Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Agricultural and Food Chemistry

• Publication date

  2009-10-28

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1021/jf901718uPMID 19919125
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo.

  2009cited by this paper
• Bcl-2 family members as molecular targets in cancer therapy.

  2008cited by this paper
• Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4.

  2008cited by this paper
• Cancer Statistics, 2008

  2008cited by this paper
• Allergic Inflammation and Adipocytokines

  2008cited by this paper
• Novel triterpenoid from Citrus aurantium L. possesses chemopreventive properties against human colon cancer cells.

  2008cited by this paper
• Red Mexican Grapefruit: A Novel Source for Bioactive Limonoids and their Antioxidant Activity

  2007cited by this paper
• Simultaneous determination of citrus limonoid aglycones and glucosides by high performance liquid chromatography.

  2007cited by this paper
• Polymethoxylated flavones induce Ca(2+)-mediated apoptosis in breast cancer cells.

  2006cited by this paper
• Suppression of colon carcinogenesis by bioactive compounds in grapefruit.

  2006cited by this paper
• Flavonoid Composition of Fruit Tissues of Citrus Species

  2006cited by this paper
• The p53 tumor suppressor participates in multiple cell cycle checkpoints

  2006cited by this paper
• The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells.

  2006cited by this paper
• The rutin/beta-cyclodextrin interactions in fully aqueous solution: spectroscopic studies and biological assays.

  2005cited by this paper
• Citrus limonoids induce apoptosis in human neuroblastoma cells and have radical scavenging activity.

  2005cited by this paper
• Pancreatic cancer

  2004cited by this paper
• A prospective randomized study of gemcitabine with doxifluridine versus paclitaxel with doxifluridine in concurrent chemoradiotherapy for locally advanced pancreatic cancer.

  2004cited by this paper
• Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries.

  2003cited by this paper
• Control of apoptosis by p53

  2003cited by this paper
• Chemopreventive Agents Induce Suppression of Nuclear Factor‐κB Leading to Chemosensitization

  2002cited by this paper
• Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models.

  2002cited by this paper
• Cancer preventive effects of flavonoids--a review.

  2002cited by this paper
• Differential Inhibition of Human Cancer Cell Proliferation by Citrus Limonoids

  2001cited by this paper
• Phenol antioxidant quantity and quality in foods: fruits.

  2001cited by this paper
• Quantitation of flavonoid constituents in citrus fruits.

  1999cited by this paper
• Antioxidant effectiveness as influenced by phenolic content of fresh orange juices.

  1999cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• The characterization of antioxidants.

  1995cited by this paper
• A prospective study of pancreatic cancer in the elderly

  1994cited by this paper
• Metabolic activation of pesticides with proestrogenic activity.

  1987cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper

• Inhibition of nasopharynx cancer cells by selected flavonoids in vitro and molecular docking analysis of BCL‑w anti‑apoptotic protein

  2025cites this paper
• Unlocking the Potential of Bioactive Compounds in Pancreatic Cancer Therapy: A Promising Frontier

  2025cites this paper
• Effect of squeezed orange, mandarin and grapefruit juices on bioactive properties, phenolic constituents and sensory evaluations of wheat bread

  2025influential citation
• Citrus aurantifolia essential oil: antiaging potential through integrated in vitro and in silico studies

  2025cites this paper
• Virtual Screening, Molecular Docking and Molecular Dynamics Simulation of Bioactive Compounds from Various Indonesian Medicinal Plants as Potential Inhibitors of Human Papillomavirus Type 16 E6 Protein in Cervical Cancer Development

  2025cites this paper
• Study of Antibacterial Activities of Selected Fruit Peels against Gram-positive Bacteria

  2025cites this paper
• A Review on Analytical Approaches for Identifying Citrus Phytochemicals

  2025cites this paper
• Mechanistic and metabolic exploration of neohesperidin against lung cancer cell lines through ROS-mediated mitochondrial apoptosis: An in-silico and in-vitro approach.

  2025cites this paper
• Isolation and identification of anticancer flavonoids from Valentia orange peel extract: In vitro evaluation

  2024cites this paper
• The protective effect of hydroalcoholic Citrus aurantifolia peel extract against doxorubicin-induced nephrotoxicity

  2024cites this paper
• Citrus Essential Oils: A Rational View on its Chemical Profiles, Mode of Action of Anticancer Effects/Antiproliferative Activity on Various Human Cancer Cell Lines

  2023cites this paper
• Scopus indexed scholarly publications of academics at the University of Agricultural Sciences,Dharwad: A Bibliometric analysis

  2023cites this paper
• Limonoids and alkaloids from Tetradium austrosinense (Hand.-Mazz.) T.G.Hartley.

