Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Biochemistry

• Publication date

  1999-04-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1021/BI982900MPMID 10194355
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP–32 and spinophilin

  1999cited by this paper
• Characterization of the Inhibition of Protein Phosphatase-1 by DARPP-32 and Inhibitor-2*

  1999cited by this paper
• Isolation and Characterization of PNUTS, a Putative Protein Phosphatase 1 Nuclear Targeting Subunit*

  1998cited by this paper
• Neurabin-II/Spinophilin

  1998cited by this paper
• Inhibitor-1 Interaction Domain That Mediates the Inhibition of Protein Phosphatase-1*

  1998cited by this paper
• Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.

  1998cited by this paper
• Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins.

  1997cited by this paper
• Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

  1997cited by this paper
• Interactions of the Subunits of Smooth Muscle Myosin Phosphatase*

  1997cited by this paper
• Neurabin: A Novel Neural Tissue–specific Actin Filament–binding Protein Involved in Neurite Formation

  1997cited by this paper
• Properties and Phosphorylation Sites of Baculovirus-expressed Nuclear Inhibitor of Protein Phosphatase-1 (NIPP-1)*

  1997cited by this paper
• The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N-methyl-D-aspartate responses.

  1997cited by this paper
• NIPP-1, a Nuclear Inhibitory Subunit of Protein Phosphatase-1, Has RNA-binding Properties*

  1997cited by this paper
• Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines.

  1997cited by this paper
• Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family.

  1996cited by this paper
• Identification of protein-phosphatase-1-binding domains on the glycogen and myofibrillar targetting subunits.

  1996cited by this paper
• Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle.

  1996cited by this paper
• Cell signalling: MAGUK magic.

  1996cited by this paper
• Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.

  1996cited by this paper
• Purification of the hepatic glycogen‐associated form of protein phosphatase‐1 by microcystin‐Sepharose affinity chromatography

  1995cited by this paper
• Amino acid sequence and expression of the hepatic glycogen‐binding (GL‐subunit of protein phosphatase‐1

  1995cited by this paper
• The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines.

  1995cited by this paper
• Differential expression of protein phosphatase 1 isoforms in mammalian brain

  1995cited by this paper
• Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons.

  1995cited by this paper
• Protein Phosphatase‐1 Regulates Outward K+ Currents in Sensory Neurons of Aplysia californica

  1995cited by this paper
• Molecular Cloning of NIPP-1, a Nuclear Inhibitor of Protein Phosphatase-1, Reveals Homology with Polypeptides Involved in RNA Processing (*)

  1995cited by this paper
• Mechanism of inhibition of protein phosphatase 1 by DARPP-32: studies with recombinant DARPP-32 and synthetic peptides.

  1995cited by this paper
• Serine/threonine protein phosphatases.

  1995cited by this paper
• Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

  1994cited by this paper
• Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M

  1994cited by this paper
• Protein serine/threonine phosphatases--new avenues for cell regulation.

  1994cited by this paper
• Purification of type 1 protein (serine/threonine) phosphatases by microcystin‐Sepharose affinity chromatography

  1994cited by this paper
• Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle.

  1994cited by this paper
• Postsynaptic integration of glutamatergic and dopaminergic signals in the striatum.

  1994cited by this paper
• A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants.

  1993cited by this paper
• On target with a new mechanism for the regulation of protein phosphorylation.

  1993cited by this paper
• The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.

  1992cited by this paper
• Predicting coiled coils from protein sequences

  1991cited by this paper
• Molecular cloning and expression of the regulatory (RG1) subunit of the glycogen-associated protein phosphatase.

  1991cited by this paper
• Synthetic peptide analogs of DARPP-32 (Mr 32,000 dopamine- and cAMP-regulated phosphoprotein), an inhibitor of protein phosphatase-1. Phosphorylation, dephosphorylation, and inhibitory activity.

  1990cited by this paper
• Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle.

  1988cited by this paper

• Spinophilin‐dependent regulation of GluN2B‐containing NMDAR‐dependent calcium influx, GluN2B surface expression, and cleaved caspase expression

  2023cites this paper
• Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease

  2023cites this paper
• SPINOPHILIN: A multiplayer tumor suppressor.

  2022cites this paper
• Modulation of dendritic spines by protein phosphatase-1.

  2021cites this paper
• Brain region- and metal-specific effects of embedded metals in a shrapnel wound model in the rat.

