Current Views on the Mechanism of Action of Thiazolidinedione Insulin Sensitizers

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Diabetes Technology & Therapeutics

• Publication date

  1999-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1089/152091599317189PMID 11475273
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The influence of obesity on the development of non-insulin-dependent diabetes mellitus

  2000cited by this paper
• Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes.

  1999cited by this paper
• Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action.

  1998cited by this paper
• Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene.

  1998cited by this paper
• Thiazolidinediones Stimulate Uncoupling Protein-2 Expression in Cell Lines Representing White and Brown Adipose Tissues and Skeletal Muscle.

  1998cited by this paper
• Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner*

  1998cited by this paper
• Troglitazone effects on gene expression in human skeletal muscle of type II diabetes involve up-regulation of peroxisome proliferator-activated receptor-gamma.

  1998cited by this paper
• The Determinants of Glycemic Responses to Diet Restriction and Weight Loss in Obesity and NIDDM

  1998cited by this paper
• TNF-alpha and insulin resistance: summary and future prospects.

  1998cited by this paper
• Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.

  1998cited by this paper
• Peroxisome Proliferator-Activated Receptor-γ Agonist, Rosiglitazone, Protects Against Nephropathy and Pancreatic Islet Abnormalities in Zucker Fatty Rats

  1998cited by this paper
• Skeletal muscle peroxisome proliferator- activated receptor-gamma expression in obesity and non- insulin-dependent diabetes mellitus.

  1998cited by this paper
• Thiazolidinedione Exposure Increases the Expression of Uncoupling Protein 1 in Cultured Human Preadipocytes

  1998cited by this paper
• Protein kinase C isoforms α, δ and θ require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)

  1998cited by this paper
• Thiazolidinediones Inhibit Lipoprotein Lipase Activity in Adipocytes*

  1998cited by this paper
• Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes.

  1998cited by this paper
• Abdominal obesity.

  1998cited by this paper
• PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes.

  1998cited by this paper
• Baseline factors affecting the efficacy of troglitazone on plasma glucose in Japanese patients with non-insulin-dependent diabetes mellitus.

  1998cited by this paper
• Insulin Resistance and Human Disease: A Short History

  1998cited by this paper
• Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance.

  1998cited by this paper
• Fatty acids and insulin resistance.

  1998cited by this paper
• Cardiovascular risk continuum: implications of insulin resistance and diabetes.

  1998cited by this paper
• Pioglitazone time-dependently reduces tumour necrosis factor-α level in muscle and improves metabolic abnormalities in Wistar fatty rats

  1998cited by this paper
• Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner.

  1998cited by this paper
• Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats*

  1998cited by this paper
• PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

  1998cited by this paper
• Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

  1998cited by this paper
• Troglitazone reduces free fatty acid-induced insulin resistance in perfused rat hindquarter.

  1998cited by this paper
• BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones.

  1998cited by this paper
• Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

  1998cited by this paper
• Troglitazone increases system A amino acid transport in 3T3-L1 cells.

  1998cited by this paper
• Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.

  1997cited by this paper
• Thiazolidinediones.

  1997cited by this paper
• Acute non‐insulin‐like stimulation of rat muscle glucose metabolism by troglitazone in vitro

  1997cited by this paper
• Pioglitazone and Metformin Reverse Insulin Resistance Induced by Tumor Necrosis Factor-Alpha in Liver Cells

  1997cited by this paper
• The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat.

  1997cited by this paper
• Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.

  1997cited by this paper
• TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

  1997cited by this paper
• Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.

  1997cited by this paper
• PPAR-gamma gene expression is elevated in skeletal muscle of obese and type II diabetic subjects.

  1997cited by this paper
• Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

  1997cited by this paper
• PPAR-γ Gene Expression Is Elevated in Skeletal Muscle of Obese and Type II Diabetic Subjects

  1997cited by this paper
• PATHOGENESIS OF TYPE 2 DIABETES: METABOLIC AND MOLECULAR IMPLICATIONS FOR IDENTIFYING DIABETES GENES

  1997cited by this paper
• Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action

  1997cited by this paper
• Pioglitazone: in vitro effects on rat hepatoma cells and in vivo liver hypertrophy in KKAy mice.

  1997cited by this paper
• Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.

