Prion glycoprotein: structure, dynamics, and roles for the sugars.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Biochemistry

• Publication date

  2001-03-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI002625FPMID 11300755
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Microglia is a component of the prion protein amyloid plaque in the Gerstmann-Sträussler-Scheinker syndrome

  2004cited by this paper
• Intracellular transport of GPI‐anchored proteins

  2000cited by this paper
• Molecular dynamics simulation of human prion protein including both N-linked oligosaccharides and the GPI anchor.

  2000cited by this paper
• Impaired prion replication in spleens of mice lacking functional follicular dendritic cells.

  2000cited by this paper
• A yeast prion provides a mechanism for genetic variation and phenotypic diversity

  2000cited by this paper
• Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt-Jakob disease.

  1999cited by this paper
• Solution structure of Syrian hamster prion protein rPrP(90-231).

  1999cited by this paper
• A statistical analysis of N- and O-glycan linkage conformations from crystallographic data.

  1999cited by this paper
• Oligosaccharide analysis and molecular modeling of soluble forms of glycoproteins belonging to the Ly-6, scavenger receptor, and immunoglobulin superfamilies expressed in Chinese hamster ovary cells.

  1999cited by this paper
• Glycoproteins: glycan presentation and protein-fold stability.

  1999cited by this paper
• Glycosylation differences between the normal and pathogenic prion protein isoforms.

  1999cited by this paper
• Functionally different GPI proteins are organized in different domains on the neuronal surface

  1999cited by this paper
• Copper binding to the prion protein: structural implications of four identical cooperative binding sites.

  1999cited by this paper
• The acute inflammatory response in CNS following injection of prion brain homogenate or normal brain homogenate

  1999cited by this paper
• Prion Protein Glycosylation Is Sensitive to Redox Change*

  1999cited by this paper
• Site-specific characterization of the N-linked glycans of murine prion protein by high-performance liquid chromatography/electrospray mass spectrometry and exoglycosidase digestions.

  1999cited by this paper
• Ultrastructural studies on scrapie prion protein crystals obtained from reverse micellar solutions.

  1999cited by this paper
• Identification of Lectin‐Purified Neural Glycoproteins, GPs 180, 116, and 110, with NMDA and AMPA Receptor Subunits: Conservation of Glycosylation at the Synapse

  1998cited by this paper
• The amino acid following an asn-X-Ser/Thr sequon is an important determinant of N-linked core glycosylation efficiency.

  1998cited by this paper
• Structure and Origin of Ordered Lipid Domains in Biological Membranes

  1998cited by this paper
• Pathologic conformations of prion proteins.

  1998cited by this paper
• Neutral N-glycans in adult rat brain tissue--complete characterisation reveals fucosylated hybrid and complex structures.

  1998cited by this paper
• Sialylated N-glycans in adult rat brain tissue--a widespread distribution of disialylated antennae in complex and hybrid structures.

  1998cited by this paper
• Blockade of Glycosylation Promotes Acquistion of Scrapie-like Properties by the Prion Protein in Cultured Cells*

  1997cited by this paper
• Selective neuronal targeting in prion disease.

  1997cited by this paper
• Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.

  1997cited by this paper
• COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform.

  1997cited by this paper
• Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains.

  1996cited by this paper
• NMR structure of the mouse prion protein domain PrP(121–231)

  1996cited by this paper
• Altered circadian activity rhythms and sleep in mice devoid of prion protein

  1996cited by this paper
• Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

  1996cited by this paper
• The Amino Acid at the X Position of an Asn-X-Ser Sequon Is an Important Determinant of N-Linked Core-glycosylation Efficiency (*)

  1996cited by this paper
• Evidence for an early inflammatory response in the central nervous system of mice with scrapie.

  1996cited by this paper
• Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

  1996cited by this paper
• Molecular basis of phenotypic variability in sporadc creudeldt‐jakob disease

  1996cited by this paper
• Stereochemistry of the N-glycosylation sites in glycoproteins.

