Neuroprotective strategies for NMDAR-mediated excitotoxicity in Huntington’s Disease

No abstract is available for this paper.

• Publication year

  2016

• Venue

  bioRxiv

• Publication date

  2016-09-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11515-016-1425-z
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

  2016cited by this paper
• Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects.

  2015influential reference
• Aberrant palmitoylation in Huntington disease.

  2015cited by this paper
• Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.

  2015cited by this paper
• Excitotoxicity and stroke: identifying novel targets for neuroprotection.

  2014cited by this paper
• Stroke in 2013: Disappointments and advances in acute stroke intervention

  2014cited by this paper
• Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation

  2014cited by this paper
• Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice.

  2014influential reference
• Extrasynaptic NMDA receptor involvement in central nervous system disorders.

  2014cited by this paper
• Alterations in STriatal‐Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model

  2014cited by this paper
• Critical Role of Increased PTEN Nuclear Translocation in Excitotoxic and Ischemic Neuronal Injuries

  2013cited by this paper
• Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.

  2013cited by this paper
• Distinct Roles for μ-Calpain and m-Calpain in Synaptic NMDAR-Mediated Neuroprotection and Extrasynaptic NMDAR-Mediated Neurodegeneration

  2013cited by this paper
• Activation of extrasynaptic NMDA receptors induces LTD in rat hippocampal CA1 neurons.

  2013cited by this paper
• Cardiac Dysautonomia in Huntington's Disease

  2013cited by this paper
• Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N-methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity*

  2013cited by this paper
• Triheteromeric NMDA Receptors at Hippocampal Synapses

  2013cited by this paper
• The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

  2012cited by this paper
• Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.

  2012cited by this paper
• Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.

  2012influential reference
• A Translational Paradigm for the Preclinical Evaluation of the Stroke Neuroprotectant Tat-NR2B9c in Gyrencephalic Nonhuman Primates

  2012cited by this paper
• Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

  2012cited by this paper
• Donepezil and memantine for moderate-to-severe Alzheimer's disease.

  2012cited by this paper
• Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

  2012influential reference
• Synaptic NMDA Receptors Mediate Hypoxic Excitotoxic Death

  2012cited by this paper
• Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases.

  2012cited by this paper
• Selective Regulation of NR2B by Protein Phosphatase-1 for the Control of the NMDA Receptor in Neuroprotection

  2012cited by this paper
• Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice.

  2012cited by this paper
• Palmitoylation at Two Cysteine Clusters on the C-Terminus of GluN2A and GluN2B Differentially Control Synaptic Targeting of NMDA Receptors

  2012cited by this paper
• Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial.

  2012cited by this paper
• Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections

  2012cited by this paper
• Huntington’s Disease and the Striatal Medium Spiny Neuron: Cell-Autonomous and Non-Cell-Autonomous Mechanisms of Disease

  2012cited by this paper
• Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.

  2012cited by this paper
• Neuroprotection for Stroke: Current Status and Future Perspectives

  2012cited by this paper
• Striatal-Enriched Protein Tyrosine Phosphatase Expression and Activity in Huntington's Disease: A STEP in the Resistance to Excitotoxicity

  2011cited by this paper
• Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

  2011cited by this paper
• Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function.

  2011cited by this paper
• Failures and successes of NMDA receptor antagonists: Molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults

  2011influential reference
• Epidemiology and the global burden of stroke.

  2011cited by this paper
• Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

  2011cited by this paper
• Soluble Aβ Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

  2011influential reference
• Stroke intervention pathways: NMDA receptors and beyond.

  2011cited by this paper
• Caspase-6 and neurodegeneration.

  2011cited by this paper
• A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

  2011cited by this paper
• Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine.

  2011cited by this paper
• PTEN is recruited to the postsynaptic terminal for NMDA receptor‐dependent long‐term depression

  2010cited by this paper
• Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

  2010cited by this paper
• Organization of NMDA receptors at extrasynaptic locations.

  2010cited by this paper
• Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice.

  2010cited by this paper
• Blocking the deadly effects of the NMDA receptor in stroke.

  2010cited by this paper
• Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease.

  2010cited by this paper
• DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.

  2010cited by this paper
• Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo

  2010cited by this paper
• Molecular mechanisms and potential therapeutical targets in Huntington's disease.