  1997cited by this paper
• Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome.

  1997cited by this paper
• PPAR gamma and the molecular control of adipogenesis.

  1997cited by this paper
• Pioglitazone Induces In Vivo Adipocyte Differentiation in the Obese Zucker fa/fa Rat

  1997cited by this paper
• Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

  1997cited by this paper
• Acute effects of pioglitazone on glucose metabolism in perfused rat liver

  1997cited by this paper
• Troglitazone Improves Defects in Insulin Action , Insulin Secretion , Ovarian Steroidogenesis , and Fibrinolysis in Women with Polycystic Ovary Syndrome *

  1997cited by this paper
• Trans-differentiation of myoblasts to adipoblasts: triggering effects of fatty acids and thiazolidinediones.

  1997cited by this paper
• Impaired Glucose Tolerance is Normalized by Treatment With the Thiazolidinedione Troglitazone

  1997cited by this paper
• Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha.

  1996cited by this paper
• IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

  1996cited by this paper
• Adult human chondrocytes cultured in alginate form a matrix similar to native human articular cartilage.

  1996cited by this paper
• Troglitazone enhances differentiation, basal glucose uptake, and Glut1 protein levels in 3T3-L1 adipocytes.

  1996cited by this paper
• An antidiabetic thiazolidinedione potentiates insulin stimulation of glycogen synthase in rat adipose tissues.

  1996cited by this paper
• Effect of Troglitazone on Leptin Production: Studies In Vitro and in Human Subjects

  1996cited by this paper
• Effect of Troglitazone on Insulin Sensitivity and Pancreatic β-Cell Function in Women at High Risk for NIDDM

  1996cited by this paper
• Pioglitazone attenuates the inhibitory effect of phorbol ester on epidermal growth factor receptor autophosphorylation and tyrosine kinase activity.

  1996cited by this paper
• Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone.

  1996cited by this paper
• The thiazolidinedione insulin sensitiser, BRL 49653, increases the expression of PPAR-gamma and aP2 in adipose tissue of high-fat-fed rats.

  1996cited by this paper
• Insulin Secretory Defect in Zucker fa/fa Rats Is Improved by Ameliorating Insulin Resistance

  1995cited by this paper
• Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

  1995cited by this paper
• Insulin sensitization in diabetic rat liver by an antihyperglycemic agent.

  1995cited by this paper
• Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells (*)

  1995cited by this paper
• The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

  1995cited by this paper
• Repeat Treatment of Obese Mice With BRL 49653, a New Potent Insulin Sensitizer, Enhances Insulin Action in White Adipocytes: Association With Increased Insulin Binding and Cell-Surface GLUT4 as Measured by Photoaffinity Labeling

  1995cited by this paper
• An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) (*)

  1995cited by this paper
• An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).

  1995cited by this paper
• Effects of a New Oral Hypoglycaemic Agent (CS‐045) on Metabolic Abnormalities and Insulin Resistance in Type 2 Diabetes

  1994cited by this paper
• Mechanisms of fatty acid-induced inhibition of glucose uptake.

  1994cited by this paper
• Copyright � 1995, American Society for Microbiology PPAR�2 Regulates Adipose Expression of the

  1994cited by this paper
• CS-045, a new oral antidiabetic agent, stimulates fructose-2,6-bisphosphate production in rat hepatocytes.

  1994cited by this paper
• Pioglitazone promotes insulin-induced activation of phosphoinositide 3-kinase in 3T3-L1 adipocytes by inhibiting a negative control mechanism.

  1994cited by this paper
• Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.

  1994cited by this paper
• Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

  1994cited by this paper
• Pioglitazone promotes insulin-induced activation of phosphoinositide 3-kinase in 3T3-L1 adipocytes by inhibiting a negative control mechanism.

  1994cited by this paper
• Pioglitazone Increases Insulin Sensitivity, Reduces Blood Glucose, Insulin, and Lipid Levels, and Lowers Blood Pressure, in Obese, Insulin-Resistant Rhesus Monkeys

  1994cited by this paper
• Troglitazone Prevents Glucose-Induced Insulin Resistance of Insulin Receptor in Rat-1 Fibroblasts

  1994cited by this paper
• Tumor necrosis factor-alpha prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells.

