The role of protein kinases in adaptational growth of the heart.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  International Journal of Biochemistry and Cell Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/1357-2725(95)00142-5PMID 8624839
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracellular signalling through protein kinases in the heart.

  1995cited by this paper
• M1Muscarinic Receptors Heterologously Expressed in Cardiac Myocytes Mediate Ras-dependent Changes in Gene Expression (*)

  1995cited by this paper
• Protein kinase C isoform diversity in the heart.

  1995cited by this paper
• Ras recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation.

  1995cited by this paper
• Role of p70 S6 Protein Kinase in Angiotensin II-induced Protein Synthesis in Vascular Smooth Muscle Cells (*)

  1995cited by this paper
• M-CAT, CArG, and Sp1 elements are required for alpha 1-adrenergic induction of the skeletal alpha-actin promoter during cardiac myocyte hypertrophy. Transcriptional enhancer factor-1 and protein kinase C as conserved transducers of the fetal program in cardiac growth.

  1995cited by this paper
• Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling.

  1995cited by this paper
• Angiotensin-converting enzyme inhibition and ventricular remodeling after myocardial infarction.

  1995cited by this paper
• Gβγ interactions with PH domains and Ras-MAPK signaling pathways

  1995cited by this paper
• Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes.

  1995cited by this paper
• Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.

  1995cited by this paper
• Hypertrophic Agonists Stimulate the Activities of the Protein Kinases c-Raf and A-Raf in Cultured Ventricular Myocytes (*)

  1995cited by this paper
• Expression of protein kinase C isoforms during cardiac ventricular development.

  1995cited by this paper
• Regulation of Ras-mediated signalling: more than one way to skin a cat.

  1995cited by this paper
• Protein kinase C in the transduction of signals toward and within the cell nucleus.

  1995cited by this paper
• Localization of protein kinases by anchoring proteins: a theme in signal transduction.

  1995cited by this paper
• Nuclear signaling by endothelin-1. A Ras pathway for activation of the c-fos serum response element

  1995cited by this paper
• G beta gamma interactions with PH domains and Ras-MAPK signaling pathways.

  1995cited by this paper
• Angiotensin II and Other Hypertrophic Stimuli Mediated by G Protein–Coupled Receptors Activate Tyrosine Kinase, Mitogen-Activated Protein Kinase, and 90-kD S6 Kinase in Cardiac Myocytes The Critical Role of Ca2+-Dependent Signaling

  1995cited by this paper
• Protein kinase C and lipid signaling for sustained cellular responses

  1995cited by this paper
• Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.

  1994cited by this paper
• Regulating 56 kinase

  1994cited by this paper
• Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.

  1994cited by this paper
• Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro.

  1994cited by this paper
• Protein kinase C isoform expression and regulation in the developing rat heart.

  1994cited by this paper
• Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

  1994cited by this paper
• Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.

  1994cited by this paper
• Classical, novel and atypical isoforms of PKC stimulate ANF‐ and TRE/AP‐1‐regulated‐promoter activity in ventricular cardiomyocytes

  1994cited by this paper
• MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.

  1994cited by this paper
• Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.

  1994cited by this paper
• PHAS-I as a link between mitogen-activated protein kinase and translation initiation.

  1994cited by this paper
• Signal transduction. Regulating S6 kinase.

  1994cited by this paper
• Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

  1994cited by this paper
• Ternary complex factors: growth factor regulated transcriptional activators.

  1994cited by this paper
• Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy.

  1994cited by this paper
• Enhanced phosphorylation of the C‐terminal domain of RNA polymerase II upon serum stimulation of quiescent cells: possible involvement of MAP kinases.

  1994cited by this paper
• Receptor protein-tyrosine kinases and their signal transduction pathways.

  1994cited by this paper
• Characterization of stimulation of phosphoinositide hydrolysis by alpha 1-adrenergic agonists in adult rat hearts.

  1994cited by this paper
• Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes.

  1994cited by this paper
• The ins and outs of Raf kinases.

  1994cited by this paper
• In situ determination of [Ca2+]i threshold for translocation of the alpha-protein kinase C isoform.

  1994cited by this paper
• Localization of protein kinase C isozymes in cardiac myocytes.

  1994cited by this paper
• Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression.

  1994cited by this paper
• Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy

  1994cited by this paper
• Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts.

  1994cited by this paper
• Ras activity is required for phenylephrine-induced activation of mitogen-activated protein kinase in cardiac muscle cells.