  2010cited by this paper
• Synaptic Activity and Nuclear Calcium Signaling Protect Hippocampal Neurons from Death Signal-associated Nuclear Translocation of FoxO3a Induced by Extrasynaptic N-Methyl-d-aspartate Receptors*

  2010cited by this paper
• Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term Potentiation

  2010influential reference
• Fashioning drugs for stroke

  2010cited by this paper
• Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

  2010cited by this paper
• Activation of NR2A Receptors Induces Ischemic Tolerance through CREB Signaling

  2010cited by this paper
• In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

  2010cited by this paper
• Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

  2010influential reference
• Calcium, ischemia and excitotoxicity.

  2010cited by this paper
• Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease.

  2010cited by this paper
• Pre-ischemic treatment with memantine reversed the neurochemical and behavioural parameters but not energy metabolites in middle cerebral artery occluded rats.

  2009cited by this paper
• Human Caspases: Activation, Specificity, and Regulation*

  2009cited by this paper
• In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death.

  2009cited by this paper
• Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

  2009cited by this paper
• Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease

  2009cited by this paper
• Kidins220/ARMS downregulation by excitotoxic activation of NMDARs reveals its involvement in neuronal survival and death pathways

  2009cited by this paper
• Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking.

  2009cited by this paper
• GluN2B subunit-containing NMDA receptor antagonists prevent Aβ-mediated synaptic plasticity disruption in vivo

  2009cited by this paper
• Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias

  2009cited by this paper
• Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake.

  2009cited by this paper
• Interaction of Postsynaptic Density Protein-95 with NMDA Receptors Influences Excitotoxicity in the Yeast Artificial Chromosome Mouse Model of Huntington's Disease

  2009influential reference
• Nerve cell loss in the thalamic centromedian-parafascicular complex in patients with Huntington’s disease

  2009cited by this paper
• Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation.

  2009cited by this paper
• Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

  2009cited by this paper
• Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

  2009influential reference
• Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries

  2009cited by this paper
• Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

  2009cited by this paper
• Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.

  2008cited by this paper
• Memantine protects rat cortical cultured neurons against β‐amyloid‐induced toxicity by attenuating tau phosphorylation

  2008cited by this paper
• Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse.

  2008cited by this paper
• Long‐term potentiation inhibition by low‐level N‐methyl‐D‐aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen‐activated protein kinase

  2008influential reference
• Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.

  2008cited by this paper
• Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95

  2008cited by this paper
• Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity

  2008cited by this paper
• Glutamate Uptake is Reduced in Prefrontal Cortex in Huntington’s Disease

  2008cited by this paper
• Decrease of Protein Phosphatase 2A and its Association with Accumulation and Hyperphosphorylation of Tau in Down Syndrome

  2008cited by this paper
• Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance

  2008cited by this paper
• Calcium Homeostasis and Mitochondrial Dysfunction in Striatal Neurons of Huntington Disease*

  2008cited by this paper
• Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand

  2008cited by this paper
• Altered NMDA Receptor Trafficking in a Yeast Artificial Chromosome Transgenic Mouse Model of Huntington's Disease

  2007cited by this paper
• Protein Kinase C ζ

  2007cited by this paper
• Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration

  2007cited by this paper
• Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices

  2007cited by this paper
• PTEN enters the nuclear age.

  2007cited by this paper
• NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo

  2007influential reference
• Ubiquitination regulates PTEN nuclear import and tumor suppression.

  2007cited by this paper
• Regulation of mitogen‐activated protein kinases by glutamate receptors

  2007cited by this paper

• Harnessing biomaterial application strategies for neurorestoration after ischemic stroke injury: An emerging treatment option

  2025cites this paper
• Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase-B for the Treatment of Alzheimer’s Disease

  2025cites this paper
• In vivo Protection of Vitamin K in NMDA-Induced Memory Impairment

  2024cites this paper
• – Why We See Faces Everywhere : The Pareidolia Phenomenon Patryk Wekwejt

  2020cites this paper
• Differential regulation of Kidins220 isoforms in Huntington's disease

  2019cites this paper
• Triclosan-Evoked Neurotoxicity Involves NMDAR Subunits with the Specific Role of GluN2A in Caspase-3-Dependent Apoptosis

  2018cites this paper