Structure of the complex of an Fab fragment of a neutralizing antibody with foot‐and‐mouth disease virus: positioning of a highly mobile antigenic loop

No abstract is available for this paper.

• Publication year

  1997

• Venue

  EMBO Journal

• Publication date

  1997-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/16.7.1492PMID 9130694PMCID PMC1169753
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The model-based approach

  1998cited by this paper
• Structure of a neutralizing antibody bound bivalently to human rhinovirus 2.

  1996influential reference
• Induced pocket to accommodate the cell attachment Arg-Gly-Asp motif in a neutralizing antibody against foot-and-mouth-disease virus.

  1996cited by this paper
• A model-based approach for determining orientations of biological macromolecules imaged by cryoelectron microscopy.

  1996cited by this paper
• Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon

  1996cited by this paper
• Three-dimensional reconstruction of icosahedral particles--the uncommon line.

  1996cited by this paper
• Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity.

  1996cited by this paper
• Structure of the complex between the Fab fragment of a neutralizing antibody for type 1 poliovirus and its viral epitope

  1995cited by this paper
• Antibody recognition of picornaviruses and escape from neutralization: a structural view.

  1995influential reference
• Structure of the major antigenic loop of foot‐and‐mouth disease virus complexed with a neutralizing antibody: direct involvement of the Arg‐Gly‐Asp motif in the interaction.

  1995cited by this paper
• Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67.

  1995cited by this paper
• Two dominant neutralizing antigenic determinants of canine parvovirus are found on the threefold spike of the virus capsid.

  1994cited by this paper
• Crystal structure of a human rhinovirus neutralizing antibody complexed with a peptide derived from viral capsid protein VP2.

  1994cited by this paper
• The structure of a neutralized virus: canine parvovirus complexed with neutralizing antibody fragment.

  1994cited by this paper
• Crystallization and preliminary x‐ray diffraction studies of a monoclonal antibody fab fragment against foot‐and‐mouth disease virus and of its complex with the main antigenic site peptide

  1994cited by this paper
• RGD sequence of foot-and-mouth disease virus is essential for infecting cells via the natural receptor but can be bypassed by an antibody-dependent enhancement pathway.

  1994cited by this paper
• Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites

  1994cited by this paper
• Crystal structure of the principal neutralization site of HIV-1.

  1994cited by this paper
• The structure and antigenicity of a type C foot-and-mouth disease virus.

  1994cited by this paper
• The viral canyon.

  1993cited by this paper
• The viral canyon

  1993cited by this paper
• Structure of a major immunogenic site on foot-and-mouth disease virus

  1993influential reference
• Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibody

  1993cited by this paper
• Neutralization of Animal Viruses

  1993cited by this paper
• Use of substituted and tandem‐repeated peptides to probe the relevance of the highly conserved RGD tripeptide in the immune response against foot‐and‐mouth disease virus

  1993cited by this paper
• Virus-ligand structures: the viral canyon.

  1993cited by this paper
• Structure of a human rhinovirus complexed with its receptor molecule.

  1993cited by this paper
• Structure of a human rhinovirus-bivalently bound antibody complex: implications for viral neutralization and antibody flexibility.

  1993cited by this paper
• Amino acid changes outside the G-H loop of capsid protein VP1 of type O foot-and-mouth disease virus confer resistance to neutralization by antipeptide G-H serum.

  1993cited by this paper
• Structure of bluetongue virus particles by cryoelectron microscopy.

  1992cited by this paper
• Identification of a Fab interaction footprint site on an icosahedral virus by cryoelectron microscopy and X-ray crystallography

  1992cited by this paper
• New approaches to vaccination against foot-and-mouth disease.

  1992cited by this paper
• Three-dimensional reconstruction of baculovirus expressed bluetongue virus core-like particles by cryo-electron microscopy.

  1992cited by this paper
• Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus.

  1992cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• Genetic Variability and Antigenic Diversity of Foot-and-Mouth Disease Virus

  1990cited by this paper
• Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus

  1990influential reference
• The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

  1989cited by this paper
• The T=4 envelope of Sindbis virus is organized by interactions with a complementary T=3 capsid.