  1993cited by this paper
• Effect of pioglitazone on insulin receptors of skeletal muscles from high-fat-fed rats.

  1993cited by this paper
• Pioglitazone ameliorates high glucose induced desensitization of insulin receptor kinase in Rat 1 fibroblasts in culture.

  1993cited by this paper
• Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects

  1992cited by this paper
• Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells.

  1992cited by this paper
• Pioglitazone Increases Insulin Sensitivity by Activating Insulin Receptor Kinase

  1992cited by this paper
• Metabolism of adipose tissue in intraabdominal depots in severely obese men and women.

  1990cited by this paper
• A potent in vivo effect of ciglitazone on muscle insulin resistance induced by high fat feeding of rats.

  1989cited by this paper
• Ciglitazone reverses cAMP‐induced post‐insulin receptor resistance in rat adipocytes in vitro

  1984cited by this paper
• The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.

  1963cited by this paper
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Troglitazone Regulation of Glucose Metabolism in Human Skeletal Muscle Cultures from Obese Type II Diabetic Subjects*

  year unknowncited by this paper

• A Review on Drug Interactions in Oral Hypoglycemic Drugs by Mechanism of Cytochrome P450 Enzyme Inhibition

  2017cites this paper
• Oral and Injectable (Non-insulin) Pharmacological Agents for Type 2 Diabetes

  2016cites this paper
• Biological and Chemical Investigation of Panamanian Plants for Potential Utility against Metabolic Syndrome

  2016cites this paper
• Metabolic and other effects of pioglitazone as an add-on therapy to metformin in the treatment of polycystic ovary syndrome (PCOS)

  2013cites this paper
• Use of Rosiglitazone for Clomiphene Resistant Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial

  2013cites this paper
• Targeting peroxisome proliferator-activated receptor gamma for generation of antidiabetic drug.

  2013cites this paper
• Insulin Resistance, Metabolic Syndrome, and Therapy

  2012cites this paper
• Actualización sobre el manejo de la diabetes

  2012cites this paper
• The Ideal Diabetes Therapy: What Will It Look Like? How Close Are We?

  2012cites this paper
• The Nuts and Bolts of Subcutaneous Insulin Therapy in Non-Critical Care Hospital Settings

  2010cites this paper
• PPAR-γ Agonists and Their Role in Type 2 Diabetes Mellitus Management

  2010influential citation
• Glitazones: Beyond glucose lowering!

  2007cites this paper
• Serum Concentrations of Adiponectin and Serum Amyloid A in Patients with End-Stage Renal Disease and Following Successful Kidney Transplantation

  2006cites this paper
• The effects of rosiglitazone and metformin on menstrual cyclicityand hirsutism in polycystic ovary syndrome

  2005cites this paper
• Novel Approach to Treat Insulin Resistance, Type 2 Diabetes, and the Metabolic Syndrome: Simultaneous Activation of PPARα, PPARγ, and PPARδ

  2005cites this paper
• The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome.

  2005cites this paper
• The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome

  2005cites this paper
• Adiponectin in anorexia nervosa and bulimia nervosa.

  2004cites this paper
• Elevated Plasma Levels of the Atherogenic Mediator Soluble CD40 Ligand in Diabetic Patients: A Novel Target of Thiazolidinediones

  2003cites this paper
• Are the metabolic effects of rosiglitazone influenced by baseline glycaemic control?

  2003cites this paper
• Introduction and summary statements

  2003cites this paper
• Trends in Management of Type 2 Diabetes: Role of Thiazolidinediones

  2003cites this paper
• Potential Utility of Insulin Sensitizers in the Treatment of Patients with Polycystic Ovary Syndrome

  2002cites this paper
• Insulin resistance as the core defect in type 2 diabetes mellitus.

  2002cites this paper
• Peroxisome Proliferator-Activated Receptor Ligands as Antiatherogenic Agents: Panacea or Another Pandora's Box?

  2002cites this paper
• Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone.

  2002cites this paper
• Reappraisal of the pharmacologic approach to treatment of type 2 diabetes mellitus.

  2002cites this paper
• Tratamiento farmacológico para la diabetes mellitus

  2002cites this paper
• Rosiglitazone

  2000cites this paper