  1995cited by this paper
• Inflammation in the nervous system.

  1995cited by this paper
• Structures of the Glycosyl-phosphatidylinositol Anchors of Porcine and Human Renal Membrane Dipeptidase

  1995cited by this paper
• Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy

  1994cited by this paper
• Prion protein is necessary for normal synaptic function

  1994cited by this paper
• Relationship of microglia and scrapie amyloid-immunoreactive plaques in kuru, Creutzfeldt-Jakob disease and Gerstmann-Sträußler syndrome

  1994cited by this paper
• Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

  1993cited by this paper
• Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

  1992cited by this paper
• Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

  1992cited by this paper
• Glycosylinositol phospholipid anchors of the scrapie and cellular prion proteins contain sialic acid.

  1992cited by this paper
• Molecular basis of the enhanced susceptibility of the erythrocytes of paroxysmal nocturnal hemoglobinuria to hemolysis in acidified serum.

  1991cited by this paper
• Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.

  1990cited by this paper
• Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein.

  1989cited by this paper
• Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein

  1988cited by this paper
• Biogenesis and Transmembrane Orientation of the Cellular Isoform of the Scrapie Prion Protein

  1987cited by this paper
• Tissue‐specific N‐glycosylation, site‐specific oligosaccharide patterns and lentil lectin recognition of rat Thy‐1.

  1987cited by this paper
• Evidence for a secretory form of the cellular prion protein.

  1987cited by this paper
• Scrapie prion protein contains a phosphatidylinositol glycolipid.

  1987cited by this paper
• Novel proteinaceous infectious particles cause scrapie.

  1982cited by this paper

• Structure and Dynamics of the Misfolding Intermediate in the Pathogenic T183A Prion Protein Mutant

  2025cites this paper
• Partial Deletion of the Carboxyl‐Terminal Signal Sequence of the Cellular Prion Protein Alters Protein Expression via Endoplasmic Reticulum–Associated Degradation

  2025cites this paper
• What is the role of lipids in prion conversion and disease?

  2023cites this paper
• Chronic Wasting Disease (CWD) in Cervids and the Consequences of a Mutable Protein Conformation

  2022cites this paper
• Proteins

  2022cites this paper
• Site-specific analysis of N-glycans from different sheep prion strains

  2021cites this paper
• Short and sweet: How glycans impact prion conversion, cofactor interactions, and cross-species transmission

  2021cites this paper
• Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease.

  2020cites this paper
• Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation

  2020cites this paper
• Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease.

  2020cites this paper
• Prebiotic Peptides: Molecular Hubs in the Origin of Life.

  2020cites this paper
• Modeling PrPSc Generation Through Deformed Templating

  2020cites this paper
• Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination

  2020cites this paper
• Neurodegenerative Disorders

  2019cites this paper
• A PRNP -Disrupted Human Neuroblastoma Cell Line and Its Stable Transformants Expressing Prion Protein Variants

  2019cites this paper
• Inflammatory mediators reduce surface PrPc on human BMVEC resulting in decreased barrier integrity

  2018cites this paper
• Glycosylation Significantly Inhibits the Aggregation of Human Prion Protein and Decreases Its Cytotoxicity

  2018cites this paper
• Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures.

  2018cites this paper
• In silico investigation of the prion protein glycosylation profiles in relation to scrapie disease resistance in domestic sheep (Ovis aries).

  2018cites this paper
• Role of Prion protein in premature senescence of human fibroblasts.

  2017cites this paper
• Synthesis of homogeneous N-glycosylated- and GPI-anchored peptides for semi-synthesis of the prion protein

  2017influential citation
• Prions: Beyond a Single Protein DE NOVO GENERATION OF PRIONS WITH RECOMBINANT PRION PROTEIN

  2016cites this paper
• Selective Inhibition of Aggregation and Toxicity of a Tau-Derived Peptide using Its Glycosylated Analogues.

