IFN gamma inhibits porcine reproductive and respiratory syndrome virus replication in macrophages.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Archives of Virology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10446652
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lactate Dehydrogenase-Elevating Virus, Equine Arteritis Virus, and Simian Hemorrhagic Fever Virus: A New Group of Positive-Strand RNA Viruses

  2008cited by this paper
• Interferon cures cells lytically and persistently infected with African swine fever virus in vitro

  2005cited by this paper
• Structural polypeptides of the American (VR-2332) strain of porcine reproductive and respiratory syndrome virus

  2005cited by this paper
• Nidovirales: a new order comprising Coronaviridae and Arteriviridae.

  1997cited by this paper
• Porcine reproductive and respiratory syndrome virus replicates in testicular germ cells, alters spermatogenesis, and induces germ cell death by apoptosis

  1997cited by this paper
• Cell-Mediated Immunity to Porcine Reproductive and Respiratory Syndrome Virus in Swine

  1997cited by this paper
• Interferon gamma and interleukin 1, but not interferon alfa, inhibit rotavirus entry into human intestinal cell lines

  1997cited by this paper
• Homologous challenge of porcine reproductive and respiratory syndrome virus immunity in pregnant swine.

  1997cited by this paper
• Interferon-gamma protects against herpes simplex virus type 1-mediated neuronal death.

  1997cited by this paper
• Immunity to PRRSV: Double-edged sword

  1997cited by this paper
• Cellular responses to interferon-gamma.

  1997cited by this paper
• Exacerbated viral hepatitis in IFN-gamma receptor-deficient mice is not suppressed by IL-12.

  1996cited by this paper
• Diagnosis of porcine reproductive and respiratory syndrome using infected alveolar macrophages collected from live pigs.

  1996cited by this paper
• Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis

  1995cited by this paper
• Pathogenesis of Porcine Reproductive and Respiratory Syndrome Virus Infection in Gnotobiotic Pigs

  1995cited by this paper
• Interferon-gamma-induced downregulation of CD4 inhibits the entry of human immunodeficiency virus type-1 in primary monocytes.

  1995cited by this paper
• IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice.

  1995cited by this paper
• An essential role for type 1 interferon-gamma in terminating persistent viral infection.

  1995cited by this paper
• Interferon-gamma inhibits endocytosis of soluble animated beta-1,3-D-glucan and neutral red in mouse peritoneal macrophages.

  1995cited by this paper
• Interaction of porcine reproductive and respiratory syndrome virus with swine monocytes

  1994cited by this paper
• Experimental Porcine Reproductive and Respiratory Syndrome Virus Infection in One-, Four-, and 10-Week-Old Pigs

  1994cited by this paper
• Interferon-gamma-activated monocytes impair infectivity of HIV particles by an oxygen metabolite-dependent reaction.

  1993cited by this paper
• Colony stimulating factors, cytokines and monocyte-macrophages--some controversies.

  1993cited by this paper
• Pathogenesis of porcine reproductive and respiratory syndrome virus infection in mid-gestation sows and fetuses.

  1993cited by this paper
• Differentiation of U.S. and European isolates of porcine reproductive and respiratory syndrome virus by monoclonal antibodies

  1993cited by this paper
• Comparison of Porcine Alveolar Macrophages and CL 2621 for the Detection of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus and Anti-PRRS Antibody

  1993cited by this paper
• Isolation of Swine Infertility and Respiratory Syndrome Virus (Isolate ATCC VR-2332) in North America and Experimental Reproduction of the Disease in Gnotobiotic Pigs

  1992cited by this paper
• Isolation of a Cytopathic Virus from Weak Pigs on Farms with a History of Swine Infertility and Respiratory Syndrome

  1992cited by this paper
• Pathological, ultrastructural, and immunohistochemical changes caused by Lelystad virus in experimentally induced infections of mystery swine disease (synonym: porcine epidemic abortion and respiratory syndrome (PEARS)).

  1991cited by this paper
• Mystery swine disease in The Netherlands: the isolation of Lelystad virus.

