Pioglitazone Increases Insulin Sensitivity by Activating Insulin Receptor Kinase

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Diabetes

• Publication date

  1992-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2337/diab.41.4.476PMID 1318856
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Impaired Autophosphorylation of Insulin Receptors From Abdominal Skeletal Muscles in Nonobese Subjects With NIDDM

  1991cited by this paper
• Mutations in Insulin-Receptor Gene in Insulin-Resistant Patients

  1990cited by this paper
• Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals.

  1990cited by this paper
• The Insulin Receptor: A Multifunctional Protein

  1990cited by this paper
• Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats.

  1990cited by this paper
• Effects of pioglitazone on hepatic and peripheral insulin resistance in Wistar fatty rats.

  1990cited by this paper
• Binding specificity and intramolecular signal transmission of uncleaved insulin proreceptor in transformed lymphocytes from a patient with extreme insulin resistance

  1989cited by this paper
• Postreceptor Effects of Sulfonylurea on Skeletal Muscle Glycogen Synthase Activity in Type II Diabetic Patients

  1989cited by this paper
• Mechanism of Defective Insulin-Receptor Kinase Activity in NIDDM: Evidence for Two Receptor Populations

  1989cited by this paper
• Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

  1989cited by this paper
• Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.

  1988cited by this paper
• Alteration of Insulin-Receptor Kinase Activity by High-Fat Feeding

  1988cited by this paper
• Improvement of Glucose Tolerance in NIDDM by Clofibrate Randomized Double-Blind Study

  1988cited by this paper
• The insulin receptor and the molecular mechanism of insulin action.

  1988cited by this paper
• Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

  1988cited by this paper
• Insulin Resistance by Uncleaved Insulin Proreceptor: Emergence of Binding Site by Trypsin

  1988cited by this paper
• Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.

  1988cited by this paper
• Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

  1987cited by this paper
• Effect of chlorpropamide on glucose transport in rat adipocytes in the absence of changes in insulin binding and receptor-associated tyrosine kinase activity.

  1987cited by this paper
• Role of Lipid Oxidation in Pathogenesis of Insulin Resistance of Obesity and Type II Diabetes

  1987cited by this paper
• After insulin binds.

  1987cited by this paper
• Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

  1985cited by this paper
• Phosphorylation of Insulin Receptors Solubilized from Rat Skeletal Muscle

  1984cited by this paper
• A new potentiator of insulin action

  1983cited by this paper
• A New Genetically Obese-Hyperglycemic Rat (Wistar Fatty)

  1981cited by this paper

• Immunoglobulin A-producing cells mediate the clinical benefits of metformin via interleukin-10.

  2026cites this paper
• Loranthus parasiticus extract ameliorates hyperglycemia and improves insulin sensitivity in C57BL/Ksj-db/db mice

  2025cites this paper
• Efficacy and Safety of Pioglitazone Add‐On in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin and Dapagliflozin: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials

  2025cites this paper
• Efficient and Safe Induction of Diabetes in Experimental Animals: A Review on Alternative Models and Techniques

  2024cites this paper
• Systemic Treatment with Pioglitazone Reverses Vision Loss in Preclinical Glaucoma Models

  2022cites this paper
• Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics

  2022cites this paper
• Simultaneous Pharmacokinetics Estimation of Nateglinide and Pioglitazone by RP-HPLC: Computational Study to Unlock the Synergism.

  2019cites this paper
• Chromatographic analysis of phytochemicals in Costus igneus and computational studies of flavonoids

  2018cites this paper
• E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling

  2018cites this paper
• Neurolytic celiac plexus block enhances skeletal muscle insulin signaling and attenuates insulin resistance in GK rats.

  2016cites this paper
• PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice.

  2016cites this paper
• Measurement of Blood Glucose-Lowering and Antidiabetic Activity

  2015cites this paper
• Genetically Diabetic Animals

  2015cites this paper
• Impact of alogliptin and pioglitazone on lipid metabolism in islets of prediabetic and diabetic Zucker Diabetic Fatty rats.

  2015cites this paper
• The beneficial effects of tetracosanol on insulin-resistance by insulin receptor kinase sensibilisation

  2015cites this paper
• Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice

  2015cites this paper
• Jicama (Pachyrhizus erosus) extract increases insulin sensitivity and regulates hepatic glucose in C57BL/Ksj-db/db mice

  2015cites this paper
• Effect of Highbush blueberry consumption on markers of metabolic syndrome : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Nutritional Science at Massey University, Palmerston North, New Zealand

  2014cites this paper
• Genetically Obese Animals

  2014cites this paper
• Safety Pharmacology in Metabolism Pharmacology

  2013cites this paper
• Endocrinology of the Vasculature

  2013cites this paper
• NOVEL POLAROGRAPHIC METHODS FOR DETERMINATION OF PIOGLITAZONE HCL IN PURE FORM AND PHARMACEUTICAL FORMULATIONS

  2013cites this paper
• Pioglitazone

  2012cites this paper
• Dual therapy of rosiglitazone/pioglitazone with glimepiride on diabetic nephropathy in experimentally induced type 2 diabetes rats

  2011cites this paper
• Ishige okamurae ameliorates hyperglycemia and insulin resistance in C57BL/KsJ-db/db mice.

