein IIb gene and characterization of the 5' flanking region.

  1988cited by this paper
• Laminin receptor on platelets is the integrin VLA-6

  1988cited by this paper
• Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures.

  1988cited by this paper
• Platelet glycoproteins Ia, Ic, and IIa are physicochemically indistinguishable from the very late activation antigens adhesion-related proteins of lymphocytes and other cell types.

  1988cited by this paper
• Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor.

  1988cited by this paper
• Membrane glycoprotein abnormalities in pathological platelets.

  1988cited by this paper
• Regulation of the fibronectin receptor affinity by divalent cations.

  1988cited by this paper
• Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa.

  1988cited by this paper
• Platelet glycoproteins IIb and IIIa as a calcium channel in liposomes.

  1988cited by this paper
• The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.

  1988cited by this paper
• Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi

  1988cited by this paper
• Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex.

  1988cited by this paper
• Xenopus laevis integrins. Structural conservation and evolutionary divergence of integrin beta subunits.

  1988cited by this paper
• Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets

  1988cited by this paper
• Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors.

  1988cited by this paper
• The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.

  1988cited by this paper
• Physical linkage of the genes for platelet membrane glycoproteins IIb and IIIa.

  1988cited by this paper
• Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.

  1988cited by this paper
• Alternative proteolytic processing of platelet membrane glycoprotein IIb.

  1988cited by this paper
• Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17.

  1988cited by this paper
• Exposure of binding sites for vitronectin on platelets following stimulation.

  1988cited by this paper
• Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets.

  1987cited by this paper
• Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

  1987cited by this paper
• Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins.

  1987cited by this paper
• Localization of surface vWF on resting and stimulated platelets.

  1987cited by this paper
• von Willebrand factor is present on the surface of platelets stimulated in plasma by ADP.

  1987cited by this paper
• Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion.

  1987cited by this paper
• Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.

  1987cited by this paper
• Amino acid sequence of the human fibronectin receptor

  1987cited by this paper
• An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2

  1987cited by this paper
• Increased surface expression of the membrane glycoprotein IIb/IIIa complex induced by platelet activation. Relationship to the binding of fibrinogen and platelet aggregation.

  1987cited by this paper
• The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

  1987cited by this paper
• On the association of the platelet-specific alloantigen, Pena, with glycoprotein IIIa. Evidence for heterogeneity of glycoprotein IIIa.

  1987cited by this paper
• Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to "integrin".

  1987cited by this paper
• Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb.

  1987cited by this paper
• A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody.

  1987cited by this paper
• Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1).

  1987cited by this paper
• The primary structure of the beta‐subunit of the cell surface adhesion glycoproteins LFA‐1, CR3 and p150,95 and its relationship to the fibronectin receptor.

  1987cited by this paper
• Integrins: a family of cell surface receptors.

  1987cited by this paper
• Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

  1987cited by this paper
• The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments.

  1987cited by this paper
• The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.

  1987cited by this paper
• Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified platelet glycoprotein IIb-IIIa.

  1987cited by this paper
• Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family.

  1987cited by this paper
• Platelet glycoprotein IIb. Chromosomal localization and tissue expression.

  1987cited by this paper
• Competition for related but nonidentical binding sites on the glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins.

  1987cited by this paper
• Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen.

  1986cited by this paper
• Resting platelets contain a substantial centrally located pool of glycoprotein IIb-IIIa complex which may be accessible to some but not other extracellular proteins.

  1986cited by this paper
• Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules.

  1986cited by this paper
• Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin.

  1986cited by this paper
• Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins

  1986cited by this paper
• Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells.

  1986cited by this paper
• Isolation and biochemical characterization of the alpha- and beta-subunits of glycoprotein IIb of human platelet plasma membrane.

  1986cited by this paper
• Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinases.

  1986cited by this paper
• Interaction of thrombospondin with resting and stimulated human platelets.

  1986cited by this paper
• von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia.

  1986cited by this paper
• The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

  1985cited by this paper
• Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion.

  1985cited by this paper
• Role of factor VIII-von Willebrand factor and fibronectin in the interaction of platelets in flowing blood with monomeric and fibrillar human collagen types I and III.

  1985cited by this paper
• Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets.

  1985cited by this paper
• Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia

  1985cited by this paper
• The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.

  1985cited by this paper

• Novel aspects of glutamine synthetase in ammonia homeostasis.

  2020cites this paper
• Cells for Tissue Engineering

  2014cites this paper
• Key references: Antiplatelet therapy as an adjunct to thrombolysis and coronary angioplasty

  2005cites this paper
• Coagulation Factor Deficiencies and Pregnancy Loss

  2003cites this paper
• Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis

  2001cites this paper
• Mechanism of blood coagulation. Newer aspects of anticoagulant and antithrombotic therapy

  2000cites this paper
• Glykoproteinrezeptoren der Thrombozytenmembran: Biochemie, Molekularbiologie und Physiologie

  1999cites this paper
• Identification of low molecular weight GP IIb/IIIa antagonists that bind preferentially to activated platelets.

  1998cites this paper
• Adhesion molecules in clinical medicine.

  1998cites this paper
• Alterations in platelet function in patients receiving interleukin-6 as cytokine therapy.

  1996cites this paper
• Platelet-streptococcal interactions in endocarditis.

  1996cites this paper
• Pharmacologic Studies on Synthetic Analogues of Heparin with Selective Affinity to Endogenous Serine Protease Inhibitors

  1996cites this paper
• Enhancing safety and outcomes with the newer antithrombotic and antiplatelet agents.

  1995cites this paper
• Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.

  1995cites this paper
• Platelet receptors for the Streptococcus sanguis adhesin and aggregation-associated antigens are distinguished by anti-idiotypical monoclonal antibodies

  1995cites this paper
• Clues for Understanding the Structure and Function of a Prototypic Human Integrin: The Platelet Glycoprotein IIb/IIIa Complex

  1994cites this paper
• Antibodies to GPIIbα (300-312) Inhibit Fg Binding, Clot Retraction, and Platelet Adhesion to Multiple Ligands

  1994cites this paper
• Chimeric 7E3 Prevents Carotid Artery Thrombosis in Cynomolgus Monkeys

  1994cites this paper
• Antithrombotic agents from salivary glands of hematophagous animals.

  1992cites this paper
• Antithrombotic Effects of a Platelet Fibrinogen Receptor Antagonist in a Canine Model of Carotid Artery Thrombosis

  1992influential citation