Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Clinical Investigation

• Publication date

  2005-10-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI25256PMID 16184193PMCID PMC1224299
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats.

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• Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver.

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• Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues Published, JLR Papers in Press, January 1, 2005. DOI 10.1194/jlr.M400261-JLR200

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• Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues.

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• Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver.

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• Modulation of carbohydrate response element-binding protein gene expression in 3T3-L1 adipocytes and rat adipose tissue.

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• Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes*

  2004cited by this paper
• Hepatic Glucokinase Is Required for the Synergistic Action of ChREBP and SREBP-1c on Glycolytic and Lipogenic Gene Expression*

  2004cited by this paper
• Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription.

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• Fatty Acid Regulation of Gene Transcription

  2004cited by this paper
• Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

  2004cited by this paper
• Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.

  2004cited by this paper
• Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle*

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• The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

  2003cited by this paper
• Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver

  2003cited by this paper
• Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c*

  2002cited by this paper
• Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage.

  2002cited by this paper
• Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription

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• Suppression of fatty acid synthase promoter by polyunsaturated fatty acids.

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• The Role of SREBP-1c in Nutritional Regulation of Lipogenic Enzyme Gene Expression*

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• Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay*

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• Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein

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• Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells*

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• A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

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• Regulation of gene expression by dietary fat.

  1999cited by this paper
• Sterol Regulatory Element Binding Protein-1 Expression Is Suppressed by Dietary Polyunsaturated Fatty Acids

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• A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids*

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• ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

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• Sterol Response Element-binding Protein 1c (SREBP1c) Is Involved in the Polyunsaturated Fatty Acid Suppression of Hepatic S14 Gene Transcription*

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• The 5′‐AMP‐activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex

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• Polyunsaturated Fatty Acids Decrease Expression of Promoters with Sterol Regulatory Elements by Decreasing Levels of Mature Sterol Regulatory Element-binding Protein*

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• AMP-activated Protein Kinase Inhibits the Glucose-activated Expression of Fatty Acid Synthase Gene in Rat Hepatocytes*

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• Polyunsaturated fatty acids inhibit the expression of the glucose-6-phosphate dehydrogenase gene in primary rat hepatocytes by a nuclear posttranscriptional mechanism.

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• Effect of different basic helix-loop-helix leucine zipper factors on the glucose response unit of the L-type pyruvate kinase gene.

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• Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations.

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• Transcriptional Glucose Signaling through The Glucose Response Element Is Mediated by the Pentose Phosphate Pathway (*)

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• Posttranscriptional regulation of glucose-6-phosphate dehydrogenase by dietary polyunsaturated fat.

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• Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids.

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• Dietary polyunsaturated fatty acids interfere with the insulin/glucose activation of L-type pyruvate kinase gene transcription.

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• Functional characterization of the L-type pyruvate kinase gene glucose response complex

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  1990cited by this paper
• Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture.

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• Ethanol-glucocorticoid regulation of hepatic glucose-6-phosphate dehydrogenase.

  1985cited by this paper
• Coordinate suppression of liver acetyl-CoA carboxylase and fatty acid synthetase by polyunsaturated fat.

  1981cited by this paper

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