  2023cites this paper
• Exploring the Potential of Hesperidin in Preventing Hypertrophic Scars: Insights from a Rabbit Ear Model

  2023cites this paper
• Enriching the Bioactive Components and Antioxidant Capacity of Concentrated Lime Juices Prepared by Cryogenic and Vacuum Processes

  2023cites this paper
• Bioactive Components and Their Activities from Different Parts of Citrus aurantifolia (Christm.) Swingle for Food Development

  2023cites this paper
• Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review

  2022influential citation
• Anti-inflammatory, viral replication suppression and hepatoprotective activities of bitter kola - Lime juice, - Honey mixture in HBeAg seropositive patients

  2022cites this paper
• Pharmacological activities of limonin from Khasi Mandarin as therapeutic applications

  2022cites this paper
• Exploring in vitro anti-proliferative and anti-inflammatory activities of Prasachandaeng remedy, and its bioactive compounds

  2022cites this paper
• The Potential Use of Citrus aurantifolia L. Essential Oils for Decay Control, Quality Preservation of Agricultural Products, and Anti-Insect Activity

  2022cites this paper
• Herbals and Plants in the Treatment of Pancreatic Cancer: A Systematic Review of Experimental and Clinical Studies

  2022cites this paper
• Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

  2022cites this paper
• HPTLC-DPPH• and HPTLC-tyrosinase methods for hot water-soluble contents of kumquat, limequat and mexican lime fruit powders

  2021cites this paper
• Cold-pressed oil from Citrus aurantifolia inhibits the proliferation of vascular smooth muscle cells via regulation of PI3K/MAPK signaling pathways

  2021cites this paper
• Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.

  2021cites this paper
• Marmin from the blossoms of Citrus maxima (Burm.) Merr. exerts lipid-lowering effect via inducing 3T3-L1 preadipocyte apoptosis

  2021cites this paper
• Microencapsulation of Extracts from Corn Hair: A Study on Drug Release and Anticancer Activity

  2021cites this paper
• Detection of fraud in lime juice using pattern recognition techniques and FT‐IR spectroscopy

  2021cites this paper
• Citrus aurantiifolia (Christm) Swingle: Biological potential and safety profile of essential oils from leaves and fruit peels

  2021cites this paper
• Study of the analgesic effect of the aqueous extract of the leaves of Citrus aurantifolia (Rutaceae) in mice

  2021cites this paper
• Agro-industrial wastes as sources of bioactive compounds for food and fermentation industries

  2020cites this paper
• Antioxidant, Antimicrobial, and Other Biological Properties of Pompia Juice

  2020cites this paper
• Phytochemical Screening, Therapeutic Benefits, and Adverse Effects of Citrus aurantifolia - A Review

  2020influential citation
• The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

  2020cites this paper
• Citrus aurantifolia (Christm.) Swingle (lime) Fruit Extract Inhibits the Activities of Polyol Pathway Enzymes

  2020cites this paper
• Physicochemical and microbiological characterization of pectin-based gelled emulsions coating applied on pre-cut carrots

  2020cites this paper
• Histomorphologic Effect of Citrus aurantiifolia against Cadmium Chloride Induced Toxicity in the Liver and Kidney of Adult Wistar Rats

  2020cites this paper
• Bioactive ingredients screening and antibacterial activity of Citrus aurantifolia leaf extract against some enteric isolates

  2020cites this paper
• Traditional knowledge for antidiabetic herbs from Majuli Island (Assam), India

  2020cites this paper
• Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models.

  2020cites this paper
• Grapefruit

  2020cites this paper
• Ethnopharmacological analysis from Thai traditional medicine called Prasachandaeng remedy as a potential antipyretic drug.

  2020cites this paper
• A comprehensive review on Citrus aurantifolia essential oil: its phytochemistry and pharmacological aspects

  2020cites this paper
• Tamarillo (Solanum betaceum Cav.): A Review of Physicochemical and Bioactive Properties and Potential Applications

  2020cites this paper
• Role of limonin in anticancer effects of Evodia rutaecarpa on ovarian cancer cells

  2020cites this paper
• Flavonoids: Biosynthesis, Metabolism, Mechanism of Antioxidation and Clinical Implications: A Review

  2020cites this paper
• Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics

  2019cites this paper
• Antimicrobial Properties of Encapsulated Antimicrobial Natural Plant Products for Ready-to-Eat Carrots

  2019cites this paper
• Comparative study of five different squashes stored at room temperature

  2018cites this paper
• By blocking hexokinase-2 phosphorylation, limonin suppresses tumor glycolysis and induces cell apoptosis in hepatocellular carcinoma

  2018cites this paper
• Hesperidin Induces ROS-Mediated Apoptosis along with Cell Cycle Arrest at G2/M Phase in Human Gall Bladder Carcinoma

  2018cites this paper
• Comparison of the Histomorphology of Testes in Albino Wistar Rats Following Separate and Co-Administration of Citrus aurantifolia and Caffeine

  2018cites this paper
• Isolation and Characterization of Antibiotic-producing Endophytic Bacteria from Citrus aurantifolia Swingle

  2018cites this paper
• Trianthema portulacastrum L. extract protects against gamma radiation induced human red blood cell membrane damage in vitro

  2018cites this paper
• Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression

  2018cites this paper
• Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies

  2017influential citation
• Punica granatum L. mesocarp suppresses advanced glycation end products (AGEs)- and H2O2-induced oxidative stress and pro-inflammatory biomarkers

  2017cites this paper
• Nanoformulation and characterization of nomilin with different poly (lactic-co-glycolic acid) resomers and surfactants for the enhanced inhibition of α-amylase and angiotensin-converting-enzyme

  2017cites this paper
• Citrus peels prevent cancer.

