Current status of the structural and functional basis of glomerular filtration and proteinuria.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Seminars in Nephrology

• Publication date

  1991-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.5555/URI:PII:027092959190061NPMID 1947494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Macrophages and cellular immunity in experimental glomerulonephritis

  2005cited by this paper
• Transforming growth factor-beta regulates production of proteoglycans by mesangial cells.

  1990cited by this paper
• Distribution of familial nephritis antigen in normal tissue and renal basement membranes of patients with homozygous and heterozygous Alport familial nephritis. Relationship of familial nephritis and Goodpasture antigens to novel collagen chains and type IV collagen.

  1989cited by this paper
• Thin-basement-membrane nephropathy in adults with persistent hematuria.

  1989cited by this paper
• Role of reactive oxygen metabolites in experimental glomerular disease

  1989cited by this paper
• Role of reactive oxygen metabolites in experimental glomerular disease.

  1989cited by this paper
• Involvement of IL-6 in mesangial proliferative glomerulonephritis.

  1989cited by this paper
• Transmission of infectious agents by inadequately sterilized ENT instruments.

  1989cited by this paper
• HIV receptors (CD4 antigen) in normal human glomerular cells.

  1989cited by this paper
• Goodpasture syndrome: molecular architecture and function of basement membrane antigen.

  1989cited by this paper
• A beta 1-integrin receptor for fibronectin in human kidney glomeruli.

  1989cited by this paper
• Common acute lymphoblastic leukemia antigen expressed on leukemia and melanoma cell lines has neutral endopeptidase activity.

  1989cited by this paper
• Transforming growth factor-beta. Murine glomerular receptors and responses of isolated glomerular cells.

  1989cited by this paper
• Role of proteoglycans in renal development.

  1988cited by this paper
• Studies on binding and mitogenic effect of insulin and insulin-like growth factor I in glomerular mesangial cells.

  1988cited by this paper
• Degradation of glomerular basement membrane by purified mammalian metalloproteinases.

  1988cited by this paper
• Activation of human neutrophil gelatinase by endogenous serine proteinases.

  1988cited by this paper
• Hydroxyl radical scavengers ameliorate proteinuria in rat immune complex glomerulonephritis.

  1988cited by this paper
• Nephritogenicity of proteoglycans. II. A model of immune complex nephritis.

  1988cited by this paper
• Morphologic correlates of glomerular oxidant injury induced by the myeloperoxidase-hydrogen peroxide-halide system of the neutrophil.

  1988cited by this paper
• Evidence suggesting a role for hydroxyl radical in puromycin aminonucleoside-induced proteinuria.

  1988cited by this paper
• Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody.

  1988cited by this paper
• Identification of cDNA clones encoding different domains of the basement membrane heparan sulfate proteoglycan.

  1988cited by this paper
• Glomerular size and charge selectivity in insulin-dependent diabetes mellitus.

  1988cited by this paper
• New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.

  1987cited by this paper
• The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of alpha 1-antiproteinase against inactivation by hypochlorous acid.

  1987cited by this paper
• Immune complex effects on glomerular eicosanoid production and renal hemodynamics.

  1987cited by this paper
• Oxygen radicals and human disease.

  1987cited by this paper
• Degradation of human glomerular basement membrane by stimulated neutrophils. Activation of a metalloproteinase(s) by reactive oxygen metabolites.

  1987cited by this paper
• Status of glomerular proteoglycans in aminonucleoside nephrosis.

  1987cited by this paper
• Participation of the myeloperoxidase-H2O2-halide system in immune complex nephritis.

  1987cited by this paper
• New perspectives in cell adhesion: RGD and integrins.

  1987cited by this paper
• Immune complexes bind to cultured rat glomerular mesangial cells to stimulate superoxide release. Evidence for an Fc receptor.

  1987cited by this paper
• Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol.

  1986cited by this paper
• Nephritogenicity of antibodies to proteoglycans of the glomerular basement membrane--I.

  1986cited by this paper
• Arg-Gly-Asp: a versatile cell recognition signal.

  1986cited by this paper
• A role for oxygen free radicals in aminonucleoside nephrosis.

  1986cited by this paper
• Fragmentation of proteins by free radicals and its effect on their susceptibility to enzymic hydrolysis.

  1986cited by this paper
• Complement membrane attack complex stimulates production of reactive oxygen metabolites by cultured rat mesangial cells.

