The Role of Thymus-Expressed Chemokine and Its Receptor CCR9 on Lymphocytes in the Regional Specialization of the Mucosal Immune System1

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Immunology

• Publication date

  2000-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.165.9.5069PMID 11046037
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• CCR9A and CCR9B: Two Receptors for the Chemokine CCL25/TECK/Ckβ-15 That Differ in Their Sensitivities to Ligand

  2000cited by this paper
• Chemokines: a new classification system and their role in immunity.

  2000cited by this paper
• Inflammatory skin diseases, T cells, and immune surveillance.

  1999cited by this paper
• Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

  1999cited by this paper
• The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

  1999cited by this paper
• Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

  1999cited by this paper
• Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

  1999cited by this paper
• CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.

  1999cited by this paper
• CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.

  1999cited by this paper
• Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine–Mediated Chemotaxis

  1999influential reference
• TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor.

  1999cited by this paper
• CTACK, A Skin-Associated Chemokine That Preferentially Attracts Skin-Homing Memory T Cells.

  1999cited by this paper
• Selective expression of liver and activation‐regulated chemokine (LARC) in intestinal epithelium in mice and humans

  1999cited by this paper
• Macrophage Inflammatory Protein 3α Is Involved in the Constitutive Trafficking of Epidermal Langerhans Cells

  1999cited by this paper
• In Vivo–Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines

  1999cited by this paper
• Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

  1999cited by this paper
• BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma.

  1999cited by this paper
• Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK.

  1999cited by this paper
• Lymphocyte trafficking and regional immunity.

  1999cited by this paper
• Factors regulating stem cell recruitment to the fetal thymus.

  1999influential reference
• Cutting edge: developmental switches in chemokine responses during T cell maturation.

  1999cited by this paper
• The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo.

  1999cited by this paper
• The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow.

  1999cited by this paper
• The chemokine system: redundancy for robust outputs.

  1999cited by this paper
• CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3α

  1999cited by this paper
• CCR5 is characteristic of Th1 lymphocytes

  1998cited by this paper
• Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

  1998cited by this paper
• Chemokines--chemotactic cytokines that mediate inflammation.

  1998influential reference
• Chemokines and the arrest of lymphocytes rolling under flow conditions.

  1998cited by this paper
• Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

  1998cited by this paper
• Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses.

  1998cited by this paper
• T helper 1 and T helper 2 cells respond differentially to chemokines.

  1998cited by this paper
• The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7

  1998cited by this paper
• Chemokines and leukocyte traffic

  1998cited by this paper
• Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells.

  1997cited by this paper
• Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells.

  1997cited by this paper
• Expression of mucosal homing receptor alpha4beta7 by circulating CD4+ cells with memory for intestinal rotavirus.

  1997cited by this paper
• TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development.

  1997influential reference
• Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

  1996cited by this paper
• A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen.

  1996cited by this paper
• Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue.

  1996cited by this paper
• Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.

  1995cited by this paper
• Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa.

  1995cited by this paper
• α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

  1993cited by this paper
• Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.

  1993cited by this paper

• Hyperbaric oxygen protects against periodontal bone loss by modulating inflammation and bone remodeling via RANKL/OPG expression in ligature-induced periodontitis

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• Role of mucosal chemokines in the development of tissue-resident CD4+ and CD8+ TRM cells to fend off herpes simplex infections.

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• Analysis of CCR9, CXCR5 and ICOS in Circulating Follicular Helper T Cell-like Populations in Sjögren's Disease.

  2026cites this paper
• Cimifugin relieves the relapse of allergic asthma via inhibiting ILC2 migration by targeting CCR9.

  2026cites this paper
• CCL25 targeting by de novo protein binders differentially suppress CCR9 and ACKR4 activation and transform CCL25 into a biased agonist

  2026cites this paper
• GPCR kinase 3 phosphorylates atypical chemokine receptor 4 independent of G proteins

  2026cites this paper
• Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis

  2025cites this paper
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• Gut–Liver Axis, Microbiota, Bile Acids, and Immune Response in Pathogenesis of Primary Sclerosing Cholangitis: An Overview

  2025cites this paper
• Chemokine receptors in GtoPdb v.2025.3

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• A specific microbial consortium enhances Th1 immunity, improves LCMV viral clearance but aggravates LCMV disease pathology in mice

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• Multiple-testing corrections in selection scans using identity-by-descent segments.