  2017cites this paper
• The Protective Role of β-Carotene and Hesperidin on Some Hematological and Myocardial Measurements against Imidacloprid Toxicity in Albino Rats

  2017cites this paper
• Accepted Manuscript Citrus peels prevent cancer

  2017influential citation
• Phytochemistry and bioactivity of Citrus flavonoids: a focus on antioxidant, anti-inflammatory, anticancer and cardiovascular protection activities

  2017cites this paper
• Strategies to Target Glucose Metabolism in Tumor Microenvironment on Cancer by Flavonoids

  2017cites this paper
• Nanocapsules of Catechin Rich Extract for Enhanced Antioxidant Potential and In Vitro Bioavailability

  2017cites this paper
• Pro-apoptotic and anti-proliferative effects of corn silk extract on human colon cancer cell lines.

  2017cites this paper
• Antioxidant Capacity, Anticancer Ability and Flavonoids Composition of 35 Citrus (Citrus reticulata Blanco) Varieties

  2017cites this paper
• Activation of Secondary Metabolism in Citrus Plants Is Associated to Sensitivity to Combined Drought and High Temperatures

  2017cites this paper
• Comparative suppressing effects of black and green teas on the formation of advanced glycation end products (AGEs) and AGE-induced oxidative stress.

  2017cites this paper
• Citrus nomilin down-regulates TNF-α-induced proliferation of aortic smooth muscle cells via apoptosis and inhibition of IκB.

  2017cites this paper
• Recovery and purification of limonin from pummelo [Citrus grandis] peel using water extraction, ammonium sulfate precipitation and resin adsorption.

  2017cites this paper
• Treating leishmaniasis in Amazonia: A review of ethnomedicinal concepts and pharmaco-chemical analysis of traditional treatments to inspire modern phytotherapies.

  2017cites this paper
• Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults.

  2016cites this paper
• Anticancer Activity of Key Lime, Citrus aurantifolia

  2016cites this paper
• Hesperetin Liposomes for Cancer Therapy.

  2016cites this paper
• Phenolics profile and anti-proliferative activity of Cyphomandra Betacea fruit in breast and liver cancer cells

  2016cites this paper
• Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

  2016cites this paper
• The Chemistry and Pharmacology of Citrus Limonoids

  2016influential citation
• Development and Application of a Multiplex Real-Time PCR Assay as an Indicator of Potential Allergenicity in Citrus Fruits.

  2016cites this paper
• Bioactive compounds and antioxidant activity of citrus juices produced from varieties cultivated in Calabria

  2016cites this paper
• Anticancer potential of selected Fallopia Adans species.

  2015cites this paper
• Chemopreventive Actions of Blond and Red-Fleshed Sweet Orange Juice on the Loucy Leukemia Cell Line.

  2015cites this paper
• IN VITRO ANTHELMINTIC EFFICACY OF EXTRACTS OF CITRUS AURANTIFOLIA (CHRISTM) SWINGLE FRUIT PEELS AGAINST HELIGMOSOMOIDES BAKERI OVA AND LARVAE

  2015cites this paper
• The Preventive Approach of Biocompounactives (2): A Review in Recent Advances in Common Fruits

  2015cites this paper
• Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells

  2015cites this paper
• Suppression of intestinal carcinogenesis in Apc-mutant mice by limonin

  2015cites this paper
• Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest

  2015cites this paper
• Therapeutic potentials of fisetin, hesperetin and vitexin on chronic myeloid leukemia and acute myeloid leukemia cells

  2015cites this paper
• Bioactive extracts of Citrus aurantifolia swingle seeds obtained by supercritical CO2 and organic solvents comparing its cytotoxic activity against L5178Y leukemia lymphoblasts

  2015cites this paper
• Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway

  2015cites this paper
• Lime Juice Induces Ovarian Follicle Degeneration and Reduces Serum Gonadotrophin Level in Rats Model

  2015cites this paper
• Hesperetin exerts apoptotic effect on A431 skin carcinoma cells by regulating mitogen activated protein kinases and cyclins.

  2015cites this paper
• Hesperidin Inhibits Vascular Formation by Blocking the AKT / mTOR Signaling Pathways

  2015cites this paper
• Status of Bioactive Compounds in Foods, with Focus on Fruits and Vegetables

  2015influential citation
• Hesperidin Inhibits Vascular Formation by Blocking the AKT/mTOR Signaling Pathways.

  2015cites this paper
• Apoptosis induced by farrerol in human gastric cancer SGC-7901 cells through the mitochondrial-mediated pathway

  2015cites this paper
• Cytotoxicity of obacunone and obacunone glucoside in human prostate cancer cells involves Akt-mediated programmed cell death.

  2015cites this paper
• Non-targeted metabolite profiling of citrus juices as a tool for variety discrimination and metabolite flow analysis

  2015influential citation
• Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer.

  2014cites this paper
• Nutrition and pancreatic cancer.

  2014cites this paper