  1986cited by this paper
• Immunoelectron microscopic demonstration of Thy-1 antigen on the surfaces of mesangial cells in the rat glomerulus.

  1986cited by this paper
• The effect of oxidants on neutrophil-mediated degradation of glomerular basement membrane collagen.

  1986cited by this paper
• Mechanisms and consequences of proteinuria.

  1986cited by this paper
• Prostaglandins and other arachidonic acid metabolites in the kidney.

  1986cited by this paper
• Reduced sialylation of podocalyxin--the major sialoprotein of the rat kidney glomerulus--in aminonucleoside nephrosis.

  1985cited by this paper
• Basement membrane heparan sulfate proteoglycans are concentrated in the laminae rarae and in podocytes of the rat renal glomerulus.

  1985cited by this paper
• Contractile properties of cultured glomerular mesangial cells.

  1985cited by this paper
• Heparin and glomerular epithelial cell-secreted heparin-like species inhibit mesangial-cell proliferation.

  1985cited by this paper
• Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis.

  1985cited by this paper
• Role of terminal complement pathway in the heterologous phase of antiglomerular basement membrane nephritis.

  1985cited by this paper
• Podoendin. A new cell surface protein of the podocyte and endothelium

  1985cited by this paper
• Heteroporous model of glomerular size selectivity: application to normal and nephrotic humans.

  1985cited by this paper
• The role of platelets and polycationic mediators in glomerular vascular injury.

  1985cited by this paper
• Glomerular cell culture.

  1985cited by this paper
• Agonist-induced isotonic contraction of cultured mesangial cells after multiple passage.

  1985cited by this paper
• Glomerular cell culture.

  1985cited by this paper
• Self-assembly of basement membrane collagen.

  1984cited by this paper
• Identification and characterization of podocalyxin--the major sialoprotein of the renal glomerular epithelial cell

  1984cited by this paper
• Mechanisms of Immune Complex Formation and Deposition in Glomeruli

  1984cited by this paper
• Binding of platelet factor four (PF 4) to glomerular polyanion.

  1984cited by this paper
• Laminin, proteoglycan, nidogen and collagen IV: structural models and molecular interactions.

  1984cited by this paper
• Size and charge selective permeability defects induced in glomerular basement membrane by a polycation.

  1984cited by this paper
• Effect of beta-D-xyloside on the glomerular proteoglycans. I. Biochemical studies

  1984cited by this paper
• Alterations in proteoglycan metabolism in the nephrotic syndrome induced by the aminonucleoside of puromycin.

  1984cited by this paper
• De novo cellular synthesis of sulfated proteoglycans of the developing renal glomerulus in vivo.

  1984cited by this paper
• Evidence for the role of oxygen radicals in acute nephrotoxic nephritis.

  1984cited by this paper
• Biophysiology of glomerular filtration and proteinuria.

  1984cited by this paper
• Effect of antibody charge and concentration on deposition of antibody to glomerular basement membrane.

  1984cited by this paper
• Characterization of heparan sulfate-proteoglycan of glomerular basement membranes.

  1984cited by this paper
• New avian model of experimental glomerulonephritis consistent with mediation by cellular immunity. Nonhumorally mediated glomerulonephritis in chickens.

  1984cited by this paper
• Distribution of de novo synthesized sulfated glycosaminoglycans in the glomerular basement membrane and mesangial matrix.

  1983cited by this paper
• Loss of heparan sulfate proteoglycan from glomerular basement membrane of nephrotic rats.

  1983cited by this paper
• Heparan sulfate--rich anionic sites in the human glomerular basement membrane. Decreased concentration in congenital nephrotic syndrome.

  1983cited by this paper
• Stimulation of rat mesangial cell proliferation by macrophage interleukin 1.

  1983cited by this paper
• Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats

  1983cited by this paper
• Neutral proteinase activity produced in vitro by cells of the glomerular mesangium.

  1983cited by this paper
• Decreased de novo synthesis of glomerular proteoglycans in diabetes: biochemical and autoradiographic evidence.

  1983cited by this paper
• Regional distribution of N-acetyl-D-galactosamine residues in the glycocalyx of glomerular podocytes

  1983cited by this paper
• Stages of renal ontogenesis identified by monoclonal antibodies reactive with lymphohemopoietic differentiation antigens

  1983cited by this paper
• Macromolecular associations, antigenicity, and variation in disease

  1983cited by this paper
• Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics.

  1983cited by this paper
• Glomerular permeability and polyanion in adriamycin nephrosis in the rat.