  2016cites this paper
• Prions: Beyond a Single Protein

  2016cites this paper
• Trafic de la protéine prion dans les cellules MDCK polarisées

  2015cites this paper
• Insoluble Proteins

  2015cites this paper
• Recombinant glycoprotein production in human cell lines.

  2015cites this paper
• Protein Misfolding, Aggregation and Diseases

  2015cites this paper
• Modelling human prion replication in cell-free systems

  2014cites this paper
• In vitro amplification of scrapie and chronic wasting disease PrPres using baculovirus-expressed recombinant PrP as substrate

  2014cites this paper
• Modeling the Cell Biology of Prions

  2013cites this paper
• Production of recombinant therapeutic proteins in human cells: current achievements and future perspectives.

  2013cites this paper
• Prions and Diseases

  2013cites this paper
• Prions and Diseases

  2013cites this paper
• Role of Protein Aggregation in Neurodegenerative Diseases

  2013influential citation
• Acquisition of Drug Resistance and Dependence by Prions

  2013cites this paper
• The Role of Crowded Physiological Environments in Prion and Prion-like Protein Aggregation

  2013cites this paper
• Propagation of RML Prions in Mice Expressing PrP Devoid of GPI Anchor Leads to Formation of a Novel, Stable Prion Strain

  2012cites this paper
• Du rôle du cuivre et de la protéine Prion dans le vieillissement cellulaire

  2012cites this paper
• The role of RNA in mammalian prion protein conversion

  2012cites this paper
• Allosteric function and dysfunction of the prion protein

  2011cites this paper
• Part I: Investigation of mechanism(s) of Cu(II) and Zn(II) neurotoxicity Part II: Pre-steady state kinetics of the reduction of cytochrome b561 with ascorbate

  2011cites this paper
• Prion Protein Misfolding at the Synapse

  2011cites this paper
• Fate of prions in soil: a review.

  2011cites this paper
• Probing structural differences between PrP(C) and PrP(Sc) by surface nitration and acetylation: evidence of conformational change in the C-terminus.

  2011cites this paper
• Normal modes of prion proteins: from native to infectious particle.

  2011cites this paper
• Prion Protein Expression and Functional Importance in Skeletal Muscle

  2011cites this paper
• Sialylated and O‐glycosidically linked glycans in prion protein deposits in a case of Gerstmann‐Sträussler‐Scheinker disease

  2011cites this paper
• Abrogation of Complex Glycosylation by Swainsonine Results in Strain- and Cell-specific Inhibition of Prion Replication*

  2011cites this paper
• Toll-like Receptors (TLRs) And Prion Disease: Relevance To Pathology And Novel Therapy

  2011cites this paper
• Glycosylation of PrPC Determines Timing of Neuroinvasion and Targeting in the Brain following Transmissible Spongiform Encephalopathy Infection by a Peripheral Route

  2010cites this paper
• PrP interactions with nucleic acids and glycosaminoglycans in function and disease.

  2010cites this paper
• Establishment of a stable PrP(Sc) panel from brain tissues of experimental hamsters with scrapie strain 263K.

  2009cites this paper
• Glycosylation-related genes are variably expressed depending on the differentiation state of a bioaminergic neuronal cell line: implication for the cellular prion protein

  2009cites this paper
• Species and Strain Glycosylation Patterns of PrPSc

  2009cites this paper
• Prion Protein Glycosylation Is Not Required for Strain-Specific Neurotropism

  2009cites this paper
• Glycosylation-related gene expression profiling in the brain and spleen of scrapie-affected mouse.

  2009cites this paper
• Prion Protein Misfolding

  2009cites this paper
• Thoughts on mammalian prion strains.