  1991cited by this paper
• Efficiency and effectiveness of cloned virus-specific cytotoxic T lymphocytes in vivo.

  1989cited by this paper
• Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice

  1989cited by this paper
• Interactions of Pseudorabies virus with swine alveolar macrophages I: virus replication

  1989cited by this paper
• Effect of interferon-alpha, interferon-gamma and tumour necrosis factor on African swine fever virus replication in porcine monocytes and macrophages.

  1988cited by this paper
• Antiviral and Antigenic Properties of Recombinant Porcine Interferon Gamma

  1988cited by this paper
• Comparative effects of various classes of mouse interferons on macrophage activation for tumor cell killing.

  1985cited by this paper
• Preparation and characterization of monoclonal antibodies reactive with porcine PBL.

  1984cited by this paper
• Potent activation of mouse macrophages by recombinant interferon-gamma.

  1984cited by this paper
• Use of gelatin/plasma coated flasks for isolating human peripheral blood monocytes.

  1983cited by this paper
• Direct evidence for a bone marrow origin of the alveolar macrophage in man.

  1976cited by this paper

• Effect of vaccination route (intradermal vs. intramuscular) against porcine reproductive and respiratory syndrome using a modified live vaccine on systemic and mucosal immune response and virus transmission in pigs

  2024cites this paper
• Knock down of transforming growth factor beta improves expressions of co-stimulatory molecules, type I interferon-regulated genes, and pro-inflammatory cytokine in PRRSV-inoculated monocyte-derived macrophages

  2024cites this paper
• Recombinant Lactococcus lactis Expressing Human LL-37 Prevents Deaths from Viral Infections in Piglets and Chicken

  2023cites this paper
• The host transcriptome change involved in the inhibitory effect of exogenous interferon-γ on Getah virus replication

  2023cites this paper
• Construction of an infectious cloning system of porcine reproductive and respiratory syndrome virus and identification of glycoprotein 5 as a potential determinant of virulence and pathogenicity

  2023cites this paper
• Identification of MHC-I-Presented Porcine Respiratory and Reproductive Syndrome Virus (PRRSV) Peptides Reveals Immunogenic Epitopes within Several Non-Structural Proteins Recognized by CD8+ T Cells

  2022cites this paper
• The Swine IFN System in Viral Infections: Major Advances and Translational Prospects

  2022cites this paper
• Influence of PRRSV-1 vaccination and infection on mononuclear immune cells at the maternal-fetal interface

  2022cites this paper
• Evaluation of the Cross-Protective Efficacy of a Chimeric PRRSV Vaccine against Two Genetically Diverse PRRSV2 Field Strains in a Reproductive Model

  2021cites this paper
• Commercial PRRS Modified-Live Virus Vaccines

  2021cites this paper
• Activation of Fc gamma receptor IIb up-regulates the production of interferon-alpha and interferon-gamma in porcine alveolar macrophages during PRRSV infection.

  2020cites this paper
• Evaluation of a type 2 modified live porcine reproductive and respiratory syndrome vaccine against heterologous challenge of a lineage 3 highly virulent isolate in pigs

  2020cites this paper
• A DNA-Modified Live Vaccine Prime–Boost Strategy Broadens the T-Cell Response and Enhances the Antibody Response against the Porcine Reproductive and Respiratory Syndrome Virus

  2019cites this paper
• IFI16 Inhibits Porcine Reproductive and Respiratory Syndrome Virus 2 Replication in a MAVS-Dependent Manner in MARC-145 Cells

  2019cites this paper
• Actinobacillus pleuropneumoniae culture supernatant antiviral effect against porcine reproductive and respiratory syndrome virus occurs prior to the viral genome replication and transcription through actin depolymerization

  2018cites this paper
• Co-administration of saponin quil A and PRRSV-1 modified-live virus vaccine up-regulates gene expression of type I interferon-regulated gene, type I and II interferon, and inflammatory cytokines and reduces viremia in response to PRRSV-2 challenge.