  1983cited by this paper
• Laminin in glomerular basement membranes of aminonucleoside nephrotic rats. Increased proteinuria induced by antilaminin immunoglobulin G.

  1983cited by this paper
• Role of the terminal complement pathway in experimental membranous nephropathy in the rabbit.

  1983cited by this paper
• Altered glomerular permeability as a result of focal detachment of the visceral epithelium.

  1982cited by this paper
• Prostaglandin production by homogeneous cultures of rat glomerular epithelial and mesangial cells.

  1982cited by this paper
• Mechanisms of proteinuria in diabetic nephropathy: a study of glomerular barrier function.

  1982cited by this paper
• Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

  1982cited by this paper
• Removal of sulfated (heparan sulfate) or nonsulfated (hyaluronic acid) glycosaminoglycans results in increased permeability of the glomerular basement membrane to 125I-bovine serum albumin.

  1982cited by this paper
• Localization of an Ia-bearing glomerular cell in the mesangium

  1982cited by this paper
• Preservation of mesangium and immunohistochemically defined antigens in glomerular basement membrane isolated by detergent extraction.

  1982cited by this paper
• Clogging of the glomerular basement membrane

  1982cited by this paper
• Ultrastructural localization of type V collagen in rat kidney

  1982cited by this paper
• Altered glomerular permselectivity and progressive sclerosis following extreme ablation of renal mass.

  1982cited by this paper
• 35S-Glycosaminoglycan and 35S-Glycopeptide Metabolism by Diabetic Glomeruli and Aorta

  1982cited by this paper
• Glomerular charge alterations in human minimal change nephropathy.

  1982cited by this paper
• Distribution of intramembrane particles and filipin-sterol complexes in plasma membranes of kidney. I. Corpuscle of Malpighi.

  1982cited by this paper
• Biology of disease: free radicals and tissue injury.

  1982cited by this paper
• Phagocyte-generated oxygen metabolites and cellular injury

  1982cited by this paper
• Alterations in the Basement Membrane (Heparan Sulfate) Proteoglycan in Diabetic Mice

  1982cited by this paper
• Phagocyte-generated oxygen metabolites and cellular injury.

  1982cited by this paper

• Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats.

  2020cites this paper
• BMP regulates both podocyte injury and mesangial expansion in the diabetic nephropathy

  2019cites this paper
• MAGI-2 and scaffold proteins in glomerulopathy.

  2018cites this paper
• Efecto del sulodexide en la permeabilidad vascular renal en ratas diabéticas

  2018cites this paper
• Intravital imaging of adriamycin-induced renal pathology using two-photon microscopy and optical coherence tomography

  2018cites this paper
• Investigating the effects of soy phytoestrogens on Nephrin and Akt podocyte survival signaling pathway

  2017cites this paper
• The Physiology of the Glomerulus

  2017cites this paper
• A REVIEW ON COMPREHENSIVE OVERVIEW IN THE MANAGEMENT OF NEPHROTIC DISORDERS

  2016cites this paper
• Preparation of Inert Polystyrene Latex Particles as MicroRNA Delivery Vectors by Surfactant-Free RAFT Emulsion Polymerization.

  2016cites this paper
• Investigating intracellular SNARE-mediated trafficking of the kidney slit diaphragm protein nephrin

  2016cites this paper
• Hyperlipidemia in Children With Nephrotic Syndrome in Khartoum State

  2015cites this paper
• Minimal change disease and focal segmental glomerulosclerosis in adults: response to steroids and risk of renal failure.

  2015cites this paper
• CHARACTERIZATION OF NOVEL GLOMERULAR PROTEINS: ROLE IN PHYSIOLOGY AND DISEASE

  2014cites this paper
• Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.

  2014cites this paper
• Development of a Novel Polyclonal Antibody-Based Immunoassay for the Quantitation of Non-Albumin Urinary Proteins

  2013cites this paper
• Can vitamin C and E supplementation ameliorate post-exercise protienuria?

  2013cites this paper
• Unchanged Distribution Density of Anionic Sites on the Glomerular Wall in Rats with Active Heymann Nephritis

  2013cites this paper
• Novel insights into the relationship between glomerular pathology and progressive kidney disease.