  2011cites this paper
• Childhood Obesity and Blood Pressure Regulation

  2011cites this paper
• Antihyperglycemic effect of aqueous extract of sea buckthorn (hippophae rhamnoides l.) seed residues in streptozotocin-treated and high fat-diet-fed rats

  2010cites this paper
• New therapeutic agents for the treatment of NIDDM.

  2009cites this paper
• Molecular Biology of Insulin Resistance

  2009cites this paper
• Antidiabetic Effect of Korean Traditional Baechu (Chinese Cabbage) Kimchi in a Type 2 Diabetes Model of Rats

  2009cites this paper
• Effects of Dietary Onion (Allium cepa L.) in a High-Fat Diet Streptozotocin-Induced Diabetes Rodent Model

  2008cites this paper
• A Validated Adsorptive Stripping Voltammetric Determination of Antidiabetic Agent Pioglitazone HCl in Tablets and Biological Fluids

  2008cites this paper
• Comparison of the Effects of Pioglitazone and Metformin on Hepatic and Extra-Hepatic Insulin Action in People With Type 2 Diabetes

  2008cites this paper
• Chinese cabbage (Brassica campestris L.) does not improve glucose tolerance, serum insulin, or blood lipid profiles in a rat model of type-2 diabetes.

  2008cites this paper
• The anti-diabetic effects of ethanol extract from two variants of Artemisia princeps Pampanini in C57BL/KsJ-db/db mice.

  2007cites this paper
• Multiple hypotheses for chromium(III) biochemistry: Why the essentiality of chromium(III) is still questioned

  2007cites this paper
• Pioglitazone ameliorates endothelial dysfunction in obese rats with nephropathy.

  2007cites this paper
• Thiazolidinediones Exert Different Effects on Resistance between Dexamethasone-Treated and Wistar Fatty Rats Insulin Rats

  2006cites this paper
• Regulators for blood glucose level affect gene expression of aquaporin 3.

  2006cites this paper
• Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line.

  2006cites this paper
• Pioglitazone but Not Glibenclamide Improves Cardiac Expression of Heat Shock Protein 72 and Tolerance Against Ischemia/Reperfusion Injury in the Heredity Insulin-Resistant Rat

  2006cites this paper
• Tumor necrosis factor-α-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line

  2006cites this paper
• Reduction of Risk Factors for Cardiovascular Complications by BM 17.0744

  2006cites this paper
• Pioglitazone Mimics Preconditioning in the Isolated Perfused Rat Heart: A Role for the Prosurvival Kinases PI3K and P42/44MAPK

  2005cites this paper
• Postprandial lipaemia in type 2 diabetes : relationship to insulin sensitivity

  2004cites this paper
• Reversed-phase HPLC methods for purity test and assay of pioglitazone hydrochloride in tablets.

  2004cites this paper
• Pediatric Hypertension

  2004cites this paper
• Simultaneous determination of pioglitazone and its two active metabolites in human plasma by LC-MS/MS.

  2003cites this paper
• Development of insulin resistance and reversal by thiazolidinediones in C2C12 skeletal muscle cells.

  2003cites this paper
• The Effects of K-111, a New Insulin-sensitizer, on Metabolic Syndrome in Obese Prediabetic Rhesus Monkeys

  2003cites this paper
• The effects of K-111, a new insulin-sensitizer, on metabolic syndrome in obese prediabetic rhesus monkeys.

  2003cites this paper
• Clinical effect of combination therapy of pioglitazone and an α-glucosidase inhibitor

  2003cites this paper
• Clinical evaluation of pioglitazone in patients with type 2 diabetes using α‐glucosidase inhibitor and examination of its efficacy profile

  2003cites this paper
• Tratamento medicamentoso oral da hiperglicemia no diabete melito tipo 2

  2003cites this paper
• Antidiabetic activity 1

  2002cites this paper
• Metabolic Efficacy and Safety of Once-Daily Pioglitazone Monotherapy in Patients with Type 2 Diabetes: A Double-Blind, Placebo-Controlled Study

  2002cites this paper
• Effects Of Combined Pioglitazone And Metformin On Diabetes And Obesity In Wistar Fatty Rats

  2002cites this paper
• Improvement of Aortic Wall Distensibility and Reduction of Oxidative Stress by Pioglitazone in Pre-diabetic Stage of Otsuka Long-Evans Tokushima Fatty Rats

  2002cites this paper
• [Discovery and development of a new insulin sensitizing agent, pioglitazone].