  1994cited by this paper
• Raf meets Ras: completing the framework of a signal transduction pathway.

  1994cited by this paper
• The tyrosine kinase inhibitor, genistein, prevents alpha-adrenergic-induced cardiac muscle cell hypertrophy by inhibiting activation of the Ras-MAP kinase signaling pathway.

  1994cited by this paper
• Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

  1993cited by this paper
• Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.

  1993cited by this paper
• Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

  1993cited by this paper
• Cardiac alpha 1-adrenoceptors: an overview.

  1993cited by this paper
• The mitogen-activated protein kinase signal transduction pathway.

  1993cited by this paper
• Endothelin‐1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes

  1993cited by this paper
• Protein kinase Cα activates RAF-1 by direct phosphorylation

  1993cited by this paper
• Transcriptional regulation during cardiac growth and development.

  1993cited by this paper
• The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain.

  1993cited by this paper
• Reconstitution of the Raf-1—MEK—ERK Signal Transduction Pathway In Vitro

  1993cited by this paper
• Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin.

  1993cited by this paper
• Signal transduction via the MAP kinases: proceed at your own RSK.

  1993cited by this paper
• Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase.

  1993cited by this paper
• HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

  1993cited by this paper
• Protein kinase C alpha activates RAF-1 by direct phosphorylation.

  1993cited by this paper
• Insulinlike Growth Factor‐I Induces Hypertrophy With Enhanced Expression of Muscle Specific Genes in Cultured Rat Cardiomyocytes

  1993cited by this paper
• A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity

  1993cited by this paper
• Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.

  1993cited by this paper
• Protein kinase C alpha, delta, epsilon and zeta in C6 glioma cells. TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC zeta.

  1993cited by this paper
• Effect of phorbol esters on protein kinase C-zeta.

  1992cited by this paper
• The serum response element.

  1992cited by this paper
• Signal transduction within the nucleus by mitogen-activated protein kinase.

  1992cited by this paper
• Signal transduction from cell surface to nucleus in development and disease

  1992cited by this paper
• Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs.

  1992cited by this paper
• An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.

  1992cited by this paper
• Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase.

  1992cited by this paper
• The MARCKS brothers: a family of protein kinase C substrates.

  1992cited by this paper
• Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.

  1992cited by this paper
• A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.

  1992cited by this paper
• Translocation of protein kinase C isozymes in thrombin-stimulated human platelets. Correlation with 1,2-diacylglycerol levels.

  1992cited by this paper
• Domain interactions in protein kinase C.

  1991cited by this paper
• Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

  1991cited by this paper
• Growth factors, proto-oncogenes, and plasticity of the cardiac phenotype.

  1991cited by this paper
• Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

  1991cited by this paper
• ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.

  1991cited by this paper
• Domain interactions in protein kinase C.

  1991cited by this paper
• Sympathetic activity: modulator of myocardial hypertrophy.

  1991cited by this paper
• Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene.

  1991cited by this paper
• Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

  1983cited by this paper
• Chloride impermeability in cystic fibrosis

  1983cited by this paper

• Regulatory role of some protein kinases in signal transduction pathways in heart health and disease

  2023cites this paper
• Involvement of protein kinases associated signal transduction mechanisms in cardiac diseases

  2023cites this paper
• Harnessing RKIP to Combat Heart Disease and Cancer

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• mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification.

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• The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

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• Key role of ERK1/2 molecular scaffolds in heart pathology

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• Review Article New frontiers in heart hypertrophy during pregnancy

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• New frontiers in heart hypertrophy during pregnancy.

  2012cites this paper
• Nicorandil Prevents Gαq-Induced Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice

  2012cites this paper
• β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway.

  2012cites this paper
• Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure.

  2011cites this paper
• Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes.

  2011cites this paper
• Protein Kinases as Drug Development Targets for Heart Disease Therapy

  2010cites this paper
• PKA, Rap1, ERK1/2, and p90RSK mediate PGE2 and EP4 signaling in neonatal ventricular myocytes.

  2010cites this paper
• Transient upregulation of protein kinase C in pressure-overloaded neonatal rat myocardium.

  2010cites this paper
• Evidence of altered guinea pig ventricular cardiomyocyte protein expression and growth in response to a 5 min in vitro exposure to H(2)O(2).