  2012cites this paper
• Characterization of novel podocyte proteins in the glomerular filtration barrier

  2012cites this paper
• Unchanged Distribution Density of Anionic Sites on the Glomerular Wall in Rats with Streptozotocin-Induced Diabetic Nephropathy

  2012cites this paper
• Caracterización inmunohistoquimica de la función renal en un riñon transplantado en paciente portador de sindrome uremico hemolitico atipico por deficit de factor H

  2011cites this paper
• Relevance of VEGF and Nephrin Expression in Glomerular Diseases

  2011cites this paper
• Identification and characterization of novel glomerulus-associated genes and proteins

  2010cites this paper
• The Emerging Role of Biomarkers in Diabetic and Hypertensive Chronic Kidney Disease

  2010cites this paper
• Cardiovascular , Pulmonary and Renal Pathology Alterations in Fatty Acid Utilization and an Impaired Antioxidant Defense Mechanism Are Early Events in Podocyte Injury A Proteomic Analysis

  2010cites this paper
• Expresión de nefrina, podocina y alfa-actinina-4 en tejido renal de pacientes con proteinuria

  2009cites this paper
• Alterations in fatty acid utilization and an impaired antioxidant defense mechanism are early events in podocyte injury: a proteomic analysis.

  2009cites this paper
• Losartan chemistry and its effects via AT1 mechanisms in the kidney.

  2009cites this paper
• [Expression of nephrin, podocin and a-actinine-4 in renal tissue of patients with proteinuria].

  2009cites this paper
• Tumor targeting using liposomal antineoplastic drugs

  2008cites this paper
• Brothers and sisters: molecular insights into arterial-venous heterogeneity.

  2008cites this paper
• CHAPTER 74 – Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria

  2008cites this paper
• Complications of type 1 diabetes: new molecular findings.

  2008cites this paper
• Recent Progress in the Pathogenesis of Nephrotic Proteinuria

  2008cites this paper
• The molecular basis of childhood nephrotic syndrome.

  2007cites this paper
• Removal of heparan sulfate from the glomerular basement membrane blocks protein passage.

  2007cites this paper
• Novel conditional mouse models for targeted kidney research : Emphasis on the analysis of the biological function of nephrin

  2007cites this paper
• The Use of Vitamin E in Type 2 Diabetes Mellitus

  2007cites this paper
• Expression of glomerular heparan sulphate domains in murine and human lupus nephritis.

  2007cites this paper
• Glomerular endothelial glycocalyx constitutes a barrier to protein permeability.

  2007cites this paper
• Treatment of Experimental Nephrotic Syndrome with Artesunate

  2007cites this paper
• [Proteinuria].

  2006cites this paper
• Erythrocyte Membrane Anionic Content and Urinary Glycosaminoglycan Excretion in Type 1 Diabetes: Association with Retinopathy

  2006cites this paper
• Hereditary proteinuria syndromes and mechanisms of proteinuria.

  2006cites this paper
• Biphasic Pattern of Exercise-Induced Proteinuria in Sedentary and Trained Men

  2006cites this paper
• Renal disease: the anesthesiologist's perspective.

  2006cites this paper
• Clinical impact of research on the podocyte slit diaphragm

  2006cites this paper
• How does the kidney filter plasma?

  2005cites this paper
• Alterations in Glomerular Proteoglycans: Biochemical and Tissue Autoradiographic Aspects1

  2005cites this paper
• Chapter 7.

  2005cites this paper
• New insights into the molecular biology of the glomerular filtration barrier and associated disease

  2005cites this paper
• Excretion and Proteinuria After Renal Transplantation1

  2005cites this paper
• Impact of Cyclosporin on Podocyte ZO-1 Expression in Puromycin Aminonucleoside Nephrosis Rats

  2005cites this paper
• From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy.

  2005cites this paper
• Nephrin : role in the renal ultrafilter and involvement in proteinuria

  2004cites this paper
• Molecular Basis of Proteinuria

  2004cites this paper
• Angiotensin II type 1-receptor mediated changes in heparan sulfate proteoglycans in human SV40 transformed podocytes.

  2004cites this paper
• The Nephrotic Syndrome Series

  2004cites this paper
• M‐2000, as a New Anti‐inflammatory Molecule in Treatment of Experimental Nephrosis

  2004cites this paper
• A new mouse model for renal lesions produced by intravenous injection of diphtheria toxin A-chain expression plasmid

  2004cites this paper
• Early Glomerular Filtration Defect and Severe Renal Disease in Podocin-Deficient Mice

  2004influential citation
• Proximo-distal specialization of epithelial transport processes within the Xenopus pronephric kidney tubules.