  2002cites this paper
• Anti-obesity activity1

  2002cites this paper
• Thiazolidinediones

  2002cites this paper
• Thiazolidinedione Derivatives as Novel Therapeutic Agents to Prevent the Development of Chronic Pancreatitis

  2002cites this paper
• Anti-obesity activity 1

  2002cites this paper
• New trends in the development of oral antidiabetic drugs.

  2002cites this paper
• Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study.

  2001cites this paper
• Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma.

  2001cites this paper
• Pioglitazone Improves Left Ventricular Diastolic Function and Decreases Collagen Accumulation in Prediabetic Stage of a Type II Diabetic Rat

  2001cites this paper
• [Insulin resistance-reducing effect of a new thiazolidinedione derivative, pioglitazone].

  2001cites this paper
• Pioglitazone Ameliorates Tumor Necrosis Factor-α–Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator–Activated Receptor-γ

  2001cites this paper
• Isolation of Antidiabetic Components from White-Skinned Sweet Potato (Ipomoea batatas L.)

  2001cites this paper
• Insulin‐sensitizing action of rosiglitazone is enhanced by preventing hyperphagia

  2001cites this paper
• Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats.

  2001cites this paper
• The Use of Explant Lens Culture to Assess Cataractogenic Potential

  2000cites this paper
• Thiazolidinediones exert different effects on insulin resistance between dexamethasone-treated rats and wistar fatty rats.

  2000cites this paper
• Troglitazone and related compounds: therapeutic potential beyond diabetes.

  2000cites this paper
• JTT-501, a new oral hypoglycemic agent, reverses hypertriglyceridemia in Zucker fatty and ventromedial hypothalamus-lesioned obese rats.

  2000cites this paper
• Insulin is the essential factor maintaining the constitutive expression of hepatic sterol 14-demethylase P450 (CYP51).

  2000cites this paper
• Antidiabetic activity of white skinned sweet potato (Ipomoea batatas L.) in obese Zucker fatty rats.

  2000cites this paper
• Effect of Troglitazone on Exocrine Pancreas in Rats with Streptozotocin-Induced Diabetes Mellitus

  2000cites this paper
• Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.

  1999cites this paper
• Current Views on the Mechanism of Action of Thiazolidinedione Insulin Sensitizers

  1999cites this paper
• Thiazolidinediones: a new class of antidiabetic drugs

  1999cites this paper
• Elimination of hyperinsulinemia after pancreas transplantation in rats.

  1999cites this paper
• [Insulin resistance: therapeutic approaches].

  1999cites this paper
• Imidapril, an angiotensin-converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat.

  1999cites this paper
• Differential Effects of Palmitate on Glucose Uptake in Rat-1 Fibroblasts and 3T3-L1 Adipocytes

  1999cites this paper
• Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity.

  1999cites this paper
• A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle

  1999cites this paper
• Complementary measures for promoting insulin sensitivity in skeletal muscle.

  1998cites this paper
• Effects of troglitazone and pioglitazone on the action potentials and membrane currents of rabbit ventricular myocytes.

  1998cites this paper
• Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet

  1998cites this paper
• PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes.

  1998cites this paper
• Pioglitazone enhances splanchnic glucose uptake as well as peripheral glucose uptake in non-insulin-dependent diabetes mellitus. AD-4833 Clamp-OGL Study Group.

  1998cites this paper
• Effects of troglitazone on dexamethasone-induced insulin resistance in rats.

  1998cites this paper
• JTT‐501, a novel oral antidiabetic agent, improves insulin resistance in genetic and non‐genetic insulin‐resistant models

  1998cites this paper
• The new antidiabetic drug MCC-555 acutely sensitizes insulin signaling in isolated cardiomyocytes.

  1998cites this paper
• Insulin action on protein phosphatase-1 activation is enhanced by the antidiabetic agent pioglitazone in cultured diabetic hepatocytes

  1998cites this paper
• Effects of troglitazone on hepatic and peripheral insulin resistance induced by growth hormone excess in rats.

  1998cites this paper
• Implications of the hyperinsulinaemia-diabetes-cancer link for preventive efforts.

  1998cites this paper
• Acute effects of pioglitazone on glucose metabolism in perfused rat liver

  1997cites this paper