Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Clinical Immunology

• Publication date

  2007-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CLIM.2007.08.003PMID 17897887
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Anti–TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β

  2007cited by this paper
• Expression and functional characterization of FOXP3+CD4+ regulatory T cells in ulcerative colitis

  2007cited by this paper
• Toll-like receptor 2 controls expansion and function of regulatory T cells.

  2006cited by this paper
• Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells.

  2006cited by this paper
• The immune paradox of sarcoidosis and regulatory T cells

  2006cited by this paper
• An Inverse Correlation of Human Peripheral Blood Regulatory T Cell Frequency with the Disease Activity of Ulcerative Colitis

  2006cited by this paper
• Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity

  2006cited by this paper
• Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis.

  2006cited by this paper
• Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.

  2005cited by this paper
• FoxP3+CD4+CD25+ T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease

  2005cited by this paper
• CD4+CD25+ T Cells Prevent the Development of Organ-Specific Autoimmune Disease by Inhibiting the Differentiation of Autoreactive Effector T Cells

  2005cited by this paper
• Mechanisms of suppression by suppressor T cells

  2005cited by this paper
• Transforming growth factor β induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis

  2005cited by this paper
• Toll-Like Receptor 8-Mediated Reversal of CD4+ Regulatory T Cell Function

  2005cited by this paper
• Dysfunctional Blood and Target Tissue CD4+CD25high Regulatory T Cells in Psoriasis: Mechanism Underlying Unrestrained Pathogenic Effector T Cell Proliferation1

  2005cited by this paper
• Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

  2005cited by this paper
• Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease.

  2005cited by this paper
• Mechanisms of suppression by suppressor T cells

  2005cited by this paper
• Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single‐cell level

  2005cited by this paper
• Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

  2004cited by this paper
• Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

  2004cited by this paper
• Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

  2004cited by this paper
• Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II

  2004cited by this paper
• CD4+CD25bright T Cells in Human Intestinal Lamina Propria as Regulatory Cells1

  2004cited by this paper
• Immune Regulation in the Intestine: A Balancing Act between Effector and Regulatory T Cell Responses

  2004cited by this paper
• Regulatory T Cell Suppression and Anergy Are Differentially Regulated by Proinflammatory Cytokines Produced by TLR-Activated Dendritic Cells1

  2004cited by this paper
• CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

  2003cited by this paper
• Phenotype and genotype of interfollicular large B cells, a subpopulation of lymphocytes often with dendritic morphology.

  2003cited by this paper
• CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

  2003cited by this paper
• Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

  2003cited by this paper
• Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25− CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells1

  2003cited by this paper
• CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes.

  2003cited by this paper
• Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells

  2003cited by this paper
• An essential role for Scurfin in CD4+CD25+ T regulatory cells

  2003cited by this paper
• Supporting Online Material

  2003cited by this paper
• Inhibition of Human CD4+CD25+high Regulatory T Cell Function1

  2002cited by this paper
• Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

  2002cited by this paper
• Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

  2001cited by this paper
• Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

  2001cited by this paper
• CD4+CD25high Regulatory Cells in Human Peripheral Blood1

  2001cited by this paper
• The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

  2001cited by this paper
• Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

  2001cited by this paper
• X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

  2001cited by this paper
• Lymphocyte migration in the intestinal mucosa: entry, transit and emigration of lymphoid cells and the influence of antigen.

  1999cited by this paper
• Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

  1996cited by this paper

• Pathobiont-triggered induction of goblet cell response drives regional susceptibility to Inflammatory Bowel Disease.

  2026cites this paper
• Distinct B Cell Subsets Changes as Potential Biomarkers of Response to Biologic Therapy in Crohn’s Disease

  2025cites this paper
• FoxP3-positive T regulatory cells and its effector mechanisms in Crohn’s disease: an immunohistochemical and image morphometric analysis on endoscopic mucosal biopsies

  2025cites this paper
• Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE)

  2025cites this paper
• Advances in Understanding Intestinal Homeostasis: Lessons from Inflammatory Bowel Disease and Monogenic Intestinal Disorder Pathogenesis

  2025cites this paper
• Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease

  2025cites this paper
• Gut microbiota in regulatory T cell generation and function: mechanisms and health implications

  2025cites this paper
• The Heteromeric Dopamine Receptor D2:D3 Controls the Gut Recruitment and Suppressive Activity of Regulatory T-Cells

  2025cites this paper
• T Regulatory Cells in Inflammatory Bowel Disease—Are They Major Players?

  2025cites this paper
• The FOXP3+ Pro-inflammatory T cell: A Potential Therapeutic Target in Crohn's Disease.

  2024cites this paper
• Improving regulatory T cell production through mechanosensing.