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• Signal termination of the chemokine receptor CCR9 is governed by an arrestin-independent phosphorylation mechanism.

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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2021cites this paper
• COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types

  2021cites this paper
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• New intratumoral immunotherapeutic approaches to inhibit the tumor growth and metastasis in breast cancer

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• Recent advances in roles of G-protein coupled receptors in intestinal intraepithelial lymphocytes

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Chemokine receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Recent advances upper gastrointestinal lymphomas: molecular updates and diagnostic implications

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis

  2019cites this paper
• Return to sender: Lymphocyte trafficking mechanisms as contributors to primary sclerosing cholangitis.

  2019cites this paper
• Transcriptomic analysis of Nibea albiflora skin in response to infection by Cryptocaryon irritans.

  2019cites this paper
• Discovery of small-molecule candidates against inflammatory bowel disease.

  2019cites this paper
• Molecular characterization and expression analysis of the CCR9 gene from cobia (Rachycentron canadum) following bacterial and poly I:C challenge

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• Preferential Small Intestine Homing and Persistence of CD8 T Cells in Rhesus Macaques Achieved by Molecularly Engineered Expression of CCR9 and Reduced Ex Vivo Manipulation

  2019cites this paper
• Chemokine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Immune Cell Trafficking to the Liver.

  2019cites this paper
• Emerging roles for chemokines and cytokines as orchestrators of immunopathology in Sjögren's syndrome.

  2019cites this paper
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  2019cites this paper
• Function and dysfunction of plasma cells in intestine

  2019cites this paper
• Adaptationen von T Helferlymphozyten an chronische Entzündungen

  2018cites this paper
• Efecto del ácido retinoico sobre la expresión del receptor CCR9 y la integrina alfa 4 beta 7 en leucocitos sanguíneos de alpacas(Vicugna pacos)

  2018cites this paper
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  2018cites this paper
• Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.

  2018cites this paper
• Chemokines and Chemokine Receptors as Therapeutic Targets in Inflammatory Bowel Disease; Pitfalls and Promise

  2018cites this paper
• CCL25 chemokine-guided stem cell attraction: an assessment of possible benefits and risks.

  2018cites this paper
• T Cells That Help B Cells in Chronically Inflamed Tissues

  2018cites this paper
• Chemokines and receptors in intestinal B lymphocytes

  2018cites this paper
• Role of chemokine receptors and intestinal epithelial cells in the mucosal inflammation and tolerance

  2017cites this paper
• Elevated CCL25 and CCR9-Expressing T Helper Cells in Salivary Glands of Primary Sjögren's Syndrome Patients: Potential New Axis in Lymphoid Neogenesis

  2017influential citation
• Mucosal Chemokines

  2017cites this paper
• Acute Simian Immunodeficiency Virus Infection Triggers Early and Transient Interleukin-7 Production in the Gut, Leading to Enhanced Local Chemokine Expression and Intestinal Immune Cell Homing

  2017cites this paper
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  2017cites this paper
• Marker-free T cell phenotyping - towards a label-free diagnostic and prognostic platform

  2017cites this paper
• Chemokine receptors in allergic diseases

  2017cites this paper
• Altered homeostatic regulation of innate and adaptive immunity in lower gastrointestinal tract GVHD pathogenesis

  2017cites this paper
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  2017cites this paper
• Differential expression of GPR15 on T cells during ulcerative colitis.

  2017cites this paper
• Cytokines in the management of rotavirus infection: A systematic review of in vivo studies

  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Leukocyte Trafficking to the Small Intestine and Colon.

  2016cites this paper
• Randomised, Double-blind, Placebo-controlled Trial of CCR9-targeted Leukapheresis Treatment of Ulcerative Colitis Patients.

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  2016cites this paper
• The role of intestinal mononuclear phagocytes in control of mucosal T cell homeostasis

  2016cites this paper