  2021cites this paper
• Spinophilin limits GluN2B-containing NMDAR activity and sequelae associated with excessive hippocampal NMDAR function

  2021cites this paper
• Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits.

  2020cites this paper
• cAMP regulation of protein phosphatases PP1 and PP2A in brain.

  2019cites this paper
• SDS22 selectively recognizes and traps metal-deficient inactive PP1

  2019cites this paper
• A multi-state model of the CaMKII dodecamer suggests a role for calmodulin in maintenance of autophosphorylation

  2019cites this paper
• Neuronal scaffolding protein spinophilin is integral for cocaine-induced behavioral sensitization and ERK1/2 activation

  2019cites this paper
• Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization

  2018cites this paper
• Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin.

  2018cites this paper
• Proteomic differences in brain vessels of Alzheimer’s disease mice: Normalization by PPARγ agonist pioglitazone

  2017cites this paper
• KCTD12 and ULK2 partner to regulate habenular dendritogenesis and behavior / spinophilin regulates dendritic spine formation and F-actin dynamics in hippocampal neurons

  2016influential citation
• BRI2 and BRI3 are functionally distinct phosphoproteins.

  2016cites this paper
• Role of Spinophilin in Group I Metabotropic Glutamate Receptor Endocytosis, Signaling, and Synaptic Plasticity*

  2016cites this paper
• Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors

  2016cites this paper
• Spinophilin-Targeted Protein Phosphatase-1 Alleviated Inflammatory Pain by Negative Control of MEK/ERK Signaling in Spinal Cord Dorsal Horn of Rats

  2015cites this paper
• Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases

  2015cites this paper
• Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1

  2015cites this paper
• Dissociation of SHP-1 from Spinophilin during Platelet Activation Exposes an Inhibitory Binding Site for Protein Phosphatase-1 (PP1)

  2015cites this paper
• Profiling the Lipid Raft Proteome from Human MEC1 Chronic Lymphocytic Leukemia Cells

  2014cites this paper
• Protein phosphatase 1 catalytic isoforms: specificity toward interacting proteins.

  2014cites this paper
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• Proteomic characterisation of chronic lymphocytic leukaemia cells treated with rituximab

  2014cites this paper
• Integrated workflow for quantitative phosphoproteomic analysis of the selected brain structures in development of morphine dependence

  2014cites this paper
• 131001 pS RGS18 clean-revised

  2014cites this paper
• Spinophilin Loss Correlates with Poor Patient Prognosis in Advanced Stages of Colon Carcinoma

  2013cites this paper
• Low expression of the putative tumour suppressor spinophilin is associated with higher proliferative activity and poor prognosis in patients with hepatocellular carcinoma

  2013cites this paper
• Aging-Induced Proteostatic Changes in the Rat Hippocampus Identify ARP3, NEB2 and BRAG2 as a Molecular Circuitry for Cognitive Impairment

  2013cites this paper
• Myosin 16 levels fluctuate during the cell cycle and are downregulated in response to DNA replication stress

  2013cites this paper
• Cyclic Nucleotide Dependent Dephosphorylation of Regulator of G-Protein Signaling 18 in Human Platelets

  2013cites this paper
• Structural basis for protein phosphatase 1 regulation and specificity

  2013cites this paper
• Differential association of postsynaptic signaling protein complexes in striatum and hippocampus

  2013cites this paper
• Regulation of the actin cytoskeleton in dendritic spines.

  2012cites this paper
• Protein Phosphatase 1γ Isoforms Linked Interactions in the Brain

  2012cites this paper
• Selective interactions of spinophilin with the C-terminal domains of the δ- and μ-opioid receptors and G proteins differentially modulate opioid receptor signaling.

  2012cites this paper
• PPP1R9B (protein phosphatase 1, regulatory subunit 9B)

  2012cites this paper
• Age-Dependent Targeting of Protein Phosphatase 1 to Ca2+/Calmodulin-Dependent Protein Kinase II by Spinophilin in Mouse Striatum

  2012cites this paper
• Rôle de la protéine phosphatase 1 dans les mécanismes d’action de la cocaïne et implication des modifications épigénétiques dans sa régulation

  2012cites this paper
• Spinophilin: a new tumor suppressor at 17q21.

  2012cites this paper
• Development of an in vitro assay system for protein phosphatase inhibitor-1 antagonists

  2012cites this paper
• Spinophilin loss contributes to tumorigenesis in vivo

  2011cites this paper
• Dysregulated phosphorylation of Ca2+/calmodulin‐dependent protein kinase II‐α in the hippocampus of subjects with mild cognitive impairment and Alzheimer’s disease

  2011cites this paper
• Flexibility in the PP1:spinophilin holoenzyme

  2011cites this paper
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• Identification of AKAP79 as a protein phosphatase 1 catalytic binding protein.