  1987cited by this paper
• Reactivity with monoclonal antibodies of viruses from an episode of foot-and-mouth disease.

  1987cited by this paper
• Continuous and discontinuous protein antigenic determinants

  1986cited by this paper
• Structure of a human common cold virus and functional relationship to other picornaviruses

  1985cited by this paper
• Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.

  1982cited by this paper
• Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

  1982cited by this paper
• Location and characterization of the antigenic portion of the FMDV immunizing protein.

  1982cited by this paper
• Early interactions of foot-and-mouth disease virus with cultured cells.

  1980cited by this paper
• Structure of foot-and-mouth disease virus capsid.

  1979cited by this paper
• Procedures for three-dimensional reconstruction of spherical viruses by Fourier synthesis from electron micrographs.

  1971cited by this paper

• Virus-Receptor Interactions and Receptor-Mediated Virus Entry into Host Cells.

  2024cites this paper
• Integrative Approaches to Study Virus Structures.

  2024cites this paper
• A broadly reactive ultralong bovine antibody that can determine the integrity of foot-and-mouth disease virus capsids

  2024cites this paper
• Prediction of Paratope–Epitope Pairs Using Convolutional Neural Networks

  2024cites this paper
• A meta-analysis: the efficacy and effectiveness of polypeptide vaccines protect pigs from foot and mouth disease

  2022cites this paper
• Trans-Encapsidation of Foot-and-Mouth Disease Virus Genomes Facilitates Escape from Neutralizing Antibodies

  2022cites this paper
• Electron microscopy holdings of the Protein Data Bank: the impact of the resolution revolution, new validation tools, and implications for the future

  2022cites this paper
• Evolution of standardization and dissemination of cryo-EM structures and data jointly by the community, PDB, and EMDB

  2021cites this paper
• Icosahedral virus structures and the protein data bank

  2021cites this paper
• Structures of Foot-and-Mouth Disease Virus with Bovine Neutralizing Antibodies Reveal the Determinant of Intraserotype Cross-Neutralization

  2021cites this paper
• Two Cross-Protective Antigen Sites on Foot-and-Mouth Disease Virus Serotype O Structurally Revealed by Broadly Neutralizing Antibodies from Cattle

  2021cites this paper
• Functional and in silico Characterization of Neutralizing Interactions Between Antibodies and the Foot-and-Mouth Disease Virus Immunodominant Antigenic Site

  2021cites this paper
• Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization

  2021cites this paper
• Vertebrate and Invertebrate Respiratory Proteins, Lipoproteins and other Body Fluid Proteins

  2020cites this paper
• Antigen-Antibody Complexes.

  2020cites this paper
• In silico site-directed mutagenesis of neutralizing mAb 4C4 and analysis of its interaction with G-H loop of VP1 to explore its therapeutic applications against FMD

  2018cites this paper
• Generation and characterisation of recombinant FMDV antibodies: Applications for advancing diagnostic and laboratory assays

  2018cites this paper
• Evidence of VP1 of duck hepatitis A type 1 virus as a target of neutralizing antibodies and involving receptor-binding activity.

  2017cites this paper
• Preserved immunogenicity of an inactivated vaccine based on foot-and-mouth disease virus particles with improved stability.

  2017cites this paper
• Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site

  2017cites this paper
• The VP1 S154D mutation of type Asia1 foot-and-mouth disease virus enhances viral replication and pathogenicity.

  2016cites this paper
• Transmission electron microscopy and the molecular structure of icosahedral viruses.

  2015cites this paper
• The in silico prediction of foot-and-mouth disease virus (FMDV) epitopes on the South African territories (SAT)1, SAT2 and SAT3 serotypes

  2015cites this paper
• Structural Basis of Human Parechovirus Neutralization by Human Monoclonal Antibodies

  2015cites this paper
• Analysis of the bacteriophage P22 viral spread within bacterial populations and its characterization as immunobiosensor

  2015cites this paper
• The 3-dimensional play of human parechovirus infection; Cell, virus and antibody

  2014cites this paper
• Three-dimensional structure of foot-and-mouth disease virus and its biological functions

  2014cites this paper
• Structure and Physics of Viruses

  2013cites this paper
• Evaluation and Use of In-Silico Structure-Based Epitope Prediction with Foot-and-Mouth Disease Virus

  2013cites this paper
• Virus-Receptor Interactions and Receptor-Mediated Virus Entry into Host Cells

  2013cites this paper
• Combined approaches to study virus structures.