  2018cites this paper
• Dynamic changes in bronchoalveolar macrophages and cytokines during infection of pigs with a highly or low pathogenic genotype 1 PRRSV strain

  2017cites this paper
• Investigation of porcine interferons as a metaphylactic intervention against classical swine fever virus

  2017influential citation
• Antiviral Strategies against PRRSV Infection.

  2017cites this paper
• Comparison of commercial type 1 and type 2 PRRSV vaccines against heterologous dual challenge

  2016cites this paper
• Establishing Porcine Monocyte-Derived Macrophage and Dendritic Cell Systems for Studying the Interaction with PRRSV-1

  2016cites this paper
• Anti-PRRSV effect and mechanism of tetrahydroaltersolanol C in vitro

  2016cites this paper
• Evaluation of the Cross-Protective Efficacy of a Chimeric Porcine Reproductive and Respiratory Syndrome Virus Constructed Based on Two Field Strains

  2016cites this paper
• The Non-structural Protein 5 and Matrix Protein Are Antigenic Targets of T Cell Immunity to Genotype 1 Porcine Reproductive and Respiratory Syndrome Viruses

  2016cites this paper
• Recombinant beta interferon could clear the low-dose infected porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells.

  2016cites this paper
• Porcine respiratory disease complex: Interaction of vaccination and porcine circovirus type 2, porcine reproductive and respiratory syndrome virus, and Mycoplasma hyopneumoniae.

  2016cites this paper
• Comparison of protection provided by type 1 and type 2 porcine reproductive and respiratory syndrome field viruses against homologous and heterologous challenge.

  2016cites this paper
• Challenges in Veterinary Vaccine Development and Immunization

  2015cites this paper
• Cross-protection of a new type 2 porcine reproductive and respiratory syndrome virus (PRRSV) modified live vaccine (Fostera PRRS) against heterologous type 1 PRRSV challenge in growing pigs.

  2015cites this paper
• Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells.

  2015cites this paper
• Comparative Analysis of Immune Responses in Pigs to High and Low Pathogenic Porcine Reproductive and Respiratory Syndrome Viruses Isolated in China.

  2015cites this paper
• Characterization of Actinobacillus pleuropneumoniae antiviral effect against porcine reproductive and respiratory syndrome virus in porcine alveolar macrophages

  2015influential citation
• Comparison of in/ex vivo replication characteristics of different porcine reproductive and respiratory syndrome virus strains

  2015cites this paper
• Adjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs

  2014cites this paper
• Actinobacillus pleuropneumoniae Possesses an Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus

  2014cites this paper
• Vaccination of sows against type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) before artificial insemination protects against type 2 PRRSV challenge but does not protect against type 1 PRRSV challenge in late gestation

  2014cites this paper
• Interaction between single-dose Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus vaccines on dually infected pigs.

  2014cites this paper
• Evaluation of the efficacy of a new modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Fostera PRRS) against heterologous PRRSV challenge.

  2014cites this paper
• Genome-wide association and genomic prediction for host response to porcine reproductive and respiratory syndrome virus infection

  2014cites this paper
• Immune Control of PRRS: Lessons to be Learned and Possible Ways Forward

  2014cites this paper
• Utilities of reverse genetics system as a platform for the development of Porcine Reproductive and Respiratory Syndrome (PRRS) virus vaccine

  2013cites this paper
• Plasmids expressing porcine interferon gamma up-regulate pro-inflammatory cytokine and co-stimulatory molecule expression which are suppressed by porcine reproductive and respiratory syndrome virus.

  2013cites this paper
• Emergency vaccination alleviates highly pathogenic porcine reproductive and respiratory syndrome virus infection after contact exposure

  2013cites this paper
• In vitro screening for compounds derived from traditional chinese medicines with antiviral activities against porcine reproductive and respiratory syndrome virus.