  2010cites this paper
• Alterations of Cardiac ERK1/2 Expression and Activity Due to Volume Overload Were Attenuated by the Blockade of RAS

  2010cites this paper
• Opposing Actions of Extracellular Signal-regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy*

  2010cites this paper
• PKA , Rap 1 , ERK 1 / 2 , and p 90 RSK mediate PGE 2 and EP 4 signaling in neonatal ventricular myocytes

  2009cites this paper
• Phosphorylation of Williams Syndrome Transcription Factor by MAPK Induces a Switching between Two Distinct Chromatin Remodeling Complexes*

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• A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy

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• Implication of G-proteins in Cardiovascular Disease

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• Site specific differential activation of ras/raf/ERK signaling in rabbit isoproterenol-induced left ventricular hypertrophy.

  2006cites this paper
• Inhibition of cross-bridge formation has no effect on contraction-associated phosphorylation of p38 MAPK in mouse skeletal muscle.

  2005cites this paper
• Ins(1,4,5)P3 receptors and inositol phosphates in the heart-evolutionary artefacts or active signal transducers?

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• Propranolol prevents enhanced stress signaling in Gsα cardiomyopathy: potential mechanism for β-blockade in heart failure

  2004cites this paper
• Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.

  2004cites this paper
• Protein kinase C--induced hypertrophy of neonatal rat ventricular myocytes

  2004cites this paper
• Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes.

  2004cites this paper
• Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy

  2004cites this paper
• Characterization of a new human isoform of the enigma homolog family specifically expressed in skeletal muscle.

  2004cites this paper
• PI 3-kinase-Akt-p70 S6 kinase in hypertrophic responses to leukemia inhibitory factor in cardiac myocytes.

  2003cites this paper
• UTP but not ATP causes hypertrophic growth in neonatal rat cardiomyocytes.

  2003cites this paper
• Role of mitogen-activated protein kinase in cardiac hypertrophy and heart failure.

  2003cites this paper
• Role of USF1 phosphorylation on cardiac alpha-myosin heavy chain promoter activity.

  2002cites this paper
• Role of USF1 phosphorylation on cardiac α-myosin heavy chain promoter activity

  2002cites this paper
• Inositol Polyphosphate 1-Phosphatase Is a Novel Antihypertrophic Factor*

  2002cites this paper
• Adenoviral-Directed Expression of the Type 1A Angiotensin Receptor Promotes Cardiomyocyte Hypertrophy via Transactivation of the Epidermal Growth Factor Receptor

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• Mitogen-activated protein kinases in the heart

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• Regulation of developmental hypertrophy in mouse heart

  2001cites this paper
• Hypertensive End-Organ Damage and Premature Mortality Are p38 Mitogen-Activated Protein Kinase–Dependent in a Rat Model of Cardiac Hypertrophy and Dysfunction

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• Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes.

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  2000cites this paper
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  2000cites this paper
• PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits.

  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
• Collagen type VIII

  1998cites this paper
• Contractile activity is required for sarcomeric assembly in phenylephrine-induced cardiac myocyte hypertrophy

  1998cites this paper
• Regulation of Protein Synthesis in Ventricular Myocytes by Vasopressin

  1998cites this paper
• Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.

  1998cites this paper
• Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart.

  1998cites this paper
• Contractile activity is required for sarcomeric assembly in phenylephrine-induced cardiac myocyte hypertrophy.

  1998cites this paper
• Expression of second messenger‐ and cyclin‐ dependent protein kinases during postnatal development of rat heart

  1998cites this paper
• (cid:98) 1 Integrins Participate in the Hypertrophic Response of Rat Ventricular Myocytes

  1998cites this paper
• Effect of inhibitors of signal transduction on IGF‐1‐induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes

  1998cites this paper
• Phenylephrine, endothelin, prostaglandin F2alpha' and leukemia inhibitory factor induce different cardiac hypertrophy phenotypes in vitro.

  1998cites this paper
• Phenylephrine, endothelin, prostaglandin F2α, and leukemia inhibitory factor induce different cardiac hypertrophy phenotypes in vitro, and leukemia inhibitory factor induce different cardiac hypertrophy phenotypes in vitro

  1998cites this paper
• The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure.

  1998cites this paper
• A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.

  1998cites this paper
• The Raf-MEK-ERK Cascade Represents a Common Pathway for Alteration of Intracellular Calcium by Ras and Protein Kinase C in Cardiac Myocytes*

  1998cites this paper
• Effect of a dominant negative ras on myocardial hypertrophy by using adenoviral-mediated gene transfer.

  1997cites this paper
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  1997cites this paper
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  1997cites this paper
• Mechanical stress-cell function relationships in renal cells.

  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1996cites this paper
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  1996cites this paper