  2013cites this paper
• DNA-sustained , nanoparticulate architecture of 3 artificial viruses build by multifunctional proteins

  2013cites this paper
• Development and characterization of artificial viruses for gene therapy

  2013cites this paper
• Nanoparticulate architecture of protein-based artificial viruses is supported by protein-DNA interactions.

  2011cites this paper
• Identification of a conformational epitope on the VP1 G-H Loop of type Asia1 foot-and-mouth disease virus defined by a protective monoclonal antibody.

  2011cites this paper
• Effects of macromolecular crowding on the inhibition of virus assembly and virus-cell receptor recognition.

  2011cites this paper
• Neutralization Efficiency Is Greatly Enhanced by Bivalent Binding of an Antibody to Epitopes in the V4 Region and the Membrane-Proximal External Region within One Trimer of Human Immunodeficiency Virus Type 1 Glycoproteins

  2010cites this paper
• Antibody–Antigen Recognition and Conformational Changes

  2010cites this paper
• The three-dimensional structure of Infectious flacherie virus capsid determined by cryo-electron microscopy

  2009cites this paper
• Structural Comparison of Different Antibodies Interacting with Parvovirus Capsids

  2009cites this paper
• Structure and dynamics of the GH loop of the foot-and-mouth disease virus capsid.

  2009cites this paper
• Non-toxic Pseudomonas aeruginosa exotoxin A expressing the FMDV VP1 G-H loop for mucosal vaccination of swine against foot and mouth disease virus.

  2007cites this paper
• Guinea Pig-Adapted Foot-and-Mouth Disease Virus with Altered Receptor Recognition Can Productively Infect a Natural Host

  2007cites this paper
• Minute Virus of Mice, a Parvovirus, in Complex with the Fab Fragment of a Neutralizing Monoclonal Antibody

  2007cites this paper
• Productive entry of type C foot-and-mouth disease virus into susceptible cultured cells requires clathrin and is dependent on the presence of plasma membrane cholesterol.

  2007cites this paper
• Specificity of the VP1 GH Loop of Foot-and-Mouth Disease Virus for αv Integrins

  2006cites this paper
• Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins.

  2006cites this paper
• Specificity of the VP1 GH Loop of Foot-and-Mouth Disease Virus for (cid:2) v Integrins

  2006cites this paper
• 19.7. Nuclear magnetic resonance (NMR) spectroscopy

  2006cites this paper
• The structure of foot-and-mouth disease virus.

  2005cites this paper
• Early events in cell entry by foot-and-mouth disease virus.

  2005cites this paper
• Analysis of the immune response against mixotope peptide libraries from a main antigenic site of foot-and-mouth disease virus.

  2005cites this paper
• Valency of antibody binding to virions and its determination by surface plasmon resonance

  2004cites this paper
• Structure of foot-and-mouth disease virus particles.

  2004cites this paper
• Functional and structural aspects of the interaction of foot-and-mouth disease virus with antibodies.

  2004cites this paper
• Foot-and-mouth disease virus peptide vaccines.

  2004cites this paper
• Evolution of Cell Recognition by Viruses: A Source of Biological Novelty with Medical Implications

  2004cites this paper
• Valency of Antibody Binding to Enveloped Virus Particles as Determined by Surface Plasmon Resonance

  2003cites this paper
• Recovery of Infectious Foot-and-Mouth Disease Virus from Suckling Mice after Direct Inoculation with In Vitro-Transcribed RNA

  2003cites this paper
• Structure and receptor binding.

  2003cites this paper
• Docking of atomic models into reconstructions from electron microscopy.

  2003cites this paper
• Antigenic sites of coxsackie A9 virus inducing neutralizing monoclonal antibodies protective in mice.

  2003cites this paper
• Hybrid vigor: hybrid methods in viral structure determination.