  2013cites this paper
• Oral Administration of EC-12 Increases the Baseline Gene Expression of Antiviral Cytokine Genes, IFN-γ and TNF-α, in Splenocytes and Mesenteric Lymph Node Cells of Weaning Piglets

  2013cites this paper
• Enhanced immunogenicity induced by an alphavirus replicon-based pseudotyped baculovirus vaccine against porcine reproductive and respiratory syndrome virus.

  2013cites this paper
• Plasmids expressing interleukin-10 short hairpin RNA mediate IL-10 knockdown and enhance tumor necrosis factor alpha and interferon gamma expressions in response to porcine reproductive and respiratory syndrome virus.

  2012cites this paper
• Immunohistochemical expression of IL-12, IL-10, IFN-α and IFN-γ in lymphoid organs of porcine reproductive and respiratory syndrome virus-infected pigs.

  2012cites this paper
• Immunogenicity study of plant-made oral subunit vaccine against porcine reproductive and respiratory syndrome virus (PRRSV).

  2012cites this paper
• Mucosal vaccines to prevent porcine reproductive and respiratory syndrome: a new perspective

  2012influential citation
• Differential expression of proinflammatory cytokines in the lymphoid organs of porcine reproductive and respiratory syndrome virus-infected pigs.

  2012cites this paper
• Effects of Astragalus Polysaccharide on Immune Responses of Porcine PBMC Stimulated with PRRSV or CSFV

  2012cites this paper
• Cell-Mediated Immunity in Porcine Reproductive and Respiratory Syndrome Virus

  2012cites this paper
• Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs

  2012cites this paper
• Evaluation of a DNA vaccine candidate co-expressing GP3 and GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) with interferon α/γ in immediate and long-lasting protection against HP-PRRSV challenge

  2012cites this paper
• Construction and immunogenicity of recombinant adenovirus expressing ORF2 of PCV2 and porcine IFN gamma.

  2011cites this paper
• Molecular cloning, expression and antiviral activity of porcine interleukin-29 (poIL-29).

  2011cites this paper
• Antiviral activity of type I and type III interferons against porcine reproductive and respiratory syndrome virus (PRRSV).

  2011cites this paper
• Marked differences between MARC-145 cells and swine alveolar macrophages in IFNβ-induced activation of antiviral state against PRRSV.

  2011cites this paper
• Effect of the infection with porcine reproductive and respiratory syndrome virus on the regulation of cytokines - tumor necrosis factor-alpha and interleukin-10

  2011cites this paper
• Patogenia del síndrome reproductivo y respiratorio porcino: evaluación de la expresión de citoquinas y fenómenos de apoptosis en órganos linfoides y su papel en la respuesta inmune.

  2011influential citation
• The glycoproteins of porcine reproductive and respiratory syndrome virus and their role in infection and immunity

  2010cites this paper
• Comparative Measurement of Cell-Mediated Immune Responses of Swine to the M and N Proteins of Porcine Reproductive and Respiratory Syndrome Virus

  2010cites this paper
• Cytokine mRNA expression profiles in peripheral blood mononuclear cells from piglets experimentally co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2.

  2010cites this paper
• Certainties, doubts and hypotheses in porcine reproductive and respiratory syndrome virus immunobiology.

  2010cites this paper
• Genomic structure and characterization of mRNA expression pattern of porcine interferon gamma receptor 1 gene

  2010cites this paper
• Modulation of host cell responses and evasion strategies for porcine reproductive and respiratory syndrome virus

  2010cites this paper
• The Cysteine Protease Domain of Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 2 Possesses Deubiquitinating and Interferon Antagonism Functions

  2010cites this paper
• arked differences between MARC-145 cells and swine alveolar acrophages in IFN-induced activation of antiviral state against

  2010cites this paper
• Patogenia de la forma respiratoria del sindrome reproductivo y respiratorio porcino: el papel modulador de las citoquinas en la respuesta inmune

  2009influential citation
• Secretory expression of porcine interferon-gamma in baculovirus using HBM signal peptide and its inhibition activity on the replication of porcine reproductive and respiratory syndrome virus.