  2024cites this paper
• Circulating and intestinal regulatory T cells in inflammatory bowel disease: A systemic review and meta-analysis

  2023influential citation
• Ileocecal involvement in intestinal Behçet's disease and Crohn's disease: comparison of clinicopathological and immunophenotypic features

  2023influential citation
• The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease

  2023cites this paper
• Intestinal Immune Imbalance is an Alarm in the Development of IBD

  2023cites this paper
• Bifidobacterium bifidum FJSWX19M5 alleviated 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced chronic colitis by mitigating gut barrier injury and increasing regulatory T cells.

  2023cites this paper
• Blood regulatory T cells in inflammatory bowel disease, a systematic review, and meta-analysis.

  2023cites this paper
• Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate–induced colitis in mice lacking microsomal prostaglandin E synthase-1

  2022cites this paper
• Rapamycin rescues loss of function in blood-brain barrier–interacting Tregs

  2022cites this paper
• Joint together: The etiology and pathogenesis of ankylosing spondylitis

  2022cites this paper
• Human CD4 + CD8α + Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation

  2022cites this paper
• Impact of gut microenvironment on epigenetic signatures of intestinal T helper cell subsets.

  2022cites this paper
• Human CD4+/CD8α+ regulatory T cells induced by Faecalibacterium prausnitzii protect against intestinal inflammation

  2022cites this paper
• Pro-inflammatory innate-like T cells are expanded in the blood and inflamed intestine in Crohn's Disease

  2022cites this paper
• Improving the Efficacy of Regulatory T Cell Therapy

  2021influential citation
• New Insights on CD8+ T Cells in Inflammatory Bowel Disease and Therapeutic Approaches

  2021cites this paper
• Immunological Networks Defining the Heterogeneity of Inflammatory Bowel Diseases

  2021cites this paper
• Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice

  2021cites this paper
• Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease

  2021cites this paper
• Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation

  2020cites this paper
• Advances in the role of helper T cells in autoimmune diseases

  2020cites this paper
• Immunological outcomes in infants with ROP after dexamethasone and aminophylline

  2020cites this paper
• Dissecting the Heterogeneity in T-Cell Mediated Inflammation in IBD

  2020cites this paper
• Enhancement of Circulating and Intestinal T Regulatory Cells and Their Expression of Helios and Neuropilin-1 in Children with Inflammatory Bowel Disease

  2020cites this paper
• Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α.

  2019cites this paper
• Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease

  2019cites this paper
• Response to LTE 19-01163.

  2019cites this paper
• Regulatory T cells in Crohn's disease following anti‐TNF‐α therapy

  2019cites this paper
• Epigenetic regulation of T helper cells and intestinal pathogenicity

  2019cites this paper
• T-Cell-Driven Inflammation as a Mediator of the Gut-Brain Axis Involved in Parkinson's Disease

  2019cites this paper
• Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease—Focusing on Intestinal Barrier Function

  2019cites this paper
• A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

  2019cites this paper
• pVAX1-A20 alleviates colitis in mice by promoting regulatory T cells.

  2019cites this paper
• Increased frequency of regulatory T cells in pediatric inflammatory bowel disease at diagnosis: a compensative role?

  2019cites this paper
• Immunological mechanisms underpinning faecal microbiota transplantation for the treatment of inflammatory bowel disease

  2019cites this paper
• CD4+CD25+CD127low FoxP3+ regulatory T cells in Crohn’s disease

  2018cites this paper
• GM-CSF Antibodies and Peripheral Treg Cells as Potential Markers of Disease Activity to Guide Therapeutic Decisions in Pediatric IBD

  2018cites this paper
• A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease.

  2018cites this paper
• Immunotherapy in inflammatory bowel disease: Novel and emerging treatments

  2018cites this paper
• Old and New Lymphocyte Players in Inflammatory Bowel Disease

  2018cites this paper
• Current, experimental, and future treatments in inflammatory bowel disease: a clinical review

  2018cites this paper
• Disruption of FOXP3–EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation

  2018cites this paper
• Bacterial imbalance and gut pathologies: Association and contribution of E. coli in inflammatory bowel disease

  2018cites this paper
• CD4+ CD25+ FOXP3+ T cell frequency in the peripheral blood is a biomarker that distinguishes intestinal tuberculosis from Crohn’s disease

  2018cites this paper
• Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis

  2018cites this paper
• Mucosal Immunity Related to FOXP3+ Regulatory T Cells, Th17 Cells and Cytokines in Pediatric Inflammatory Bowel Disease

  2018cites this paper
• Protective Effect of Pogostone on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis via Inhibition of T Helper Cell

  2017cites this paper
• Mouse Models of Chronic Intestinal Inflammation: Characterization and Use in Pharmacological Intervention Studies

  2017cites this paper
• Immunomodulatory tetracyclines: Facing the complexity of intestinal inflammation

  2017cites this paper
• Crosstalk between intestinal epithelial cell and adaptive immune cell in intestinal mucosal immunity

  2017cites this paper
• Different Features of the Regulatory T Cells in Gastrointestinal Tract Cancers and Disorders

  2017cites this paper
• Mucosal immunology and imaging in early Inflammatory Bowel Disease

  2017cites this paper
• Digestive system in psoriasis: an update

  2017cites this paper
• Protein Arginine Methyltransferase 5 Inhibition Upregulates Foxp3+ Regulatory T Cells Frequency and Function during the Ulcerative Colitis

  2017cites this paper
• Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease

  2017cites this paper
• Inflammatory cues enhance TGFβ activation by distinct subsets of human cells via αvβ8.