  2003cites this paper
• CHAPTER 6 – Antibody–Antigen Recognition and Conformational Changes

  2003cites this paper
• Structural quality assurance.

  2003cites this paper
• Structural studies on antibody-virus complexes.

  2003cites this paper
• Structures of Host Range-Controlling Regions of the Capsids of Canine and Feline Parvoviruses and Mutants

  2003cites this paper
• Evidence of the Coevolution of Antigenicity and Host Cell Tropism of Foot-and-Mouth Disease Virus In Vivo

  2003cites this paper
• Foot-and-mouth disease virus.

  2002cites this paper
• Duration and fitness dependence of quasispecies memory.

  2002cites this paper
• Antibody Interactions with Rhinovirus

  2002cites this paper
• Occupancy and mechanism in antibody-mediated neutralization of animal viruses.

  2002cites this paper
• Error Frequencies of Picornavirus RNA Polymerases: Evolutionary Implications for Virus Populations

  2002cites this paper
• A novel three-dimensional variant of the watershed transform for segmentation of electron density maps.

  2002cites this paper
• Antigenic Variation in Foot-and-Mouth Disease Virus

  2002cites this paper
• Picornavirus Structure Overview

  2002cites this paper
• Antibody inhibition of the transcriptase activity of the rotavirus DLP: a structural view.

  2001cites this paper
• RGD Tripeptide of Bluetongue Virus VP7 Protein Is Responsible for Core Attachment to Culicoides Cells

  2001cites this paper
• Do Bioactive Peptides Display Native-Like Conformations When Bound to a Solid Support?

  2001cites this paper
• Antibody interactions with rhinovirus: lessons for mechanisms of neutralization and the role of immunity in viral evolution.

  2001cites this paper
• Structural studies on antibody interacting with viruses.

  2001cites this paper
• Evidence that Equine Rhinitis A Virus VP1 Is a Target of Neutralizing Antibodies and Participates Directly in Receptor Binding

  2001cites this paper
• Epidémiologie moléculaire de la fièvre aphteuse

  2001cites this paper
• Foot-and-mouth disease virus lacking the VP1 G-H loop: the mutant spectrum uncovers interactions among antigenic sites for fitness gain.

  2001cites this paper
• Phosphorylation Status of the Parvovirus Minute Virus of Mice Particle: Mapping and Biological Relevance of the Major Phosphorylation Sites

  2000cites this paper
• Cell Recognition by Foot-and-Mouth Disease Virus That Lacks the RGD Integrin-Binding Motif: Flexibility in Aphthovirus Receptor Usage

  2000cites this paper
• The cellular receptor to human rhinovirus 2 binds around the 5‐fold axis and not in the canyon: a structural view

  2000cites this paper
• Mechanisms and in-vivo Significance of HIV-1 Neutralisation

  2000cites this paper
• A multiply substituted G-H loop from foot-and-mouth disease virus in complex with a neutralizing antibody: a role for water molecules.

  2000cites this paper
• Surface plasmon resonance as a tool in the functional analysis of an immunodominant site in foot-and-mouth disease virus

  2000cites this paper
• Supplanting crystallography or supplementing microscopy? A combined approach to the study of an enveloped virus.

  2000cites this paper
• When two into one won't go: fitting in the presence of steric hindrance and partial occupancy.

  2000cites this paper
• The need for a shared database infrastructure: combining X-ray crystallography and electron microscopy

  2000cites this paper
• Adding the Third Dimension to Virus Life Cycles: Three-Dimensional Reconstruction of Icosahedral Viruses from Cryo-Electron Micrographs

  2000cites this paper
• The neutralizing antibody response to HIV-1: viral evasion and escape from humoral immunity.

  1999cites this paper
• Biochemical and structural studies with neutralizing antibodies raised against foot-and-mouth disease virus.

  1999cites this paper
• Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet.

  1999cites this paper
• Picornaviruses: epitopes, canyons, and pockets.

  1999cites this paper
• Immunoglobulin Structure and Function as Revealed by Electron Microscopy

  1999cites this paper
• Detection of molecular interactions by using a new peptide-displaying bacteriophage biosensor.

  1999cites this paper