  2004cites this paper
• Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.

  2004cites this paper
• NEPHRIN AND ITS ASSOCIATED PROTEIN COMPLEX IN THE KIDNEY AND PANCREAS

  2003cites this paper
• Expressionsanalyse der Integrin Linked Kinase (ILK) bei Schädigung der glomerulären Filtrationsbarriere

  2003cites this paper
• Diseases of the Glomerular Filtration Barrier: Alport Syndrome and Congenital Nephrosis (NPHS1)

  2003cites this paper
• Development of the Glomerular Capillary and Its Basement Membrane

  2003cites this paper
• The effect of reactive oxidant generation in acute exercise-induced proteinuria in trained and untrained rats

  2003cites this paper
• Pattern of renal dysfunction associated with myocardial revascularization surgery and cardiopulmonary bypass

  2003cites this paper
• Nephrin and Neph1 Co-localize at the Podocyte Foot Process Intercellular Junction and Form cis Hetero-oligomers*

  2003cites this paper
• Increased Expression of CD54, CD18, MHC Class II Molecules, and Proliferating Cell Nuclear Antigen in Acute Puromycin Aminonucleoside Nephrosis

  2003cites this paper
• Nephrotic syndrome - recent advances. Proteinuria as a manifestation and a mediator of progressive renal disease

  2003cites this paper
• Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2.

  2003cites this paper
• Synthesis of sulfated proteoglycans by bovine glomerular endothelial cells in culture.

  2003cites this paper
• Proteinuria: how to evaluate an important finding.

  2003cites this paper
• Nephrin expression, localization and role as an interacting molecule : Emphasis on kidney glomerular podocytes

  2003cites this paper
• Pathophysiology of proteinuria.

  2003cites this paper
• Molecular basis of proteinuria.

  2003cites this paper
• Diabetic nephropathy. Aspects of pathophysiology and treatment.

  2003cites this paper
• Regulation of the key molecules of glomerular ultrafiltration in proteinuric models

  2002cites this paper
• Patterns of nephrin and a new proteinuria-associated protein expression in human renal diseases.

  2002cites this paper
• PATHOGENETIC FEATURES OF PROTEINURIA STUDIES ON CONGENITAL NEPHROTIC SYNDROME OF THE FINNISH TYPE

  2002cites this paper
• Podocyte-Associated Molecules in Puromycin Aminonucleoside Nephrosis of the Rat

  2002cites this paper
• The Number of Podocyte Slit Diaphragms Is Decreased in Minimal Change Nephrotic Syndrome

  2002cites this paper
• Genetic kidney diseases disclose the pathogenesis of proteinuria

  2001cites this paper
• Familial nephropathy differing from minimal change nephropathy and focal glomerulosclerosis.

  2001cites this paper
• Molecular basis of glomerular permselectivity

  2001cites this paper
• Sequence of events in the glomerular capillary wall at the onset of proteinuria in passive Heymann nephritis

  2001cites this paper
• Protéinurie

  2001cites this paper
• Expression of nephrin in pediatric kidney diseases.

  2001cites this paper
• Recurrence of Nephrotic Syndrome after Transplantation in CNF Is due to Autoantibodies to Nephrin

  2001cites this paper
• Vascular localization of heparan sulfate proteoglycans in retinas of patients with diabetes mellitus and in VEGF-induced retinopathy using domain-specific antibodies

  2001cites this paper
• Basement membrane and interstitial proteoglycans produced by MDCK cells correspond to those expressed in the kidney cortex.

  2001cites this paper
• NEPHRIN ROLE IN HUMAN GLOMERULOGENESIS AND NEPHROTIC DISORDERS

  2001cites this paper
• Clinical and Experimental Studies on Nephrin

  2001cites this paper
• Decreased Glomerular Expression of Agrin in Diabetic Nephropathy and Podocytes, Cultured in High Glucose Medium

  2001cites this paper
• The effect of aminoguanidine on urinary heparan sulphate levels in experimental diabetes

  2000cites this paper
• Glomerular filtration is required for transfection of proximal tubular cells in the rat kidney following injection of DNA complexes into the renal artery

  2000cites this paper
• Protection of alpha(3) integrin-mediated podocyte shape by superoxide dismutase in the puromycin aminonucleoside nephrosis rat.

  2000cites this paper
• Abnormal expression of glomerular basement membrane laminins in membranous glomerulonephritis.

  2000cites this paper