  2017cites this paper
• IL‐33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs

  2017cites this paper
• Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease.

  2017cites this paper
• Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis

  2016cites this paper
• Basophil-derived IL-6 regulates TH17 cell differentiation and CD4 T cell immunity

  2016cites this paper
• Psoriasis and Inflammatory Bowel Diseases: Epidemiological, Genetic and Pathogenetic Correlations: A Review of Literature

  2016cites this paper
• Disrupted regulatory T cell homeostasis in inflammatory bowel diseases.

  2016cites this paper
• The Role of T-Cell Subsets in Chronic Inflammation in Celiac Disease and Inflammatory Bowel Disease Patients: More Common Mechanisms or More Differences?

  2016cites this paper
• Effect of turmeric on colon histology, body weight, ulcer, IL-23, MPO and glutathione in acetic-acid-induced inflammatory bowel disease in rats

  2016cites this paper
• Psoriasis and inflammatory bowel disease: links and risks

  2016cites this paper
• Psoriasis and Inflammatory Bowel Diseases: Epidemiological, Genetic and Psoriasis and Inflammatory Bowel Diseases: Epidemiological, Genetic and

  2016cites this paper
• Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

  2016cites this paper
• Analysis of regulatory T cells frequency in peripheral blood and tumor tissues in papillary thyroid carcinoma with and without Hashimoto’s thyroiditis

  2015cites this paper
• DIET AND INFLAMMATION: FOCUS ON THE SMALL INTESTINE AND ADIPOSE TISSUE

  2015cites this paper
• Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

  2015cites this paper
• Anti-TNF-alpha loss of response is associated with a decreased percentage of FoxP3+ T cells and a variant NOD2 genotype in patients with Crohn’s disease

  2015cites this paper
• IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

  2015cites this paper
• Expression of T helper type 17 (Th17)-associated cytokines and toll-like receptor 4 and their correlation with Foxp3 positive cells in rectal biopsies of horses with clinical signs of inflammatory bowel disease.

  2015cites this paper
• Oral Manifestations of Crohn's Disease: A Case Report and Review of the Literature

  2015cites this paper
• Immunoregulatory Pathways Involved in Inflammatory Bowel Disease

  2015cites this paper
• Experimental colitis models: Insights into the pathogenesis of inflammatory bowel disease and translational issues.

  2015cites this paper
• STUDY OF REGULATORY T CELLS IN PATIENTS WITH CROHN DISEASE

  2015cites this paper
• The Involvement of Immune Semaphorins in the Pathogenesis of Inflammatory Bowel Diseases (IBDs)

  2015cites this paper
• T-cell Receptor Sequencing Reveals the Clonal Diversity and Overlap of Colonic Effector and FOXP3+ T Cells in Ulcerative Colitis

  2015cites this paper
• The involvement of gut microbiota in inflammatory bowel disease pathogenesis: potential for therapy.

  2015cites this paper
• Human Blood and Mucosal Regulatory T Cells Express Activation Markers and Inhibitory Receptors in Inflammatory Bowel Disease

  2015cites this paper
• Genome-wide gene expression analysis for target genes to differentiate patients with intestinal tuberculosis and Crohn’s disease and discriminative value of FOXP3 mRNA expression

  2015cites this paper
• Promises and paradoxes of regulatory T cells in inflammatory bowel disease.

  2015cites this paper
• Regulatory T-cells in autoimmune diseases: challenges, controversies and--yet--unanswered questions.

  2015cites this paper
• The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut.

  2014cites this paper
• In vitro generation of human FOXP3+ regulatory T cells

  2014cites this paper
• Alteration in frequency and function of CD4⁺CD25⁺FOXP3⁺ regulatory T cells in patients with immune thrombocytopenic purpura.

  2014cites this paper
• The Dopaminergic System in Autoimmune Diseases

  2014cites this paper
• Effects of Dietary Glutamine on the Homeostasis of CD4+ T Cells in Mice with Dextran Sulfate Sodium-Induced Acute Colitis

  2014cites this paper
• Functional dynamics of Foxp3+ regulatory T cells in mice and humans

  2014cites this paper