  2009cites this paper
• Avaliação da expressão de PrP c na interação neurônio-glia, em astrócitos e os mecanismos de secreção de STI1

  2009cites this paper
• Effects of Differential Glycosylation of Glycodelins on Lymphocyte Survival*

  2009cites this paper
• Prion Protein Glycosylation Is Not Required for Strain-Specific Neurotropism (cid:1) †

  2009cites this paper
• STRUCTURE-FUNCTION ANALYSIS OF THE ANTI-BAX FUNCTION OF THE PRION PROTEIN

  2008influential citation
• Host PrP Glycosylation: A Major Factor Determining the Outcome of Prion Infection

  2008cites this paper
• New Insight into the Species Barrier of Mammalian Prions Obtained from Structure-Based Conservation Analysis

  2008cites this paper
• Normal cellular prion protein with a methionine at position 129 has a more exposed helix 1 and is more prone to aggregate.

  2008cites this paper
• Glycobiology and Immunology

  2008cites this paper
• Human Prion Diseases

  2008cites this paper
• Efficient Synthesis of Methanesulphonate-Derived Lipid Chains for Attachment of Proteins to Lipid Membranes

  2008influential citation
• Prion diseases: a riddle wrapped in a mystery inside an enigma.

  2008cites this paper
• Altered prion protein glycosylation in the aging mouse brain

  2007cites this paper
• Prion-infection and cellular signaling : influence of scrapie-infection on lipid raft-associated proteins.

  2007cites this paper
• Mammalian Prion Protein

  2007cites this paper
• Interaction of the cellular prion protein with raft-like lipid membranes

  2007cites this paper
• Comparative analysis of the prion protein (PrP) gene in cetacean species.

  2007cites this paper
• Calnexin, calreticulin, and ERp57

  2007cites this paper
• Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death.

  2007cites this paper
• A Structural Overview of the Vertebrate Prion Proteins

  2007cites this paper
• Prion protein and the red cell

  2007cites this paper
• Glycan chains modulate prion protein binding to immobilized metal ions.

  2007cites this paper
• Prion strain discrimination in cell culture: The cell panel assay

  2007cites this paper
• Refinement of under-determined loops of human prion protein by database-derived distance constraints

  2007cites this paper
• Section: Neurotoxicology Normal Cellular Prion Protein Protects against Manganese-induced Oxidative Stress and Apoptotic Cell Death

  2007cites this paper
• L’interface neuro-immune et l’expression de la protéine prion cellulaire dans le cadre des maldies à prions. Une étude comparative des espèces bovine et humaine.

  2007cites this paper
• Exposure of sheep scrapie brain homogenate to rumen‐simulating conditions does not result in a reduction of PrPSc levels

  2007cites this paper
• Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation

  2007cites this paper
• SNAREs, 14-3-3 proteins and cholesterol dependent membrane domains

  2007cites this paper
• N-linked oligosaccharides as outfitters for glycoprotein folding, form and function.

  2006cites this paper
• Fisiopatología de las enfermedades por priones

  2006cites this paper
• Synthesis and structural characterization of a mimetic membrane‐anchored prion protein

  2006cites this paper
• Changing images of the gene.

  2006cites this paper
• Protease Domain Glycans Affect Oligomerization, Disulfide Bond Formation, and Stability of the Meprin A Metalloprotease Homo-oligomer*

  2006cites this paper
• N-Acetylglucosamine Kinase is Localized to Dendritic Lipid Rafts and Caveolae of Rat Hippocampal Neurons

  2006cites this paper
• Anterograde axonal transport of the exogenous cellular isoform of prion protein in the chick visual system.

  2006cites this paper
• Detection, quantification, and glycotyping of prion protein in specifically activated enzyme-linked immunosorbent assay plates.

  2006cites this paper
• The stoichiometry of host PrPC glycoforms modulates the efficiency of PrPSc formation in vitro.

  2006cites this paper
• Comparative analysis of the prion protein gene sequences in African lion

  2006cites this paper
• Isolation and characterization of full-length recombinant cattle PrPC protein

  2006cites this paper
• Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity.

  2006cites this paper
• Synthese und Charakterisierung von peptidischen Liganden des zellulären, humanen Prionproteins : Inhibition der Aggregation des Prionproteins

  2006cites this paper