  2009cites this paper
• Cytokine Expression by Macrophages in the Lung of Pigs Infected with the Porcine Reproductive and Respiratory Syndrome Virus

  2009influential citation
• Adenovirus-Mediated Expression of Interferon-α Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus

  2009cites this paper
• Adjuvants for porcine reproductive and respiratory syndrome virus vaccines.

  2009cites this paper
• Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology.

  2009cites this paper
• Changes in Lymphocyte Subsets and Cytokines During European Porcine Reproductive and Respiratory Syndrome: Increased Expression of IL-12 and IL-10 and Proliferation of CD4−CD8high

  2009cites this paper
• Differences in Clinical Disease and Immune Response of Pigs Challenged with a High-Dose versus Low-Dose Inoculum of Porcine Reproductive and Respiratory Syndrome Virus

  2008influential citation
• Porcine reproductive and respiratory syndrome virus: Understanding and managing persistent infection

  2008cites this paper
• Immune response against porcine reproductive and respiratory syndrome virus during acute and chronic infection.

  2008cites this paper
• A recombinant plasmid co-expressing swine ubiquitin and the GP5 encoding-gene of porcine reproductive and respiratory syndrome virus induces protective immunity in piglets.

  2008cites this paper
• Recombinant swine beta interferon protects swine alveolar macrophages and MARC-145 cells from infection with Porcine reproductive and respiratory syndrome virus.

  2007cites this paper
• Synergistic inhibition of pseudorabies virus replication by porcine alpha/beta interferon and gamma interferon in vitro.

  2007cites this paper
• A missense polymorphism in porcine interferon-γ cDNA affects antiviral activity of the protein variant

  2007cites this paper
• Innate Immune Responses to Replication of Porcine Reproductive And Respiratory Syndrome Virus in Isolated Swine Alveolar Macrophages

  2007cites this paper
• Departament de Sanitat i d'Anatomia Animals Universitat Autonoma de Barcelona

  2006cites this paper
• Cell-mediated immune response to porcine reproductive and respiratory syndrome virus

  2006cites this paper
• Correlation of cell-mediated immunity against porcine reproductive and respiratory syndrome virus with protection against reproductive failure in sows during outbreaks of porcine reproductive and respiratory syndrome in commercial herds.

  2005cites this paper
• Interleukin-12 (IL-12) ameliorates the effects of porcine respiratory and reproductive syndrome virus (PRRSV) infection.

  2005cites this paper
• Cloning and expression of interferon-alpha/gamma from a domestic porcine breed and its effect on classical swine fever virus.

  2005cites this paper
• Real-time PCR for quantitation of porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 in naturally-infected and challenged pigs.

  2005cites this paper
• The Level of Virus-Specific T-Cell and Macrophage Recruitment in Porcine Reproductive and Respiratory Syndrome Virus Infection in Pigs Is Independent of Virus Load

  2004cites this paper
• Cytokines and synthetic double-stranded RNA augment the T helper 1 immune response of swine to porcine reproductive and respiratory syndrome virus

  2004cites this paper
• Investigation of genetic susceptibility to the porcine reproductive and respiratory syndrome virus between commercial breeding stock lines of pigs

  2004cites this paper
• Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination

  2004cites this paper
• Beta-glucan enhancement of T cell IFNgamma response in swine.

  2004cites this paper
• Virological and immunological responses to porcine reproductive and respiratory syndrome virus in a large population of gilts.

  2004cites this paper
• Immunohistochemical staining of IFN-gamma positive cells in porcine reproductive and respiratory syndrome virus-infected lungs.

  2003cites this paper
• Lymphoid tissue tropism of porcine reproductive and respiratory syndrome virus replication during persistent infection of pigs originally exposed to virus in utero

  2003cites this paper
• In utero infection with porcine reproductive and respiratory syndrome virus modulates leukocyte subpopulations in peripheral blood and bronchoalveolar fluid of surviving piglets

  2003cites this paper
• Expression of interleukin-10 and interleukin-12 in piglets experimentally infected with porcine reproductive and respiratory syndrome virus (PRRSV).

  2003cites this paper