  2011cites this paper
• Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation

  2011influential citation
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  2010cites this paper
• Differential expression of equine muscle biopsy proteins during normal training and intensified training in young standardbred horses using proteomics technology.

  2010cites this paper
• Dendritic Protein Phosphatase Complexes

  2010cites this paper
• Spinophilin directs Protein Phosphatase 1 specificity by blocking substrate binding sites

  2010cites this paper
• Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators.

  2010cites this paper
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  2010cites this paper
• Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines.

  2009cites this paper
• Caracterización de la función de Espinofilina y de su capacidad de actuar como supresor tumoral in vivo

  2009influential citation
• Structure–function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin

  2008cites this paper
• Postsynaptic targeting of protein kinases and phosphatases

  2008cites this paper
• Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease*S

  2008cites this paper
• Multiple actions of spinophilin regulate mu opioid receptor function.

  2008cites this paper
• DARPP-32 Expression in Rat Brain After an Inhibitory Avoidance Task

  2008cites this paper
• Selective targeting of the 1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin

  2008cites this paper
• The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines

  2007cites this paper
• Neurabin II mediates doublecortin-dephosphorylation on actin filaments.

  2006cites this paper
• Site-specific dephosphorylation of doublecortin (DCX) by protein phosphatase 1 (PP1).

  2006cites this paper
• Repo-Man recruits PP1γ to chromatin and is essential for cell viability

  2006cites this paper
• Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory.

  2006cites this paper
• Spinophilin: from partners to functions.

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• Characterization of the protein phosphatase 1-binding motifs of inhibitor-2 and DARPP-32 by surface plasmon resonance.

  2005cites this paper
• GPS: a comprehensive www server for phosphorylation sites prediction

  2005cites this paper
• Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).

  2005cites this paper
• Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation.

  2005cites this paper
• Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP‐32‐dependent and independent pathways

  2005cites this paper
• The Stability of a Stochastic CaMKII Switch: Dependence on the Number of Enzyme Molecules and Protein Turnover

  2005cites this paper
• The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology.

  2005cites this paper
• Molecular mechanisms of dendritic spine development and remodeling.

  2005cites this paper
• Balancing Hepatic Glucose Disposal and Production

  2004cites this paper
• Subcellular distribution of neurabin immunolabeling in primate prefrontal cortex: comparison with spinophilin.

  2004cites this paper
• Protein Phosphatases and Calcium/Calmodulin-Dependent Protein Kinase II-Dependent Synaptic Plasticity

  2004cites this paper
• The role of protein phosphatase‐1 in the modulation of synaptic and structural plasticity

  2004cites this paper
• Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex: Localization to and within dendritic spines

  2004cites this paper
• Spinophilin is phosphorylated by Ca2+/calmodulin‐dependent protein kinase II resulting in regulation of its binding to F‐actin

  2004cites this paper
• DARPP-32: an integrator of neurotransmission.

  2004cites this paper
• Functional plasticity in the organization of signaling complexes in the striatum.

  2004cites this paper
• Functional proteomics in phosphatase research

  2004cites this paper
• Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments*

  2003cites this paper
• Degeneracy and Function of the Ubiquitous RVXF Motif That Mediates Binding to Protein Phosphatase-1*

  2003cites this paper
• CHAPTER 188 – Dendritic Protein Phosphatase Complexes

  2003cites this paper
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  2003cites this paper
• Preparation and characterization of recombinant protein phosphatase 1.

  2003cites this paper
• PNUTS, a Protein Phosphatase 1 (PP1) Nuclear Targeting Subunit

  2003cites this paper
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  2003cites this paper
• A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence.

  2003cites this paper
• Ion Pump‐Interacting Proteins: Promising New Partners

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• Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortex.

  2003cites this paper
• Distribution of mGluR1α and mGluR5 immunolabeling in primate prefrontal cortex

  2003cites this paper
• Jcb: Article Introduction

  2002cites this paper
• Regulated Interactions of the α2A Adrenergic Receptor with Spinophilin, 14-3-3ζ, and Arrestin 3*

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• KEPI, a PKC-dependent Protein Phosphatase 1 Inhibitor Regulated by Morphine*

  2002cites this paper